ROBO4 and VEGF signaling crosstalk (Homo sapiens)

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1PermeabilityAngiogenesisRAC1KDRVEGFAROBO4SLIT2SRC


Description

This pathway is based on Figure 2 of "Robo4" (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637482/). The gene Robo4 plays a role in regulating vascular stability in mice. Robo4 inhibits the gene Notch1, which regulates tip cell formation, in order to create more tip cells. Robo4 also inhibits cell migration, decreasing vessel complexity. The combination of Slit2 and Robo4 inhibits the activation of Src by VEGF-165 and VEGFR2. This inhibition reduces vascular leakage of Evans Blue from retinal blood vessels. More experimentation is necessary to determine whether Robo4 will inhibit other members of the Src family. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

Comments

HomologyMapper 
This pathway was inferred from Mus musculus pathway "Robo4 and VEGF Signaling Pathways Crosstalk", WP3864 revision 89750, with a 100.0% conversion rate.

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Ontology Terms

 

Bibliography

  1. Weitzman M, Bayley EB, Naik UP; ''Robo4: a guidance receptor that regulates angiogenesis.''; Cell Adh Migr, 2008 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129742view01:54, 22 May 2024EweitzModified title
117818view14:54, 22 May 2021EweitzModified title
106492view21:42, 4 September 2019KhanspersModified description
105805view22:52, 15 August 2019KhanspersModified description
90823view18:50, 14 December 2016KhanspersOntology Term : 'Notch signaling pathway' added !
90822view18:49, 14 December 2016KhanspersOntology Term : 'regulatory pathway' added !
90821view18:48, 14 December 2016KhanspersNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
KDRGeneProductENSG00000128052 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000062960
RAC1GeneProductENSG00000136238 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000001847
ROBO4GeneProductENSG00000154133 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000032125
SLIT2GeneProductENSG00000145147 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000031558
SRCGeneProductENSG00000197122 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000027646
VEGFAGeneProductENSG00000112715 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000023951

Annotated Interactions

No annotated interactions
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