IL-6 signaling pathway (Rattus norvegicus)

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DInhibitionEarly EndosomesGODMTCY->NUMolecule in the pathwayEndoplasmic reticulumPhosphorylationDDNUEnzyme complexDCYPalmitoylationDLigandMethylationDGolgi apparatusExtracellularDeacetylationRecruitmentProteins in a complex interactionCY->ENAcetylationControlGlycosylationGene SymbolTranslocationDCY->NUEndosomeENERDCY->NUSumoylationPlasma membraneProteolytic cleavageDD(Protein-Protein interaction)CY->NUReactions through unknown mechanisms/moleculesECActivationNucleusDephosphorylationReceptorMitochondrionDeubiquitinationAccession Number: NetPath 18CytoplasmMolecular associationCY->NUDUbiquitinationCY->NUDesumoylationAutophosphorylationDDComplex formationPMDemethylationMapk8Stat5bPpp2r1aRGD1565643BtkPtk2bPpp2r2aStat5aPPP2R5CCasp3Ppp2r2cCdk5Ppp2r3aStat3Il6stNfkb1Ppp2r5eSos1Jak2TYK2PrkcdDaxxPpp2r5bCdk9CebpbTnfrsf5Ppp2cbSgkPpp2caShc1Stat3RGD1564385Rps6ka2Ppp2r2bFosGrb2Map3k7Gsk3bSgkIl6raHspcaPxnStat1Jak1CrebbpPlcg1Mapk3Tcf1Ppp2r4ArAkt1Stat3Foxo1aPpp2r5dStat3Socs3Ptk2Mapkapk2Hdac1Ppp2r5aEp300Eif4eInppl1Ptpn11JunHspb1Mapk14FgrRGD1561201HrasMap2k4Vav1Stat3Stat3LynMap3k4Erbb3PPP2R3BHckStat1Il6stEif2aNfkb1Pik3r2Map2k1Inpp5dRps6kb1Map2k2Ncoa1FynMapk14MAPTErbb2Stat3Eif4ebp1BadTecMap3k7Mapk1CebpbRaf1RGD1561602Il6raStat3Pik3r1Stat1Stat1Foxo3aPpp2r1bMap2k6Rac1Gab2Cdk5r1Il6Rb1Casp9Il6Gab1


Description

No description

Comments

GenMAPP notes 
NetPath 18 - IL-6 signaling pathway. NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.
GenMAPP remarks 
http://www.netpath.org

