Selenium metabolism and selenoproteins (Bos taurus)

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1-3, 6, 7, 10...SeCnucleusRedoxsignallingThyroid hormonemetabolismSecsynthesisdemethylationSeryl-tRNA[ser](sec)Body proteinsPhosphoseryl-tRNA[ser](sec)coding regionProtein foldingDietSe = Selenium, SeMet = SelenoMethionine, SeC = Selcysteine, H2Se = Selenide, GSH = gluthatione, Trx = ThioredoxinAUGSec tRNA[ser]secGSHSeCTrXSelenoproteinsSelenocysteyl-tRNA secSe transportand storageUnkownfunctionTranscription FactorsAntioxidantenzymesINORGANIC SeORGANIC SeSeC BiosynthesisSelenium binding proteinsSTOPmethyl transferaseRPL30DIO3SeleniteSARS2TXNRD2SeleniteFOS_BOVINNP_001071295.1CremGPX4DIO1SeMetPouf2f1SBP2SP3SelenateSephs2SBP2SelenateSelOSELSSeMetSarsGPX1FABP1EEFSECSCLYUGASelenophosphateSelTSEPX1SeCSp1SeCGPX6Nfe2l2PstkTXNRD1Cystathionine g-lyaseRELASep15TRNAU1APSELINFKB1SEPN1GPX3TXNRD1DIO2SELKSEPSECSSelVSelHTXNRD3SBP2TXNRD3Sephs1GPX2TXNRD2SepWSPS2SELENBP1H2SeEEFSECMethylSelenol MeSeHSEPP1SelM4, 8, 95, 8


Description

* Comments belonging to specific genes on the Selenoprotein pathway
    • TRXND3 gene: Although the geneID is correct, the sequence of this gene was guessed by analogy.
    • Cystathionine gamma-lyase is the mammalian form of bacterial methionine gamma-lyase
    • A selenoprotein database exists at: http://www.selenodb.org.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP28(r30051) with a 50% conversion rate.

