IL-3 signaling pathway (Bos taurus)

From WikiPathways

Revision as of 23:07, 9 May 2013 by MaintBot (Talk | contribs)
Jump to: navigation, search
Golgi apparatusDSumoylationDGlycosylationDPalmitoylationDControlMT->CYDephosphorylationDDesumoylationDMAMitochondrionDDeubiquitinationNucleusECMolecular AssociationD(Protein-protein interaction)DDemethylationCY->PMProteolytic cleavageCY->NUEndoplasmic reticulumDCY->PMERInhibitionPlasma membraneExtracellularReaction through unknown mechanisms/moleculesLigandDTranslocationPhosphorylationNUEnzyme complexMethylationDDAutophosphorylationMARecruitmentActivationReceptorDPMDCY->NUDAcetylationENMAMAEndosomeUbiquitinationMTCY->PMProteins in a complex interactionCYMolecule in the pathwayGODMAMAAccession Number: NetPath 15DDDeacetylationCytoplasmGSK3BYWHAQATF2SRCTECSPI1PAK1YWHABBAXSYKBIRC5CRKSTAT1KCNIP3FYNSHC1CSF2RBATF1MMP9PIK3R2MAPK1IL3RAPRKCAIL3GAB1HSPB1MAPK9MAPK8YWHAZSLC2A1SOCS2BMXSTAT5AGAB2CRKLMAPKAPK2GSK3AMAPK3BCL2MAPK14CISHJAK2MRASMATKRAPGEF1MAP2K1SLC2A1PTPN6RAC1RARASTAT6HRASPRKACALOC506618PILRBMAPK3FESLCKPTK2KRASCSF2RBSTAT5BCHEK1NFKB1CREB1DNM1IL3GNB2L1PIK3CAIL3NFKB1SOCS3TYK2Gene SymbolHCKBCL2L11BCL2L1PXNMMP2RAP1ARAF1FCER2SELPSTAT3IL3PPP2CAID1RXRAGRB2PRKCBIL3RASHC1PIK3CDPIK3R1INPP5DMAPK7GATA2CBLRAC2SOS1TNFRSF1BRPS6KB2JAK1LYNBADVAV1AKT1BADVCLPRKCAGATA1CDC42PTPN11


Description

Interleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common beta chain, which is shared between all members of this cytokine family. Binding of IL-3 to IL3RA recruits the beta chain to the complex, which activates the JAK/STAT, MAPK and PI 3-kinase signaling modules. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_15

Comments

GenMAPP notes 
NetPath:15 - IL-3 Signaling Pathway. NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.
GenMAPP remarks 
http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP286(r21281) with a 86% conversion rate.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

