miRNA regulation of DNA damage response (Homo sapiens)

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3222553551, 6, 17, 25, 26, 41...21516303010, 13, 26, 33, 402, 231432718461, 6, 17, 25, 26, 41...52830538243046239473432202332222839951537, 393634342, 231, 6, 17, 25, 26, 41...12282, 23443511916, 3151, 6, 17, 25, 26, 41...55895222, 2352, 231, 6, 17, 25, 26, 41...1, 6, 17, 25, 26, 41...449231, 6, 17, 25, 26, 41...4728216DNA damage ATM dependentDouble-strand breaksDNA repairBulky DNA lesionCaption:G2/M transitionChange in the Cell conditionDNA repair and damage preventionTextG1/S transitionExogenous: Cigarette Smoke Caffeine Radiation (UV) Clastogenes Hypoxia Genotoxic drugsPathway LinkExtral cellular SpaceROSCellBlocked transcriptionMetaboliteDNA adductG2/M checkpointmiR polycistronTextChromatin alterationInhibition G2/M CheckpointmicroRNAReplication stressSpecialized: Somatic hypermutaion V(D)J recombination Class switchingROSBlocked replicationAlkylating agentsGene productDifferent pathwayDNA damage sourceActivationCell membraneMitochondrial membraneEndogenous: Collapsed replication forks Single stranded DNA replication breaks Free radicals (ROS)Cell survivalTextCell-cycle progressionChromatin remodellingMRE11CCNG1hsa-mir-16BBC3hsa-mir-17CHEK2GADD45ACell CycleCCNE2CDK1CDC25Cc-MycCCNE1hsa-mir-143/145CDK4hsa-mir-15b/16-2hsa-mir-210hsa-mir-29bTLK1hsa-mir-15a/16-1TLK2RFChsa-mir-222PMLhsa-mir-34b/34cBIDRAD50SESN1TP53RAD17hsa-mir-449aCDK6RAD52GADD45AFASCDKN1BGADD45Bhsa-miR-106b/25GADD45GSFNhsa-mir-17hsa-mir-15aRRM2Bhsa-mir-16hsa-let-7a-1/7dRAD1hsa-mir-20ahsa-mir-21hsa-mir-29aEstradiolhsa-mir-221CREB1has-miR-195/497hsa-mir-424hsa-mir-195hsa-miR-17/92a-1E2F1hsa-mir-16DDB2hsa-miR-449c/449a7-hydroxystaurosporineCCND3CASP3RB1GADD45BRAD9APRKDChsa-mir-373hsa-mir-24CDK2hsa-mir-15b/16-2hsa-mir-106bTP53AIP1CASP8PMAIP1CCND1HUS1CCND2hsa-mir-203H2AFXTNFRSF10BCCNB2NBNCaffeineGADD45Ghsa-mir-449aBAXhsa-mir-330FANCD2hsa-mir-449bABL1RPA2CDKN1ACYCShsa-mir-145ATRE2F1hsa-mir-223hsa-mir-34bRB1MDM2Senescencehsa-miR-29b-1/29ahsa-mir-181aATMmiR-143/145 polycistronATRIPCDC25ACDK5ApoptosisPIDDCASP9CCNB3BRCA1hsa-mir-29cCHEK1APAF1RAD51SMC1Ahsa-mir-421hsa-mir-122CCNB1


Description

This is the first out of two pathways which deals with the DNA damage response. It is comprised of two central gene products (ATM and ATR) influenced by different sources of DNA damage (in blue). The two central genes can both be divides into their most important genes. For the ATM pathway these are TP53 and CHEK2, while CHEK1 is most important for the ATR pathway.

The goal of this first pathway is to provide an overview of the most important gene products, processes and changes in cell condition elicited by the DNA damage response while keeping it clear and understandable. Also some microRNAs are implemented to visualize the possible effects they can induce. By doing so a better understanding of the role microRNA play in the DNA damage response might arise.

All processes take place in the cytoplasm, except when mentioned differently.

