Apoptosis (Bos taurus)

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2bDegradationInterferon regulatory factorsDNA FragmentationCaspbpActivator of Cell DeathApoptosisMitochondrioneIGF1R signaling pathwayeInhibitor of Cell Deathp53 RelatedpFas LigandbCYCTBCL2L2MAP3K1TRAF2DIABLONFKBIENFKBIBMCL1TRAF1APAF1BAK1TNFRSF21HRKNFKBIAFASLGIGF1RBCL2L1BIRC2CRADDBCL2L11BOKCFLARDFFAIRF1IGF1TRAF3IRF4DFFBTP63AKT1NFKBIBFADDBCL2TP73MDM2NFKBIABAXCHUKTNFRSF1AIGF2NFKB1TNFRSF1ACASP1CDKN2AJUNBIDRIPK1MAP2K4CYCSGZMBTNFSF10CASP10BADPIK3R1CASP8CASP4IRF2TNFRSF25IRF3MAPK10PMAIP1CASP7BIRC3RELAFASCASP6MYCPRF1IRF5RIPK1NFKBIETRADDBADTNFIKBKBRELANFKB1TNFRSF1BCASP11IRF6TP53IKBKGBBC3CASP9LTATRADDXIAPCASP3HELLSBIRC5IRF7CASP2BNIP3LTNFRSF10B1


