Model depicting endoderm specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell lines, following differentiation to multiple lineages (ectoderm, mesoderm, endoderm, embryoid body). The underlying genomic data can be obtained from:
https://www.synapse.org/#!Synapse:syn1773109
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway WP2853(80410) with a 39.0% conversion rate.
Kang, Won, Rhee, Ro; ''Siah ubiquitin ligases modulate nodal signaling during zebrafish embryonic development.''; Molecules and Cells, 2014 PubMedEurope PMCScholia
Lewis SL, Khoo PL, De Young RA, Steiner K, Wilcock C, Mukhopadhyay M, Westphal H, Jamieson RV, Robb L, Tam PP; ''Dkk1 and Wnt3 interact to control head morphogenesis in the mouse.''; Development, 2008 PubMedEurope PMCScholia
Sui, Mfopou, Geens, Sermon, Bouwens; ''FGF signaling via MAPK is required early and improves Activin A-induced definitive endoderm formation from human embryonic stem cells.''; Biochem Biophys Res Commun., 2012 PubMedEurope PMCScholia
Bourillot, Aksoy, Schreiber, Wianny, Schulz, Hummel, Hubner, Savatier; ''Novel STAT3 target genes exert distinct roles in the inhibition of mesoderm and endoderm differentiation in cooperation with Nanog.''; Stem Cells, 2009 PubMedEurope PMCScholia
Tsuneyoshi, Tan, Poobalan, Sumi, Nakatsuji, Suemori, Dunn; ''The SMAD2/3 corepressor SNON maintains pluripotency through selective repression of mesendodermal genes in human ES cells.''; Genes Dev., 2012 PubMedEurope PMCScholia
Chappell, Sun, Singh, Dalton; ''MYC/MAX control ERK signaling and pluripotency by regulation of dual-specificity phosphatases 2 and 7''; Genes Dev, 2013 PubMedEurope PMCScholia
Putzke, Rothman; ''Repression of Wnt signaling by a Fer-type nonreceptor tyrosine kinase.''; Proc Natl Acad Sci USA, 2010 PubMedEurope PMCScholia
Kim, Yoon, Chuong, Oyolu, Wills, Gupta, Baker; ''Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs''; Developmental Biology, 2011 PubMedEurope PMCScholia
Futaki, Hayashi, Emoto, Weber, Sekiguchi; ''Sox7 plays crucial roles in parietal endoderm differentiation in F9 embryonal carcinoma cells through regulating Gata-4 and Gata-6 expression.''; Mol Cell Biol., 2004 PubMedEurope PMCScholia
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