Calcium regulation in cardiac cells (Canis familiaris)

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Adenylyl Cyclases2+K+2+GG alpha i/o/zCaCalsequestrin S-CaEpinephrineCaarrestin/GRKK+IP3 Receptors2+IP4Protein Kinase ACacAMPbCytosolCaM kinaseCytosolic CabgPhopholambanCaNa+beta ArrestinGCa2+ADP + PiCyclasesPProtein Kinase AGap Junctions (Connexins)GCaAdrenergic ReceptorRegulators of G-protein2+Ca2+FKBP12EpinephrinebDAGSRCagG2+2+PKA InhibitorsNa+Dihydropyridine-SensitiveG alpha i/o/zConnexinK+aNa2+IP3PCaM kinaseGRK2+Cytosolic CaPIP2ConnexinbgProtein Kinase CCalmodulin2+2+Adrenergic ReceptorIP3 Receptors2+M1 Muscarinic ReceptorAdenylylNa+/Ca2+ Exchanger2+RepolarizationMembrane
DepolarizationL-Type Ca2+ ChannelbbgADP + PiGCytosolic Ca2+Na+/K+ ATPasebCalreticulin-CaSignalingCalsequestrin C-CaPKC inhibitor Protein-1Caarrestin/GRK2+RGS18RGS9ADCY5CALM2FKBP1AADPGNAQRYR3YWHAQADCY1GJD2CHRM2ATPGJB6PRKCARGS19ADRB1PRKACBCHRM1CAMK4PRKCHGNAI2PRKAR2AGJA3YWHABRGS7YWHAHGNG5GNG2KCNJ3YWHAGCACNB1PRKAR2BATP2B2PRKAR1BLOC611349ADCY7RGS5GNAZGJB2ADRB3CALM1PRKCQGJA10RGS2RYR1CAMK2DADCY9ATP1B2PRKCGADRB2ANXA6PLNGNG12ATPGNB2PRKCBGJA12RGS3RGS10ITPR3RGS6ADCY3KCNB1ADRA1ACACNA1AATP1A4KCNJ5PLCB3GNB5PKIAITPR2ARRB2GRK4CACNA1DCACNA1SGJB4RGS14AcetylcholinePLCB3CACNA1CCALRGJA5GRK6GNB3FXYD2RYR2ATP2B3GNB1ITPR1CAMK2BGNB4CHRM4PRKCZGJA4ADCY2CAMK2AATP2A3RGS17SLC8A1YWHAZRGS20GJB3CACNB3GNG8YWHAEPRKCHCASQ1CALM3GNAO1CHRM3ATP2A2GNAI1RGS1PRKD1GNG7PRKCDGJA8GJA1GNA11Adcy6CAMK2GGNGT1PRKCEGRK5GNASATP2B1PRKACAARRB1GJC1PKIBCHRM5PKIGATP1B3ATPRGS11RGS4CASQ2GNG4GJB5GNAI3SFNPRKAR1ACACNA1EATPADRA1BCACNA1BGNG3RGS8ADRA1DCAMK1ADCY4GJB1ATP1B1SLC8A3GNG11ADCY8RHOXF2


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP536(r21808) with a 80% conversion rate.

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Ontology Terms

 

