MAPK signaling pathway (Danio rerio)

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1-7, 9, 108Transcription factorsDNADNA damageProliferation, differentiationERK5 pathwayDAGp53 signaling pathwayp38Proliferation, differentiationSerum, cytotoxic drugs, irradiation,heatshock, reactive oxy speciesLPS and other stressSerum, EGF,reactive oxygen species.or Srk tyrokinase downstreamHeteromeric G-proteinDNADNACycleMAPKKLPSIP3PTPDNAJNKClassical MAP kinase PathwayMAPKKKCellProliferation, differentiation,inflammationDNAPTPProliferation, inflammation, anti-apoptosisWnt signaling pathwayJNK & p38 MAP kinase pathwayApoptosisCa2+MAPKMKPPhosphatidylinositolsignaling systemMAPKKKKnlk2dusp7LOC100004576LOC556506MINK1casp9fgfrLOC100005183LOC100007590NTF5jundrap1agna12nr4a1NFKB1mapk6MAP4K1casp8IL1AgckmrasegfrMAP3K6cdc25fasLOC100149273ACVR1CmaxprkczmosCH211-67F24.8LOC559247MAP3K7IP2map3k5MAP4K4RASGRF2PLA2G5rap1bmap3k7si:dkey-12o15.1cAMPecsitLOC559524bdnfmapk3tgfb3zgc:158799RASGRP4PPP3CCLOC560549LOC564899ARRB2dusp6zgc:110801egfMEKK2/3ATF4ikbkbwu:fc83c01DDIT3LOC100005446pdgfrbmapkapk5IL1R2sap1aPRKCDPTPN7LOC567833fgf4raf1hspa5stk3zgc:194486tp53STMN1mkk3MAPK8IP3mapk4LOC100007590zgc:172124ntrk1atf2lPPP3R2daxxrps6ka3bpak1MAP3K11pp2cbrac2map3k7ip1LOC792354im:7136778pp2ca2cdc42lnrasMAP3K14grb2msk1/2tgfb2LOC563727LOC568412TNFhspb2FLNAPDGFBcrkmapk7LOC100007304mef2cbtraf6dusp5mapk1arrb1map3k12foscasp2tgfbr1btmem37mapk10GADD45Amap2k1hspb1zgc:172209LOC559524prkcb1akt2casp6junmapkapk2arac1LOC564337mnk1/2RASA2Sap1azgc:172137elk1crklHSPA1ATAOK2ATF4faslgsrfmapksp1TGFB1krasDUSP4LOC799204map2k6PPP3CBtgfbr2PPP3CACD14nfat2/4dusp1hspa8brafMAPK12zgc:92162CASP1LOC560913PRKCDpak2aMYCLOC567895casp7PTPN7IL1BLOC100003514rasa1NGFBCASP3ACVR1Bzgc:172250mapk14aikbkg


Description

The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli. Source: KEGG http://www.genome.jp/dbget-bin/www_bget?pathway:map04010

Comments

GenMAPP remarks 
Converted to human by GenMAPP.org
 
This pathway was inferred from Homo sapiens pathway WP382(r28779) with a 68% conversion rate.

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Ontology Terms

 

