Polycystic kidney disease pathway (Homo sapiens)
From WikiPathways
Description
A putative PKD pathway proposed in Torres 2009 (Figure 2), showing up or down regulated genes.
Quality Tags
Ontology Terms
Pathway Ontology : signaling pathway kidney disease pathway
Disease : polycystic kidney disease
Cell Type : kidney cell
Bibliography
- Torres VE, Harris PC; ''Autosomal dominant polycystic kidney disease: the last 3 years.''; Kidney Int, 2009 PubMed Europe PMC Scholia
- ''Growth hormone synthesis, secretion and action''; https://www.genome.jp/pathway/hsa04935,
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
ADCY6 | GeneProduct | ADCY6 (HGNC) | |
ADP | Metabolite | CHEBI:16761 (ChEBI) | |
AMP | Metabolite | CHEBI:16027 (ChEBI) | |
AMP | Metabolite | CHEBI:16027 (ChEBI) | |
ATP | Metabolite | CHEBI:15422 (ChEBI) | |
BRAF | GeneProduct | ENSG00000157764 (Ensembl) | |
CCND1 | GeneProduct | ENSG00000110092 (Ensembl) | |
CFTR | GeneProduct | CFTR (HGNC) | |
CTNNB1 | GeneProduct | ENSG00000168036 (Ensembl) | |
Ca2+ | Metabolite | CHEBI:29108 (ChEBI) | |
Cl- | Metabolite | CHEBI:17996 (ChEBI) | |
DVL1 | GeneProduct | DVL1 (HGNC) | |
DVL2 | GeneProduct | DVL2 (HGNC) | |
DVL3 | GeneProduct | DVL3 (HGNC) | |
EGF | GeneProduct | ENSG00000138798 (Ensembl) | |
ERBB2 | GeneProduct | ERBB2 (HGNC) | |
ERK1 | GeneProduct | ENSG00000102882 (Ensembl) | |
FLT1 | GeneProduct | FLT1 (HGNC) | |
FOS | GeneProduct | FOS (HGNC) | |
FZD10 | GeneProduct | FZD10 (HGNC) | |
FZD1 | GeneProduct | FZD1 (HGNC) | |
FZD2 | GeneProduct | FZD2 (HGNC) | |
FZD3 | GeneProduct | FZD3 (HGNC) | |
FZD4 | GeneProduct | FZD4 (HGNC) | |
FZD5 | GeneProduct | FZD5 (HGNC) | |
FZD6 | GeneProduct | FZD6 (HGNC) | |
FZD7 | GeneProduct | FZD7 (HGNC) | |
FZD8 | GeneProduct | FZD8 (HGNC) | |
FZD9 | GeneProduct | FZD9 (HGNC) | |
GNA11 | GeneProduct | GNA11 (HGNC) | |
GNAI1 | GeneProduct | GNAI1 (HGNC) | |
GNAI2 | GeneProduct | GNAI2 (HGNC) | |
GNAI3 | GeneProduct | GNAI3 (HGNC) | |
GNAQ | GeneProduct | GNAQ (HGNC) | |
GNAS | GeneProduct | GNAS (HGNC) | |
GSK3B | GeneProduct | GSK3B (HGNC) | |
HRAS | GeneProduct | HRAS (HGNC) | |
IGF1 | GeneProduct | ENSG00000017427 (Ensembl) | |
IGF1R | GeneProduct | IGF1R (HGNC) | |
IKBKB | GeneProduct | ENSG00000104365 (Ensembl) | |
IP3 | Metabolite | CHEBI:16595 (ChEBI) | |
JUN | GeneProduct | ENSG00000177606 (Ensembl) | |
K+ | Metabolite | CHEBI:29103 (ChEBI) | |
KCNN4 | GeneProduct | KCNN4 (HGNC) | |
KDR | GeneProduct | KDR (HGNC) | |
KRAS | GeneProduct | KRAS (HGNC) | |
LKB1 | GeneProduct | ENSG00000118046 (Ensembl) | |
MAP2K2 | GeneProduct | MAP2K2 (HGNC) | |