Bibliography

  1. Marks AR; ''Calcium and the heart: a question of life and death.''; J Clin Invest, 2003 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117441view10:51, 21 May 2021EweitzModified title
107090view14:17, 17 September 2019MaintBotChEBI identifier normalization
106055view11:57, 16 August 2019MaintBotHMDB identifier normalization
95758view14:13, 19 January 2018MkutmonHomology conversion update
68583view23:10, 5 July 2013MaintBotUpdated to 2013 gpml schema
67771view13:54, 26 June 2013Christine ChichesterOntology Term : 'calcium/calcium-mediated signaling pathway' added !
48161view19:00, 9 May 2012MaintBotUpdating from human to fix xrefs
40742view21:54, 1 March 2011MaintBotRemoved redundant pathway information and comments
35454view11:49, 12 February 2010Thomasadd literature
35453view11:48, 12 February 2010ThomasModified description
34017view18:44, 9 December 2009MaintBotAutomatic update of empty xrefs
32254view12:57, 15 August 2009MaintBotFixed text labels
31775view12:09, 14 August 2009MaintBotFixed group labels
31276view20:00, 13 August 2009MaintBotFixed text labels
30728view22:58, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADCY1GeneProductCYA1 HUMAN
ADCY2GeneProduct478624 (Entrez Gene) There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
ADCY3GeneProduct482994 (Entrez Gene)
ADCY4GeneProduct480271 (Entrez Gene) There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
ADCY5GeneProduct403859 (Entrez Gene) There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
ADCY7GeneProduct487289 (Entrez Gene)
ADCY8GeneProduct482045 (Entrez Gene)
ADCY9GeneProduct490031 (Entrez Gene)
ADPGeneProduct
ADRA1AGeneProduct403866 (Entrez Gene)
ADRA1BGeneProduct403962 (Entrez Gene)
ADRA1DGeneProduct
ADRB1GeneProduct493972 (Entrez Gene)
ADRB2GeneProduct403910 (Entrez Gene)
ADRB3GeneProduct442979 (Entrez Gene)
ANXA6GeneProduct479325 (Entrez Gene)
ARRB1GeneProduct485189 (Entrez Gene)
ARRB2GeneProduct
ATP1A4GeneProduct488637 (Entrez Gene)
ATP1B1GeneProduct403966 (Entrez Gene)
ATP1B2GeneProduct489479 (Entrez Gene)
ATP1B3GeneProduct477098 (Entrez Gene)
ATP2A2GeneProduct403878 (Entrez Gene)
ATP2A3GeneProduct491437 (Entrez Gene)
ATP2B1GeneProduct403480 (Entrez Gene)
ATP2B2GeneProduct476535 (Entrez Gene)
ATP2B3GeneProduct492238 (Entrez Gene)
ATPGeneProduct
AcetylcholineGeneProduct
Adcy6GeneProduct477625 (Entrez Gene)
CACNA1AGeneProduct
CACNA1BGeneProduct
CACNA1CGeneProduct403516 (Entrez Gene)
CACNA1DGeneProduct484724 (Entrez Gene)
CACNA1EGeneProduct490305 (Entrez Gene)
CACNA1SGeneProduct490244 (Entrez Gene)
CACNB1GeneProduct491030 (Entrez Gene)
CACNB3GeneProduct486563 (Entrez Gene)
CALM1GeneProduct
CALM2GeneProduct
CALM3GeneProduct
CALRGeneProduct476694 (Entrez Gene)
CAMK1GeneProduct484665 (Entrez Gene)
CAMK2AGeneProduct612941 (Entrez Gene)
CAMK2BGeneProduct
CAMK2DGeneProduct610764 (Entrez Gene)
CAMK2GGeneProduct489050 (Entrez Gene)
CAMK4GeneProduct
CASQ1GeneProduct608401 (Entrez Gene)
CASQ2GeneProduct483134 (Entrez Gene)
CHRM1GeneProduct483776 (Entrez Gene)
CHRM2GeneProduct403858 (Entrez Gene)
CHRM3GeneProduct403827 (Entrez Gene)
CHRM4GeneProduct611314 (Entrez Gene)
CHRM5GeneProduct487472 (Entrez Gene)
FKBP1AGeneProduct
FXYD2GeneProduct608594 (Entrez Gene)
GJA10GeneProduct
GJA12GeneProduct
GJA1GeneProduct403418 (Entrez Gene)
GJA3GeneProduct486052 (Entrez Gene)
