IL-5 signaling pathway (Homo sapiens)

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STAT5BPSTAT5A27, 103PRPS6KB1124, 212MAPK3P109, 130, 212, 346AKT1P130, 160, 212274, 336151, 208, 218, 311121, 235367, 43543, 159194119, 187308, 43534, 311, 411374, 408130, 4088585, 121, 274435412121, 2744385, 167, 257107, 274311, 370374, 40836874, 408311194127, 185130408439Ras-MAPK cascade dependentgene expressiongene expressionAKT dependentNUCYHRASGTP162, 270PIK3R1GSK3ABTKELK1PIK3CGLYNPIK3R2PTPN11JAK1RPS6KA1GSK3BJAK2SPRED-1PPPPPPPPPP142, 64, 76, 103, 109...374266, 288266, 288448, 4592, 103, 274124448448MAP2K2P167SHC1P217, 256, 448IL5IL5STAT5BBCL2JUNFOSRPS6JUNP449MTORSOS1RAF1P167MAP2K1IL5RACSF2RBCSF2RBIL5RAPPUb66, 103, 27485101, 385STAT3P50, 170, 429MAPK1P130, 212, 346FOXO3AP266, 288STAT1P158, 442GRB2RPS6KB2STAT5A19, 167, 257257SYK257, 408PIL-5 Signal Transduction Pathway257Enzyme complexInhibitionAuto catalysisTransportPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionTranslocation UbiquitinationDeubiquitinationSumoylationInduced catalysisProtein-protein interactionAcetylationDephosphorylationLEGENDPhosphorylationProteinmRNAProteinReceptorLigandDeacetylationGolgi apparatusEndosomeNucleusMitochondrionDesumoylationMethylationDemethylationPalmitoylationCytoplasmECPlasma membraneMTEndoplasmic reticulumCYPMGONUExtracellularERENProteolytic cleavagePIM1MYC


Description

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Bibliography

  1. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A; ''NetPath: a public resource of curated signal transduction pathways.''; Genome Biol, 2010 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
126270view16:18, 19 April 2023EgonwLicense is CCZero
120669view01:18, 23 December 2021EweitzStandardize font, weight, case
116634view11:22, 9 May 2021EweitzModified title
115944view07:11, 22 March 2021EgonwModified description
108326view21:07, 6 December 2019L DupuisConverted interactions to graphical lines in legend
78498view10:28, 7 January 2015MaintBotadded missing graphIds
70017view01:50, 12 July 2013AlexanderPicoModified title
68063view17:57, 29 June 2013MaintBotOntology Term : 'DOID:4' removed !
67853view12:34, 27 June 2013Noopur144Ontology Term : 'Disease' added !
67380view10:44, 26 June 2013Christine ChichesterOntology Term : 'interleukin-5 signaling pathway' added !
64648view15:03, 31 May 2013AndraAdded reference from the description in the pathway
63212view20:58, 8 May 2013MaintBotUpdating gpml version
48438view14:36, 24 May 2012NetPathModified description
45368view20:59, 7 October 2011AlexanderPicoOntology Term : 'DOID:8406' removed !
45132view00:52, 7 October 2011AlexanderPicofixed db refs
44847view09:47, 6 October 2011MartijnVanIerselOntology Term : 'Interleukin mediated signaling pathway' added !
44626view18:05, 22 September 2011KhanspersUpdating content to NetSlim
44104view20:23, 24 August 2011KhanspersReverted to version '23:13, 1 March 2011' by Khanspers
44021view22:48, 22 August 2011KhanspersAdded category
44020view22:48, 22 August 2011KhanspersModified description
44019view22:46, 22 August 2011KhanspersUpdating pathway from NetSlim
41029view23:13, 1 March 2011MaintBotRemoved redundant pathway information and comments
35644view21:34, 12 February 2010KhanspersModified description
20949view11:30, 14 November 2008MaintBot[[Pathway:Homo sapiens:IL-5 NetPath 17]] moved to [[Pathway:WP127]]: Moved to stable identifier
8182view13:46, 7 January 2008MaintBot[[Pathway:Human:IL-5 NetPath 17]] moved to [[Pathway:Homo sapiens:IL-5 NetPath 17]]: Renaming species
7711view16:12, 18 December 2007MaintBotfixed category names
7250view12:41, 4 November 2007MaintBotAdded categories to GPML
6338view22:18, 22 May 2007A.Pandeygpml file for [[Human:IL-5_NetPath_17]]

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1GeneProduct207 (Entrez Gene)
BCL2GeneProduct596
BTKGeneProduct695 (Entrez Gene)
CSF2RBGeneProduct1439 (Entrez Gene)
ELK1GeneProduct2002 (Entrez Gene)
FOSGeneProduct2353
FOXO3AGeneProduct2309 (Entrez Gene)
GRB2GeneProduct2885 (Entrez Gene)
GSK3AGeneProduct2931 (Entrez Gene)
GSK3BGeneProduct2932 (Entrez Gene)
HRASGeneProduct3845 (Entrez Gene)
IL5GeneProduct3558 (Entrez Gene)
IL5RAGeneProduct3568 (Entrez Gene)
JAK1 GeneProduct3716
JAK2GeneProduct3717 (Entrez Gene)
JUNGeneProduct3725 (Entrez Gene)
LYNGeneProduct4067
LigandGeneProduct7040 (Entrez Gene)
MAP2K1GeneProduct5604 (Entrez Gene)
MAP2K2GeneProduct5605 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3GeneProduct5595
MTORGeneProduct4137 (Entrez Gene)
MYCGeneProduct4609 (Entrez Gene)
PIK3CGGeneProduct
PIK3R1GeneProduct5295 (Entrez Gene)
PIK3R2GeneProduct5296 (Entrez Gene)
PIM1GeneProduct2353 (Entrez Gene)
PTPN11GeneProduct5781 (Entrez Gene)
ProteinProtein5894 (Entrez Gene)
ProteinProtein
RAF1GeneProduct5894 (Entrez Gene)
RPS6GeneProduct6194 (Entrez Gene)
RPS6KA1GeneProduct6195 (Entrez Gene)
RPS6KB1GeneProduct6198 (Entrez Gene)
RPS6KB2GeneProduct6199 (Entrez Gene)
ReceptorGeneProduct7040 (Entrez Gene)
SHC1GeneProduct6464 (Entrez Gene)
SOS1GeneProduct6654 (Entrez Gene)
SPRED-1GeneProduct161742
STAT1GeneProduct6772
STAT3GeneProduct6774 (Entrez Gene)
STAT5AGeneProduct6776 (Entrez Gene)
STAT5BGeneProduct6777 (Entrez Gene)
SYKGeneProduct6850 (Entrez Gene)
mRNAProtein

Annotated Interactions

No annotated interactions

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