DIV (Homo sapiens)

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7EXPR NO PRLOW=GOOD PRPRKXMAPKLOW=BAD PRLOW=MOD GOOD PRLOW=MOB BAD PRDNAProliferation, differentiationCa2+MKPPTPMAPKKKKp38Classical MAP kinase PathwayHeteromeric G-proteinMAPKIP3Serum, EGF,reactive oxygen species.or Srk tyrokinase downstreamDAGProliferation, differentiation,inflammationCyclePhosphatidylinositolsignaling systemProliferation, differentiationDNALPSMAPKKKDNAApoptosisERK5 pathwayMAPKKProliferation, inflammation, anti-apoptosisDNA damageWnt signaling pathwayPTPJNKSerum, cytotoxic drugs, irradiation,heatshock, reactive oxy speciesLPS and other stressp53 signaling pathwayTranscription factorsDNAJNK & p38 MAP kinase pathwayDNACellCASP9CASP3KRASPTPN7MAP3K7cAMPGRB2MAP4K3BRAFelk-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Bibliography


History

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CompareRevisionActionTimeUserComment
40450view15:04, 28 February 2011AmcuserDeleted pathway: obsolete
37356view21:50, 30 May 2010AmcuserPeriodical save, work in progress
37355view21:39, 30 May 2010AmcuserPeriodical save, work in progress
37313view21:50, 26 May 2010AmcuserPeriodical save, work in progress
37312view21:39, 26 May 2010AmcuserPeriodical save, work in progress
37311view21:28, 26 May 2010AmcuserPeriodical save, work in progress
37310view21:18, 26 May 2010AmcuserPeriodical save, work in progress
37309view21:07, 26 May 2010AmcuserPeriodical save, work in progress
37308view20:51, 26 May 2010AmcuserPeriodical save, work in progress
37307view17:21, 26 May 2010AmcuserPeriodical save, work in progress
37306view17:10, 26 May 2010AmcuserPeriodical save, work in progress
37304view16:14, 26 May 2010Amcuser26-5-2010
37277view21:10, 23 May 2010AmcuserPeriodical save, work in progress
37276view20:48, 23 May 2010AmcuserPeriodical save, work in progress
37275view20:37, 23 May 2010AmcuserPeriodical save, work in progress
37272view20:17, 23 May 2010AmcuserPeriodical save, work in progress
37271view20:04, 23 May 2010AmcuserPeriodical save, work in progress
37270view19:54, 23 May 2010AmcuserPeriodical save, work in progress
37269view19:43, 23 May 2010AmcuserPeriodical save, work in progress
37267view19:33, 23 May 2010AmcuserPeriodical save, work in progress
37266view19:22, 23 May 2010AmcuserPeriodical save, work in progress
37265view19:11, 23 May 2010AmcuserPeriodical save, work in progress
37264view19:00, 23 May 2010AmcuserPeriodical save, work in progress
37263view18:38, 23 May 2010AmcuserPeriodical save, work in progress
37262view18:28, 23 May 2010AmcuserPeriodical save, work in progress
37261view18:17, 23 May 2010AmcuserPeriodical save, work in progress
37260view18:07, 23 May 2010AmcuserPeriodical save, work in progress
37245view10:17, 23 May 2010AmcuserPeriodical save, work in progress
37238view20:48, 22 May 2010AmcuserPeriodical save, work in progress
37235view20:38, 22 May 2010AmcuserPeriodical save, work in progress
37234view20:27, 22 May 2010AmcuserPeriodical save, work in progress
37233view20:16, 22 May 2010AmcuserPeriodical save, work in progress
37232view20:06, 22 May 2010AmcuserPeriodical save, work in progress
37231view19:55, 22 May 2010AmcuserPeriodical save, work in progress