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Bibliography

View all...
  1. Kong YW, Cannell IG, de Moor CH, Hill K, Garside PG, Hamilton TL, Meijer HA, Dobbyn HC, Stoneley M, Spriggs KA, Willis AE, Bushell M; ''The mechanism of micro-RNA-mediated translation repression is determined by the promoter of the target gene.''; Proc Natl Acad Sci U S A, 2008 PubMed Europe PMC Scholia
  2. Brosh R, Shalgi R, Liran A, Landan G, Korotayev K, Nguyen GH, Enerly E, Johnsen H, Buganim Y, Solomon H, Goldstein I, Madar S, Goldfinger N, Bâˆڑأ‰آ¬âˆڈrresen-Dale AL, Ginsberg D, Harris CC, Pilpel Y, Oren M, Rotter V; ''p53-Repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation.''; Mol Syst Biol, 2008 PubMed Europe PMC Scholia
  3. Lâˆڑأ‰آ¬أکâˆڑأ‡آ¬أ¸âˆڑأ‡آ¬خ©âˆڑأ‰آ¬أکâˆڑأ‡آ¬أ¸âˆڑأ‡آ¬خ©âˆڑأ‰آ¬أ©âˆڑأ‡آ¬آ©brich M, Jeggo PA; ''The impact of a negligent G2/M checkpoint on genomic instability and cancer induction.''; Nat Rev Cancer, 2007 PubMed Europe PMC Scholia
  4. Fornari F, Gramantieri L, Ferracin M, Veronese A, Sabbioni S, Calin GA, Grazi GL, Giovannini C, Croce CM, Bolondi L, Negrini M; ''MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma.''; Oncogene, 2008 PubMed Europe PMC Scholia
  5. Cannell IG, Kong YW, Johnston SJ, Chen ML, Collins HM, Dobbyn HC, Elia A, Kress TR, Dickens M, Clemens MJ, Heery DM, Gaestel M, Eilers M, Willis AE, Bushell M; ''p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication.''; Proc Natl Acad Sci U S A, 2010 PubMed Europe PMC Scholia
  6. Sherr CJ, Roberts JM; ''Living with or without cyclins and cyclin-dependent kinases.''; Genes Dev, 2004 PubMed Europe PMC Scholia
  7. Ohtsuka T, Jensen MR, Kim HG, Kim KT, Lee SW; ''The negative role of cyclin G in ATM-dependent p53 activation.''; Oncogene, 2004 PubMed Europe PMC Scholia
  8. Wong P, Iwasaki M, Somervaille TC, Ficara F, Carico C, Arnold C, Chen CZ, Cleary ML; ''The miR-17-92 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expression.''; Cancer Res, 2010 PubMed Europe PMC Scholia
  9. Zhou BB, Bartek J; ''Targeting the checkpoint kinases: chemosensitization versus chemoprotection.''; Nat Rev Cancer, 2004 PubMed Europe PMC Scholia
  10. Lal A, Pan Y, Navarro F, Dykxhoorn DM, Moreau L, Meire E, Bentwich Z, Lieberman J, Chowdhury D; ''miR-24-mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cells.''; Nat Struct Mol Biol, 2009 PubMed Europe PMC Scholia
  11. Toledo F, Wahl GM; ''Regulating the p53 pathway: in vitro hypotheses, in vivo veritas.''; Nat Rev Cancer, 2006 PubMed Europe PMC Scholia
  12. Cuesta R, Martâˆڑأ‰آ¬â‰ nez-Sâˆڑأ‰آ¬آ°nchez A, Gebauer F; ''miR-181a regulates cap-dependent translation of p27(kip1) mRNA in myeloid cells.''; Mol Cell Biol, 2009 PubMed Europe PMC Scholia
  13. Zhao JJ, Lin J, Lwin T, Yang H, Guo J, Kong W, Dessureault S, Moscinski LC, Rezania D, Dalton WS, Sotomayor E, Tao J, Cheng JQ; ''microRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma.''; Blood, 2010 PubMed Europe PMC Scholia
  14. Sylvestre Y, De Guire V, Querido E, Mukhopadhyay UK, Bourdeau V, Major F, Ferbeyre G, Chartrand P; ''An E2F/miR-20a autoregulatory feedback loop.''; J Biol Chem, 2007 PubMed Europe PMC Scholia
  15. Reshmi SC, Gollin SM; ''Chromosomal instability in oral cancer cells.''; J Dent Res, 2005 PubMed Europe PMC Scholia
  16. Pagano M, Jackson PK; ''Wagging the dogma; tissue-specific cell cycle control in the mouse embryo.''; Cell, 2004 PubMed Europe PMC Scholia
