Folic acid network (Rattus norvegicus)

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1952028146118911, 2326162, 2721241713, 223TTTTBInterconversionNegative effectBBBReactionBBBUnspecified effectPositive effectMain functionsBBBBBTransformationBTBTBBNucleotide biosynthesisFormation of methionineTransportBBGeneric enzymeUnspecified interactionMETABOLITEIEBindingInfluence on expressionINTRACELULARCNSynthesis of cholineBTBINORGANIC IONConversionTBPLASMATBBBBBCompetitionBFormation of HemeBMtrPtgisIronFADLA (n-6)Niacin2-Ketobutyric acidLeukotriene B4BUric acidUric acidAA (n-6)a-tocopherolEPA (n-3)ZincEPA (n-3)FOLIC ACID5,10-METHYL-THFCalciumTCystathionePtgdsSepw1Txnrd2GlutathioneLeukotriene C4ALA (n-3)S-Adenosylmethionine15-HETENADPHTranscobalaminDHA (n-3)PtgesL-Glutamic acidAscorbic acidCopperSerineSod1CarnitineIETryptophanPGE2H2O2Gpx3a TocopherolPGF2aH2OManganeseHomocysteineSeleniumAdipic acid F2-IsoprostaneCOX2Leukotriene B4O2LeukotrieneE4GlutathioneiPF2-alphaBetaineFOLIC ACIDGlutathione disulfideXdh1-methylnicotinamidePNPONADPPGD2HypoxanthineLipoic acidZincPGI2Leukotriene A4Leukotriene F4Methionine sulfoxideIronPGE2Txnrd1CysteineMthfrS-Adenosylmethionine Methylmalonic acid 5-HPETEGlycinePGG2BCOX1ALA (n-3)TRXR 3Methylmalonic acidThromboxane A2Leukotriene D4Leukotriene D4CobalaminCatL-Glutamic acidS-Adenosylhomocysteine TTPGFS15-HETESepx1FMN12-Ketobutyric acidPGE3NADPHPyrodoxal-5'-phosphateMethionineRiboflavinVitamin B12CbsEthanolamineAA (n-6)PGG3PGH2CobalaminThioredoxinSerine1-MethylnicotinamideLipoxin B4CholineC22:5 (n-6)Tromboxane A2S-Adenosylhomocysteine 5,10-METHYL-THFAscorbic acidAdipic acidGpx4HomocysteineGlycinePGF2aNADPEthanolamineGpx6SelkVitamin B12Alox5PGH3PGD2ROSTHASLeukotriene C4CalciumDHA (n-3)Gpx1LA (n-6)LeukotrieneE4Lipoxin A4Thromboxane B2KmoCNGsrHypoxanthined5 desaturaseCopperSeleniumPGI2CysteineXanthineNicotinamideLipoxin A4d4 desaturaseFads2Pyrodoxal-5'-phosphateHemeGpx2L-MethionineEndoperoxidaseC22:5 (n-6)4810715, 251229


Description

The folic acid-centred micronutrient biological network. The most relevant biochemical processes related to folic acid in the context of metabolism, oxidation and inflammation are represented. Also, the compartmental separation (intracellular vs. plasma) is presented, identifying the folic acid centred plasma metabolome.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP176(r30153) with a 58% conversion rate.

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Bibliography

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  1. Lu C, Qiu F, Zhou H, Peng Yp, Hao W, Xu J, Yuan J, Wang S, Qiang B, Xu C, Peng X.; ''Identification and characterization of selenoprotein K: an antioxidant in cardiomyocytes.''; FEBS Lett., 2006 PubMed Europe PMC Scholia
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  3. Ben van Ommen, Susan Fairweather-Tait, Andreas Freidig, Alwine Kardinaal, Augustin Scalbert, Suzan Wopereis; ''A network biology model of micronutrient related health''; Br J Nutr, 2008 PubMed Europe PMC Scholia
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  7. ''Food and Nutrition Board, Institute of Medicine. Vitamin B6. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B6, Vitamin B12, Pantothenic Acid, Biotin, and Choline.''; Washington D.C.: National Academies Press, 1998
  8. Proctor PH.; ''Free radicals, uric acid, and human disease.''; Free Radic Biol Med., 1996 PubMed Europe PMC Scholia
  9. Petersen Shay K, Moreau RF, Smith EJ, Hagen TM.; ''Is alpha-lipoic acid a scavenger of reactive oxygen species in vivo? Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant capacity.''; IUBMB Life., 2008 PubMed Europe PMC Scholia
  10. Leclerc D, Campeau E, Goyette P, Adjalla CE, Christensen B, Ross M, Eydoux P, Rosenblatt DS, Rozen R, Gravel RA.; ''Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders. ''; Hum Mol Genet. , 1996 PubMed Europe PMC Scholia
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  14. Vladimir Kery, Loelle Poneleit, Jeffrey D. Meyer, Mark C. Manning, Jan P. Kraus; ''Binding of Pyridoxal 5'-Phosphate to the Heme Protein Human Cystathionine β-Synthase''; Biochemistry 38(9), 1999 DOI Scholia
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  18. Wilson A, Platt R, Wu Q, Leclerc D, Christensen B, Yang H, Gravel RA, Rozen R; ''A common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida. ''; Molecular genetics and metabolism, 1999 PubMed Europe PMC Scholia
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History

