Cell junction organization (Homo sapiens)

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1513, 192131421152988882061, 24652630711832517, 28199, 271274, 10, 181622, 23Necl-1 dimer [plasmamembrane]PVRL3 dimer [plasmamembrane]Nectin cis-homodimer[plasma membrane]Necl-3 dimer [plasmamembrane]Nectin [plasmamembrane]BP230:BP180:Plectin:integrinalpha 6 beta4:Laminin 332[plasma membrane]Par3:Par6:aPKCcomplex [cytosol]Laminin-332[extracellularregion]cytosolIntegrin alpha6:beta4:Plectin:BP180:Laminin-322complex [plasmamembrane]Necl-3 dimer [plasmamembrane]Nectin-3:Necl-2trans heterodimer[cell junction]Necl-1/Necl-2/Necl-3trans homodimer[cell junction]Type IIhemidesmosome[plasma membrane]Integrin alpha6:beta 4:Plectincomplex [plasmamembrane]Necl-1 dimer [plasmamembrane]Nectin transhomodimer [celljunction]ParvB/Affixin:Alpha-Pix[cytosol]PVRL3 dimer [plasmamembrane]Necl-2 dimer [plasmamembrane]Integrin alpha6beta4[plasma membrane]Laminin-332[extracellularregion]MIG-2:MIGFILIN[cytosol]claudintrans-homodimer[cell junction]PAR-6 [cytosol]CRB3:PALS1:PATJcomplex [plasmamembrane]Integrin alpha6beta4[plasma membrane]BP230:BP180:Plectin:integrinalpha 6 beta4:Laminin 332[plasma membrane]ILK:Integrin beta-1[plasma membrane]Necl-1/Necl-2/Necl-3homodimer [plasmamembrane]Necl-1:Necl-2 transheterodimer [celljunction]MIGFILIN:VASP[cytosol]Integrinalpha6:beta4:Plectin:BP180complex [plasmamembrane]cytosolNectin-4 cishomodimer [plasmamembrane]Cadherin:Catenincomplex [plasmamembrane]Integrin alpha6:beta4:Plectin:BP180:Laminin-322complex [plasmamembrane]Necl-1:Nectin-3trans heterodimer[cell junction]Nectin-1 cishomodimer [plasmamembrane]Necl-1/Necl-2/Necl-3homodimer [plasmamembrane]Integrin alpha6:beta 4:Plectincomplex [plasmamembrane]Nectin [plasmamembrane]Nectin-1 cishomodimer [plasmamembrane]PRV:PVRL3 transheterodimer [celljunction]PAR-6 [plasmamembrane]Filamin [cytosol]Integrin alpha6:beta 4:Plectincomplex [plasmamembrane]Integrin alpha6:beta 4:Plectincomplex [plasmamembrane]Integrin alpha6beta4[plasma membrane]Nectin-1:Nectin-4trans heterodimer[cell junction]Beta-catenin/gammacatenin [plasmamembrane]Nectin-2 cishomodimer [plasmamembrane]CD151:BP230:BP180:Plectin:Integrinalpha 6 beta 4:Laminin [plasmamembrane]Classic Cadherin[plasma membrane]Classic Cadherin[plasma membrane]Integrin alpha6beta4[plasma membrane]Laminin-332[extracellularregion]CD151:BP230:BP180:Plectin:Integrinalpha 6 beta 4:Laminin [plasmamembrane]PVRL3 dimer [plasmamembrane]Integrin alpha6beta4[plasma membrane]PINCH-ILK-parvincomplex [cytosol]Integrin alpha6:beta4:Plectin:BP180:Laminin-322complex [plasmamembrane]JAM-A:PAR-aPKCcomplex [plasmamembrane]PINCH [cytosol]Integrin alpha6:beta 4:Plectincomplex [plasmamembrane]Integrin alpha6beta4[plasma membrane]Nectin-2 cishomodimer [plasmamembrane]PARVB:alpha actinin[cytosol]Nectin [plasmamembrane]Laminin-332[extracellularregion]Par3:Par6:aPKCcomplex [plasmamembrane]PARVA:TESK1[cytosol]Rsu-1:Pinch1 complex[cytosol]Nectin-1:PVRL3 transheterodimer [celljunction]BP230:BP180:Plectin:integrinalpha 6 beta4:Laminin 332[plasma membrane]Afadin:F-actin[cytosol]Integrin alpha6beta4[plasma membrane]Integrin alpha6:beta 4:Plectincomplex [plasmamembrane]Nectin-2:PVRL3transheterodimer[cell junction]Necl-1:Nectin-1trans heterodimer[cell junction]Nectin-1 cishomodimer [plasmamembrane]PARVA:Paxillin[plasma membrane]Migfilin:FilaminA:F-actin [cytosol]Integrin alpha6:beta4:Plectin:BP180:Laminin-322complex [plasmamembrane]Nectin:afadincomplex [plasmamembrane]Nectin-4 cishomodimer [plasmamembrane]Nectin cis-homodimer[plasma membrane]Cadherintrans-homodimer[cell junction]Laminin-332[extracellularregion]Necl-2 dimer [plasmamembrane]INADLCDH18 [plasmamembrane]Nectin transhomodimerCOL17A1(1-1497)[plasma membrane]PARVA:Paxillinclaudintrans-homodimerCDH2 [plasmamembrane]ITGA6(24-1130)[plasma membrane]MIG-2:MIGFILINPVRL1 [plasmamembrane]Laminin-332CRB3 [plasmamembrane]CDH24 [plasmamembrane]Necl-1:Necl-2 transheterodimerNectin-1 cishomodimerCDH8 [plasmamembrane]CADM1Integrin alpha6beta4PARVA:TESK1PVRL2 [plasmamembrane]PVRL4 [plasmamembrane]TESK1 [cytosol]Nectin cis-homodimerRSU1PVRL3 [plasmamembrane]ILK [cytosol]PLEC [cytosol]PARVB:alpha actininCDH10 [plasmamembrane]FilaminJUP [plasmamembrane]PVRL3 [plasmamembrane]CADM3 [plasmamembrane]CDH3 [plasmamembrane]LIMS1 [cytosol]PVRL3 [plasmamembrane]CDH2 [plasmamembrane]ILK:Integrin beta-1MLLT4-2 [cytosol]PLECILK [cytosol]MLLT4-2 [cytosol]PVRL1 [plasmamembrane]MPP5CDH11 [plasmamembrane]PARVAPARD6A [plasmamembrane]Nectin-1:PVRL3 transheterodimerITGB4 [plasmamembrane]PXN [plasmamembrane]PARVBCOL17A1(1-1497)[plasma membrane]ACTN1 [cytosol]Nectin:afadincomplexPVRL3 [plasmamembrane]PVRL3 [plasmamembrane]CDH5 [plasmamembrane]F1QFP3ACTN1CTNNA1PVRL3 [plasmamembrane]PLEC [cytosol]CDH6 [plasmamembrane]Integrin alpha6:beta 4:PlectincomplexVASP [cytosol]CTNND1LAMB3 [extracellularregion]ITGA6(24-1130)[plasma membrane]FBLIM1 [cytosol]ITGB1BP230PARVA [cytosol]F1QFP3PINCH-ILK-parvincomplexILKNecl-1:Nectin-1trans heterodimerBeta-catenin/gammacateninPVRL1CDH11 [plasmamembrane]JAM-A:PAR-aPKCcomplexCDH13 [plasmamembrane]PVRL4 [plasmamembrane]CDH12 [plasmamembrane]PVRL3 [plasmamembrane]CD151:BP230:BP180:Plectin:Integrinalpha 6 beta 4:LamininCADM3 [plasmamembrane]CADM3 [plasmamembrane]CADM2 [plasmamembrane]Classic CadherinCDH10 [plasmamembrane]PVRL3 [plasmamembrane]LIMS1BP230:BP180:Plectin:integrinalpha 6 beta4:Laminin 332PLEC [cytosol]Keratin 5/14LAMC2 [extracellularregion]Afadin:F-actinPARD6G [cytosol]Nectin-1:Nectin-4trans heterodimerCDH5 [plasmamembrane]Necl-1:Nectin-3trans heterodimerPLEC [cytosol]PVRL2 [plasmamembrane]PLEC [cytosol]Nectin-4 cishomodimerPVRL4 [plasmamembrane]Integrin alpha6:beta4:Plectin:BP180:Laminin-322complexCDH9 [plasmamembrane]ITGA6(24-1130)[plasma