Eukaryotic transcription initiation (Drosophila melanogaster)

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1, 2Steps 1) TBP binds TATA box33(small stable RNAs)dsDNAPrimary RNA transcriptTFIIBRNA polymerase IIGene Regulatory ProteinsRNA polymerase III553TFIIE55TFIIF3Steps 3) DNA melting by association with TFIIHTFIIDTFIIA3RNA polymerase ITFIIFRNA pol IIcell growth3Steps 2) Association of TIFs and RNA polymerase(large ribosomal RNAs)(recognize surface DNA geometry)TATA Box binding5TFIIFSteps 5) RNA elongation with CDT phosphorylation53TFIIBTATA(mRNA, snRNPs)5proteinTFIIHTFIIATFIIETranscription Initiation Factors (TIFs)3TATA53Steps 4) Transcription elongation by NTPs5TFIIDTATATFIIH5hayRpII15TfIIEbetaTaf12Rpb7SinRpb11Taf6POLR3DMat1XpdTAF9TfIIFbetaTaf7RpII33CycHRpb5Polr1eTaf13CG7339Tfb4RpII140GTF2H2RpIII128POLR1DRpI135Cdk7TfIIA-STfb2RpII18TbpTfb1Taf5RpI1IlkPOLR2KTfIIBTfIIEalphaRpII215Rpb8CG33785


Description

In eukaryotes, RNA polymerase, and therefore the initiation of transcription, requires the presence of a core promoter sequence in the DNA. RNA polymerase is able to bind to core promoters in the presence of various specific transcription factors. The most common type of core promoter in eukaryotes is a short DNA sequence known as a TATA box. The TATA box, as a core promoter, is the binding site for a transcription factor known as TATA binding protein (TBP), which is itself a subunit of another transcription factor, called Transcription Factor II D (TFIID). After TFIID binds to the TATA box via the TBP, five more transcription factors and RNA polymerase combine around the TATA box in a series of stages to form a preinitiation complex. One transcription factor, DNA helicase, has helicase activity and so is involved in the separating of opposing strands of double-stranded DNA to provide access to a single-stranded DNA template. However, only a low, or basal, rate of transcription is driven by the preinitiation complex alone. Other proteins known as activators and repressors, along with any associated coactivators or corepressors, are responsible for modulating transcription rate. Source: Wikipedia

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GenMAPP notes 
Reference: http://www.web-books.com/MoBio/Free/Ch4E.htm

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Bibliography

  1. Lee TI, Young RA; ''Regulation of gene expression by TBP-associated proteins.''; Genes Dev, 1998 PubMed Europe PMC Scholia
  2. Lemon B, Tjian R; ''Orchestrated response: a symphony of transcription factors for gene control.''; Genes Dev, 2000 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
118410view14:15, 27 May 2021EweitzOntology Term : 'RNA polymerase II transcription initiation pathway' added !
118409view14:15, 27 May 2021EweitzOntology Term : 'RNA polymerase I transcription initiation pathway' added !
118408view14:14, 27 May 2021EweitzOntology Term : 'RNA polymerase III transcription initiation pathway' added !
116919view09:38, 16 May 2021EweitzModified title
79652view11:49, 1 April 2015EgonwRemoved database source when no identifier was given.
79498view15:37, 23 March 2015Ryan.miller
79401view20:30, 21 March 2015Khanspersupdate schema
79400view20:29, 21 March 2015KhanspersReverted to version '13:59, 12 February 2010' by Khanspers
77398view22:30, 5 September 2014MaintBotremoved homology mapp label
71537view19:23, 17 October 2013MaintBotAutomated update of data sources
68723view21:56, 6 July 2013MaintBotUpdated to 2013 gpml schema
67211view10:21, 26 June 2013Christine ChichesterOntology Term : 'transcription pathway' added !
40898view22:35, 1 March 2011MaintBotRemoved redundant pathway information and comments
35530view13:59, 12 February 2010Thomasadded literature
35519view13:52, 12 February 2010ThomasModified description
21051view11:30, 14 November 2008MaintBot[[Pathway:Drosophila melanogaster:RNA transcription Reactome]] moved to [[Pathway:WP177]]: Moved to stable identifier
8522view14:01, 7 January 2008MaintBotAdded to category $category
8520view14:01, 7 January 2008NsalomonisUploaded new pathway

External references

DataNodes

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NameTypeDatabase referenceComment
CG33785GeneProduct3772344 (Entrez Gene)
CG7339GeneProduct39310 (Entrez Gene)
Cdk7GeneProduct31441 (Entrez Gene)
CycHGeneProduct40429 (Entrez Gene)
GTF2H2GeneProduct
IlkGeneProduct53573 (Entrez Gene)
Mat1GeneProduct36130 (Entrez Gene)
POLR1DGeneProduct
POLR2KGeneProduct
POLR3DGeneProduct
Polr1eGeneProduct
RpI135GeneProduct33210 (Entrez Gene)
RpI1GeneProduct36617 (Entrez Gene)
RpII140GeneProduct41721 (Entrez Gene)
RpII15GeneProduct41741 (Entrez Gene)
RpII18GeneProduct48312 (Entrez Gene)
RpII215GeneProduct32100 (Entrez Gene)
RpII33GeneProduct34796 (Entrez Gene)
RpIII128GeneProduct36289 (Entrez Gene)
Rpb11GeneProduct35043 (Entrez Gene)
Rpb5GeneProduct36160 (Entrez Gene)
Rpb7GeneProduct261631 (Entrez Gene)
Rpb8GeneProduct40415 (Entrez Gene)
SinGeneProduct40325 (Entrez Gene)
TAF9GeneProduct
Taf12GeneProduct41406 (Entrez Gene)
Taf13GeneProduct35297 (Entrez Gene)
Taf5GeneProduct47900 (Entrez Gene)
Taf6GeneProduct40134 (Entrez Gene)
Taf7GeneProduct40934 (Entrez Gene)
TbpGeneProduct37476 (Entrez Gene)
TfIIA-SGeneProduct42822 (Entrez Gene)
TfIIBGeneProduct34430 (Entrez Gene)
TfIIEalphaGeneProduct39313 (Entrez Gene)
TfIIEbetaGeneProduct38527 (Entrez Gene)
TfIIFbetaGeneProduct41290 (Entrez Gene)
Tfb1GeneProduct36598 (Entrez Gene)
Tfb2GeneProduct39688 (Entrez Gene)
Tfb4GeneProduct33294 (Entrez Gene)
XpdGeneProduct37414 (Entrez Gene)
hayGeneProduct39202 (Entrez Gene)

Annotated Interactions

No annotated interactions
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