  1. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A; ''NetPath: a public resource of curated signal transduction pathways.''; Genome Biol, 2010 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117538view11:14, 21 May 2021EweitzModified title
115961view08:27, 22 March 2021EgonwCopied the NetPath paper into the literature list
115951view07:13, 22 March 2021EgonwModified description
80932view15:31, 30 June 2015Mkutmonhomology conversion
63382view23:07, 9 May 2013MaintBotUpdated to 2013 gpml schema
40554view19:31, 1 March 2011MaintBotRemoved redundant pathway information and comments
35793view06:55, 13 February 2010MaintBotAdded description
33793view00:13, 9 December 2009MaintBotAutomatic update of empty xrefs
32504view12:49, 17 August 2009MaintBotFixed text labels
31202view19:33, 13 August 2009MaintBotFixed text labels
30600view22:15, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProduct280991 (Entrez Gene)
ATF1GeneProduct506967 (Entrez Gene)
ATF2GeneProduct509827 (Entrez Gene)
BADGeneProduct615013 (Entrez Gene)
BAXGeneProduct785708 (Entrez Gene)
BCL2GeneProduct281020 (Entrez Gene)
BCL2L11GeneProduct507390 (Entrez Gene)
BCL2L1GeneProduct282152 (Entrez Gene)
BIRC5GeneProduct414925 (Entrez Gene)
BMXGeneProduct531514 (Entrez Gene)
CBLGeneProduct527418 (Entrez Gene)
CDC42GeneProduct532712 (Entrez Gene)
CHEK1GeneProduct513678 (Entrez Gene)
CISHGeneProduct616753 (Entrez Gene)
CREB1GeneProduct281713 (Entrez Gene)
CRKGeneProduct512841 (Entrez Gene)
CRKLGeneProduct
CSF2RBGeneProduct528530 (Entrez Gene)
DNM1GeneProduct508794 (Entrez Gene)
FCER2GeneProduct407106 (Entrez Gene)
FESGeneProduct507304 (Entrez Gene)
FYNGeneProduct527263 (Entrez Gene)
GAB1GeneProduct540085 (Entrez Gene)
GAB2GeneProduct529346 (Entrez Gene)
GATA1GeneProduct516066 (Entrez Gene)
GATA2GeneProduct506809 (Entrez Gene)
GNB2L1GeneProduct327682 (Entrez Gene)
GRB2GeneProduct535298 (Entrez Gene)
GSK3AGeneProduct536561 (Entrez Gene)
GSK3BGeneProduct790875 (Entrez Gene)
Gene SymbolGeneProduct
HCKGeneProduct280814 (Entrez Gene)
HRASGeneProduct513012 (Entrez Gene)
HSPB1GeneProduct516099 (Entrez Gene)
ID1GeneProduct497011 (Entrez Gene)
IL3GeneProduct280823 (Entrez Gene)
IL3RAGeneProduct
INPP5DGeneProduct507329 (Entrez Gene)
JAK1GeneProduct537201 (Entrez Gene)
JAK2GeneProduct525246 (Entrez Gene)
KCNIP3GeneProduct513316 (Entrez Gene)
KRASGeneProduct541140 (Entrez Gene)
LCKGeneProduct508890 (Entrez Gene)
LOC506618GeneProduct506618 (Entrez Gene)
LYNGeneProduct534996 (Entrez Gene)
MAP2K1GeneProduct533199 (Entrez Gene)
MAPK1GeneProduct327672 (Entrez Gene)
MAPK14GeneProduct534492 (Entrez Gene)
MAPK3GeneProduct531391 (Entrez Gene)
MAPK7GeneProduct537703 (Entrez Gene)
MAPK8GeneProduct539941 (Entrez Gene)
MAPK9GeneProduct534125 (Entrez Gene)
MAPKAPK2GeneProduct788091 (Entrez Gene)
MATKGeneProduct504668 (Entrez Gene)
MMP2GeneProduct282872 (Entrez Gene)
MMP9GeneProduct282871 (Entrez Gene)
MRASGeneProduct540803 (Entrez Gene)
NFKB1GeneProduct616115 (Entrez Gene)
PAK1GeneProduct533729 (Entrez Gene)
PIK3CAGeneProduct282306 (Entrez Gene)
PIK3CDGeneProduct504531 (Entrez Gene)
PIK3R1GeneProduct282307 (Entrez Gene)
PIK3R2GeneProduct282308 (Entrez Gene)
PILRBGeneProduct
PPP2CAGeneProduct282320 (Entrez Gene)
PRKACAGeneProduct282322 (Entrez Gene)
PRKCAGeneProduct282001 (Entrez Gene)
PRKCBGeneProduct282325 (Entrez Gene)
PTK2GeneProduct506270 (Entrez Gene)
PTPN11GeneProduct533590 (Entrez Gene)
PTPN6GeneProduct512312 (Entrez Gene)
PXNGeneProduct517456 (Entrez Gene)
RAC1GeneProduct281440 (Entrez Gene)
RAC2GeneProduct327671 (Entrez Gene)
RAF1GeneProduct521196 (Entrez Gene)
RAP1AGeneProduct282031 (Entrez Gene)
RAPGEF1GeneProduct520454 (Entrez Gene)
RARAGeneProduct534280 (Entrez Gene)
RPS6KB2GeneProduct506083 (Entrez Gene)
RXRAGeneProduct507554 (Entrez Gene)
SELPGeneProduct281486 (Entrez Gene)
SHC1GeneProduct507196 (Entrez Gene)
SLC2A1GeneProduct282356 (Entrez Gene)
SOCS2GeneProduct338437 (Entrez Gene)
SOCS3GeneProduct282081 (Entrez Gene)
SOS1GeneProduct537682 (Entrez Gene)
SPI1GeneProduct507100 (Entrez Gene)
SRCGeneProduct535742 (Entrez Gene)
STAT1GeneProduct510814 (Entrez Gene)
STAT3GeneProduct508541 (Entrez Gene)
STAT5AGeneProduct282375 (Entrez Gene)
STAT5BGeneProduct282376 (Entrez Gene)
STAT6GeneProduct353105 (Entrez Gene)
SYKGeneProduct515515 (Entrez Gene)
TECGeneProduct504733 (Entrez Gene)
TNFRSF1BGeneProduct338033 (Entrez Gene)
TYK2GeneProduct512484 (Entrez Gene)
VAV1GeneProduct617345 (Entrez Gene)
VCLGeneProduct783645 (Entrez Gene)
YWHABGeneProduct286863 (Entrez Gene)
YWHAQGeneProduct768311 (Entrez Gene)
YWHAZGeneProduct287022 (Entrez Gene)

Annotated Interactions

No annotated interactions
Personal tools