membrane]ClaudinLAMA3 [extracellularregion]ParvB/Affixin:Alpha-PixLAMA3 [extracellularregion]CDH6 [plasmamembrane]PARD3 [plasmamembrane]PVR [plasmamembrane]MIGFILIN:VASPCTNNA1 [plasmamembrane]Necl-1/Necl-2/Necl-3trans homodimerPRKCI(1-587) [plasmamembrane]INADL [plasmamembrane]FBLIM1 [cytosol]PARD6B [plasmamembrane]ITGB4 [plasmamembrane]VASPITGA6(24-1130)[plasma membrane]CRB3CDH8 [plasmamembrane]CDH15 [plasmamembrane]PVRFLNC [cytosol]Cadherintrans-homodimerCADM3CDH1(155-882)[plasma membrane]CDH9 [plasmamembrane]ARHGEF6 [cytosol]PARVB [cytosol]Migfilin:FilaminA:F-actinCADM3 [plasmamembrane]LIMS1 [cytosol]Par3:Par6:aPKCcomplexCa2+COL17A1(1-1497)[plasma membrane]ITGA6(24-1130)[plasma membrane]ARHGEF6CADM1 [plasmamembrane]PARD6B [cytosol]Nectin-3:Necl-2trans heterodimerPRKCI(1-587)[cytosol]Necl-1/Necl-2/Necl-3homodimerLAMB3 [extracellularregion]CDH7 [plasmamembrane]CRB3:PALS1:PATJcomplexLIMS2 [cytosol]PARD6A [cytosol]PVRL1 [plasmamembrane]PARVA [cytosol]ITGB4 [plasmamembrane]MLLT4-2LAMA3 [extracellularregion]Nectin-2 cishomodimerCD151 [cytosol]PINCHNectin-2:PVRL3transheterodimerPRV:PVRL3 transheterodimerCDH7 [plasmamembrane]PVRL3 [plasmamembrane]CADM3 [plasmamembrane]CD151CADM1 [plasmamembrane]FERMT2LAMC2 [extracellularregion]PVRL1 [plasmamembrane]COL17A1(1-1497)CADM1 [plasmamembrane]FBLIM1CD151 [cytosol]ITGB1 [plasmamembrane]CDH18 [plasmamembrane]FLNA [cytosol]COL17A1(1-1497)[plasma membrane]ITGA6(24-1130)[plasma membrane]PVRL3 dimerPVRL3PVRL1 [plasmamembrane]ITGB4 [plasmamembrane]LAMC2 [extracellularregion]LAMB3 [extracellularregion]Rsu-1:Pinch1 complexNectinType IIhemidesmosomeCDH24 [plasmamembrane]PARVB [cytosol]CDH13 [plasmamembrane]PVRL2 [plasmamembrane]LAMA3 [extracellularregion]LAMB3 [extracellularregion]CDH3 [plasmamembrane]CDH1(155-882)[plasma membrane]ITGB4 [plasmamembrane]ITGA6(24-1130)[plasma membrane]Cadherin:CatenincomplexPVRL1 [plasmamembrane]PLEC [cytosol]LAMB3 [extracellularregion]LAMC2 [extracellularregion]F-actinPVRL2 [plasmamembrane]CTNND1 [plasmamembrane]PARD6G [plasmamembrane]COL17A1(1-1497)[plasma membrane]PVRL1 [plasmamembrane]FBLIM1 [cytosol]PVRL4 [plasmamembrane]F11R [plasmamembrane]ITGB4 [plasmamembrane]LAMC2 [extracellularregion]ITGB4 [plasmamembrane]CDH4 [plasmamembrane]PARD3 [cytosol]alpha/beta parvinTESK1Integrinalpha6:beta4:Plectin:BP180complexLAMA3 [extracellularregion]MPP5 [plasmamembrane]CDH4 [plasmamembrane]PVRL2 [plasmamembrane]RSU1 [cytosol]PVRL4 [plasmamembrane]F11RCADM2 [plasmamembrane]FERMT2 [cytosol]CADM1 [plasmamembrane]CDH12 [plasmamembrane]CDH15 [plasmamembrane]PXN


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Bibliography

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  1. Ebnet K, Aurrand-Lions M, Kuhn A, Kiefer F, Butz S, Zander K, Meyer zu Brickwedde MK, Suzuki A, Imhof BA, Vestweber D.; ''The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity.''; PubMed Europe PMC Scholia