  17. Boutros R, Lobjois V, Ducommun B; ''CDC25 phosphatases in cancer cells: key players? Good targets?''; Nat Rev Cancer, 2007 PubMed Europe PMC Scholia
  18. Sampson VB, Rong NH, Han J, Yang Q, Aris V, Soteropoulos P, Petrelli NJ, Dunn SP, Krueger LJ; ''MicroRNA let-7a down-regulates MYC and reverts MYC-induced growth in Burkitt lymphoma cells.''; Cancer Res, 2007 PubMed Europe PMC Scholia
  19. Chargari C, Toillon RA, Macdermed D, Castadot P, Magnâˆڑأ‰آ¬أکâˆڑأ‡آ¬أ¸âˆڑأ‡آ¬خ©âˆڑأ‰آ¬أکâˆڑأ‡آ¬أ¸âˆڑأ‡آ¬خ©âˆڑأ‰آ¬أ©âˆڑأ‡آ¬آ© N; ''Concurrent hormone and radiation therapy in patients with breast cancer: what is the rationale?''; Lancet Oncol, 2009 PubMed Europe PMC Scholia
  20. Lee SO, Masyuk T, Splinter P, Banales JM, Masyuk A, Stroope A, Larusso N; ''MicroRNA15a modulates expression of the cell-cycle regulator Cdc25A and affects hepatic cystogenesis in a rat model of polycystic kidney disease.''; J Clin Invest, 2008 PubMed Europe PMC Scholia
  21. Antoni L, Sodha N, Collins I, Garrett MD; ''CHK2 kinase: cancer susceptibility and cancer therapy - two sides of the same coin?''; Nat Rev Cancer, 2007 PubMed Europe PMC Scholia
  22. Harrison JC, Haber JE; ''Surviving the breakup: the DNA damage checkpoint.''; Annu Rev Genet, 2006 PubMed Europe PMC Scholia
  23. Ljungman M, Lane DP; ''Transcription - guarding the genome by sensing DNA damage.''; Nat Rev Cancer, 2004 PubMed Europe PMC Scholia
  24. Strasser A; ''The role of BH3-only proteins in the immune system.''; Nat Rev Immunol, 2005 PubMed Europe PMC Scholia
  25. Bueno MJ, Pâˆڑأ‰آ¬آ©rez de Castro I, Gâˆڑأ‰آ¬â‰¥mez de Cedrâˆڑأ‰آ¬â‰¥n M, Santos J, Calin GA, Cigudosa JC, Croce CM, Fernâˆڑأ‰آ¬آ°ndez-Piqueras J, Malumbres M; ''Genetic and epigenetic silencing of microRNA-203 enhances ABL1 and BCR-ABL1 oncogene expression.''; Cancer Cell, 2008 PubMed Europe PMC Scholia
  26. ''''; , PubMed Europe PMC Scholia
  27. Crosby ME, Kulshreshtha R, Ivan M, Glazer PM; ''MicroRNA regulation of DNA repair gene expression in hypoxic stress.''; Cancer Res, 2009 PubMed Europe PMC Scholia
  28. Woods K, Thomson JM, Hammond SM; ''Direct regulation of an oncogenic micro-RNA cluster by E2F transcription factors.''; J Biol Chem, 2007 PubMed Europe PMC Scholia
  29. Gil J, Peters G; ''Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all.''; Nat Rev Mol Cell Biol, 2006 PubMed Europe PMC Scholia
  30. Sengupta S, Harris CC; ''p53: traffic cop at the crossroads of DNA repair and recombination.''; Nat Rev Mol Cell Biol, 2005 PubMed Europe PMC Scholia
  31. Sachdeva M, Zhu S, Wu F, Wu H, Walia V, Kumar S, Elble R, Watabe K, Mo YY; ''p53 represses c-Myc through induction of the tumor suppressor miR-145.''; Proc Natl Acad Sci U S A, 2009 PubMed Europe PMC Scholia
  32. O'Donnell KA, Wentzel EA, Zeller KI, Dang CV, Mendell JT; ''c-Myc-regulated microRNAs modulate E2F1 expression.''; Nature, 2005 PubMed Europe PMC Scholia
  33. Vousden KH, Lane DP; ''p53 in health and disease.''; Nat Rev Mol Cell Biol, 2007 PubMed Europe PMC Scholia
  34. Lee KH, Chen YL, Yeh SD, Hsiao M, Lin JT, Goan YG, Lu PJ; ''MicroRNA-330 acts as tumor suppressor and induces apoptosis of prostate cancer cells through E2F1-mediated suppression of Akt phosphorylation.''; Oncogene, 2009 PubMed Europe PMC Scholia