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CompareRevisionActionTimeUserComment
125276view16:06, 31 January 2023LarsgwFix references
124809view21:44, 11 December 2022AlexanderPicofixed citations
124780view06:31, 11 December 2022AlexanderPicofixed citations
120919view06:31, 31 January 2022EgonwReplaced an old HMDB identifier with the current one
116965view10:25, 16 May 2021EweitzModified title
106963view13:42, 17 September 2019MaintBotHMDB identifier normalization
101981view20:32, 21 November 2018EgonwRemoved whitespace in PubMed identifiers.
101975view19:53, 21 November 2018EgonwRemoved whitespace in PubMed identifiers.
85048view10:14, 10 April 2016EgonwReplaced a Wikipedia ID with a ChEBI ID.
82695view18:10, 22 October 2015EgonwFixed a typo.
74472view04:09, 25 April 2014EgonwFixed a PubMed ID.
71791view20:33, 17 October 2013MaintBotAutomated update of data sources
69407view19:00, 8 July 2013MaintBotUpdated to 2013 gpml schema
69082view18:10, 8 July 2013EgonwReplaced an outdated HMDB identifier with the 3.5 one.
68386view09:46, 4 July 2013EgonwFixed the DataNode type of two nodes with gene identifiers.
68385view09:44, 4 July 2013EgonwMade the link to Wikipedia machine readable.
67255view10:27, 26 June 2013Christine ChichesterOntology Term : 'pathway of folate cycle/metabolism' added !
60223view20:00, 14 March 2013EgonwReplaced PubChem-substance with PubChem-compound.
58959view18:31, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
48281view23:34, 17 May 2012KhanspersUpdating PubChem xrefs
48270view21:58, 17 May 2012MaintBotAutomatic update of PubChem xrefs
41727view02:39, 2 March 2011MaintBotRemoved redundant pathway information and comments
34103view19:20, 9 December 2009MaintBotAutomatic update of empty xrefs
33191view18:08, 5 November 2009KhanspersModified categories
32314view13:22, 15 August 2009MaintBotFixed text labels
31908view12:49, 14 August 2009MaintBotFixed group labels
31343view20:27, 13 August 2009MaintBotFixed text labels
31017view01:07, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1-MethylnicotinamideMetaboliteHMDB00699 (HMDB)
1-methylnicotinamideMetaboliteHMDB00699 (HMDB)
15-HETEMetaboliteHMDB11134 (HMDB)
2-Ketobutyric acidMetaboliteHMDB00005 (HMDB)
5,10-METHYL-THFMetaboliteHMDB01396 (HMDB)
5-HPETEMetaboliteHMDB01193 (HMDB)
AA (n-6)MetaboliteHMDB01043 (HMDB)
ALA (n-3)MetaboliteHMDB01388 (HMDB)
Adipic acid MetaboliteHMDB00448 (HMDB)
Adipic acidMetaboliteHMDB00448 (HMDB)
Alox5Protein25290 (Entrez Gene)
Ascorbic acidMetaboliteHMDB00044 (HMDB)
BGeneProduct
BetaineMetaboliteHMDB00043 (HMDB)
C22:5 (n-6)MetaboliteHMDB01976 (HMDB)
CNGeneProduct
COX1Protein26195 (Entrez Gene)
COX2Protein26198 (Entrez Gene)
CalciumMetaboliteHMDB00464 (HMDB)
CarnitineMetaboliteHMDB00062 (HMDB)
CatProtein24248 (Entrez Gene)
CbsProtein24250 (Entrez Gene)
CholineMetaboliteHMDB00097 (HMDB)
CobalaminMetaboliteHMDB02174 (HMDB)
CopperMetaboliteHMDB00657 (HMDB)
CystathioneMetaboliteHMDB00099 (HMDB)
CysteineMetaboliteHMDB00574 (HMDB)
DHA (n-3)MetaboliteHMDB02183 (HMDB)
EPA (n-3)MetaboliteHMDB01999 (HMDB)
EndoperoxidaseProtein
EthanolamineMetaboliteHMDB00149 (HMDB)
F2-IsoprostaneMetaboliteHMDB04659 (HMDB)
FADMetabolite703 (PubChem-compound)
FMN1GeneProduct342184 (Entrez Gene)
FOLIC ACIDMetaboliteHMDB00121 (HMDB)
Fads2Protein83512 (Entrez Gene)
