Glial cell differentiation (Bos taurus)

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Description

Glial cells, consisting of microglia, astrocytes, and oligodendrocyte lineage cells as their major components, constitute a large fraction of the mammalian brain. Originally considered as purely non-functional glue for neurons, decades of research have highlighted the importance as well as further functions of glial cells. Source: [10.3389/fncel.2017.00024](https://doi.org/10.3389/fncel.2017.00024). Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP2276)

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2276(63194) with a 100.0% conversion rate.

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Ontology Terms

 

Bibliography

  1. Lehotzky A, Lau P, Tokési N, Muja N, Hudson LD, Ovádi J; ''Tubulin polymerization-promoting protein (TPPP/p25) is critical for oligodendrocyte differentiation.''; Glia, 2010 PubMed Europe PMC Scholia
  2. Cai J, Tuong CM, Zhang Y, Shields CB, Guo G, Fu H, Gozal D; ''Mouse intermittent hypoxia mimicking apnoea of prematurity: effects on myelinogenesis and axonal maturation.''; J Pathol, 2012 PubMed Europe PMC Scholia
  3. Curtis R, Hardy R, Reynolds R, Spruce BA, Wilkin GP; ''Down-regulation of GAP-43 During Oligodendrocyte Development and Lack of Expression by Astrocytes In Vivo: Implications for Macroglial Differentiation.''; Eur J Neurosci, 1991 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
142125view07:10, 4 December 2025KhanspersModified description
117053view14:17, 16 May 2021EweitzModified title
87537view02:06, 25 July 2016AlexanderPicoOntology Term : 'signaling pathway' added !
87536view02:06, 25 July 2016AlexanderPicoOntology Term : 'signaling pathway pertinent to development' added !
80792view15:26, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CNPGeneProductENSBTAG00000025762 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000173786
GAP43GeneProductENSBTAG00000006451 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000172020
MAGGeneProductENSBTAG00000017044 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105695
MBPGeneProductENSBTAG00000022890 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197971
MSNGeneProductENSBTAG00000003418 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000147065
PLP1GeneProductENSBTAG00000006977 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000123560
TPPPGeneProductENSBTAG00000047116 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000171368
bta-mir-206GeneProductENSBTAG00000036400 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000207604

Annotated Interactions

No annotated interactions
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