Bibliography

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  1. Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH; ''MAP kinases.''; Chem Rev, 2001 PubMed Europe PMC Scholia
  2. Takeda K, Ichijo H; ''Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.''; Genes Cells, 2002 PubMed Europe PMC Scholia
  3. Harper SJ, LoGrasso P; ''Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.''; Cell Signal, 2001 PubMed Europe PMC Scholia
  4. Abell AN, Granger DA, Johnson GL; ''MEKK4 stimulation of p38 and JNK activity is negatively regulated by GSK3beta.''; J Biol Chem, 2007 PubMed Europe PMC Scholia
  5. Zhu X, Lee HG, Raina AK, Perry G, Smith MA; ''The role of mitogen-activated protein kinase pathways in Alzheimer's disease.''; Neurosignals, 2002 PubMed Europe PMC Scholia
  6. Huang EJ, Reichardt LF; ''Trk receptors: roles in neuronal signal transduction.''; Annu Rev Biochem, 2003 PubMed Europe PMC Scholia
  7. Yang SH, Sharrocks AD, Whitmarsh AJ; ''Transcriptional regulation by the MAP kinase signaling cascades.''; Gene, 2003 PubMed Europe PMC Scholia
  8. Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y; ''Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.''; Toxicol Lett, 2003 PubMed Europe PMC Scholia
  9. Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S; ''MAPK pathways in radiation responses.''; Oncogene, 2003 PubMed Europe PMC Scholia
  10. Tanoue T, Nishida E; ''Docking interactions in the mitogen-activated protein kinase cascades.''; Pharmacol Ther, 2002 PubMed Europe PMC Scholia
  11. Chen CY, Weng YH, Chien KY, Lin KJ, Yeh TH, Cheng YP, Lu CS, Wang HL; ''(G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD.''; Cell Death Differ, 2012 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
116770view09:28, 13 May 2021EweitzModified title
115810view16:34, 13 March 2021EgonwReplaced a few links to human pathways to equivalents of the matching species (and made them clickable)
106072view11:58, 16 August 2019MaintBotHMDB identifier normalization
105686view20:56, 13 August 2019Khanspersremoved human-specific drug targeting and mutation
96395view09:58, 12 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
95779view14:33, 19 January 2018MkutmonHomology conversion update
95122view15:06, 16 November 2017Mkutmonadded missing homology converter comment source
84627view19:26, 10 March 2016KhanspersQuick edit to datanode annotation or property
84626view19:15, 10 March 2016KhanspersQuick edit to datanode annotation or property
84625view19:14, 10 March 2016KhanspersQuick edit to datanode annotation or property
84624view19:12, 10 March 2016KhanspersQuick edit to datanode annotation or property
84623view19:02, 10 March 2016KhanspersQuick edit to datanode annotation or property
84622view19:01, 10 March 2016KhanspersQuick edit to datanode annotation or property
78354view09:42, 7 January 2015MaintBotadded missing graphIds
77428view09:11, 8 September 2014Mkutmonudpated gene labels and added some references
68657view05:13, 6 July 2013MaintBotUpdated to 2013 gpml schema
67441view11:02, 26 June 2013DdiglesOntology Term : 'mitogen activated protein kinase signaling pathway' added !