Glutathione disulfideMetabolite65359 (PubChem-compound) Type your comment here
GlutathioneMetaboliteHMDB00125 (HMDB)
GlycineMetaboliteHMDB00123 (HMDB)
Gpx1Protein24404 (Entrez Gene)
Gpx2Protein29326 (Entrez Gene)
Gpx3Protein64317 (Entrez Gene)
Gpx4Protein29328 (Entrez Gene)
Gpx6Protein259233 (Entrez Gene)
GsrProteinENSRNOG00000014915 (Ensembl) Type your comment here
H2O2MetaboliteHMDB03125 (HMDB)
H2OMetaboliteHMDB02111 (HMDB)
HemeMetaboliteHMDB03178 (HMDB)
HomocysteineMetabolite
HomocysteineMetaboliteHMDB00742 (HMDB)
HypoxanthineMetaboliteHMDB00157 (HMDB)
IEGeneProduct
IronMetaboliteHMDB00692 (HMDB)
KmoProtein59113 (Entrez Gene)
L-Glutamic acidMetaboliteHMDB00148 (HMDB)
L-MethionineMetaboliteHMDB00696 (HMDB)
LA (n-6)MetaboliteHMDB00673 (HMDB)
Leukotriene A4MetaboliteHMDB01337 (HMDB)
Leukotriene B4MetaboliteHMDB01085 (HMDB)
Leukotriene C4MetaboliteHMDB01198 (HMDB)
Leukotriene D4MetaboliteHMDB03080 (HMDB)
Leukotriene F4Metabolite
LeukotrieneE4MetaboliteHMDB02200 (HMDB)
Lipoic acidMetaboliteHMDB01451 (HMDB)
Lipoxin A4MetaboliteHMDB04385 (HMDB)
Lipoxin B4MetaboliteHMDB05082 (HMDB)
ManganeseMetaboliteHMDB01333 (HMDB)
Methionine sulfoxideMetaboliteHMDB02005 (HMDB)
MethionineMetaboliteHMDB00696 (HMDB)
Methylmalonic acid MetaboliteHMDB00202 (HMDB)
Methylmalonic acidMetaboliteHMDB00202 (HMDB)
MthfrProtein362657 (Entrez Gene)
MtrProtein81522 (Entrez Gene)
NADPHMetaboliteHMDB00221 (HMDB)
NADPMetaboliteHMDB00217 (HMDB)
NiacinMetaboliteHMDB01406 (HMDB)
NicotinamideMetabolite936 (PubChem-compound)
O2MetaboliteHMDB01377 (HMDB)
PGD2MetaboliteHMDB01403 (HMDB)
PGE2Metabolite
PGE3MetaboliteHMDB02664 (HMDB)
PGF2aMetaboliteHMDB01139 (HMDB)
PGFSProtein
PGG2MetaboliteHMDB03235 (HMDB)
PGG3Metabolite
PGH2MetaboliteHMDB01381 (HMDB)
PGH3Metabolite
PGI2Metabolite
PGI2MetaboliteHMDB01335 (HMDB)
PNPOProtein64533 (Entrez Gene)
PtgdsProtein25526 (Entrez Gene)
PtgesProtein59103 (Entrez Gene)
PtgisProtein25527 (Entrez Gene)
Pyrodoxal-5'-phosphateMetaboliteHMDB01491 (HMDB)
ROSMetaboliteReactive oxygen species (Wikipedia) http://en.wikipedia.org/wiki/Reactive_oxygen_species
RiboflavinMetaboliteHMDB00244 (HMDB) Type your comment here
S-Adenosylhomocysteine MetaboliteHMDB00939 (HMDB)
S-Adenosylmethionine MetaboliteHMDB01185 (HMDB)
S-AdenosylmethionineMetaboliteHMDB01185 (HMDB)
SeleniumMetaboliteHMDB01349 (HMDB)
SelkProtein290549 (Entrez Gene)
Sepw1Protein25545 (Entrez Gene)
Sepx1Protein685059 (Entrez Gene)
SerineMetaboliteHMDB00187 (HMDB)
Sod1Protein24786 (Entrez Gene)
TGeneProduct292301 (Entrez Gene)
THASProtein
TRXR 3Protein
TTGeneProduct
ThioredoxinProtein7295 (Entrez Gene)
Thromboxane A2MetaboliteHMDB01452 (HMDB)
Thromboxane B2MetaboliteHMDB03252 (HMDB)
TranscobalaminProtein
Tromboxane A2MetaboliteHMDB01452 (HMDB)
TryptophanMetaboliteHMDB00929 (HMDB)
Txnrd1Protein58819 (Entrez Gene)
Txnrd2Protein50551 (Entrez Gene)
Uric acidMetaboliteHMDB00289 (HMDB)
Vitamin B12MetaboliteHMDB00607 (HMDB)
XanthineMetaboliteHMDB00292 (HMDB)
XdhProtein497811 (Entrez Gene)
ZincMetaboliteHMDB01303 (HMDB)
a TocopherolMetaboliteHMDB01893 (HMDB)
a-tocopherolMetaboliteHMDB01893 (HMDB)
d4 desaturaseProtein
d5 desaturaseProtein
iPF2-alphaMetaboliteHMDB04659 (HMDB)

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1311"
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