Estrogen metabolism (Bos taurus)

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4, 6, 822222733573237225333332732533325223361DNA adductsDNA adductsDNA adductsDNA adducts4-hydroxy-estradiol-sulfateSuperoxide4-hydroxyestrone-3-glucuronide4-Methoxyestradiol2-hydroxyestradiol-3-glucuronideCOMT_BOVINUGT2B7UGT1A1Oxygen2-MethoxyestradiolEstradiol-3,4-semiquinoneNP_777187.1NP_777187.1Estrone-3-glucuronideNP_777187.1NP_777187.1Superoxide4-MethoxyestroneUGT1A1UGT1A1NP_001029707.14-hydroxyestradiol4-Methoxyestradiol-3-glucuronideA9CSS1_BOVIN4-Hydroxyestradiol-3-glucuronideEstrone-2,3-semiquinoneUGT2B7NP_777187.1Estradiol-2,3-quinone2-hydroxy-estradiol-sulfateEstradiol-17-glucuronideEstroneGSTA1OxygenUGT1A9ST1A1_BOVINSTS4-Methoxyestrone-3-glucuronideEstrone sulfateCOMT_BOVINQ95KN3_BOVINUGT2B7A6H748_BOVINCYP3A42-MethoxyestroneOxygen2-HydroxyestroneCOMT_BOVINUGT1A9Estrone-3,4-semiquinone2-Methoxyestrone 3-glucuronide2-hydroxy-estradiol-2-glucuronideST1E1_BOVINUGT1A1Estradiol sulfateNP_777187.1ST1A1_BOVINEstradiolA6H748_BOVINQ95KN3_BOVINUGT1A1Estradiol-3-glucuronideEstrone-2,3-quinone2-Methoxyestradiol-3-glucuronide2-Hydroxyestrone-3-glucuronideSuperoxideNP_777187.1NP_001029707.1NP_777187.12-HydroxyestradiolUGT1A1UGT1A3SuperoxideOxygen4-hydroxyestroneUGT2B7NP_777187.1GSTM1ST1A1_BOVINCYP3A4Estradiol-2,3-semiquinoneEstradiol-3,4-quinoneNP_001091457.1IPI00843610.24-hydroxy-estradiol-4-glucuronideEstrone-3,4-quinoneNP_777187.116a-HydroxyestroneEstrone-17-glucuronideCOMT_BOVIN