GJA4GeneProduct482485 (Entrez Gene)
GJA5GeneProduct483155 (Entrez Gene)
GJA8GeneProduct483156 (Entrez Gene)
GJB1GeneProduct480953 (Entrez Gene)
GJB2GeneProduct403570 (Entrez Gene)
GJB3GeneProduct482486 (Entrez Gene)
GJB4GeneProduct482487 (Entrez Gene)
GJB5GeneProduct482488 (Entrez Gene)
GJB6GeneProduct
GJC1GeneProduct490936 (Entrez Gene)
GJD2GeneProduct487477 (Entrez Gene)
GNA11GeneProduct403914 (Entrez Gene)
GNAI1GeneProduct478227 (Entrez Gene)
GNAI2GeneProduct442957 (Entrez Gene)
GNAI3GeneProduct611810 (Entrez Gene)
GNAO1GeneProduct609157 (Entrez Gene)
GNAQGeneProduct
GNASGeneProduct403943 (Entrez Gene)
GNAZGeneProduct607445 (Entrez Gene)
GNB1GeneProduct403912 (Entrez Gene)
GNB2GeneProduct479733 (Entrez Gene)
GNB3GeneProduct403511 (Entrez Gene)
GNB4GeneProduct488087 (Entrez Gene)
GNB5GeneProduct608623 (Entrez Gene)
GNG11GeneProduct610002 (Entrez Gene)
GNG12GeneProduct
GNG2GeneProduct610817 (Entrez Gene)
GNG3GeneProduct483783 (Entrez Gene)
GNG4GeneProduct607513 (Entrez Gene)
GNG5GeneProduct
GNG7GeneProduct612139 (Entrez Gene)
GNG8GeneProduct484428 (Entrez Gene)
GNGT1GeneProduct403895 (Entrez Gene)
GRK4GeneProduct479075 (Entrez Gene)
GRK5GeneProduct486915 (Entrez Gene)
GRK6GeneProduct
ITPR1GeneProduct476548 (Entrez Gene)
ITPR2GeneProduct486628 (Entrez Gene)
ITPR3GeneProduct481746 (Entrez Gene)
KCNB1GeneProduct485918 (Entrez Gene)
KCNJ3GeneProduct488355 (Entrez Gene)
KCNJ5GeneProduct489284 (Entrez Gene)
LOC611349GeneProduct611349 (Entrez Gene)
PKIAGeneProduct610744 (Entrez Gene)
PKIBGeneProduct
PKIGGeneProduct610925 (Entrez Gene)
PLCB3GeneProduct476034 (Entrez Gene)
PLNGeneProduct
PRKACAGeneProduct403556 (Entrez Gene)
PRKACBGeneProduct479975 (Entrez Gene)
PRKAR1AGeneProduct480459 (Entrez Gene) KAP0 HUMAN
PRKAR1BGeneProduct480805 (Entrez Gene)
PRKAR2AGeneProduct484774 (Entrez Gene)
PRKAR2BGeneProduct475887 (Entrez Gene)
PRKCAGeneProduct490904 (Entrez Gene)
PRKCBGeneProduct489968 (Entrez Gene)
PRKCDGeneProduct494005 (Entrez Gene)
PRKCEGeneProduct609934 (Entrez Gene) This EST is listed on the Affymetrix Murine6500 chip. The SwissProt entry name is KPCE MOUSE.
PRKCGGeneProduct484316 (Entrez Gene)
PRKCHGeneProduct490722 (Entrez Gene)
PRKCQGeneProduct478013 (Entrez Gene)
PRKCZGeneProduct479577 (Entrez Gene)
PRKD1GeneProduct609091 (Entrez Gene) KPCM HUMAN
RGS10GeneProduct477840 (Entrez Gene)
RGS11GeneProduct611545 (Entrez Gene)
RGS14GeneProduct489092 (Entrez Gene)
RGS1GeneProduct488585 (Entrez Gene)
RGS17GeneProduct608867 (Entrez Gene)
RGS18GeneProduct607858 (Entrez Gene)
RGS19GeneProduct491407 (Entrez Gene)
RGS20GeneProduct486954 (Entrez Gene)
RGS2GeneProduct488584 (Entrez Gene)
RGS3GeneProduct
RGS4GeneProduct488666 (Entrez Gene)
RGS5GeneProduct488667 (Entrez Gene)
RGS6GeneProduct480380 (Entrez Gene)
RGS7GeneProduct
RGS8GeneProduct490311 (Entrez Gene)
RGS9GeneProduct490902 (Entrez Gene)
RHOXF2GeneProduct611154 (Entrez Gene)
RYR1GeneProduct
RYR2GeneProduct403615 (Entrez Gene)
RYR3GeneProduct
SFNGeneProduct487351 (Entrez Gene)
SLC8A1GeneProduct475738 (Entrez Gene)
SLC8A3GeneProduct490755 (Entrez Gene)
YWHABGeneProduct477237 (Entrez Gene)
YWHAEGeneProduct480645 (Entrez Gene)
YWHAGGeneProduct489818 (Entrez Gene)
YWHAHGeneProduct
YWHAQGeneProduct607060 (Entrez Gene)
YWHAZGeneProduct475864 (Entrez Gene) PMID: 9861170 PMID: 1317796

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1159"