  35. Hu H, Du L, Nagabayashi G, Seeger RC, Gatti RA; ''ATM is down-regulated by N-Myc-regulated microRNA-421.''; Proc Natl Acad Sci U S A, 2010 PubMed Europe PMC Scholia
  36. Lahav G, Rosenfeld N, Sigal A, Geva-Zatorsky N, Levine AJ, Elowitz MB, Alon U; ''Dynamics of the p53-Mdm2 feedback loop in individual cells.''; Nat Genet, 2004 PubMed Europe PMC Scholia
  37. Coller HA, Forman JJ, Legesse-Miller A; ''"Myc'ed messages": myc induces transcription of E2F1 while inhibiting its translation via a microRNA polycistron.''; PLoS Genet, 2007 PubMed Europe PMC Scholia
  38. Pigazzi M, Manara E, Baron E, Basso G; ''miR-34b targets cyclic AMP-responsive element binding protein in acute myeloid leukemia.''; Cancer Res, 2009 PubMed Europe PMC Scholia
  39. Yang X, Feng M, Jiang X, Wu Z, Li Z, Aau M, Yu Q; ''miR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A.''; Genes Dev, 2009 PubMed Europe PMC Scholia
  40. Galardi S, Mercatelli N, Giorda E, Massalini S, Frajese GV, Ciafrâˆڑأ‰آ¬آ® SA, Farace MG; ''miR-221 and miR-222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1.''; J Biol Chem, 2007 PubMed Europe PMC Scholia
  41. Pulikkan JA, Dengler V, Peramangalam PS, Peer Zada AA, Mâˆڑأ‰آ¬آ؛ller-Tidow C, Bohlander SK, Tenen DG, Behre G; ''Cell-cycle regulator E2F1 and microRNA-223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia.''; Blood, 2010 PubMed Europe PMC Scholia
  42. Cory S, Huang DC, Adams JM; ''The Bcl-2 family: roles in cell survival and oncogenesis.''; Oncogene, 2003 PubMed Europe PMC Scholia
  43. Gong H, Cao Y, Han G, Zhang Y, You Q, Wang Y, Pan Y; '' Current Issue Forthcoming Issue Special Issues Most Read Most Cited (Dimensions) Most Cited (CrossRef) Social Media Archive Information Online Submission Information for Authors Language Editing Information for Reviewers Editorial Policies Editorial Academy Join Editorial Academy Aims and Scope Abstracting and Indexing Bibliographic Information Information for Librarians Information for Advertisers Reprints and permissions Contact the Editor General Information About Spandidos Conferences Job Opportunities Contact Terms and Conditions p53/microRNA-374b/AKT1 regulates colorectal cancer cell apoptosis in response to DNA damage''; https://doi.org/10.3892/ijo.2017.3922, 2017 PubMed Europe PMC Scholia
  44. Wang W; ''Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins.''; Nat Rev Genet, 2007 PubMed Europe PMC Scholia
  45. Liu Q, Fu H, Sun F, Zhang H, Tie Y, Zhu J, Xing R, Sun Z, Zheng X; ''miR-16 family induces cell cycle arrest by regulating multiple cell cycle genes.''; Nucleic Acids Res, 2008 PubMed Europe PMC Scholia
  46. Pothof J, Verkaik NS, van IJcken W, Wiemer EA, Ta VT, van der Horst GT, Jaspers NG, van Gent DC, Hoeijmakers JH, Persengiev SP; ''MicroRNA-mediated gene silencing modulates the UV-induced DNA-damage response.''; EMBO J, 2009 PubMed Europe PMC Scholia
  47. Gramantieri L, Fornari F, Callegari E, Sabbioni S, Lanza G, Croce CM, Bolondi L, Negrini M; ''MicroRNA involvement in hepatocellular carcinoma.''; J Cell Mol Med, 2008 PubMed Europe PMC Scholia
  48. Sparmann A, van Lohuizen M; ''Polycomb silencers control cell fate, development and cancer.''; Nat Rev Cancer, 2006 PubMed Europe PMC Scholia
  49. Wang P, Zou F, Zhang X, Li H, Dulak A, Tomko RJ Jr, Lazo JS, Wang Z, Zhang L, Yu J; ''microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells.''; Cancer Res, 2009 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
