DNA damage response (Sus scrofa)

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108, 131414148, 138, 131, 3-5, 7...21, 3-5, 7...1, 3-5, 7...111, 3-5, 7...21, 3-5, 7...1413148, 131, 3-5, 7...14145, 6, 12, 15, 1814111411101, 3-5, 7...141110148, 1321488814Blocked transcriptionBlocked replicationMembraneMetaboliteReplication stressChange in the Cell conditionExtral cellularSpaceChromatin alterationActivationDNA adductSpecialized:Somatic hypermutaionV(D)J recombinationClass switchingROSExogenous:Cigarette SmokeCaffeineRadiation (UV)ClastogenesHypoxiaGenotoxic drugsG1/S transitionmitoch-ondrionCellInhibitionAlkylating agentsDouble-strand breaksBulky DNA lesionROSCaption:Different pathwayEndogenous:Collapsed replication forksSingle stranded DNA replication breaksFree radicals (ROS)Gene productG2/M transitionDNA damage sourceRRM2BRAD1BBC3TNFRSF10BCHEK2RAD52CCNE1MRE11NBNDNA repair anddamage preventionABL1FANCD2CDK5CaffeineCCND1ChromatinremodellingApoptosisBRCA1GADD45BCDK4CDKN1AHUS1Cell CycleATRSenescenceRAD50PMAIP1PIDDE2F1G2/M checkpointTLK1PMLRAD51CCND2GADD45GRAD17CASP9SFNRAD9ACCNB2H2AFXTP53CHEK1G2/McheckpointAPAF1CDK2CASP3SESN1GADD45AATRIPFASDNA damage ATM dependentSMC1A7-hydroxystaurosporinePRKDCCDC25AGADD45ACYCSBAXE2F1CCND3CDK6GADD45BCDKN1BCCNB1TP53AIP1DNA repairCDK1CCNE2BIDRB1CCNB3DDB2CDC25CCell Cyle progressionRFCEstradiolTLK2c-MycCASP8GADD45GATMCell survivalCREBRPA2RB1


Description

This is the first pathway out of two pathways which deals with DNA damage response. It has two central gene products (ATM and ATR) which are connected to the sources of DNA damage (in blue). The two central genes can be divides furthermore into their most important genes. In the ATM pathway are the most important genes TP53 and CHEK2 and on the other hand in the ATR pathway is this CHEK1.

If it is not mentioned different, the processes take place in the cell cytoplasm.

The goal of this first pathway is to give an overview of the most important gene products, processes and changes in the cell condition through the DNA damage response pathway and at the same time to keep it clearly arranged

