Apoptosis (Rattus norvegicus)

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1bDegradationInterferon regulatory factorsDNA FragmentationCaspbpActivator of Cell DeathApoptosisMitochondrioneIGF1R signaling pathwayeInhibitor of Cell Deathp53 RelatedpFas LigandbTp53Bcl2l2Pik3r1CyctCflarRipk1Tnfrsf25TNFRSF10BTraddBcl2Casp4RelaCasp2BBC3Tp73Casp6Traf2Irf2Mdm2Tp63CraddBaxIrf5NfkbiaNfkbieCdkn2aDffaNfkbieCasp9Igf2BidMycDiabloTraf3TnfBirc3Igf1rLtaFasCasp8PMAIP1Irf1HrkIrf6CycsIkbkgTnfrsf1bTnfsf10Igf1Casp7Apaf1Mcl1BokDffbBnip3lNfkbiaHellsTraddNfkbibFaslgTnfrsf1aIrf7Bak1Mapk10Prf1TRAF1ChukAkt1XiapMap2k4Bcl2l1Casp3Nfkb1Irf3Tnfrsf21Bcl2l11BadCASP11IkbkbCASP10RelaGZMBBirc2Tnfrsf1aBadIrf4Map3k1FaddJunNfkbibBIRC5Ripk1Nfkb1Casp12


Description

Apoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and membrane blebbing characterize apoptosis in general. Mitochondria remain morphologically unchanged. In 1972 Kerr et al introduced the concept of apoptosis as a distinct form of "cell-death", and the mechanisms of various apoptotic pathways are still being revealed today.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP254(r29955) with a 92% conversion rate.

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Ontology Terms

 