  2. Dantzig AH, Hoskins JA, Tabas LB, Bright S, Shepard RL, Jenkins IL, Duckworth DC, Sportsman JR, Mackensen D, Rosteck PR.; ''Association of intestinal peptide transport with a protein related to the cadherin superfamily.''; PubMed Europe PMC Scholia
  3. Zhang Y, Tu Y, Gkretsi V, Wu C.; ''Migfilin interacts with vasodilator-stimulated phosphoprotein (VASP) and regulates VASP localization to cell-matrix adhesions and migration.''; PubMed Europe PMC Scholia
  4. Pellissier F, Gerber A, Bauer C, Ballivet M, Ossipow V.; ''The adhesion molecule Necl-3/SynCAM-2 localizes to myelinated axons, binds to oligodendrocytes and promotes cell adhesion.''; PubMed Europe PMC Scholia
  5. Wang X, Fukuda K, Byeon IJ, Velyvis A, Wu C, Gronenborn A, Qin J.; ''The structure of alpha-parvin CH2-paxillin LD1 complex reveals a novel modular recognition for focal adhesion assembly.''; PubMed Europe PMC Scholia
  6. Padhi AK, Banerjee K, Gomes J, Banerjee M.; ''Computational and functional characterization of Angiogenin mutations, and correlation with amyotrophic lateral sclerosis.''; PubMed Europe PMC Scholia
  7. Yamaji S, Suzuki A, Kanamori H, Mishima W, Yoshimi R, Takasaki H, Takabayashi M, Fujimaki K, Fujisawa S, Ohno S, Ishigatsubo Y.; ''Affixin interacts with alpha-actinin and mediates integrin signaling for reorganization of F-actin induced by initial cell-substrate interaction.''; PubMed Europe PMC Scholia
  8. Kaufman L, Yang G, Hayashi K, Ashby JR, Huang L, Ross MJ, Klotman ME, Klotman PE.; ''The homophilic adhesion molecule sidekick-1 contributes to augmented podocyte aggregation in HIV-associated nephropathy.''; PubMed Europe PMC Scholia
  9. Tu Y, Huang Y, Zhang Y, Hua Y, Wu C.; ''A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreading.''; PubMed Europe PMC Scholia
  10. Lopez M, Aoubala M, Jordier F, Isnardon D, Gomez S, Dubreuil P.; ''The human poliovirus receptor related 2 protein is a new hematopoietic/endothelial homophilic adhesion molecule.''; PubMed Europe PMC Scholia
  11. Yamagata M, Weiner JA, Sanes JR.; ''Sidekicks: synaptic adhesion molecules that promote lamina-specific connectivity in the retina.''; PubMed Europe PMC Scholia
  12. Dong X, Xu F, Gong Y, Gao J, Lin P, Chen T, Peng Y, Qiang B, Yuan J, Peng X, Rao Z.; ''Crystal structure of the V domain of human Nectin-like molecule-1/Syncam3/Tsll1/Igsf4b, a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule.''; PubMed Europe PMC Scholia
  13. Hopkinson SB, Jones JC.; ''The N terminus of the transmembrane protein BP180 interacts with the N-terminal domain of BP230, thereby mediating keratin cytoskeleton anchorage to the cell surface at the site of the hemidesmosome.''; PubMed Europe PMC Scholia
  14. de Pereda JM, Lillo MP, Sonnenberg A.; ''Structural basis of the interaction between integrin alpha6beta4 and plectin at the hemidesmosomes.''; PubMed Europe PMC Scholia