47927view22:33, 18 April 2012Khanspersupdated xref
40826view22:18, 1 March 2011MaintBotRemoved redundant pathway information and comments
35664view22:28, 12 February 2010KhanspersDescription and lit refs
34212view21:32, 9 December 2009MaintBotAutomatic update of empty xrefs
32321view13:25, 15 August 2009MaintBotFixed text labels
31926view12:54, 14 August 2009MaintBotFixed group labels
31356view20:32, 13 August 2009MaintBotFixed text labels
31047view01:20, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACVR1BGeneProduct30183 (Entrez Gene)
ACVR1CGeneProduct
ARRB2GeneProduct
ATF4GeneProduct406514 (Entrez Gene)
CASP1GeneProduct
CASP3GeneProduct
CD14GeneProduct
CH211-67F24.8GeneProduct561670 (Entrez Gene)
DDIT3GeneProduct
DUSP4GeneProduct394146 (Entrez Gene)
FLNAGeneProduct562529 (Entrez Gene)
GADD45AGeneProduct431763 (Entrez Gene)
HSPA1AGeneProduct
IL1AGeneProduct
IL1BGeneProduct405770 (Entrez Gene)
IL1R2GeneProduct
LOC100003514GeneProduct100003514 (Entrez Gene)
LOC100004576GeneProduct100004576 (Entrez Gene)
LOC100005183GeneProduct100005183 (Entrez Gene)
LOC100005446GeneProduct100005446 (Entrez Gene)
LOC100007304GeneProduct100007304 (Entrez Gene)
LOC100007590GeneProduct100007590 (Entrez Gene)
LOC100149273GeneProduct100149273 (Entrez Gene)
LOC556506GeneProduct556506 (Entrez Gene)
LOC559247GeneProduct559247 (Entrez Gene)
LOC559524GeneProduct559524 (Entrez Gene)
LOC560549GeneProduct560549 (Entrez Gene)
LOC560913GeneProduct560913 (Entrez Gene)
LOC563727GeneProduct563727 (Entrez Gene)
LOC564337GeneProduct564337 (Entrez Gene)
LOC564899GeneProduct564899 (Entrez Gene)
LOC567833GeneProduct567833 (Entrez Gene)
LOC567895GeneProduct567895 (Entrez Gene)
LOC568412GeneProduct568412 (Entrez Gene)
LOC792354GeneProduct792354 (Entrez Gene)
LOC799204GeneProduct799204 (Entrez Gene)
MAP3K11GeneProduct
MAP3K14GeneProduct
MAP3K6GeneProduct
MAP3K7IP2GeneProduct494163 (Entrez Gene)
MAP4K1GeneProduct
MAP4K4GeneProduct
MAPK12GeneProduct30681 (Entrez Gene)
MAPK8IP3GeneProduct
MEKK2/3GeneProduct
MINK1GeneProduct100038799 (Entrez Gene)
MYCGeneProduct
NFKB1GeneProduct565756 (Entrez Gene)
NGFBGeneProduct
NTF5GeneProduct
PDGFBGeneProduct565324 (Entrez Gene)
PLA2G5GeneProduct
PPP3CAGeneProduct
PPP3CBGeneProduct
PPP3CCGeneProduct
PPP3R2GeneProduct
PRKCDGeneProduct334571 (Entrez Gene)
PTPN7GeneProduct
RASA2GeneProduct
RASGRF2GeneProduct553520 (Entrez Gene)
RASGRP4GeneProduct
STMN1GeneProduct
Sap1aGeneProduct
TAOK2GeneProduct
TGFB1GeneProduct359834 (Entrez Gene)
TNFGeneProduct
akt2GeneProduct378972 (Entrez Gene)
arrb1GeneProduct553266 (Entrez Gene)
atf2lGeneProduct100006516 (Entrez Gene)
bdnfGeneProduct58118 (Entrez Gene)
brafGeneProduct403065 (Entrez Gene)
cAMPMetaboliteHMDB00058 (HMDB)
casp2GeneProduct373118 (Entrez Gene)
casp6GeneProduct552927 (Entrez Gene)
casp7GeneProduct553634 (Entrez Gene)
casp8GeneProduct58022 (Entrez Gene)
casp9GeneProduct492763 (Entrez Gene)
cdc25GeneProduct57925 (Entrez Gene)
cdc42lGeneProduct793158 (Entrez Gene)
crkGeneProduct445234 (Entrez Gene)
crklGeneProduct556443 (Entrez Gene)
daxxGeneProduct561006 (Entrez Gene)
dusp1GeneProduct406340 (Entrez Gene)
dusp5GeneProduct114436 (Entrez Gene)
dusp6GeneProduct353314 (Entrez Gene)