126392view15:22, 26 April 2023EgonwLicense is CCZero
124175view12:54, 23 September 2022VanessaSousaAKT1 gene involved in miRNA regulation of DNA damage response
118120view11:08, 24 May 2021EweitzModified description
116539view12:09, 7 May 2021EweitzModified title
113793view09:04, 24 November 2020Finterlysmall graphical update
107119view14:19, 17 September 2019MaintBotChEBI identifier normalization
105862view23:21, 15 August 2019KhanspersModified description
103023view15:52, 31 January 2019Mkutmonupdated ensembl ids
102986view12:46, 31 January 2019SusanRe-annotated microRNAs
98336view13:26, 23 August 2018EgonwUpdated the MIR21 identifier.
94738view15:05, 5 October 2017Ryanmillerconnected lines
84694view21:01, 15 March 2016KhanspersQuick edit to datanode annotation or property
79564view17:47, 25 March 2015Zarichanged ID for PRKDC
78503view10:29, 7 January 2015MaintBotadded missing graphIds
75268view21:48, 13 May 2014Khanspersupdated miRNAs and lines
71711view20:03, 17 October 2013MaintBotremoved data source from nodes without identifier
70992view21:04, 21 September 2013EgonwAdded the missing DB names.
70112view19:09, 12 July 2013MaintBotupdated to 2013 schema
70023view01:52, 12 July 2013AlexanderPicoModified title
68400view08:12, 5 July 2013EgonwConverted the "alkylating agent" label into a DataNode with ChEBI identifier.
59081view21:57, 21 February 2013MaintBotUpdated Ensembl data source
45379view21:45, 7 October 2011KhanspersOntology Term : 'DNA repair pathway' added !
44908view10:26, 6 October 2011MartijnVanIerselOntology Term : 'miRNA pathway' added !
41096view23:21, 1 March 2011MaintBotRemoved redundant pathway information and comments
40043view15:20, 1 February 2011AndraPeriodical save, work in progress
39801view15:52, 20 January 2011Stan.gaj
39800view15:51, 20 January 2011Stan.gaj
39799view15:48, 20 January 2011Stan.gaj
39717view11:00, 14 January 2011Stan.gaj
38644view12:16, 23 September 2010Mkutmonadded some pathway links
38435view08:40, 13 September 2010Stan.gajAdded miRNA-122/Cyclin G1/MDM2/p53 regulatory network
38434view08:10, 13 September 2010Stan.gajSpecify description
38432view08:00, 13 September 2010Stan.gajPeriodical save, work in progress
37425view15:16, 1 June 2010J.krumeichSpecify description
37424view15:14, 1 June 2010J.krumeichSpecify description
37423view15:04, 1 June 2010J.krumeichPeriodical save, work in progress
37422view14:34, 1 June 2010J.krumeichPeriodical save, work in progress
37296view09:18, 25 May 2010J.krumeichPeriodical save, work in progress
37195view09:25, 21 May 2010J.krumeichPeriodical save, work in progress
37189view11:30, 20 May 2010J.krumeichModified description
37188view11:23, 20 May 2010J.krumeichPeriodical save, work in progress
37187view11:12, 20 May 2010J.krumeichPeriodical save, work in progress
37186view10:02, 20 May 2010J.krumeichSpecify description
37185view09:59, 20 May 2010J.krumeichPeriodical save, work in progress
37184view09:49, 20 May 2010J.krumeichPeriodical save, work in progress
37183view09:39, 20 May 2010J.krumeichPeriodical save, work in progress
37182view09:23, 20 May 2010J.krumeichSpecify description
37181view09:22, 20 May 2010J.krumeichSpecify description
37180view09:18, 20 May 2010J.krumeichPeriodical save, work in progress
37179view09:08, 20 May 2010J.krumeichPeriodical save, work in progress