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Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
125589view19:30, 2 March 2023AlexanderPicoadded description
116986view10:46, 16 May 2021EweitzModified title
83583view07:23, 26 November 2015EgonwAdded two missing gene identifiers.
83528view19:53, 20 November 2015Khanspersupdated missing ids
82974view23:24, 16 November 2015MkutmonUpdated identifiers
82865view16:04, 10 November 2015JmeliusCorrect outdated id
69356view18:53, 8 July 2013MaintBotUpdated to 2013 gpml schema
67383view10:45, 26 June 2013Christine ChichesterOntology Term : 'interleukin-6 signaling pathway' added !
41668view02:35, 2 March 2011MaintBotRemoved redundant pathway information and comments
28140view23:55, 27 January 2009KhanspersChanged name
20965view11:30, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:IL-6 NetPath 18]] moved to [[Pathway:WP135]]: Moved to stable identifier
8192view13:46, 7 January 2008MaintBot[[Pathway:Rat:IL-6 NetPath 18]] moved to [[Pathway:Rattus norvegicus:IL-6 NetPath 18]]: Renaming species
7716view16:12, 18 December 2007MaintBotfixed category names
7255view12:41, 4 November 2007MaintBotAdded categories to GPML
6563view22:20, 22 May 2007A.Pandeygpml file for [[Rat:IL-6_NetPath_18]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Akt1GeneProduct24185 (Entrez Gene)
ArGeneProduct24208 (Entrez Gene)
BadGeneProduct64639 (Entrez Gene)
BtkGeneProduct367901 (Entrez Gene)
Casp3GeneProduct25402 (Entrez Gene)
Casp9GeneProduct58918 (Entrez Gene)
Cdk5GeneProduct140908 (Entrez Gene)
Cdk5r1GeneProduct116671 (Entrez Gene)
Cdk9GeneProduct362110 (Entrez Gene)
CebpbGeneProduct24253 (Entrez Gene)
CrebbpGeneProduct54244 (Entrez Gene)
DaxxGeneProduct140926 (Entrez Gene)
Eif2aGeneProduct502531 (Entrez Gene)
Eif4eGeneProduct117045 (Entrez Gene)
Eif4ebp1GeneProduct116636 (Entrez Gene)
Ep300GeneProduct170915 (Entrez Gene)
Erbb2GeneProduct24337 (Entrez Gene)
Erbb3GeneProduct29496 (Entrez Gene)
FgrGeneProduct79113 (Entrez Gene)
FosGeneProduct314322 (Entrez Gene)
Foxo1aGeneProduct84482 (Entrez Gene)
Foxo3aGeneProduct294515 (Entrez Gene)
FynGeneProduct25150 (Entrez Gene)
Gab1GeneProduct361388 (Entrez Gene)
Gab2GeneProduct84477 (Entrez Gene)
Grb2GeneProduct81504 (Entrez Gene)
Gsk3bGeneProduct84027 (Entrez Gene)
HckGeneProduct25734 (Entrez Gene)
Hdac1GeneProduct297893 (Entrez Gene)
HrasGeneProduct293621 (Entrez Gene)
Hspb1GeneProduct24471 (Entrez Gene)
HspcaGeneProduct299331 (Entrez Gene)
Il6GeneProduct24498 (Entrez Gene)
Il6raGeneProduct24499 (Entrez Gene)
Il6stGeneProduct25205 (Entrez Gene)
Inpp5dGeneProduct54259 (Entrez Gene)
Inppl1GeneProduct65038 (Entrez Gene)
Jak1GeneProduct84598 (Entrez Gene)
Jak2GeneProduct24514 (Entrez Gene)
JunGeneProduct24516 (Entrez Gene)
LynGeneProduct81515 (Entrez Gene)
MAPTGeneProduct (Entrez Gene)
Map2k1GeneProduct170851 (Entrez Gene)
Map2k2GeneProduct58960 (Entrez Gene)
Map2k4GeneProduct287398 (Entrez Gene)
Map2k6GeneProduct114495 (Entrez Gene)
Map3k4GeneProduct308106 (Entrez Gene)
Map3k7GeneProduct313121 (Entrez Gene)
Mapk1GeneProduct116590 (Entrez Gene)
Mapk14GeneProduct81649 (Entrez Gene)
Mapk3GeneProduct50689 (Entrez Gene)
Mapk8GeneProduct116554 (Entrez Gene)
Mapkapk2GeneProduct289014 (Entrez Gene)
Ncoa1GeneProduct313929 (Entrez Gene)
Nfkb1GeneProduct81736 (Entrez Gene)
PPP2R3BGeneProduct (Entrez Gene)
PPP2R5CGeneProduct (Entrez Gene)
Pik3r1GeneProduct25513 (Entrez Gene)
Pik3r2GeneProduct29741 (Entrez Gene)
Plcg1GeneProduct25738 (Entrez Gene)
Ppp2caGeneProduct24672 (Entrez Gene)
Ppp2cbGeneProduct24673 (Entrez Gene)
Ppp2r1aGeneProduct117281 (Entrez Gene)
Ppp2r1bGeneProduct315648 (Entrez Gene)
Ppp2r2aGeneProduct117104 (Entrez Gene)
Ppp2r2bGeneProduct60660 (Entrez Gene)
Ppp2r2cGeneProduct117256 (Entrez Gene)
Ppp2r3aGeneProduct363122 (Entrez Gene)
Ppp2r4GeneProduct362102 (Entrez Gene)
Ppp2r5aGeneProduct312754 (Entrez Gene)
Ppp2r5bGeneProduct309179 (Entrez Gene)
Ppp2r5dGeneProduct363193 (Entrez Gene)
Ppp2r5eGeneProduct299147 (Entrez Gene)
PrkcdGeneProduct170538 (Entrez Gene)
Ptk2GeneProduct25614 (Entrez Gene)
Ptk2bGeneProduct50646 (Entrez Gene)
Ptpn11GeneProduct25622 (Entrez Gene)
PxnGeneProduct360820 (Entrez Gene)
RGD1561201GeneProduct302415 (Entrez Gene)
RGD1561602GeneProduct497961 (Entrez Gene)
RGD1564385GeneProduct361597 (Entrez Gene)
RGD1565643GeneProduct367786 (Entrez Gene)
Rac1GeneProduct363875 (Entrez Gene)
Raf1GeneProduct24703 (Entrez Gene)
Rb1GeneProduct24708 (Entrez Gene)
Rps6ka2GeneProduct117269 (Entrez Gene)
Rps6kb1GeneProduct83840 (Entrez Gene)
SgkGeneProduct29517 (Entrez Gene)
Shc1GeneProduct85385 (Entrez Gene)
Socs3GeneProduct89829 (Entrez Gene)
Sos1GeneProduct313845 (Entrez Gene)
Stat1GeneProduct25124 (Entrez Gene)
Stat3GeneProduct25125 (Entrez Gene)
Stat5aGeneProduct24918 (Entrez Gene)
Stat5bGeneProduct25126 (Entrez Gene)
TYK2GeneProduct (Entrez Gene)
Tcf1GeneProduct24817 (Entrez Gene)
TecGeneProduct84492 (Entrez Gene)
Tnfrsf5GeneProduct171369 (Entrez Gene)
Vav1GeneProduct25156 (Entrez Gene)

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP135"