  15. Mishima W, Suzuki A, Yamaji S, Yoshimi R, Ueda A, Kaneko T, Tanaka J, Miwa Y, Ohno S, Ishigatsubo Y.; ''The first CH domain of affixin activates Cdc42 and Rac1 through alphaPIX, a Cdc42/Rac1-specific guanine nucleotide exchanging factor.''; PubMed Europe PMC Scholia
  16. LaLonde DP, Brown MC, Bouverat BP, Turner CE.; ''Actopaxin interacts with TESK1 to regulate cell spreading on fibronectin.''; PubMed Europe PMC Scholia
  17. Lorenz S, Vakonakis I, Lowe ED, Campbell ID, Noble ME, Hoellerer MK.; ''Structural analysis of the interactions between paxillin LD motifs and alpha-parvin.''; PubMed Europe PMC Scholia
  18. Rosenberger G, Jantke I, Gal A, Kutsche K.; ''Interaction of alphaPIX (ARHGEF6) with beta-parvin (PARVB) suggests an involvement of alphaPIX in integrin-mediated signaling.''; PubMed Europe PMC Scholia
  19. Michel D, Arsanto JP, Massey-Harroche D, Béclin C, Wijnholds J, Le Bivic A.; ''PATJ connects and stabilizes apical and lateral components of tight junctions in human intestinal cells.''; PubMed Europe PMC Scholia
  20. Masuda M, Yageta M, Fukuhara H, Kuramochi M, Maruyama T, Nomoto A, Murakami Y.; ''The tumor suppressor protein TSLC1 is involved in cell-cell adhesion.''; PubMed Europe PMC Scholia
  21. Kakunaga S, Ikeda W, Itoh S, Deguchi-Tawarada M, Ohtsuka T, Mizoguchi A, Takai Y.; ''Nectin-like molecule-1/TSLL1/SynCAM3: a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule localizing at non-junctional contact sites of presynaptic nerve terminals, axons and glia cell processes.''; PubMed Europe PMC Scholia
  22. Tu Y, Wu S, Shi X, Chen K, Wu C.; ''Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation.''; PubMed Europe PMC Scholia
  23. Takahashi K, Nakanishi H, Miyahara M, Mandai K, Satoh K, Satoh A, Nishioka H, Aoki J, Nomoto A, Mizoguchi A, Takai Y.; ''Nectin/PRR: an immunoglobulin-like cell adhesion molecule recruited to cadherin-based adherens junctions through interaction with Afadin, a PDZ domain-containing protein.''; PubMed Europe PMC Scholia
  24. Hannigan GE, Leung-Hagesteijn C, Fitz-Gibbon L, Coppolino MG, Radeva G, Filmus J, Bell JC, Dedhar S.; ''Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase.''; PubMed Europe PMC Scholia
  25. Mueller S, Wimmer E.; ''Recruitment of nectin-3 to cell-cell junctions through trans-heterophilic interaction with CD155, a vitronectin and poliovirus receptor that localizes to alpha(v)beta3 integrin-containing membrane microdomains.''; PubMed Europe PMC Scholia
  26. Ebnet K, Suzuki A, Horikoshi Y, Hirose T, Meyer Zu Brickwedde MK, Ohno S, Vestweber D.; ''The cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM).''; PubMed Europe PMC Scholia
  27. Sterk LM, Geuijen CA, Oomen LC, Calafat J, Janssen H, Sonnenberg A.; ''The tetraspan molecule CD151, a novel constituent of hemidesmosomes, associates with the integrin alpha6beta4 and may regulate the spatial organization of hemidesmosomes.''; PubMed Europe PMC Scholia
