Toll-like receptor signaling pathway (Mus musculus)

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MyD88-dependent pathway(Neutrophil, immature DC,Specific pathwayin pDCsCpG DNA(T cell)Proinflammatory+peffects+pPeptidoglycan(G+)+pMAPK signaling pathway+p(anti-viral compounds)LPS(G-)Zymosan (Yeast)ApoptosisChemotacticLipoarabinomannanComplement andInflammatory cytokinesT cell stimulation+p+pDegradation+pbiosynthesisImidazoquinolinInflammatory cytokinesUbiquitin mediated proteolysisUnmethylatedcoagulation cascadesCostimulatory moleculeseffectsJak-STAT signaling pathway+pFlagellar assemblyinteractionEndosomedsRNANK cell)Antiviral effects+cytokine receptor+pChemotacticMyD88-independent pathway+pLipopolysaccharideAutocrine / ParacrineIKK+p(Mycobacteria)Flagellin+p+peffects+pssRNACytokine-Lipoprotein+p+IFNA14Ifnar2FaddIFNA10Map2k4Mapk14LbpAkt1Ifnar1IFNA1Mapk13Il6Nfkb1Tlr2IkbkeIkbkgIrak4Tlr1Tlr3Nfkb1Mapk9Tlr8Ly96Cd80TirapChukCxcl11NfkbiaCxcl9TnfMapk11Pik3cgIrak4Pik3caIL8IFNA4Pik3cdSpp1TirapTraf6Mapk8Tlr6Mapk1IFNA16Ticam2TollipMap3k7ip1IFNA17IFNA2Map3k7Irak1Map3k7ip2IkbkbIfnb1Tlr7Myd88FosMyd88IFNA8Tlr5Irak1Pik3r3IFNA6IFNA21Irf3Tlr9Pik3r1Tlr4Traf6Irf7Nfkb2Ripk1Pik3r2Pik3cbCCL3Akt2Ifnb1Akt3Rac1Ifnb1Stat1Il12bMap2k6Traf3IFNA7Myd88RelaTlr2Mapk10Il1bJunMap2k7Map3k8Ccl5Cd14Tbk1IFNA5Irf5Mapk12Mapk3ChukCd40Cd86IFNA13Ticam1Map2k1Il12aMap2k3Traf6Cxcl10Pik3r5Ccl4Map2k2Casp8Myd88


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP75(r30264) with a 86% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

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CompareRevisionActionTimeUserComment
118907view21:51, 3 June 2021EweitzOntology Term : 'Toll-like receptor signaling pathway' added !
118906view21:51, 3 June 2021EweitzOntology Term : 'signaling pathway pertinent to development' added !
114027view15:36, 17 December 2020Fehrhartconnect unconnected lines
107769view18:37, 1 November 2019AgustinGVFix missing Entrez ID
107768view18:35, 1 November 2019AgustinGVFix missing Entrez IDs, remove non orthologues
87795view11:16, 25 July 2016MirellaKalafatiOntology Term : 'signaling pathway' added !
