EGFR1 signaling pathway (Canis familiaris)

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1NUECCYMAPMCYLigandNUCYCYENNUNUCYNUCYMANUReceptorGene Symbol(Protein-protein interaction)NUPMCYCYReaction through unknown mechanisms/moleculesPhosphorylationGolgi apparatusRecruitmentExtracellularCYCYNUNUPlasma membranePMCYCytoplasmDeacetylationCYCYPMMANUPMNUProteolytic cleavageCYActivationCYCYPMPMCYMACYAccession Number : NetPath 4; cellmap:4Proteins in a complex interactionNUSumoylationPMMANUMACYMAMACYPMNUDeubiquitinationMAMAMAInhibitionAutophosphorylationDemethylationNUDMAPMPMMAMolecular associationGOMACYNUPMNUMAENPMNucleusNUDPMENEndoplasmic reticulumERPalmitoylationCYMTCYMethylationMACYGlycosylationCYPMCYAutodephosphorylationCYNUDephosphorylationControlPMEnzyme complexMACYCYCYAcetylationCYDUbiquitinationPMMACYNUCYPMPMMitochondrionPMTranslocationPMCYDesumoylationMAMolecule in the pathwayMACYMAEndosomePMMYCMAPK1RFXANKRALGDSKRT18SHC1WNK1SRCSMAD3FOSITCHPIK3CASNCAKRT17JAK2PLCG1MAP3K3PIK3CDMAP2K1FOXO1HIP1ABI1PIK3CGUSP6NLRPS6KA3ARF4SMAD2DOK2STAT5AMAP2K1STAT2STXBP1MAPK1PLD1BCAR1STAT1DUSP1PRKAR1ASTAT5ASTAT3EPS8EGFTNIP1GRB2KRT7PTPN5EEF1A2PIK3R2PTK6FOXO1CAV2GRB7MTA2HIST3H3RALBP1ARAFRALBMAP3K1PIK3CBRAF1RPS6KA3RPS6KA1NCK2BCAR1PLEC1MAP2K5PKN2CEACAM1DNM1SH2D3CELK4RIPK1HTTGAB1PRKCIASAP1PRKCZMAPK14NRASGAB2ZNF259ZNF259CBLBCEBPBMAP2K2PLCG2PTPN6ATF1MAP3K4PEBP1STAT3SOS2SH3GL2KRT8JUNMAPK3EPPK1ELF3PLCG1SH3GL2NCK1TNK2JAK1STAT2VAV2AKT1EPS15L1PTPRRLOC487309HRASSTAT3JUNDSTAT1ARF4AP2A1PRKD1CRKSMAD2CDC42PTPN6KLF11MAP3K2SPRY2MAPK8CASP9MAP3K14PLCG2DUSP1SNRPD2GRB14APPL2PRKCBCSKPITPNASH3BGRLRPS6KA5PAK1SOCS3EEF1A2PIK3R1PXNGAB1MAP3K2NDUFA13MAPK7EGFPTPN11CAV1VAV1MAP2K7CBLCREB1GJA1EPN1VAV3STXBP1LOC478799EGFRAPPL2PRKCAELF3STAT1RAC1SHOC2PIK3C2BSPRY2YWHABMAP2K3INPPL1PTPN12SOCS1CBLCCRKLEPS15EGFRRGS8EGFRRASA1SH3KBP1HRASCAMK2ARAB5AGRB10EPS15SMAD3SHC1GIT1RBBP7APPL1APPL1SH3GL3REPS2ARF4RPS6KA2PLD2WASLTGIFELK1SIN3APIK3R3EGFSTAT5BCEBPARAF1PLD1APPL1MCF2ERRFI1REPS1CTNND1EGFRPRKCGSP1SOS1PRKCASH2D3CPTK2BPLSCR1


Description

The androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among others, dimerize and bind to DNA. Its ligands include testosterone, dehydroepiandrosterone and androstenedione. Stimulation of the receptor activates the SMAD signaling module. Source: http://www.netpath.org/pathways?path_id=NetPath_4

Comments

GenMAPP notes 
NetPath 4; cellmap:4 - EGFR1 Signaling Pathway.This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP437(r21600) with a 92% conversion rate.