Description

Apoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and membrane blebbing characterize apoptosis in general. Mitochondria remain morphologically unchanged. In 1972 Kerr et al introduced the concept of apoptosis as a distinct form of "cell-death", and the mechanisms of various apoptotic pathways are still being revealed today.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP254(r41184) with a 88% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Lakin ND, Jackson SP; ''Regulation of p53 in response to DNA damage.''; Oncogene, 1999 PubMed Europe PMC Scholia
  2. Bose I, Ghosh B; ''The p53-MDM2 network: from oscillations to apoptosis.''; J Biosci, 2007 PubMed Europe PMC Scholia
  3. Mott JL, Kobayashi S, Bronk SF, Gores GJ; ''mir-29 regulates Mcl-1 protein expression and apoptosis.''; Oncogene, 2007 PubMed Europe PMC Scholia
  4. Xiong Y, Fang JH, Yun JP, Yang J, Zhang Y, Jia WH, Zhuang SM; ''Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma.''; Hepatology, 2010 PubMed Europe PMC Scholia
  5. Park SY, Lee JH, Ha M, Nam JW, Kim VN; ''miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42.''; Nat Struct Mol Biol, 2009 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
95783view14:36, 19 January 2018MkutmonHomology conversion update
81196view14:01, 3 August 2015Mkutmonfixed unconnected lines
80915view15:31, 30 June 2015Mkutmonhomology conversion
67048view09:59, 26 June 2013Christine ChichesterOntology Term : 'apoptotic cell death pathway' added !
63305view20:51, 9 May 2013MaintBotUpdated to 2013 gpml schema
63304view20:50, 9 May 2013MaintBotReverted to version '05:46, 9 May 2012' by MaintBot
63303view20:49, 9 May 2013MaintBotUpdated to 2013 gpml schema
48127view05:46, 9 May 2012MaintBotUpdating from human to fix xref duplication
40509view19:29, 1 March 2011MaintBotRemoved redundant pathway information and comments
36238view18:20, 11 March 2010KhanspersAdded APAF1 xref
35100view13:07, 11 February 2010MartijnVanIerseladded lit. ref.
33752view23:59, 8 December 2009MaintBotAutomatic update of empty xrefs
31659view11:38, 14 August 2009MaintBotFixed group labels
30587view22:11, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1GeneProduct280991 (Entrez Gene)
APAF1GeneProduct537782 (Entrez Gene)
BADGeneProduct615013 (Entrez Gene)
BAK1GeneProduct514090 (Entrez Gene)
BAXGeneProduct280730 (Entrez Gene)
BBC3GeneProduct
BCL2GeneProduct281020 (Entrez Gene)
BCL2L11GeneProduct
BCL2L1GeneProduct282152 (Entrez Gene)
BCL2L2GeneProduct767601 (Entrez Gene)
BIDGeneProduct510373 (Entrez Gene)
BIRC2GeneProduct
BIRC3GeneProduct514386 (Entrez Gene)
BIRC5GeneProduct414925 (Entrez Gene)
BNIP3LGeneProduct534615 (Entrez Gene)
BOKGeneProduct504851 (Entrez Gene)
CASP10GeneProduct
CASP11GeneProduct
CASP1GeneProduct514214 (Entrez Gene)
CASP2GeneProduct531419 (Entrez Gene)
CASP3GeneProduct408016 (Entrez Gene)
CASP4GeneProduct338039 (Entrez Gene)
CASP6GeneProduct538409 (Entrez Gene)
CASP7GeneProduct526279 (Entrez Gene)
CASP8GeneProduct507481 (Entrez Gene)
CASP9GeneProduct100140945 (Entrez Gene)
CDKN2AGeneProduct
CFLARGeneProduct497199 (Entrez Gene)
CHUKGeneProduct281073 (Entrez Gene)
CRADDGeneProduct
CYCSGeneProduct
CYCTGeneProduct
DFFAGeneProduct507981 (Entrez Gene)
DFFBGeneProduct512730 (Entrez Gene)
DIABLOGeneProduct493999 (Entrez Gene)
FADDGeneProduct493720 (Entrez Gene)
FASGeneProduct282488 (Entrez Gene)
FASLGGeneProduct407111 (Entrez Gene)
GZMBGeneProduct508646 (Entrez Gene)
HELLSGeneProduct540933 (Entrez Gene)
HRKGeneProduct787139 (Entrez Gene)
IGF1GeneProduct281239 (Entrez Gene)
IGF1RGeneProduct281848 (Entrez Gene)
IGF2GeneProduct281240 (Entrez Gene)
IKBKBGeneProduct281854 (Entrez Gene)
IKBKGGeneProduct281855 (Entrez Gene)
IRF1GeneProduct789216 (Entrez Gene)
IRF2GeneProduct337916 (Entrez Gene)
IRF3GeneProduct516979 (Entrez Gene)
IRF4GeneProduct506141 (Entrez Gene)
IRF5GeneProduct615340 (Entrez Gene)
IRF6GeneProduct614253 (Entrez Gene)
IRF7GeneProduct100125591 (Entrez Gene)
JUNGeneProduct280831 (Entrez Gene)
LTAGeneProduct280845 (Entrez Gene)
MAP2K4GeneProduct526469 (Entrez Gene)
MAP3K1GeneProduct523962 (Entrez Gene)
MAPK10GeneProduct537631 (Entrez Gene)
MCL1GeneProduct788087 (Entrez Gene)
MDM2GeneProduct540378 (Entrez Gene)
MYCGeneProduct511077 (Entrez Gene)
NFKB1GeneProduct616115 (Entrez Gene)
NFKBIAGeneProduct282291 (Entrez Gene)
NFKBIBGeneProduct525408 (Entrez Gene)
NFKBIEGeneProduct506727 (Entrez Gene)
PIK3R1GeneProduct282307 (Entrez Gene)
PMAIP1GeneProduct
PRF1GeneProduct369025 (Entrez Gene)
RELAGeneProduct508233 (Entrez Gene)
RIPK1GeneProduct504727 (Entrez Gene)
TNFGeneProduct280943 (Entrez Gene)
TNFRSF10BGeneProduct
TNFRSF1AGeneProduct282527 (Entrez Gene)
TNFRSF1BGeneProduct338033 (Entrez Gene)
TNFRSF21GeneProduct537922 (Entrez Gene)
TNFRSF25GeneProduct783432 (Entrez Gene)
TNFSF10GeneProduct507215 (Entrez Gene)
TP53GeneProduct281542 (Entrez Gene)
TP63GeneProduct615335 (Entrez Gene)
TP73GeneProduct515105 (Entrez Gene)
TRADDGeneProduct504707 (Entrez Gene)
TRAF1GeneProduct540944 (Entrez Gene)
TRAF2GeneProduct512355 (Entrez Gene)
TRAF3GeneProduct506182 (Entrez Gene)
XIAPGeneProduct281647 (Entrez Gene)

Annotated Interactions

No annotated interactions
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