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP697(r30275) with a 75% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Shatalova EG, Walther SE, Favorova OO, Rebbeck TR, Blanchard RL; ''Genetic polymorphisms in human SULT1A1 and UGT1A1 genes associate with breast tumor characteristics: a case-series study.''; Breast Cancer Res, 2005 PubMed Europe PMC Scholia
  2. Bianco NR, Perry G, Smith MA, Templeton DJ, Montano MM; ''Functional implications of antiestrogen induction of quinone reductase: inhibition of estrogen-induced deoxyribonucleic acid damage.''; Mol Endocrinol, 2003 PubMed Europe PMC Scholia
  3. Abel EL, Lyon RP, Bammler TK, Verlinde CL, Lau SS, Monks TJ, Eaton DL; ''Estradiol metabolites as isoform-specific inhibitors of human glutathione S-transferases.''; Chem Biol Interact, 2004 PubMed Europe PMC Scholia
  4. Cavalieri EL, Stack DE, Devanesan PD, Todorovic R, Dwivedy I, Higginbotham S, Johansson SL, Patil KD, Gross ML, Gooden JK, Ramanathan R, Cerny RL, Rogan EG; ''Molecular origin of cancer: catechol estrogen-3,4-quinones as endogenous tumor initiators.''; Proc Natl Acad Sci U S A, 1997 PubMed Europe PMC Scholia
  5. Rogan EG, Badawi AF, Devanesan PD, Meza JL, Edney JA, West WW, Higginbotham SM, Cavalieri EL; ''Relative imbalances in estrogen metabolism and conjugation in breast tissue of women with carcinoma: potential biomarkers of susceptibility to cancer.''; Carcinogenesis, 2003 PubMed Europe PMC Scholia
  6. Guillemette C, Belanger A, Lepine J; ''Metabolic inactivation of estrogens in breast tissue by UDP-glucuronosyltransferase enzymes: an overview.''; Breast Cancer Res, 2004 PubMed Europe PMC Scholia
  7. Raftogianis R, Creveling C, Weinshilboum R, Weisz J; ''Estrogen metabolism by conjugation.''; J Natl Cancer Inst Monogr, 2000 PubMed Europe PMC Scholia
  8. Lakhani NJ, Sarkar MA, Venitz J, Figg WD; ''2-Methoxyestradiol, a promising anticancer agent.''; Pharmacotherapy, 2003 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
106011view11:53, 16 August 2019MaintBotHMDB identifier normalization
86855view07:22, 14 July 2016Mkutmonfixed ontology tags
86854view07:20, 14 July 2016MkutmonOntology Term : 'C18-steroid hormone biosynthetic pathway' added !
80678view15:21, 30 June 2015Mkutmonhomology conversion
72370view09:53, 13 November 2013EgonwFixed the PubChem-compound database name.
72161view12:17, 25 October 2013Nunoconnected lines
70169view00:31, 13 July 2013AlexanderPicoModified title
63466view17:19, 10 May 2013MaintBotUpdated to 2013 gpml schema
58828view23:19, 20 February 2013MaintBotUpdated Ensembl and UniProt data source
40602view19:34, 1 March 2011MaintBotRemoved redundant pathway information and comments
33839view00:31, 9 December 2009MaintBotAutomatic update of empty xrefs
31687view11:45, 14 August 2009MaintBotFixed group labels
30622view22:23, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
16a-HydroxyestroneMetaboliteHMDB00335 (HMDB)
2-HydroxyestradiolMetaboliteHMDB00338 (HMDB)
2-Hydroxyestrone-3-glucuronideMetabolite
2-HydroxyestroneMetaboliteHMDB00343 (HMDB)
2-Methoxyestradiol-3-glucuronideMetabolite
2-MethoxyestradiolMetaboliteHMDB00405 (HMDB)
2-Methoxyestrone 3-glucuronideMetaboliteHMDB04482 (HMDB)
2-MethoxyestroneMetaboliteHMDB00010 (HMDB)
2-hydroxy-estradiol-2-glucuronideMetabolite
2-hydroxy-estradiol-sulfateMetabolite
2-hydroxyestradiol-3-glucuronideMetabolite
4-Hydroxyestradiol-3-glucuronideMetabolite
4-Methoxyestradiol-3-glucuronideMetabolite
4-MethoxyestradiolMetaboliteHMDB00405 (HMDB)
4-MethoxyestroneMetabolite
4-Methoxyestrone-3-glucuronideMetabolite
4-hydroxy-estradiol-4-glucuronideMetabolite
4-hydroxy-estradiol-sulfateMetabolite
4-hydroxyestradiolMetabolite
4-hydroxyestroneMetabolite
4-hydroxyestrone-3-glucuronideMetabolite
A6H748_BOVINGeneProductENSBTAG00000000085 (Ensembl)
A9CSS1_BOVINGeneProductENSBTAG00000010531 (Ensembl)
COMT_BOVINGeneProductENSBTAG00000019516 (Ensembl)
CYP3A4GeneProduct507988 (Entrez Gene)
EstradiolMetabolite
Estradiol sulfateMetabolite
Estradiol-17-glucuronideMetabolite
Estradiol-2,3-quinoneMetabolite
Estradiol-2,3-semiquinoneMetabolite
Estradiol-3,4-quinoneMetabolite
Estradiol-3,4-semiquinoneMetabolite
Estradiol-3-glucuronideMetaboliteHMDB06224 (HMDB)
Estrone sulfateMetaboliteHMDB01425 (HMDB)
Estrone-17-glucuronideMetaboliteHMDB04483 (HMDB)
Estrone-2,3-quinoneMetabolite148381 (PubChem-compound)
Estrone-2,3-semiquinoneMetabolite
Estrone-3,4-quinoneMetabolite114862 (PubChem-compound)
Estrone-3,4-semiquinoneMetabolite
Estrone-3-glucuronideMetaboliteHMDB04483 (HMDB)
EstroneMetaboliteHMDB00145 (HMDB)
GSTA1GeneProduct777644 (Entrez Gene)
GSTM1GeneProduct783879 (Entrez Gene)
IPI00843610.2GeneProductENSBTAG00000039889 (Ensembl)
NP_001029707.1GeneProductENSBTAG00000020632 (Ensembl)
NP_001091457.1GeneProductENSBTAG00000014932 (Ensembl)
NP_777187.1GeneProductENSBTAG00000026181 (Ensembl)
OxygenMetaboliteHMDB01377 (HMDB)
Q95KN3_BOVINGeneProductENSBTAG00000001021 (Ensembl)
ST1A1_BOVINGeneProductENSBTAG00000008635 (Ensembl)
ST1E1_BOVINGeneProductENSBTAG00000011952 (Ensembl)
STSGeneProduct509206 (Entrez Gene)
SuperoxideMetaboliteHMDB02168 (HMDB)
UGT1A1GeneProduct751790 (Entrez Gene)
UGT1A3GeneProduct
UGT1A9GeneProduct
UGT2B7GeneProduct

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1053"