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Ontology Terms

 

Bibliography

  1. Hornberg JJ, Binder B, Bruggeman FJ, Schoeberl B, Heinrich R, Westerhoff HV; ''Control of MAPK signalling: from complexity to what really matters.''; Oncogene, 2005 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117445view10:52, 21 May 2021EweitzModified title
68551view22:36, 5 July 2013MaintBotUpdated to 2013 gpml schema
67175view10:16, 26 June 2013Christine ChichesterOntology Term : 'epidermal growth factor/neuregulin signaling pathway' added !
40708view21:51, 1 March 2011MaintBotRemoved redundant pathway information and comments
35722view23:29, 12 February 2010AlexanderPico
35434view11:31, 12 February 2010MichielAdded ref
33988view18:34, 9 December 2009MaintBotAutomatic update of empty xrefs
30665view22:38, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABI1GeneProduct607247 (Entrez Gene)
AKT1GeneProduct490878 (Entrez Gene)
AP2A1GeneProduct484375 (Entrez Gene)
APPL1GeneProduct484716 (Entrez Gene)
APPL2GeneProduct481297 (Entrez Gene)
ARAFGeneProduct491857 (Entrez Gene)
ARF4GeneProduct607073 (Entrez Gene)
ASAP1GeneProduct482044 (Entrez Gene)
ATF1GeneProduct486545 (Entrez Gene)
BCAR1GeneProduct479648 (Entrez Gene)
CAMK2AGeneProduct612941 (Entrez Gene)
CASP9GeneProduct487432 (Entrez Gene)
CAV1GeneProduct403980 (Entrez Gene)
CAV2GeneProduct475294 (Entrez Gene)
CBLGeneProduct
CBLBGeneProduct487965 (Entrez Gene)
CBLCGeneProduct612343 (Entrez Gene)
CDC42GeneProduct607535 (Entrez Gene)
CEACAM1GeneProduct612435 (Entrez Gene)
CEBPAGeneProduct
CEBPBGeneProduct
CREB1GeneProduct607922 (Entrez Gene)
CRKGeneProduct
CRKLGeneProduct608125 (Entrez Gene)
CSKGeneProduct487649 (Entrez Gene)
CTNND1GeneProduct483489 (Entrez Gene)
DNM1GeneProduct491319 (Entrez Gene)
DOK2GeneProduct486133 (Entrez Gene)
DUSP1GeneProduct489117 (Entrez Gene)
EEF1A2GeneProduct403506 (Entrez Gene)
EGFGeneProduct403657 (Entrez Gene)
EGFRGeneProduct404306 (Entrez Gene)
ELF3GeneProduct490235 (Entrez Gene)
ELK1GeneProduct491860 (Entrez Gene)
ELK4GeneProduct488574 (Entrez Gene)
EPN1GeneProduct608964 (Entrez Gene)
EPPK1GeneProduct475117 (Entrez Gene)
EPS15GeneProduct475356 (Entrez Gene)
EPS15L1GeneProduct484849 (Entrez Gene)
EPS8GeneProduct477686 (Entrez Gene)
ERRFI1GeneProduct489636 (Entrez Gene)
FOSGeneProduct490792 (Entrez Gene)
FOXO1GeneProduct477295 (Entrez Gene)
GAB1GeneProduct483808 (Entrez Gene)
GAB2GeneProduct485167 (Entrez Gene)
GIT1GeneProduct491180 (Entrez Gene)
GJA1GeneProduct403418 (Entrez Gene)
GRB10GeneProduct
GRB14GeneProduct478770 (Entrez Gene)
GRB2GeneProduct483312 (Entrez Gene)
GRB7GeneProduct491021 (Entrez Gene)
HIP1GeneProduct489814 (Entrez Gene)
HIST3H3GeneProduct
HRASGeneProduct
HRASGeneProduct403735 (Entrez Gene)
HTTGeneProduct479074 (Entrez Gene)
INPPL1GeneProduct485209 (Entrez Gene)
ITCHGeneProduct477199 (Entrez Gene)
JAK1GeneProduct442952 (Entrez Gene)
JAK2GeneProduct484185 (Entrez Gene)
JUNGeneProduct609429 (Entrez Gene)
JUNDGeneProduct609409 (Entrez Gene)
KLF11GeneProduct475665 (Entrez Gene)
KRT17GeneProduct490977 (Entrez Gene)
KRT18GeneProduct477601 (Entrez Gene)
KRT7GeneProduct477602 (Entrez Gene)
KRT8GeneProduct486513 (Entrez Gene)
LOC478799GeneProduct478799 (Entrez Gene)
LOC487309GeneProduct487309 (Entrez Gene)
MAP2K1GeneProduct478347 (Entrez Gene)
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MAP2K5GeneProduct
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MAP3K1GeneProduct478061 (Entrez Gene)
MAP3K2GeneProduct612902 (Entrez Gene)
MAP3K3GeneProduct480481 (Entrez Gene)
MAP3K4GeneProduct476262 (Entrez Gene)
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MAPK1GeneProduct477575 (Entrez Gene)