External references

DataNodes

View all...
NameTypeDatabase referenceComment
7-hydroxystaurosporineMetabolite65225 (Chemspider)
ABL1GeneProductENSG00000097007 (Ensembl)
APAF1GeneProductENSG00000120868 (Ensembl)
ATMGeneProductENSG00000149311 (Ensembl)
ATRGeneProductENSG00000175054 (Ensembl)
ATRIPGeneProduct84126 (Entrez Gene)
Alkylating agentsMetaboliteCHEBI:22333 (ChEBI)
ApoptosisPathwayWP254 (WikiPathways)
BAXGeneProductENSG00000087088 (Ensembl)
BBC3GeneProductENSG00000105327 (Ensembl)
BIDGeneProductENSG00000015475 (Ensembl)
BRCA1GeneProductENSG00000012048 (Ensembl)
CASP3GeneProductENSG00000164305 (Ensembl)
CASP8GeneProductENSG00000064012 (Ensembl)
CASP9GeneProductENSG00000132906 (Ensembl)
CCNB1GeneProductENSG00000134057 (Ensembl)
CCNB2GeneProductENSG00000157456 (Ensembl)
CCNB3GeneProductENSG00000147082 (Ensembl)
CCND1GeneProductENSG00000110092 (Ensembl)
CCND2GeneProductENSG00000118971 (Ensembl)
CCND3GeneProductENSG00000112576 (Ensembl)
CCNE1GeneProductENSG00000105173 (Ensembl)
CCNE2GeneProductENSG00000175305 (Ensembl)
CCNG1GeneProductENSG00000113328 (Ensembl)
CDC25AGeneProductENSG00000164045 (Ensembl)
CDC25CGeneProductENSG00000158402 (Ensembl)
CDK1GeneProductENSG00000170312 (Ensembl)
CDK2GeneProductENSG00000123374 (Ensembl)
CDK4GeneProductENSG00000135446 (Ensembl)
CDK5GeneProductENSG00000164885 (Ensembl)
CDK6GeneProductENSG00000105810 (Ensembl)
CDKN1AGeneProductENSG00000124762 (Ensembl)
CDKN1BGeneProductENSG00000111276 (Ensembl)
CHEK1GeneProductENSG00000149554 (Ensembl)
CHEK2GeneProductENSG00000183765 (Ensembl)
CREB1GeneProduct1385 (Entrez Gene)
CYCSGeneProductENSG00000172115 (Ensembl)
CaffeineMetabolite2424 (Chemspider)
Cell CyclePathwayWP179 (WikiPathways)
DDB2GeneProductENSG00000134574 (Ensembl)
E2F1GeneProductENSG00000101412 (Ensembl)
EstradiolMetabolite16469 (ChEBI)
FANCD2GeneProductENSG00000144554 (Ensembl)
FASGeneProductENSG00000026103 (Ensembl)
GADD45AGeneProductENSG00000116717 (Ensembl)
GADD45BGeneProductENSG00000099860 (Ensembl)
GADD45GGeneProductENSG00000130222 (Ensembl)
H2AFXGeneProductENSG00000188486 (Ensembl)
HUS1GeneProductENSG00000188996 (Ensembl)
MDM2GeneProductENSG00000135679 (Ensembl)
MRE11GeneProduct4361 (Entrez Gene)
NBNGeneProduct4683 (Entrez Gene)
PIDDGeneProduct55367 (Entrez Gene)
PMAIP1GeneProductENSG00000141682 (Ensembl)
PMLGeneProductENSG00000140464 (Ensembl)