69089view18:11, 8 July 2013MaintBotUpdated to 2013 gpml schema
49294view11:55, 13 July 2012Thomaslinked several interactions
49293view11:53, 13 July 2012Thomaslinked and grouped several genes
41276view00:21, 2 March 2011MaintBotRemoved redundant pathway information and comments
34381view22:47, 9 December 2009MaintBotAutomatic update of empty xrefs
32299view13:16, 15 August 2009MaintBotFixed text labels
31871view12:38, 14 August 2009MaintBotFixed group labels
31328view20:21, 13 August 2009MaintBotFixed text labels
30898view00:23, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Akt1GeneProduct11651 (Entrez Gene) Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208
Akt2GeneProduct11652 (Entrez Gene) Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208
Akt3GeneProduct23797 (Entrez Gene) Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208
CCL3GeneProduct20302 (Entrez Gene) Original kegg element: gene;44;hsa:6348
Casp8GeneProduct12370 (Entrez Gene) Original kegg element: gene;87;hsa:841
Ccl4GeneProduct20303 (Entrez Gene) Original kegg element: gene;38;hsa:6351
Ccl5GeneProduct20304 (Entrez Gene) Original kegg element: gene;58;hsa:6352
Cd14GeneProduct12475 (Entrez Gene) Original kegg element: gene;84;hsa:929
Cd40GeneProduct21939 (Entrez Gene) Original kegg element: gene;29;hsa:958
Cd80GeneProduct12519 (Entrez Gene) Original kegg element: gene;69;hsa:941
Cd86GeneProduct12524 (Entrez Gene) Original kegg element: gene;28;hsa:942
ChukGeneProduct12675 (Entrez Gene) Original kegg element: gene;42;hsa:1147
Cxcl10GeneProduct15945 (Entrez Gene) Original kegg element: gene;25;hsa:3627
Cxcl11GeneProduct56066 (Entrez Gene) Original kegg element: gene;23;hsa:6373
Cxcl9GeneProduct17329 (Entrez Gene) Original kegg element: gene;24;hsa:4283
FaddGeneProduct14082 (Entrez Gene) Original kegg element: gene;56;hsa:8772
FosGeneProduct14281 (Entrez Gene) Original kegg element: gene;35;hsa:2353 hsa:3725
IFNA10GeneProduct110296 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA1GeneProduct15962 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA13GeneProduct230396 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA14GeneProduct404549 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA16GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA17GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA21GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA2GeneProduct15965 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA4GeneProduct15967 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA5GeneProduct15968 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA6GeneProduct15969 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA7GeneProduct15970 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA8GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IL8GeneProductOriginal kegg element: gene;43;hsa:3576
Ifnar1GeneProduct15975 (Entrez Gene) Original kegg element: gene;49;hsa:3454 hsa:3455
Ifnar2GeneProduct15976 (Entrez Gene) Original kegg element: gene;49;hsa:3454 hsa:3455
Ifnb1GeneProduct15977 (Entrez Gene) Original kegg element: gene;1;hsa:3456
IkbkbGeneProduct16150 (Entrez Gene) Original kegg element: gene;36;hsa:3551
IkbkeGeneProduct56489 (Entrez Gene) Original kegg element: gene;54;hsa:9641
IkbkgGeneProduct16151 (Entrez Gene) Original kegg element: gene;85;hsa:8517
Il12aGeneProduct16159 (Entrez Gene) Original kegg element: gene;45;hsa:3592 hsa:3593
Il12bGeneProduct16160 (Entrez Gene) Original kegg element: gene;45;hsa:3592 hsa:3593
Il1bGeneProduct16176 (Entrez Gene) Original kegg element: gene;51;hsa:3553
Il6GeneProduct16193 (Entrez Gene) Original kegg element: gene;57;hsa:3569
Irak1GeneProduct16179 (Entrez Gene) Original kegg element: gene;41;hsa:3654
Irak4GeneProduct266632 (Entrez Gene) Original kegg element: gene;86;hsa:51135
Irf3GeneProduct54131 (Entrez Gene) Original kegg element: gene;67;hsa:3661
Irf5GeneProduct27056 (Entrez Gene) Original kegg element: gene;21;hsa:3663
Irf7GeneProduct54123 (Entrez Gene) Original kegg element: gene;20;hsa:3665
JunGeneProduct16476 (Entrez Gene) Original kegg element: gene;35;hsa:2353 hsa:3725
LbpGeneProduct16803 (Entrez Gene) Original kegg element: gene;77;hsa:3929
Ly96GeneProduct17087 (Entrez Gene) Original kegg element: gene;71;hsa:23643