  28. Koster J, Geerts D, Favre B, Borradori L, Sonnenberg A.; ''Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly.''; PubMed Europe PMC Scholia
  29. Dougherty GW, Jose C, Gimona M, Cutler ML.; ''The Rsu-1-PINCH1-ILK complex is regulated by Ras activation in tumor cells.''; PubMed Europe PMC Scholia
  30. Lemmers C, Médina E, Delgrossi MH, Michel D, Arsanto JP, Le Bivic A.; ''hINADl/PATJ, a homolog of discs lost, interacts with crumbs and localizes to tight junctions in human epithelial cells.''; PubMed Europe PMC Scholia
  31. Reymond N, Fabre S, Lecocq E, Adelaïde J, Dubreuil P, Lopez M.; ''Nectin4/PRR4, a new afadin-associated member of the nectin family that trans-interacts with nectin1/PRR1 through V domain interaction.''; PubMed Europe PMC Scholia
  32. Ali J, Liao F, Martens E, Muller WA.; ''Vascular endothelial cadherin (VE-cadherin): cloning and role in endothelial cell-cell adhesion.''; PubMed Europe PMC Scholia
  33. Fontao L, Favre B, Riou S, Geerts D, Jaunin F, Saurat JH, Green KJ, Sonnenberg A, Borradori L.; ''Interaction of the bullous pemphigoid antigen 1 (BP230) and desmoplakin with intermediate filaments is mediated by distinct sequences within their COOH terminus.''; PubMed Europe PMC Scholia
  34. Hülsken J, Birchmeier W, Behrens J.; ''E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton.''; PubMed Europe PMC Scholia
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History

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CompareRevisionActionTimeUserComment
114723view16:20, 25 January 2021ReactomeTeamReactome version 75
113167view11:23, 2 November 2020ReactomeTeamReactome version 74
112395view15:33, 9 October 2020ReactomeTeamReactome version 73
101299view11:18, 1 November 2018ReactomeTeamreactome version 66
100836view20:49, 31 October 2018ReactomeTeamreactome version 65
100377view19:24, 31 October 2018ReactomeTeamreactome version 64
99924view16:08, 31 October 2018ReactomeTeamreactome version 63
99479view14:40, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99133view12:40, 31 October 2018ReactomeTeamreactome version 62
94016view13:51, 16 August 2017ReactomeTeamreactome version 61
93635view11:29, 9 August 2017ReactomeTeamreactome version 61
86749view09:25, 11 July 2016ReactomeTeamreactome version 56
83402view11:08, 18 November 2015ReactomeTeamVersion54
81600view13:08, 21 August 2015ReactomeTeamVersion53
77057view08:35, 17 July 2014ReactomeTeamFixed remaining interactions
76762view12:12, 16 July 2014ReactomeTeamFixed remaining interactions
75796view11:33, 10 June 2014ReactomeTeamReactome 48 Update
75147view14:09, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74794view08:53, 30 April 2014ReactomeTeamReactome46
44989view14:35, 6 October 2011MartijnVanIerselOntology Term : 'cell adhesion signaling pathway' added !