PRKDCGeneProductENSG00000253729 (Ensembl)
RAD17GeneProductENSG00000152942 (Ensembl)
RAD1GeneProductENSG00000113456 (Ensembl)
RAD50GeneProductENSG00000113522 (Ensembl)
RAD51GeneProductENSG00000051180 (Ensembl)
RAD52GeneProductENSG00000002016 (Ensembl)
RAD9AGeneProductENSG00000172613 (Ensembl)
RB1GeneProductENSG00000139687 (Ensembl)
RFCGeneProduct5981 (Entrez Gene)
RPA2GeneProductENSG00000117748 (Ensembl)
RRM2BGeneProductENSG00000048392 (Ensembl)
SESN1GeneProductENSG00000080546 (Ensembl)
SFNGeneProductENSG00000175793 (Ensembl)
SMC1AGeneProductENSG00000072501 (Ensembl)
SenescencePathwayWP615 (WikiPathways)
TLK1GeneProductENSG00000198586 (Ensembl)
TLK2GeneProductENSG00000146872 (Ensembl)
TNFRSF10BGeneProductENSG00000120889 (Ensembl)
TP53AIP1GeneProductENSG00000120471 (Ensembl)
TP53GeneProductENSG00000141510 (Ensembl)
c-MycGeneProduct4609 (Entrez Gene)
has-miR-195/497Rna
hsa-let-7a-1/7dRna
hsa-miR-106b/25Rna4176 (Entrez Gene)
hsa-miR-17/92a-1RnaENSG00000215417 (Ensembl)
hsa-miR-29b-1/29aRna
hsa-miR-449c/449aRna166979 (Entrez Gene)
hsa-mir-106bRnaENSG00000208036 (Ensembl)
hsa-mir-122RnaENSG00000207778 (Ensembl)
hsa-mir-143/145Rna
hsa-mir-145RnaENSG00000207700 (Ensembl)
hsa-mir-15a/16-1Rna
hsa-mir-15aRnaENSG00000207718 (Ensembl)
hsa-mir-15b/16-2Rna
hsa-mir-16RnaENSG00000208006 (Ensembl)
hsa-mir-17RnaENSG00000207745 (Ensembl)
hsa-mir-181aRnaENSG00000207759 (Ensembl)
hsa-mir-195RnaENSG00000207929 (Ensembl)
hsa-mir-203RnaENSG00000207568 (Ensembl)
hsa-mir-20aGeneProductENSG00000275534 (Ensembl)
hsa-mir-210RnaENSG00000199038 (Ensembl)
hsa-mir-21RnaENSG00000199004 (Ensembl)
hsa-mir-221RnaENSG00000207870 (Ensembl)
hsa-mir-222RnaENSG00000207725 (Ensembl)
hsa-mir-223RnaENSG00000207939 (Ensembl)
hsa-mir-24RnaENSG00000207617 (Ensembl)
hsa-mir-29aRnaENSG00000198981 (Ensembl)
hsa-mir-29bRnaENSG00000207748 (Ensembl)
hsa-mir-29cRnaENSG00000207966 (Ensembl)
hsa-mir-330RnaENSG00000199066 (Ensembl)
hsa-mir-34b/34cRna
hsa-mir-34bRnaENSG00000207811 (Ensembl)
hsa-mir-373RnaENSG00000199143 (Ensembl)
hsa-mir-421RnaENSG00000202566 (Ensembl)
hsa-mir-424RnaENSG00000199097 (Ensembl)
hsa-mir-449aRnaENSG00000198983 (Ensembl)
hsa-mir-449bRnaENSG00000207728 (Ensembl)
miR-143/145 polycistronRna

Annotated Interactions

No annotated interactions

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