dusp7GeneProduct327246 (Entrez Gene)
ecsitGeneProduct569243 (Entrez Gene)
egfGeneProduct403045 (Entrez Gene)
egfrGeneProduct378478 (Entrez Gene)
elk1GeneProduct567895 (Entrez Gene)
fasGeneProduct768248 (Entrez Gene)
faslgGeneProduct735295 (Entrez Gene)
fgf4GeneProduct570435 (Entrez Gene)
fgfrGeneProduct
fosGeneProduct394198 (Entrez Gene)
gckGeneProduct751668 (Entrez Gene)
gna12GeneProduct503589 (Entrez Gene)
grb2GeneProduct406308 (Entrez Gene)
hspa5GeneProduct378848 (Entrez Gene)
hspa8GeneProduct573376 (Entrez Gene)
hspb1GeneProduct368243 (Entrez Gene)
hspb2GeneProduct550439 (Entrez Gene)
ikbkbGeneProduct563560 (Entrez Gene)
ikbkgGeneProduct541530 (Entrez Gene)
im:7136778GeneProduct100002318 (Entrez Gene)
junGeneProduct335916 (Entrez Gene)
jundGeneProduct564873 (Entrez Gene)
krasGeneProduct445289 (Entrez Gene)
map2k1GeneProduct406728 (Entrez Gene)
map2k6GeneProduct65239 (Entrez Gene)
map3k12GeneProduct404626 (Entrez Gene)
map3k5GeneProduct555703 (Entrez Gene)
map3k7GeneProduct553788 (Entrez Gene)
map3k7ip1GeneProduct403084 (Entrez Gene)
mapk10GeneProduct569698 (Entrez Gene)
mapk1GeneProduct360144 (Entrez Gene)
mapk14aGeneProduct65237 (Entrez Gene)
mapk3GeneProduct399480 (Entrez Gene)
mapk4GeneProduct406782 (Entrez Gene)
mapk6GeneProduct565830 (Entrez Gene)
mapk7GeneProduct541323 (Entrez Gene)
mapkapk2aGeneProduct327321 (Entrez Gene)
mapkapk5GeneProduct436608 (Entrez Gene)
mapksp1GeneProduct553597 (Entrez Gene)
maxGeneProduct30467 (Entrez Gene)
mef2cbGeneProduct798771 (Entrez Gene)
mkk3GeneProduct
mnk1/2GeneProduct
mosGeneProduct795517 (Entrez Gene)
mrasGeneProduct564799 (Entrez Gene)
msk1/2GeneProduct
nfat2/4GeneProduct
nlk2GeneProduct563460 (Entrez Gene)
nr4a1GeneProduct431720 (Entrez Gene)
nrasGeneProduct30380 (Entrez Gene)
ntrk1GeneProduct30546 (Entrez Gene)
pak1GeneProduct373103 (Entrez Gene)
pak2aGeneProduct266749 (Entrez Gene)
pdgfrbGeneProduct559529 (Entrez Gene)
pp2ca2GeneProduct30704 (Entrez Gene)
pp2cbGeneProduct30672 (Entrez Gene)
prkcb1GeneProduct393953 (Entrez Gene)
prkczGeneProduct555737 (Entrez Gene)
rac1GeneProduct327204 (Entrez Gene)
rac2GeneProduct415151 (Entrez Gene)
raf1GeneProduct30716 (Entrez Gene)
rap1aGeneProduct415242 (Entrez Gene)
rap1bGeneProduct321107 (Entrez Gene)
rasa1GeneProduct100002155 (Entrez Gene)
rps6ka3bGeneProduct100009657 (Entrez Gene)
sap1aGeneProduct
si:dkey-12o15.1GeneProduct558453 (Entrez Gene)
srfGeneProduct30431 (Entrez Gene)
stk3GeneProduct324125 (Entrez Gene)
tgfb2GeneProduct369194 (Entrez Gene)
tgfb3GeneProduct369195 (Entrez Gene)
tgfbr1bGeneProduct792928 (Entrez Gene)
tgfbr2GeneProduct30739 (Entrez Gene)
tmem37GeneProduct406453 (Entrez Gene)
tp53GeneProduct30590 (Entrez Gene)
traf6GeneProduct554561 (Entrez Gene)
wu:fc83c01GeneProduct325488 (Entrez Gene)
zgc:110801GeneProduct541536 (Entrez Gene)
zgc:158799GeneProduct564064 (Entrez Gene)
zgc:172124GeneProduct100144561 (Entrez Gene)
zgc:172137GeneProduct100007679 (Entrez Gene)
zgc:172209GeneProduct562720 (Entrez Gene)
zgc:172250GeneProduct100002225 (Entrez Gene)
zgc:194486GeneProduct568951 (Entrez Gene)
zgc:92162GeneProduct436622 (Entrez Gene)

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1337"