Endochondral ossification (Bos taurus)

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1, 2Hypertrophy?CartilageDyingRemoval of extracellular matrixand invasion by bone cellsChondrocyte (pre)hypertrophyChondrocyte deathCathepsinsand CalpainsMineralisationFull differentiationBoneRemoval of cartilage matrixProliferationBMPsWNT signalingcanonical / non-canonicalOsteoblasticdifferentiationGsChondrocyte proliferationintegrinsVascular invastionIGF1FRZBOxygenENPP1HMGCS1PRKACACTSL2Thyroid hormoneSox9MMP9RUNX2DDR2RUNX2SLC38A2FGF18PTH1RTIMP3SERPINH1TGFB1ALPLTGFBIcAMPRUNX3CHST11BMP7SOX6ACANFGFR3Thyroid hormoneTHRAADAMTS4THRAPTHLHPLAUIHHGLI3TGFB2AKT1CarminerinCALM1PTHMEF2CKIF3AIGF1RPTCH1LOC517559NKX3-2SOX5COL10A1PLATADAMTS5TriiodothyronineVEGFABMPR1ACDKN1CTNAPFGFR1STAT1FGF2IGF2MGPADAMTS1COL2A1IFT88RUNX2LOC617566STAT5BGHRGrowth hormoneSCINSPP1CAB39MMP13PTCH1


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP474(r29737) with a 82% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Belluoccio D, Bernardo BC, Rowley L, Bateman JF; ''A microarray approach for comparative expression profiling of the discrete maturation zones of mouse growth plate cartilage.''; Biochim Biophys Acta, 2008 PubMed Europe PMC Scholia
  2. Mackie EJ, Ahmed YA, Tatarczuch L, Chen KS, Mirams M; ''Endochondral ossification: how cartilage is converted into bone in the developing skeleton.''; Int J Biochem Cell Biol, 2008 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117504view11:04, 21 May 2021EweitzModified title
105993view11:52, 16 August 2019MaintBotHMDB identifier normalization
87970view13:17, 25 July 2016SusanOntology Term : 'regulatory pathway' added !
80781view15:25, 30 June 2015Mkutmonhomology conversion
72217view12:55, 27 October 2013EgonwFixed the ChEBI database name.
72177view22:19, 25 October 2013AlexanderPicoAdded missing metabolite identifiers.
71279view03:59, 17 October 2013MaintBotCleaned up buggy complex
63477view17:22, 10 May 2013MaintBotupdating gpml
40540view19:30, 1 March 2011MaintBotRemoved redundant pathway information and comments
33781view00:09, 9 December 2009MaintBotAutomatic update of empty xrefs
32523view12:57, 17 August 2009MaintBotFixed text labels
32209view12:42, 15 August 2009MaintBotFixed text labels
31697view11:48, 14 August 2009MaintBotFixed group labels
31221view19:41, 13 August 2009MaintBotFixed text labels
30634view22:27, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACANGeneProduct280985 (Entrez Gene)
ADAMTS1GeneProduct512171 (Entrez Gene)
ADAMTS4GeneProduct286806 (Entrez Gene)
ADAMTS5GeneProduct286805 (Entrez Gene)
AKT1GeneProduct280991 (Entrez Gene)
ALPLGeneProduct280994 (Entrez Gene)
BMP7GeneProduct540595 (Entrez Gene)
BMPR1AGeneProduct404101 (Entrez Gene)
CAB39GeneProduct511451 (Entrez Gene)
CALM1GeneProduct617095 (Entrez Gene)
CDKN1CGeneProduct510972 (Entrez Gene)
CHST11GeneProduct528860 (Entrez Gene)
COL10A1GeneProduct282416 (Entrez Gene)
COL2A1GeneProduct407142 (Entrez Gene)
CTSL2GeneProduct281108 (Entrez Gene) Taken as homologue to mouse Cathepsin L (Ctsl)
CarminerinGeneProduct
  • Taken as human homologue of mouse Cst10
  • PMID: 13679380
DDR2GeneProduct533523 (Entrez Gene)
ENPP1GeneProduct615535 (Entrez Gene)
FGF18GeneProduct533929 (Entrez Gene)
FGF2GeneProduct281161 (Entrez Gene)
FGFR1GeneProduct281768 (Entrez Gene)
FGFR3GeneProduct281769 (Entrez Gene)
FRZBGeneProduct281170 (Entrez Gene)
GHRGeneProduct280805 (Entrez Gene)
GLI3GeneProduct785371 (Entrez Gene)
Growth hormoneGeneProduct
HMGCS1GeneProduct783184 (Entrez Gene)
IFT88GeneProduct514177 (Entrez Gene)
IGF1GeneProduct281239 (Entrez Gene)
IGF1RGeneProduct281848 (Entrez Gene)
IGF2GeneProduct281240 (Entrez Gene)
IHHGeneProduct522714 (Entrez Gene)
KIF3AGeneProduct541246 (Entrez Gene)
LOC517559GeneProduct517559 (Entrez Gene)
LOC617566GeneProduct617566 (Entrez Gene)
MEF2CGeneProduct512254 (Entrez Gene)
MGPGeneProduct282660 (Entrez Gene)
MMP13GeneProduct281914 (Entrez Gene)
MMP9GeneProduct282871 (Entrez Gene)
NKX3-2GeneProduct616907 (Entrez Gene)
OxygenMetaboliteHMDB01377 (HMDB)
PLATGeneProduct281407 (Entrez Gene)
PLAUGeneProduct281408 (Entrez Gene)
PRKACAGeneProduct282322 (Entrez Gene)
PTCH1GeneProduct520994 (Entrez Gene)
PTH1RGeneProduct507783 (Entrez Gene)
PTHGeneProduct280903 (Entrez Gene)
PTHLHGeneProduct286767 (Entrez Gene)
RUNX2GeneProduct
RUNX3GeneProduct617389 (Entrez Gene)
SCINGeneProduct281478 (Entrez Gene) PMID: 17097081
SERPINH1GeneProduct510850 (Entrez Gene)
SLC38A2GeneProduct338044 (Entrez Gene)
SOX5GeneProduct533829 (Entrez Gene)
SOX6GeneProduct534321 (Entrez Gene)
SPP1GeneProduct281499 (Entrez Gene)
STAT1GeneProduct510814 (Entrez Gene)
STAT5BGeneProduct282376 (Entrez Gene)
Sox9GeneProduct
TGFB1GeneProduct282089 (Entrez Gene)
TGFB2GeneProduct534069 (Entrez Gene)
TGFBIGeneProduct
THRAGeneProduct532621 (Entrez Gene)
TIMP3GeneProduct282094 (Entrez Gene)
TNAPGeneProduct
Thyroid hormoneMetabolite60311 (CHEBI)
Thyroid hormoneMetaboliteT4
TriiodothyronineMetabolite24864 (CHEBI)
VEGFAGeneProduct281572 (Entrez Gene)
cAMPMetaboliteHMDB00058 (HMDB)

Annotated Interactions

No annotated interactions
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