MAPK3GeneProduct486758 (Entrez Gene)
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MAPK8GeneProduct477746 (Entrez Gene)
MCF2GeneProduct492176 (Entrez Gene)
MTA2GeneProduct476057 (Entrez Gene)
MYCGeneProduct403924 (Entrez Gene)
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NDUFA13GeneProduct476659 (Entrez Gene)
NRASGeneProduct403872 (Entrez Gene)
PAK1GeneProduct607885 (Entrez Gene)
PEBP1GeneProduct477501 (Entrez Gene)
PIK3C2BGeneProduct478938 (Entrez Gene)
PIK3CAGeneProduct488084 (Entrez Gene)
PIK3CBGeneProduct477085 (Entrez Gene)
PIK3CDGeneProduct489644 (Entrez Gene)
PIK3CGGeneProduct483266 (Entrez Gene)
PIK3R1GeneProduct487235 (Entrez Gene)
PIK3R2GeneProduct609956 (Entrez Gene)
PIK3R3GeneProduct482512 (Entrez Gene)
PITPNAGeneProduct480648 (Entrez Gene)
PKN2GeneProduct490174 (Entrez Gene)
PLCG1GeneProduct485874 (Entrez Gene)
PLCG2GeneProduct489692 (Entrez Gene)
PLD1GeneProduct488167 (Entrez Gene)
PLD2GeneProduct479473 (Entrez Gene)
PLEC1GeneProduct482083 (Entrez Gene)
PLSCR1GeneProduct611500 (Entrez Gene)
PRKAR1AGeneProduct480459 (Entrez Gene)
PRKCAGeneProduct490904 (Entrez Gene)
PRKCBGeneProduct489968 (Entrez Gene)
PRKCGGeneProduct484316 (Entrez Gene)
PRKCIGeneProduct478686 (Entrez Gene)
PRKCZGeneProduct479577 (Entrez Gene)
PRKD1GeneProduct609091 (Entrez Gene)
PTK2BGeneProduct486102 (Entrez Gene)
PTK6GeneProduct
PTPN11GeneProduct477488 (Entrez Gene)
PTPN12GeneProduct483277 (Entrez Gene)
PTPN5GeneProduct485409 (Entrez Gene)
PTPN6GeneProduct486717 (Entrez Gene)
PTPRRGeneProduct481163 (Entrez Gene)
PXNGeneProduct486299 (Entrez Gene)
RAB5AGeneProduct404008 (Entrez Gene)
RAC1GeneProduct403955 (Entrez Gene)
RAF1GeneProduct484648 (Entrez Gene)
RALBGeneProduct483881 (Entrez Gene)
RALBP1GeneProduct490548 (Entrez Gene)
RALGDSGeneProduct480686 (Entrez Gene)
RASA1GeneProduct479158 (Entrez Gene)
RBBP7GeneProduct480854 (Entrez Gene)
REPS1GeneProduct476221 (Entrez Gene)
REPS2GeneProduct491756 (Entrez Gene)
RFXANKGeneProduct476662 (Entrez Gene)
RGS8GeneProduct490311 (Entrez Gene)
RIPK1GeneProduct488195 (Entrez Gene)
RPS6KA1GeneProduct487353 (Entrez Gene)
RPS6KA2GeneProduct612448 (Entrez Gene)
RPS6KA3GeneProduct491768 (Entrez Gene)
RPS6KA5GeneProduct490831 (Entrez Gene)
SH2D3CGeneProduct491326 (Entrez Gene)
SH3BGRLGeneProduct491986 (Entrez Gene)
SH3GL2GeneProduct611239 (Entrez Gene)
SH3GL3GeneProduct609858 (Entrez Gene)
SH3KBP1GeneProduct612797 (Entrez Gene)
SHC1GeneProduct490439 (Entrez Gene)
SHOC2GeneProduct477819 (Entrez Gene)
SIN3AGeneProduct478372 (Entrez Gene)
SMAD2GeneProduct480144 (Entrez Gene)
SMAD3GeneProduct610902 (Entrez Gene)
SNCAGeneProduct478478 (Entrez Gene)
SNRPD2GeneProduct
SOCS1GeneProduct490006 (Entrez Gene)
SOCS3GeneProduct442949 (Entrez Gene)
SOS1GeneProduct483042 (Entrez Gene)
SOS2GeneProduct490682 (Entrez Gene)
SP1GeneProduct486507 (Entrez Gene)
SPRY2GeneProduct485504 (Entrez Gene)
SRCGeneProduct485864 (Entrez Gene)
STAT1GeneProduct488449 (Entrez Gene)
STAT2GeneProduct481111 (Entrez Gene)
STAT3GeneProduct490967 (Entrez Gene)
STAT5AGeneProduct490968 (Entrez Gene)
STAT5BGeneProduct490969 (Entrez Gene)
STXBP1GeneProduct
TGIFGeneProduct
TNIP1GeneProduct489178 (Entrez Gene)
TNK2GeneProduct488025 (Entrez Gene)
USP6NLGeneProduct487132 (Entrez Gene)
VAV1GeneProduct485016 (Entrez Gene)
VAV2GeneProduct608060 (Entrez Gene)
VAV3GeneProduct479921 (Entrez Gene)
WASLGeneProduct475213 (Entrez Gene)
WNK1GeneProduct477728 (Entrez Gene)
YWHABGeneProduct477237 (Entrez Gene)
ZNF259GeneProduct479428 (Entrez Gene)

Annotated Interactions

No annotated interactions
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