37230view19:35, 22 May 2010AmcuserPeriodical save, work in progress
37229view19:24, 22 May 2010AmcuserPeriodical save, work in progress
37228view19:14, 22 May 2010AmcuserPeriodical save, work in progress
37227view19:03, 22 May 2010AmcuserPeriodical save, work in progress
37226view18:53, 22 May 2010AmcuserPeriodical save, work in progress
37225view18:42, 22 May 2010AmcuserPeriodical save, work in progress
37224view18:12, 22 May 2010AmcuserPeriodical save, work in progress
37223view18:02, 22 May 2010AmcuserNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProduct207 (Entrez Gene)
AKT2GeneProduct208 (Entrez Gene)
AKT3GeneProduct10000 (Entrez Gene)
ARRB1GeneProduct408 (Entrez Gene)
ARRB2GeneProduct409 (Entrez Gene)
ATF2GeneProduct1386 (Entrez Gene)
ATF4GeneProduct468 (Entrez Gene)
BDNFGeneProduct627 (Entrez Gene)
BRAFGeneProduct673 (Entrez Gene)
CASP1GeneProduct834 (Entrez Gene)
CASP2GeneProduct835 (Entrez Gene)
CASP3GeneProduct836 (Entrez Gene)
CASP6GeneProduct839 (Entrez Gene)
CASP7GeneProduct840 (Entrez Gene)
CASP8GeneProduct841 (Entrez Gene)
CASP9GeneProduct842 (Entrez Gene)
CD14GeneProduct929 (Entrez Gene)
CDC25BGeneProduct994 (Entrez Gene)
CDC42GeneProduct998 (Entrez Gene)
CRKGeneProduct1398 (Entrez Gene)
CRKLGeneProduct1399 (Entrez Gene)
DAXXGeneProduct1616 (Entrez Gene)
DDIT3GeneProduct1649 (Entrez Gene)
DUSP10GeneProduct11221 (Entrez Gene)
DUSP1GeneProduct1843 (Entrez Gene)
DUSP4GeneProduct1846 (Entrez Gene)
DUSP5GeneProduct1847 (Entrez Gene)
DUSP6GeneProduct1848 (Entrez Gene)
DUSP7GeneProduct1849 (Entrez Gene)
EGFGeneProduct1950 (Entrez Gene)
EGFRGeneProduct1956 (Entrez Gene)
ELK1GeneProduct2002 (Entrez Gene)
FASGeneProduct355 (Entrez Gene)
FASLGGeneProduct356 (Entrez Gene)
FGF4GeneProduct2249 (Entrez Gene)
FLNAGeneProduct2316 (Entrez Gene)
FOSGeneProduct2353 (Entrez Gene)
GADD45AGeneProduct1647 (Entrez Gene)
GCKGeneProduct2645 (Entrez Gene)
GNA12GeneProduct2768 (Entrez Gene)
GRB2GeneProduct2885 (Entrez Gene)
HSPA1AGeneProduct3303 (Entrez Gene)
HSPA5GeneProduct3309 (Entrez Gene)
HSPA8GeneProduct3312 (Entrez Gene)
HSPB1GeneProduct3315 (Entrez Gene)
HSPB2GeneProduct3316 (Entrez Gene)
IKBKBGeneProduct3551 (Entrez Gene)
IKBKGGeneProduct8517 (Entrez Gene)
IL1AGeneProduct3552 (Entrez Gene)
IL1BGeneProduct3553 (Entrez Gene)
IL1R1GeneProduct3554 (Entrez Gene)
IL1R2GeneProduct7850 (Entrez Gene)
JUNGeneProduct3725 (Entrez Gene)
JUNDGeneProduct3727 (Entrez Gene)
KRASGeneProduct3845 (Entrez Gene)
MAP2K1GeneProduct5604 (Entrez Gene)
MAP2K1IP1GeneProduct8649 (Entrez Gene)
MAP2K2GeneProduct5605 (Entrez Gene)
MAP2K4GeneProduct6416 (Entrez Gene)
MAP2K5GeneProduct5607 (Entrez Gene)
MAP2K6GeneProduct5608 (Entrez Gene)
MAP2K7GeneProduct5609 (Entrez Gene)
MAP3K11GeneProduct4296 (Entrez Gene)
MAP3K12GeneProduct7786 (Entrez Gene)
MAP3K13GeneProduct9175 (Entrez Gene)
MAP3K1GeneProduct4214 (Entrez Gene)
MAP3K14GeneProduct9020 (Entrez Gene)
MAP3K4GeneProduct4216 (Entrez Gene)
MAP3K5GeneProduct4217 (Entrez Gene)
MAP3K6GeneProduct9064 (Entrez Gene)
MAP3K7GeneProduct6885 (Entrez Gene)
MAP3K7IP1GeneProduct10454 (Entrez Gene)
MAP3K7IP2GeneProduct23118 (Entrez Gene)
MAP3K8GeneProduct1326 (Entrez Gene)
MAP4K1GeneProduct11184 (Entrez Gene)
MAP4K3GeneProduct8491 (Entrez Gene)