42016view21:50, 4 March 2011MaintBotAutomatic update
39819view05:51, 21 January 2011MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACTN1 [cytosol]ProteinP12814 (Uniprot-TrEMBL)
ACTN1ProteinP12814 (Uniprot-TrEMBL)
ARHGEF6 [cytosol]ProteinQ15052 (Uniprot-TrEMBL)
ARHGEF6ProteinQ15052 (Uniprot-TrEMBL)
Afadin:F-actinComplexREACT_19820 (Reactome)
BP230:BP180:Plectin:integrin

alpha 6 beta

4:Laminin 332		ComplexREACT_20979 (Reactome)
BP230ProteinREACT_25566 (Reactome)
Beta-catenin/gamma cateninProteinREACT_19976 (Reactome)
CADM1 [plasma membrane]ProteinQ9BY67 (Uniprot-TrEMBL)
CADM1ProteinQ9BY67 (Uniprot-TrEMBL)
CADM2 [plasma membrane]ProteinQ8N3J6 (Uniprot-TrEMBL)
CADM3 [plasma membrane]ProteinQ8N126 (Uniprot-TrEMBL)
CADM3ProteinQ8N126 (Uniprot-TrEMBL)
CD151 [cytosol]ProteinP48509 (Uniprot-TrEMBL)
CD151:BP230:BP180:Plectin:Integrin

alpha 6 beta 4:

Laminin		ComplexREACT_21118 (Reactome)
CD151ProteinP48509 (Uniprot-TrEMBL)
CDH1(155-882) [plasma membrane]ProteinP12830 (Uniprot-TrEMBL)
CDH10 [plasma membrane]ProteinQ9Y6N8 (Uniprot-TrEMBL)
CDH11 [plasma membrane]ProteinP55287 (Uniprot-TrEMBL)
CDH12 [plasma membrane]ProteinP55289 (Uniprot-TrEMBL)
CDH13 [plasma membrane]ProteinP55290 (Uniprot-TrEMBL)
CDH15 [plasma membrane]ProteinP55291 (Uniprot-TrEMBL)
CDH18 [plasma membrane]ProteinQ13634 (Uniprot-TrEMBL)
CDH2 [plasma membrane]ProteinP19022 (Uniprot-TrEMBL)
CDH24 [plasma membrane]ProteinQ86UP0 (Uniprot-TrEMBL)
CDH3 [plasma membrane]ProteinP22223 (Uniprot-TrEMBL)
CDH4 [plasma membrane]ProteinP55283 (Uniprot-TrEMBL)
CDH5 [plasma membrane]ProteinP33151 (Uniprot-TrEMBL)
CDH6 [plasma membrane]ProteinP55285 (Uniprot-TrEMBL)
CDH7 [plasma membrane]ProteinQ9ULB5 (Uniprot-TrEMBL)
CDH8 [plasma membrane]ProteinP55286 (Uniprot-TrEMBL)
CDH9 [plasma membrane]ProteinQ9ULB4 (Uniprot-TrEMBL)
COL17A1(1-1497) [plasma membrane]ProteinQ9UMD9 (Uniprot-TrEMBL)
COL17A1(1-1497)ProteinQ9UMD9 (Uniprot-TrEMBL)
CRB3 [plasma membrane]ProteinQ9BUF7 (Uniprot-TrEMBL)
CRB3:PALS1:PATJ complexComplexREACT_20032 (Reactome)
CRB3ProteinQ9BUF7 (Uniprot-TrEMBL)
CTNNA1 [plasma membrane]ProteinP35221 (Uniprot-TrEMBL)
CTNNA1ProteinP35221 (Uniprot-TrEMBL)
CTNND1 [plasma membrane]ProteinO60716 (Uniprot-TrEMBL)
CTNND1ProteinO60716 (Uniprot-TrEMBL)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
Cadherin trans-homodimerComplexREACT_19942 (Reactome)
