DNA replication (Saccharomyces cerevisiae)

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1-3Cdc6RFC403. DNA replication initiationCdt1Cdt1Phosphorylated Cdc6Mcm5Mcm4RFC38Orc3Ubiquitinated Cdc6Pre-replicative complexOrc complexRFC Heteropentamer:RNA primer-DNA primerOrc complexOrc complexMcm 4,6,7 trimer forms and associatesUbiquitinOrc complex4. Switching of origins to post-replicative statep180Orc3Mcm2Orc5Mcm6Ubiquitinated Orc1DNA PolymeraseRFC Heteropentamer:RNA primer-DNA primer:RNA primer-DNA primerOrc4PrimaseOriginOrc3RFC140Mcm5Cdt1Mcm2Mcm10Orc5RNA PrimerMcm7UTPOrc1Phosphorylated Orc1RFC36DNA polymerase alpha: primase: origin complexCdt1Processive complexDegraded by proteasome in cytosol2. Activation of the pre-replicative complexCdc6Cdt1Mcm7HOMOLOGY MAPPaOrc5Orc2Pre-replicative complexRNA primer-DNA primer:origin duplex:PCNAp49Mcm6Mcm3RFC37Orc Complexp70Mcm4Orc3Cdc65. Leading/lagging strand synthesisUbiquitinwith the replication forkCTPCdc61. Assembly of the pre-replicative complexOrc2Orc2Orc2Degraded by proteasome in cytosolRNA primer-DNA primerDNA polymerase alpha: primase: origin complexPhosphorylation of Mcm 2-7 complexGemininp58Mcm3Orc4PCNA homotrimerdUTPCDC45UBI4ORC3LATPMCM10RPA4ATPHYS2CDK2GTPCDC46RFC3CDC2MCM6RFC1ORC2ATPADPRFA1ASKRPA3CDC6ATPGMNNRFC4CDT1CDC47POLD4CDC54DPB2dCTPRFC5PRI2ORC4LRFC2ORC5LCDC7POL1POL2dATPORC6LPRI1RFA2POLD3MCM2RPL40AdGTPPOL30ORC1LPOL12MCM3ADP


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: [wikipedia:DNA_replication|Wikipedia]

Comments

GenMAPP notes 
http://www.genomeknowledge.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.genomeknowledge.org

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Quality Tags

Ontology Terms

 

Bibliography

  1. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia
  2. Marahrens Y, Stillman B; ''A yeast chromosomal origin of DNA replication defined by multiple functional elements.''; Science, 1992 PubMed Europe PMC Scholia
  3. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
117289view10:58, 20 May 2021EweitzModified title
102295view19:29, 17 December 2018KhanspersModified description
78398view10:25, 7 January 2015MaintBotadded missing graphIds
76275view21:24, 25 June 2014KhanspersModified description
76274view21:24, 25 June 2014Khanspersremoved genmapp comments
76273view21:22, 25 June 2014Khanspersoverhaul
71354view18:03, 17 October 2013MaintBotAutomated update of data sources
69761view11:05, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
69672view20:41, 8 July 2013MaintBotUpdated to 2013 gpml schema
67159view10:14, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
41916view04:54, 2 March 2011MaintBotRemoved redundant pathway information and comments
35199view15:38, 11 February 2010ThomasModified description
35198view15:38, 11 February 2010ThomasModified description
35197view15:37, 11 February 2010Thomasadded literature
34367view22:36, 9 December 2009MaintBotAutomatic update of empty xrefs
20699view11:29, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:DNA replication Reactome]] moved to [[Pathway:WP13]]: Moved to stable identifier
12692view07:58, 17 May 2008MaintBotautomated metabolite conversion
8540view14:02, 7 January 2008MaintBotAdded to category $category
19420view14:02, 7 January 2008D.KorenUploaded new pathway
8538view14:02, 7 January 2008KdahlquistUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADPMetabolite58-64-0 (CAS)
ASKGeneProduct
ATPMetabolite1927-31-7 (CAS)
CDC2GeneProduct851456 (Entrez Gene)
CDC45GeneProduct850793 (Entrez Gene)
CDC46GeneProduct850980 (Entrez Gene)
CDC47GeneProduct852501 (Entrez Gene)
CDC54GeneProduct856130 (Entrez Gene)
CDC6GeneProduct853244 (Entrez Gene)
CDC7GeneProduct851545 (Entrez Gene)
CDK2GeneProduct
CDT1GeneProduct
DPB2GeneProduct856305 (Entrez Gene)
GMNNGeneProduct
GTPMetabolite2564-35-4 (CAS)
HYS2GeneProduct853462 (Entrez Gene)
MCM10GeneProduct854656 (Entrez Gene)
MCM2GeneProduct852258 (Entrez Gene)
MCM3GeneProduct856680 (Entrez Gene)
MCM6GeneProduct852673 (Entrez Gene)
ORC1LGeneProduct
ORC2GeneProduct852352 (Entrez Gene)
ORC3LGeneProduct
ORC4LGeneProduct
ORC5LGeneProduct
ORC6LGeneProduct
POL12GeneProduct852245 (Entrez Gene)
POL1GeneProduct855621 (Entrez Gene)
POL2GeneProduct855459 (Entrez Gene)
POL30GeneProduct852385 (Entrez Gene)
POLD3GeneProduct
POLD4GeneProduct
PRI1GeneProduct854825 (Entrez Gene)
PRI2GeneProduct853821 (Entrez Gene)
RFA1GeneProduct851266 (Entrez Gene)
RFA2GeneProduct855404 (Entrez Gene)
RFC1GeneProduct854392 (Entrez Gene)
RFC2GeneProduct853531 (Entrez Gene)
RFC3GeneProduct855426 (Entrez Gene)
RFC4GeneProduct854059 (Entrez Gene)
RFC5GeneProduct852383 (Entrez Gene)
RPA3GeneProduct
RPA4GeneProduct
RPL40AGeneProduct854658 (Entrez Gene)
UBI4GeneProduct850620 (Entrez Gene)
dATPMetabolite1927-31-7 (CAS)
dCTPMetabolite2056-98-6 (CAS)
dGTPMetabolite2564-35-4 (CAS)

Annotated Interactions

No annotated interactions
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