Bibliography

  1. Park SY, Lee JH, Ha M, Nam JW, Kim VN; ''miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42.''; Nat Struct Mol Biol, 2009 PubMed Europe PMC Scholia
  2. Mott JL, Kobayashi S, Bronk SF, Gores GJ; ''mir-29 regulates Mcl-1 protein expression and apoptosis.''; Oncogene, 2007 PubMed Europe PMC Scholia
  3. Bose I, Ghosh B; ''The p53-MDM2 network: from oscillations to apoptosis.''; J Biosci, 2007 PubMed Europe PMC Scholia
  4. Lakin ND, Jackson SP; ''Regulation of p53 in response to DNA damage.''; Oncogene, 1999 PubMed Europe PMC Scholia
  5. Xiong Y, Fang JH, Yun JP, Yang J, Zhang Y, Jia WH, Zhuang SM; ''Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma.''; Hepatology, 2010 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
95785view14:37, 19 January 2018MkutmonHomology conversion update
71796view20:33, 17 October 2013MaintBotAutomated update of data sources
69417view19:02, 8 July 2013MaintBotUpdated to 2013 gpml schema
67050view09:59, 26 June 2013Christine ChichesterOntology Term : 'apoptotic cell death pathway' added !
47760view05:06, 6 April 2012Khanspersupdated xrefs
41740view02:40, 2 March 2011MaintBotRemoved redundant pathway information and comments
35104view13:11, 11 February 2010MartijnVanIerselAdded lit. ref.
34113view19:24, 9 December 2009MaintBotAutomatic update of empty xrefs
31891view12:43, 14 August 2009MaintBotFixed group labels
30964view00:47, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Akt1GeneProduct24185 (Entrez Gene)
Apaf1GeneProduct78963 (Entrez Gene)
BBC3GeneProduct317673 (Entrez Gene)
BIRC5GeneProduct64041 (Entrez Gene)
BadGeneProduct64639 (Entrez Gene)
Bak1GeneProduct116502 (Entrez Gene)
BaxGeneProduct24887 (Entrez Gene)
Bcl2GeneProduct24224 (Entrez Gene)
Bcl2l11GeneProduct64547 (Entrez Gene)
Bcl2l1GeneProduct24888 (Entrez Gene)
Bcl2l2GeneProduct60434 (Entrez Gene)
BidGeneProduct64625 (Entrez Gene)
Birc2GeneProduct60371 (Entrez Gene)
Birc3GeneProduct78971 (Entrez Gene)
Bnip3lGeneProduct140923 (Entrez Gene)
BokGeneProduct29884 (Entrez Gene)
CASP10GeneProduct
CASP11GeneProduct
Casp1GeneProduct25166 (Entrez Gene)
Casp2GeneProduct64314 (Entrez Gene)
Casp3GeneProduct25402 (Entrez Gene)
Casp4GeneProduct114555 (Entrez Gene)
Casp6GeneProduct83584 (Entrez Gene)
Casp7GeneProduct64026 (Entrez Gene)
Casp8GeneProduct64044 (Entrez Gene)
Casp9GeneProduct58918 (Entrez Gene)
Cdkn2aGeneProduct25163 (Entrez Gene)
CflarGeneProduct117279 (Entrez Gene)
ChukGeneProduct309361 (Entrez Gene)
CraddGeneProduct314756 (Entrez Gene)
CycsGeneProduct25309 (Entrez Gene)
CyctGeneProduct25310 (Entrez Gene)
DffaGeneProduct114214 (Entrez Gene)
DffbGeneProduct84359 (Entrez Gene)
DiabloGeneProduct288753 (Entrez Gene)
FaddGeneProduct266610 (Entrez Gene)
FasGeneProduct246097 (Entrez Gene)
FaslgGeneProduct25385 (Entrez Gene)
GZMBGeneProduct171528 (Entrez Gene)
HellsGeneProduct294071 (Entrez Gene)
HrkGeneProduct117271 (Entrez Gene)
Igf1GeneProduct24482 (Entrez Gene)
Igf1rGeneProduct25718 (Entrez Gene)
Igf2GeneProduct24483 (Entrez Gene)
IkbkbGeneProduct84351 (Entrez Gene)
IkbkgGeneProduct309295 (Entrez Gene)
Irf1GeneProduct24508 (Entrez Gene)
Irf2GeneProduct290749 (Entrez Gene)
Irf3GeneProduct292892 (Entrez Gene)
Irf4GeneProduct291100 (Entrez Gene)
Irf5GeneProduct296953 (Entrez Gene)
Irf6GeneProduct364081 (Entrez Gene)
Irf7GeneProduct293624 (Entrez Gene)
JunGeneProduct24516 (Entrez Gene)
LtaGeneProduct25008 (Entrez Gene)
Map2k4GeneProduct287398 (Entrez Gene)
Map3k1GeneProduct116667 (Entrez Gene)
Mapk10GeneProduct25272 (Entrez Gene)
Mcl1GeneProduct60430 (Entrez Gene)
Mdm2GeneProduct314856 (Entrez Gene)
MycGeneProduct24577 (Entrez Gene)
Nfkb1GeneProduct81736 (Entrez Gene)
NfkbiaGeneProduct25493 (Entrez Gene)
NfkbibGeneProduct81525 (Entrez Gene)
NfkbieGeneProduct316241 (Entrez Gene)
PMAIP1GeneProduct492821 (Entrez Gene)
Pik3r1GeneProduct25513 (Entrez Gene)
Prf1GeneProduct50669 (Entrez Gene)
RelaGeneProduct309165 (Entrez Gene)
Ripk1GeneProduct306886 (Entrez Gene)
TNFRSF10BGeneProduct364420 (Entrez Gene)
TRAF1GeneProduct
TnfGeneProduct24835 (Entrez Gene)
Tnfrsf1aGeneProduct25625 (Entrez Gene)
Tnfrsf1bGeneProduct156767 (Entrez Gene)
Tnfrsf21GeneProduct316256 (Entrez Gene)
Tnfrsf25GeneProduct500592 (Entrez Gene)
Tnfsf10GeneProduct246775 (Entrez Gene)
Tp53GeneProduct24842 (Entrez Gene)
Tp63GeneProduct246334 (Entrez Gene)
Tp73GeneProduct362675 (Entrez Gene)
TraddGeneProduct246756 (Entrez Gene)
Traf2GeneProduct311786 (Entrez Gene)
Traf3GeneProduct362788 (Entrez Gene)
XiapGeneProduct63879 (Entrez Gene)

Annotated Interactions

No annotated interactions
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