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Bibliography

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  1. Ip C, Hayes C; ''Tissue selenium levels in selenium-supplemented rats and their relevance in mammary cancer protection.''; Carcinogenesis, 1989 PubMed Europe PMC Scholia
  2. Gromer S, Eubel JK, Lee BL, Jacob J; ''Human selenoproteins at a glance.''; Cell Mol Life Sci, 2005 PubMed Europe PMC Scholia
  3. Thompson HJ, Clement IP; ''''; , PubMed Europe PMC Scholia
  4. Commandeur JN, Andreadou I, Rooseboom M, Out M, de Leur LJ, Groot E, Vermeulen NP; ''''; , PubMed Europe PMC Scholia
  5. Wang H, Zhang J, Yu H; ''Elemental selenium at nano size possesses lower toxicity without compromising the fundamental effect on selenoenzymes: comparison with selenomethionine in mice.''; Free Radic Biol Med, 2007 PubMed Europe PMC Scholia
  6. Xia Y, Hill KE, Byrne DW, Xu J, Burk RF; ''Effectiveness of selenium supplements in a low-selenium area of China.''; Am J Clin Nutr, 2005 PubMed Europe PMC Scholia
  7. Boosalis MG; ''The role of selenium in chronic disease.''; Nutr Clin Pract, 2008 PubMed Europe PMC Scholia
  8. Soda K, Oikawa T, Esaki N; ''Vitamin B6 enzymes participating in selenium amino acid metabolism.''; Biofactors, 1999 PubMed Europe PMC Scholia
  9. Small-Howard AL, Berry MJ; ''Unique features of selenocysteine incorporation function within the context of general eukaryotic translational processes.''; Biochem Soc Trans, 2005 PubMed Europe PMC Scholia
  10. Xu XM, Carlson BA, Mix H, Zhang Y, Saira K, Glass RS, Berry MJ, Gladyshev VN, Hatfield DL; ''Biosynthesis of selenocysteine on its tRNA in eukaryotes.''; PLoS Biol, 2007 PubMed Europe PMC Scholia
  11. Papp LV, Lu J, Holmgren A, Khanna KK; ''From selenium to selenoproteins: synthesis, identity, and their role in human health.''; Antioxid Redox Signal, 2007 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
116453view09:56, 7 May 2021EweitzModified title
106014view11:53, 16 August 2019MaintBotHMDB identifier normalization
80672view15:21, 30 June 2015Mkutmonhomology conversion
71422view19:02, 17 October 2013MaintBotAutomated update of data sources
63397view00:04, 10 May 2013MaintBotUpdated to 2013 gpml schema
62710view23:19, 1 May 2013MaintBotUpdated UniProt data source
58824view23:19, 20 February 2013MaintBotUpdated Ensembl and UniProt data source
40570view19:32, 1 March 2011MaintBotRemoved redundant pathway information and comments
33808view00:20, 9 December 2009MaintBotAutomatic update of empty xrefs
32503view12:49, 17 August 2009MaintBotFixed text labels
32194view12:36, 15 August 2009MaintBotFixed text labels
31670view11:41, 14 August 2009MaintBotFixed group labels
31201view19:33, 13 August 2009MaintBotFixed text labels
30599view22:15, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
CremGeneProduct540605 (Entrez Gene)
Cystathionine g-lyaseGeneProduct
DIO1GeneProduct782446 (Entrez Gene)
DIO2GeneProduct494548 (Entrez Gene)
DIO3GeneProduct494549 (Entrez Gene)
EEFSECGeneProduct532824 (Entrez Gene)
FABP1GeneProduct327700 (Entrez Gene)
FOS_BOVINGeneProductENSBTAG00000004322 (Ensembl)
GPX1GeneProduct281209 (Entrez Gene)
GPX2GeneProduct533088 (Entrez Gene)
GPX3GeneProduct281210 (Entrez Gene)
GPX4GeneProduct286809 (Entrez Gene)
GPX6GeneProduct519280 (Entrez Gene)
H2SeMetabolite
MethylSelenol MeSeHMetabolite
NFKB1GeneProduct616115 (Entrez Gene)
NP_001071295.1GeneProductENSBTAG00000004037 (Ensembl)
Nfe2l2GeneProduct497024 (Entrez Gene)
Pouf2f1GeneProduct
PstkGeneProduct511744 (Entrez Gene)
RELAGeneProduct508233 (Entrez Gene)
RPL30GeneProduct513031 (Entrez Gene)
SARS2GeneProduct282060 (Entrez Gene)
SBP2GeneProduct
SCLYGeneProduct790815 (Entrez Gene)
SELENBP1GeneProduct510154 (Entrez Gene)
SELIGeneProduct506381 (Entrez Gene)
SELKGeneProduct615114 (Entrez Gene)
SELSGeneProduct512276 (Entrez Gene)
SEPN1GeneProduct616379 (Entrez Gene)
SEPP1GeneProduct282066 (Entrez Gene)
SEPSECSGeneProduct518874 (Entrez Gene)
SEPX1GeneProduct618441 (Entrez Gene)
SP3GeneProduct540766 (Entrez Gene)
SPS2GeneProduct
SarsGeneProduct281476 (Entrez Gene)
SeCMetaboliteHMDB03288 (HMDB)
SeMetMetaboliteHMDB03966 (HMDB)
SelHGeneProduct613525 (Entrez Gene)
SelMGeneProduct787736 (Entrez Gene)
SelOGeneProduct790464 (Entrez Gene)
SelTGeneProduct783831 (Entrez Gene)
SelVGeneProduct615288 (Entrez Gene)
SelenateMetabolite
SeleniteMetabolite
SelenophosphateMetaboliteHMDB06407 (HMDB)
Sep15GeneProduct614360 (Entrez Gene)
SepWGeneProduct
Sephs1GeneProduct507470 (Entrez Gene)
Sephs2GeneProduct512060 (Entrez Gene)
Sp1GeneProduct540741 (Entrez Gene)
TRNAU1APGeneProduct532582 (Entrez Gene)
TXNRD1GeneProduct282388 (Entrez Gene)
TXNRD2GeneProduct282389 (Entrez Gene)
TXNRD3GeneProduct319097 (Entrez Gene)
UGAGeneProduct

Annotated Interactions

No annotated interactions
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