AKT signaling and ARTD family members (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none NucleusAdaptorGSK3BPHLPP1PDK1LKB1AMPKTSC1TSC2FOXO1SIRT1PARP1PARP2PARP3p27KipATPPARP1SIRT1PARP1PIK3CAPIK3CBPIK3CGPIK3CDClass 1 catalyticPIK3R1PIK3R2PIK3R3PIK3R4Class 1 regulatoryPIK3R5PIK3R6PIK3C2APIK3C2BPIK3C2GClass 2PIK3C2AClass 3PI3KRPTORMTORMLST8mTORC1RICTORMAPKAP1MLST8MTORmTORC2AKT1AKT2AKT3AKT1AKT2AKT3AKTAKTAKT1AKT2AKT3AKTIKBKGNEMOMTORATMSignalosomePARP3PARP2PARP1FOXO1LegendNon-enzymatic / unknownNF-kBJAK/STATWnt/Beta-cateninMAPKAKTARTD family membersand signaling pathwaysName: AKT signaling and ARTD family membersOrganism: Homo sapiens


Description

There are only a few conflicting findings regarding the regulation of ARTD family members by AKT signaling. In one type of astrocyte, seizure induction increased both PARP1 levels and enzymatic activity, whereas in another type, seizures resulted in a decrease in PARP1 and its activity. In both scenarios, inhibiting AKT signaling reduced PARP1 protein levels and activity. This suggests that AKT may play a role in promoting PARP1 expression and signaling. Inspired by figure 5 in [Boehi et al. (2021)](https://pmc.ncbi.nlm.nih.gov/articles/PMC8560908/#Sec22).

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Quality Tags

Image:Curated.pngReview changes for Approved
Image:MissingXref.pngAnnotate nodes

Ontology Terms

Pathway Ontology : signaling pathway
 

Bibliography

  1. Boehi F, Manetsch P, Hottiger MO; ''Interplay between ADP-ribosyltransferases and essential cell signaling pathways controls cellular responses.''; Cell Discov, 2021 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
138572view07:27, 19 April 2025Ash iyerupdated data node identifiers
138452
Approved
view03:13, 8 April 2025EweitzLabel organelle
138451view03:07, 8 April 2025EweitzClear board dimension cache
138450view03:06, 8 April 2025EweitzEconomize layout
138447view03:02, 8 April 2025EweitzAdd table of contents for ARTD pathway series
138440view02:38, 8 April 2025EweitzOntology Term : 'signaling pathway' added !
138439view02:35, 8 April 2025EweitzModified description
138438view02:29, 8 April 2025EweitzAdd literature reference
138437view02:28, 8 April 2025EweitzRemove description
138436view02:27, 8 April 2025EweitzModified description
138435view02:20, 8 April 2025EweitzAlign nodes
138434view02:19, 8 April 2025EweitzAdd legend
138433view02:18, 8 April 2025EweitzRefine interactions
138432view02:12, 8 April 2025EweitzEconomize layout
138431view02:08, 8 April 2025EweitzAdd interactions
138430view02:05, 8 April 2025EweitzAdd interactions
138429view01:52, 8 April 2025EweitzAdd interactions
138428view01:33, 8 April 2025EweitzAdd cell compartments, arrange nodes
138427view01:08, 8 April 2025EweitzArrange nodes
138426view00:46, 8 April 2025EweitzExpand "Signalo"
138425view00:25, 8 April 2025EweitzExpand AKT
138424view00:13, 8 April 2025EweitzExpand mTORC2
138423view00:07, 8 April 2025EweitzExpand mTORC1
138422view00:02, 8 April 2025EweitzExpand PI3K node
138421view23:41, 7 April 2025EweitzAdd identifiers to genes
138418view01:06, 7 April 2025EweitzArrange nodes
138330view23:22, 30 March 2025EweitzNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
AKT1GeneProductENSG00000142208 (Ensembl)
AKT2GeneProductENSG00000105221 (Ensembl)
AKT3GeneProductENSG00000117020 (Ensembl)
AKTPathwayWP5531 (WikiPathways)
AMPKGeneProduct
ATMGeneProductENSG00000149311 (Ensembl)
ATPMetabolite15422 (ChEBI)
AdaptorGeneProduct
FOXO1GeneProductENSG00000150907 (Ensembl)
GSK3BGeneProductENSG00000082701 (Ensembl)
IKBKGGeneProductENSG00000269335 (Ensembl)
JAK/STATPathwayWP5528 (WikiPathways)
LKB1GeneProduct6794 (Entrez Gene)
MAPKAP1GeneProductENSG00000119487 (Ensembl)
MAPKPathwayWP5530 (WikiPathways)
MLST8GeneProductENSG00000167965 (Ensembl)
MTORGeneProductENSG00000198793 (Ensembl)
NF-kBPathwayWP5527 (WikiPathways)
PARP1GeneProductENSG00000143799 (Ensembl)
PARP2GeneProductENSG00000129484 (Ensembl)
PARP3GeneProductENSG00000041880 (Ensembl)
PDK1GeneProductENSG00000152256 (Ensembl)
PHLPP1GeneProductENSG00000081913 (Ensembl)
PIK3C2AGeneProductENSG00000011405 (Ensembl)
PIK3C2BGeneProductENSG00000133056 (Ensembl)
PIK3C2GGeneProductENSG00000139144 (Ensembl)
PIK3CAGeneProductENSG00000121879 (Ensembl)
PIK3CBGeneProductENSG00000051382 (Ensembl)
PIK3CDGeneProductENSG00000171608 (Ensembl)
PIK3CGGeneProductENSG00000105851 (Ensembl)
PIK3R1GeneProductENSG00000145675 (Ensembl)
PIK3R2GeneProductENSG00000105647 (Ensembl)
PIK3R3GeneProductENSG00000117461 (Ensembl)
PIK3R4GeneProductENSG00000196455 (Ensembl)
PIK3R5GeneProductENSG00000141506 (Ensembl)
PIK3R6GeneProductENSG00000276231 (Ensembl)
RICTORGeneProductENSG00000164327 (Ensembl)
RPTORGeneProductENSG00000141564 (Ensembl)
SIRT1GeneProduct23411 (Entrez Gene)
SIRT1GeneProductENSG00000096717 (Ensembl)
TSC1GeneProductENSG00000165699 (Ensembl)
TSC2GeneProductENSG00000103197 (Ensembl)
Wnt/Beta-cateninPathwayWP5529 (WikiPathways)
p27KipGeneProduct

Annotated Interactions

No annotated interactions

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