Map2k1GeneProduct26395 (Entrez Gene) Original kegg element: gene;12;hsa:5604 hsa:5605
Map2k2GeneProduct26396 (Entrez Gene) Original kegg element: gene;12;hsa:5604 hsa:5605
Map2k3GeneProduct26397 (Entrez Gene) Original kegg element: gene;65;hsa:5606 hsa:5608
Map2k4GeneProduct26398 (Entrez Gene) Original kegg element: gene;63;hsa:5609 hsa:6416
Map2k6GeneProduct26399 (Entrez Gene) Original kegg element: gene;65;hsa:5606 hsa:5608
Map2k7GeneProduct26400 (Entrez Gene) Original kegg element: gene;63;hsa:5609 hsa:6416
Map3k7GeneProduct26409 (Entrez Gene) Original kegg element: gene;37;hsa:6885
Map3k7ip1GeneProduct66513 (Entrez Gene) Original kegg element: gene;59;hsa:10454
Map3k7ip2GeneProduct68652 (Entrez Gene) Original kegg element: gene;61;hsa:23118
Map3k8GeneProduct26410 (Entrez Gene) Original kegg element: gene;13;hsa:1326
Mapk10GeneProduct26414 (Entrez Gene) Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
Mapk11GeneProduct19094 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
Mapk12GeneProduct29857 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
Mapk1GeneProduct26413 (Entrez Gene) Original kegg element: gene;11;hsa:5594 hsa:5595
Mapk13GeneProduct26415 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
Mapk14GeneProduct26416 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
Mapk3GeneProduct26417 (Entrez Gene) Original kegg element: gene;11;hsa:5594 hsa:5595
Mapk8GeneProduct26419 (Entrez Gene) Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
Mapk9GeneProduct26420 (Entrez Gene) Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
Myd88GeneProduct17874 (Entrez Gene) Original kegg element: gene;47;hsa:4615
Nfkb1GeneProduct18033 (Entrez Gene) Original kegg element: gene;14;hsa:4790
Nfkb2GeneProduct18034 (Entrez Gene) Original kegg element: gene;10;hsa:4790 hsa:4791 hsa:5970
NfkbiaGeneProduct18035 (Entrez Gene) Original kegg element: gene;64;hsa:4792
Pik3caGeneProduct18706 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
Pik3cbGeneProduct74769 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
Pik3cdGeneProduct18707 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
Pik3cgGeneProduct30955 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
Pik3r1GeneProduct18708 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
Pik3r2GeneProduct18709 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
Pik3r3GeneProduct18710 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
Pik3r5GeneProduct320207 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
Rac1GeneProduct19353 (Entrez Gene) Original kegg element: gene;48;hsa:5879
RelaGeneProduct19697 (Entrez Gene) Original kegg element: gene;10;hsa:4790 hsa:4791 hsa:5970
Ripk1GeneProduct19766 (Entrez Gene) Original kegg element: gene;17;hsa:8737
Spp1GeneProduct20750 (Entrez Gene) Original kegg element: gene;15;hsa:6696
Stat1GeneProduct20846 (Entrez Gene) Original kegg element: gene;62;hsa:6772
Tbk1GeneProduct56480 (Entrez Gene) Original kegg element: gene;52;hsa:29110
Ticam1GeneProduct106759 (Entrez Gene) Original kegg element: gene;82;hsa:148022
Ticam2GeneProduct225471 (Entrez Gene) Original kegg element: gene;80;hsa:353376
TirapGeneProduct117149 (Entrez Gene) Original kegg element: gene;83;hsa:114609
Tlr1GeneProduct21897 (Entrez Gene) Original kegg element: gene;75;hsa:7096
Tlr2GeneProduct24088 (Entrez Gene) Original kegg element: gene;74;hsa:7097
Tlr3GeneProduct142980 (Entrez Gene) Original kegg element: gene;73;hsa:7098
Tlr4GeneProduct21898 (Entrez Gene) Original kegg element: gene;79;hsa:7099
Tlr5GeneProduct53791 (Entrez Gene) Original kegg element: gene;72;hsa:7100
Tlr6GeneProduct21899 (Entrez Gene) Original kegg element: gene;76;hsa:10333
Tlr7GeneProduct170743 (Entrez Gene) Original kegg element: gene;39;hsa:51284 hsa:51311
Tlr8GeneProduct170744 (Entrez Gene) Original kegg element: gene;39;hsa:51284 hsa:51311
Tlr9GeneProduct81897 (Entrez Gene) Original kegg element: gene;78;hsa:54106
TnfGeneProduct21926 (Entrez Gene) Original kegg element: gene;66;hsa:7124
TollipGeneProduct54473 (Entrez Gene) Original kegg element: gene;81;hsa:54472
Traf3GeneProduct22031 (Entrez Gene) Original kegg element: gene;16;hsa:7187
Traf6GeneProduct22034 (Entrez Gene) Original kegg element: gene;53;hsa:7189

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1271"