MAP4K4GeneProduct9448 (Entrez Gene)
MAPK10GeneProduct5602 (Entrez Gene)
MAPK12GeneProduct6300 (Entrez Gene)
MAPK13GeneProduct5603 (Entrez Gene)
MAPK14GeneProduct1432 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
MAPK4GeneProduct5596 (Entrez Gene)
MAPK6GeneProduct5597 (Entrez Gene)
MAPK7GeneProduct5598 (Entrez Gene)
MAPK8GeneProduct5599 (Entrez Gene)
MAPK8IP3GeneProduct23162 (Entrez Gene)
MAPK9GeneProduct5601 (Entrez Gene)
MAPKAPK2GeneProduct9261 (Entrez Gene)
MAPKAPK5GeneProduct8550 (Entrez Gene)
MAPTGeneProduct4137 (Entrez Gene)
MAXGeneProduct4149 (Entrez Gene)
MEF2CGeneProduct4208 (Entrez Gene)
MEKK2/3GeneProduct171492 (Entrez Gene)
MINK1GeneProduct50488 (Entrez Gene)
MOSGeneProduct4342 (Entrez Gene)
MRASGeneProduct22808 (Entrez Gene)
MYCGeneProduct4609 (Entrez Gene)
NF1GeneProduct4763 (Entrez Gene)
NFKB1GeneProduct4790 (Entrez Gene)
NGFBGeneProduct4803 (Entrez Gene)
NLKGeneProduct51701 (Entrez Gene)
NR4A1GeneProduct3164 (Entrez Gene)
NRASGeneProduct4893 (Entrez Gene)
NTF5GeneProduct4909 (Entrez Gene)
NTRK1GeneProduct4914 (Entrez Gene)
PAK1GeneProduct5058 (Entrez Gene)
PAK2GeneProduct5062 (Entrez Gene)
PDGFBGeneProduct5155 (Entrez Gene)
PDGFRBGeneProduct5159 (Entrez Gene)
PLA2G10GeneProduct8399 (Entrez Gene)
PLA2G5GeneProduct5322 (Entrez Gene)
PPM1AGeneProduct5494 (Entrez Gene)
PPM1BGeneProduct5495 (Entrez Gene)
PPP3CAGeneProduct5530 (Entrez Gene)
PPP3CBGeneProduct5532 (Entrez Gene)
PPP3CCGeneProduct5533 (Entrez Gene)
PPP3R1GeneProduct5534 (Entrez Gene)
PPP3R2GeneProduct5535 (Entrez Gene)
PPP5CGeneProduct5536 (Entrez Gene)
PRKACAGeneProduct5566 (Entrez Gene)
PRKCB1GeneProduct5579 (Entrez Gene)
PRKCDGeneProduct5580 (Entrez Gene)
PRKCGGeneProduct5582 (Entrez Gene)
PRKCHGeneProduct5583 (Entrez Gene)
PRKCZGeneProduct5590 (Entrez Gene)
PTPN5GeneProduct84867 (Entrez Gene)
PTPN7GeneProduct5778 (Entrez Gene)
PTPRRGeneProduct5801 (Entrez Gene)
RAC1GeneProduct5879 (Entrez Gene)
RAC2GeneProduct5880 (Entrez Gene)
RAF1GeneProduct5894 (Entrez Gene)
RAP1AGeneProduct5906 (Entrez Gene)
RAP1BGeneProduct5908 (Entrez Gene)
RASA1GeneProduct5921 (Entrez Gene)
RASA2GeneProduct5922 (Entrez Gene)
RASGRF2GeneProduct5924 (Entrez Gene)
RASGRP1GeneProduct10125 (Entrez Gene)
RASGRP4GeneProduct115727 (Entrez Gene)
RPS6KA3GeneProduct6197 (Entrez Gene)
SITPECGeneProduct51295 (Entrez Gene)
SOS2GeneProduct6655 (Entrez Gene)
SRFGeneProduct6722 (Entrez Gene)
STK3GeneProduct6788 (Entrez Gene)
STMN1GeneProduct3925 (Entrez Gene)
Sap1aGeneProduct
TAOK1GeneProduct57551 (Entrez Gene)
TAOK2GeneProduct9344 (Entrez Gene) TAOK2= TAO Kinase, ser Thr kinase, binds microtubules, JNK and CASP mediates removal microtub-binding domain, nuclear transloc of TAOK2 and induction of apoptosis
TGFB1GeneProduct7040 (Entrez Gene)
TGFB2GeneProduct7042 (Entrez Gene)
TGFB3GeneProduct7043 (Entrez Gene)
TMEM37GeneProduct140738 (Entrez Gene)
TNFGeneProduct7124 (Entrez Gene)
TP53GeneProduct7157 (Entrez Gene)
TRAF2GeneProduct7186 (Entrez Gene)
TRAF6GeneProduct7189 (Entrez Gene)
ZAKGeneProduct51776 (Entrez Gene)
cAMPMetaboliteHMDB00058 (HMDB)
elk-1GeneProduct
fgfrGeneProduct
mkk3GeneProduct
mnk1/2GeneProduct
msk1/2GeneProduct
nfat2/4GeneProduct
sap1aGeneProduct

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1540"