MTOR | GeneProduct | ENSG00000198793 (Ensembl) | |
MYC | GeneProduct | ENSG00000136997 (Ensembl) | |
Metformin | Metabolite | CHEBI:6801 (ChEBI) | |
Mozavaptan | Metabolite | CHEBI:135694 (ChEBI) | |
NKCC1 | GeneProduct | ENSG00000064651 (Ensembl) | |
NRAS | GeneProduct | NRAS (HGNC) | |
Na+/K+-ATPase | |||
Na+ | Metabolite | CHEBI:29101 (ChEBI) | |
PDE1A | GeneProduct | PDE1A (HGNC) | |
PKA | GeneProduct | ENSG00000165059 (Ensembl) | |
PKD1 | GeneProduct | ENSG00000008710 (Ensembl) | Also known as PKD1. |
PKD2 | GeneProduct | ENSG00000118762 (Ensembl) | Also known as PKD2. |
PLCG2 | GeneProduct | PLCG2 (HGNC) | |
PRKAA1 | GeneProduct | PRKAA1 (HGNC) | |
PRKAA2 | GeneProduct | PRKAA2 (HGNC) | |
PRKAB1 | GeneProduct | PRKAB1 (HGNC) | |
PRKAB2 | GeneProduct | PRKAB2 (HGNC) | |
PRKAG1 | GeneProduct | PRKAG1 (HGNC) | |
PRKAG2 | GeneProduct | PRKAG2 (HGNC) | |
PRKAG3 | GeneProduct | PRKAG3 (HGNC) | |
Protein synthesis | Pathway | ||
RHEB | GeneProduct | ENSG00000106615 (Ensembl) | |
RSK | GeneProduct | RPS6KA1 (HGNC) | |
SOC | GeneProduct | ||
SRC | GeneProduct | ENSG00000197122 (Ensembl) | |
SSTR2 | GeneProduct | SSTR2 (HGNC) | |
Satavaptan | Metabolite | Q7425965 (Wikidata) | |
Somatostatin | Metabolite | HMDB0013072 (HMDB) | |
TNF | GeneProduct | ENSG00000204490 (Ensembl) | |
TNF | GeneProduct | ENSG00000232810 (Ensembl) | |
TSC1 | GeneProduct | ENSG00000165699 (Ensembl) | |
TSC2 | GeneProduct | ENSG00000103197 (Ensembl) | |
Tolvaptan | Metabolite | CHEBI:32246 (ChEBI) | |
Triptolide | Metabolite | CHEBI:9747 (ChEBI) | |
V2R | AVPR2 (HGNC) | ||
VEGFB | GeneProduct | ENSG00000173511 (Ensembl) | |
Vasopressin | Metabolite | HMDB0001980 (HMDB) | |
WNT10A | GeneProduct | WNT10A (HGNC) | |
WNT10B | GeneProduct | WNT10B (HGNC) | |
WNT11 | GeneProduct | WNT11 (HGNC) | |
WNT16 | GeneProduct | WNT16 (HGNC) | |
WNT1 | GeneProduct | WNT1 (HGNC) | |
WNT2B | GeneProduct | WNT2B (HGNC) | |
WNT2 | GeneProduct | WNT2 (HGNC) | |
WNT3A | GeneProduct | WNT3A (HGNC) | |
WNT3 | GeneProduct | WNT3 (HGNC) | |
WNT4 | GeneProduct | WNT4 (HGNC) | |
WNT5A | GeneProduct | WNT5A (HGNC) | |
WNT5B | GeneProduct | WNT5B (HGNC) | |
WNT6 | GeneProduct | WNT6 (HGNC) | |
WNT7A | GeneProduct | WNT7A (HGNC) | |
WNT7B | GeneProduct | WNT7B (HGNC) | |
WNT8A | GeneProduct | WNT8A (HGNC) | |
WNT8B | GeneProduct | WNT8B (HGNC) | |
WNT9A | GeneProduct | WNT9A (HGNC) | |
WNT9B | GeneProduct | WNT9B (HGNC) | |
cAMP | Metabolite | CHEBI:17489 (ChEBI) | |
lixivaptan | Metabolite | Q6659958 (Wikidata) | |
sFRP4 | GeneProduct | ENSG00000106483 (Ensembl) |
Annotated Interactions
No annotated interactions