DNA replication (Saccharomyces cerevisiae)

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1-3Phosphorylation of Mcm 2-7 complexwith the replication forkMcm3Mcm10Mcm6Degraded by proteasome in cytosolCdc6UbiquitinCdc6RNA primer-DNA primerMcm4HOMOLOGY MAPPPrimaseMcm5Orc5Orc3Degraded by proteasome in cytosolOrc complexOrc complexRFC40Orc3Mcm7Orc5Orc complexRNA primer-DNA primer3. DNA replication initiationap180Cdt12. Activation of the pre-replicative complexOrc2RNA primer-DNA primer:origin duplex:PCNAOrc2DNA polymerase alpha: primase: origin complexMcm7DNA polymerase alpha: primase: origin complexCdc6Phosphorylated Cdc6Mcm2UbiquitinOrc2Ubiquitinated Cdc6RFC140dUTPCdt1Mcm5p58Mcm2GemininCTPProcessive complexPre-replicative complexOrc4Orc51. Assembly of the pre-replicative complexPre-replicative complexRFC36Cdt1Orc ComplexMcm 4,6,7 trimer forms and associatesMcm3RFC385. Leading/lagging strand synthesisOrc3Cdc6Orc complexRFC Heteropentamer:RNA primer-DNA primerPCNA homotrimerPhosphorylated Orc1Mcm4Orc2Mcm6RFC Heteropentamer:RNA primer-DNA primer:Cdt1Orc1p49p70RNA PrimerUTPCdt1OriginRFC374. Switching of origins to post-replicative stateOrc4DNA PolymeraseUbiquitinated Orc1Orc3CDC2dGTPORC1LRFC2DPB2ATPRPA3CDC6RFC5dATPCDC47RFC1ATPMCM2RFA2RFA1ORC6LPOLD4HYS2PRI2dCTPATPCDC46CDC7CDC54RFC3GTPRPA4MCM10ORC5LADPASKORC2CDT1POL30GMNNPOLD3POL2PRI1ORC4LADPMCM6ORC3LUBI4POL12MCM3ATPCDC45POL1RPL40ARFC4CDK2


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: [wikipedia:DNA_replication|Wikipedia]

Comments

GenMAPP notes 
http://www.genomeknowledge.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.genomeknowledge.org

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Quality Tags

Ontology Terms

 

Bibliography

  1. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia
  2. Marahrens Y, Stillman B; ''A yeast chromosomal origin of DNA replication defined by multiple functional elements.''; Science, 1992 PubMed Europe PMC Scholia
  3. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
117289view10:58, 20 May 2021EweitzModified title
102295view19:29, 17 December 2018KhanspersModified description
78398view10:25, 7 January 2015MaintBotadded missing graphIds
76275view21:24, 25 June 2014KhanspersModified description
76274view21:24, 25 June 2014Khanspersremoved genmapp comments
76273view21:22, 25 June 2014Khanspersoverhaul
71354view18:03, 17 October 2013MaintBotAutomated update of data sources
69761view11:05, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
69672view20:41, 8 July 2013MaintBotUpdated to 2013 gpml schema
67159view10:14, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
41916view04:54, 2 March 2011MaintBotRemoved redundant pathway information and comments
35199view15:38, 11 February 2010ThomasModified description
35198view15:38, 11 February 2010ThomasModified description
35197view15:37, 11 February 2010Thomasadded literature
34367view22:36, 9 December 2009MaintBotAutomatic update of empty xrefs
20699view11:29, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:DNA replication Reactome]] moved to [[Pathway:WP13]]: Moved to stable identifier
12692view07:58, 17 May 2008MaintBotautomated metabolite conversion
8540view14:02, 7 January 2008MaintBotAdded to category $category
19420view14:02, 7 January 2008D.KorenUploaded new pathway
8538view14:02, 7 January 2008KdahlquistUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADPMetabolite58-64-0 (CAS)
ASKGeneProduct
ATPMetabolite1927-31-7 (CAS)
CDC2GeneProduct851456 (Entrez Gene)
CDC45GeneProduct850793 (Entrez Gene)
CDC46GeneProduct850980 (Entrez Gene)
CDC47GeneProduct852501 (Entrez Gene)
CDC54GeneProduct856130 (Entrez Gene)
CDC6GeneProduct853244 (Entrez Gene)
CDC7GeneProduct851545 (Entrez Gene)
CDK2GeneProduct
CDT1GeneProduct
DPB2GeneProduct856305 (Entrez Gene)
GMNNGeneProduct
GTPMetabolite2564-35-4 (CAS)
HYS2GeneProduct853462 (Entrez Gene)
MCM10GeneProduct854656 (Entrez Gene)
MCM2GeneProduct852258 (Entrez Gene)
MCM3GeneProduct856680 (Entrez Gene)
MCM6GeneProduct852673 (Entrez Gene)
ORC1LGeneProduct
ORC2GeneProduct852352 (Entrez Gene)
ORC3LGeneProduct
ORC4LGeneProduct
ORC5LGeneProduct
ORC6LGeneProduct
POL12GeneProduct852245 (Entrez Gene)
POL1GeneProduct855621 (Entrez Gene)
POL2GeneProduct855459 (Entrez Gene)
POL30GeneProduct852385 (Entrez Gene)
POLD3GeneProduct
POLD4GeneProduct
PRI1GeneProduct854825 (Entrez Gene)
PRI2GeneProduct853821 (Entrez Gene)
RFA1GeneProduct851266 (Entrez Gene)
RFA2GeneProduct855404 (Entrez Gene)
RFC1GeneProduct854392 (Entrez Gene)
RFC2GeneProduct853531 (Entrez Gene)
RFC3GeneProduct855426 (Entrez Gene)
RFC4GeneProduct854059 (Entrez Gene)
RFC5GeneProduct852383 (Entrez Gene)
RPA3GeneProduct
RPA4GeneProduct
RPL40AGeneProduct854658 (Entrez Gene)
UBI4GeneProduct850620 (Entrez Gene)
dATPMetabolite1927-31-7 (CAS)
dCTPMetabolite2056-98-6 (CAS)
dGTPMetabolite2564-35-4 (CAS)

Annotated Interactions

No annotated interactions
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