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP707(r34441) with a 61% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Ljungman M, Lane DP; ''Transcription - guarding the genome by sensing DNA damage.''; Nat Rev Cancer, 2004 PubMed Europe PMC Scholia
  2. Sparmann A, van Lohuizen M; ''Polycomb silencers control cell fate, development and cancer.''; Nat Rev Cancer, 2006 PubMed Europe PMC Scholia
  3. Gil J, Peters G; ''Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all.''; Nat Rev Mol Cell Biol, 2006 PubMed Europe PMC Scholia
  4. Vousden KH, Lane DP; ''p53 in health and disease.''; Nat Rev Mol Cell Biol, 2007 PubMed Europe PMC Scholia
  5. Harrison JC, Haber JE; ''Surviving the breakup: the DNA damage checkpoint.''; Annu Rev Genet, 2006 PubMed Europe PMC Scholia
  6. Cory S, Huang DC, Adams JM; ''The Bcl-2 family: roles in cell survival and oncogenesis.''; Oncogene, 2003 PubMed Europe PMC Scholia
  7. Reshmi SC, Gollin SM; ''Chromosomal instability in oral cancer cells.''; J Dent Res, 2005 PubMed Europe PMC Scholia
  8. L��Ωbrich M, Jeggo PA; ''The impact of a negligent G2/M checkpoint on genomic instability and cancer induction.''; Nat Rev Cancer, 2007 PubMed Europe PMC Scholia
  9. Sherr CJ, Roberts JM; ''Living with or without cyclins and cyclin-dependent kinases.''; Genes Dev, 2004 PubMed Europe PMC Scholia
  10. Wang W; ''Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins.''; Nat Rev Genet, 2007 PubMed Europe PMC Scholia
  11. Boutros R, Lobjois V, Ducommun B; ''CDC25 phosphatases in cancer cells: key players? Good targets?''; Nat Rev Cancer, 2007 PubMed Europe PMC Scholia
  12. Chargari C, Toillon RA, Macdermed D, Castadot P, Magn��٠N; ''Concurrent hormone and radiation therapy in patients with breast cancer: what is the rationale?''; Lancet Oncol, 2009 PubMed Europe PMC Scholia
  13. Pagano M, Jackson PK; ''Wagging the dogma; tissue-specific cell cycle control in the mouse embryo.''; Cell, 2004 PubMed Europe PMC Scholia
  14. Toledo F, Wahl GM; ''Regulating the p53 pathway: in vitro hypotheses, in vivo veritas.''; Nat Rev Cancer, 2006 PubMed Europe PMC Scholia
  15. Sengupta S, Harris CC; ''p53: traffic cop at the crossroads of DNA repair and recombination.''; Nat Rev Mol Cell Biol, 2005 PubMed Europe PMC Scholia
  16. Strasser A; ''The role of BH3-only proteins in the immune system.''; Nat Rev Immunol, 2005 PubMed Europe PMC Scholia
  17. Antoni L, Sodha N, Collins I, Garrett MD; ''CHK2 kinase: cancer susceptibility and cancer therapy - two sides of the same coin?''; Nat Rev Cancer, 2007 PubMed Europe PMC Scholia
  18. Zhou BB, Bartek J; ''Targeting the checkpoint kinases: chemosensitization versus chemoprotection.''; Nat Rev Cancer, 2004 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
128753view12:46, 21 February 2024EweitzFix typo, remove obsolete field, upgrade disease node, standardize case
107274view14:36, 17 September 2019MaintBotChEBI identifier normalization
87238view09:50, 20 July 2016SusanOntology Term : 'DNA damage response pathway' added !
73852view00:52, 26 February 2014MaintBotupdated schema
58994view20:00, 21 February 2013MaintBotUpdated Ensembl data source
41922view05:03, 2 March 2011MaintBotRemoved redundant pathway information and comments
38659view13:30, 23 September 2010Mkutmonadded pathway links
37717view20:26, 28 June 2010MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
7-hydroxystaurosporineMetabolite65225 (Chemspider)
ABL1GeneProductENSSSCG00000005706 (Ensembl)
APAF1GeneProductENSSSCG00000000884 (Ensembl)
ATMGeneProductENSSSCG00000015007 (Ensembl)
ATRGeneProductENSSSCG00000011679 (Ensembl)
ATRIPGeneProduct
ApoptosisPathway
BAXGeneProductENSSSCG00000003144 (Ensembl)
BBC3GeneProduct
BIDGeneProductENSSSCG00000000769 (Ensembl)
BRCA1GeneProduct
CASP3GeneProductENSSSCG00000015783 (Ensembl)
CASP8GeneProductENSSSCG00000016106 (Ensembl)
CASP9GeneProductENSSSCG00000003460 (Ensembl)
CCNB1GeneProduct
CCNB2GeneProductENSSSCG00000004588 (Ensembl)
CCNB3GeneProductENSSSCG00000012307 (Ensembl)
CCND1GeneProduct
CCND2GeneProductENSSSCG00000000727 (Ensembl)
CCND3GeneProductENSSSCG00000001632 (Ensembl)
CCNE1GeneProductENSSSCG00000002855 (Ensembl)
CCNE2GeneProductENSSSCG00000006095 (Ensembl)
CDC25AGeneProduct
CDC25CGeneProductENSSSCG00000014329 (Ensembl)
CDK1GeneProductENSSSCG00000010214 (Ensembl)
CDK2GeneProductENSSSCG00000000373 (Ensembl)
CDK4GeneProductENSSSCG00000000445 (Ensembl)
CDK5GeneProduct
CDK6GeneProductENSSSCG00000015318 (Ensembl)
CDKN1AGeneProductENSSSCG00000001565 (Ensembl)
CDKN1BGeneProduct
CHEK1GeneProduct
CHEK2GeneProduct
CREBGeneProduct
CYCSGeneProduct
CaffeineMetabolite2424 (Chemspider)
Cell CyclePathway
Cell Cyle progressionPathway
Cell survivalPathway
Chromatin remodellingPathway
DDB2GeneProductENSSSCG00000013243 (Ensembl)
DNA damage ATM dependentPathway
DNA repairPathway
DNA repair and damage preventionPathway
E2F1GeneProductENSSSCG00000007268 (Ensembl)
EstradiolMetabolite16469 (ChEBI)
FANCD2GeneProductENSSSCG00000011563 (Ensembl)
FASGeneProductENSSSCG00000010448 (Ensembl)
G2/M checkpointPathway
G2/M checkpointPathway
GADD45AGeneProduct
GADD45BGeneProduct
GADD45GGeneProductENSSSCG00000009585 (Ensembl)
H2AFXGeneProduct
HUS1GeneProduct
MRE11GeneProduct
NBNGeneProduct
PIDDGeneProduct
PMAIP1GeneProduct
PMLGeneProduct
PRKDCGeneProductENSSSCG00000006274 (Ensembl)
RAD17GeneProductENSSSCG00000016960 (Ensembl)
RAD1GeneProductENSSSCG00000016826 (Ensembl)
RAD50GeneProductENSSSCG00000014280 (Ensembl)
RAD51GeneProduct
RAD52GeneProductENSSSCG00000000754 (Ensembl)
RAD9AGeneProductENSSSCG00000012914 (Ensembl)
RB1GeneProductENSSSCG00000009401 (Ensembl)
RFCGeneProduct
RPA2GeneProductENSSSCG00000003583 (Ensembl)
RRM2BGeneProductENSSSCG00000006058 (Ensembl)
SESN1GeneProductENSSSCG00000004390 (Ensembl)
SFNGeneProductENSSSCG00000003562 (Ensembl)
SMC1AGeneProductENSSSCG00000012325 (Ensembl)
SenescencePathway
TLK1GeneProductENSSSCG00000015944 (Ensembl)
TLK2GeneProductENSSSCG00000017301 (Ensembl)
TNFRSF10BGeneProduct
TP53AIP1GeneProduct
TP53GeneProductENSSSCG00000017950 (Ensembl)
c-MycGeneProduct

Annotated Interactions

No annotated interactions
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