Cadherin:Catenin complexComplexREACT_20065 (Reactome)
Classic CadherinProteinREACT_20296 (Reactome)
ClaudinProteinREACT_20372 (Reactome)
F-actinREACT_20433 (Reactome)
F11R [plasma membrane]ProteinQ9Y624 (Uniprot-TrEMBL)
F11RProteinQ9Y624 (Uniprot-TrEMBL)
F1QFP3Protein5215987 (Reactome)
FBLIM1 [cytosol]ProteinQ8WUP2 (Uniprot-TrEMBL)
FBLIM1ProteinQ8WUP2 (Uniprot-TrEMBL)
FERMT2 [cytosol]ProteinQ96AC1 (Uniprot-TrEMBL)
FERMT2ProteinQ96AC1 (Uniprot-TrEMBL)
FLNA [cytosol]ProteinP21333 (Uniprot-TrEMBL)
FLNC [cytosol]ProteinQ14315 (Uniprot-TrEMBL)
FilaminProteinREACT_20988 (Reactome)
ILK [cytosol]ProteinQ13418 (Uniprot-TrEMBL)
ILK:Integrin beta-1ComplexREACT_20766 (Reactome)
ILKProteinQ13418 (Uniprot-TrEMBL)
INADL [plasma membrane]ProteinQ8NI35 (Uniprot-TrEMBL)
INADLProteinQ8NI35 (Uniprot-TrEMBL)
ITGA6(24-1130) [plasma membrane]ProteinP23229 (Uniprot-TrEMBL)
ITGB1 [plasma membrane]ProteinP05556 (Uniprot-TrEMBL)
ITGB1ProteinP05556 (Uniprot-TrEMBL)
ITGB4 [plasma membrane]ProteinP16144 (Uniprot-TrEMBL)
Integrin

alpha6:beta4:Plectin:BP180

complex		ComplexREACT_21046 (Reactome)
Integrin alpha

6:beta 4:Plectin:BP180:Laminin-322

complex		ComplexREACT_20915 (Reactome)
Integrin alpha

6:beta 4:Plectin

complex		ComplexREACT_21067 (Reactome)
Integrin alpha6beta4ComplexREACT_14337 (Reactome)
JAM-A:PAR-aPKC complexComplexREACT_20246 (Reactome)
JUP [plasma membrane]ProteinP14923 (Uniprot-TrEMBL)
Keratin 5/14REACT_20869 (Reactome)
LAMA3 [extracellular region]ProteinQ16787 (Uniprot-TrEMBL)
LAMB3 [extracellular region]ProteinQ13751 (Uniprot-TrEMBL)
LAMC2 [extracellular region]ProteinQ13753 (Uniprot-TrEMBL)
LIMS1 [cytosol]ProteinP48059 (Uniprot-TrEMBL)
LIMS1ProteinP48059 (Uniprot-TrEMBL)
LIMS2 [cytosol]ProteinQ7Z4I7 (Uniprot-TrEMBL)
Laminin-332ComplexREACT_14602 (Reactome)
MIG-2:MIGFILINComplexREACT_21097 (Reactome)
MIGFILIN:VASPComplexREACT_21228 (Reactome)
MLLT4-2 [cytosol]ProteinP55196-2 (Uniprot-TrEMBL)
MLLT4-2ProteinP55196-2 (Uniprot-TrEMBL)
MPP5 [plasma membrane]ProteinQ8N3R9 (Uniprot-TrEMBL)
MPP5ProteinQ8N3R9 (Uniprot-TrEMBL)
Migfilin:Filamin A:F-actinComplexREACT_20733 (Reactome) Interaction of Filamin with Migfiln mediates the association with the Migfilin with actin filaments (Tu et al., 2002).
Necl-1/Necl-2/Necl-3 homodimerComplexREACT_19578 (Reactome)
Necl-1/Necl-2/Necl-3 trans homodimerComplexREACT_19789 (Reactome)
Necl-1:Necl-2 trans heterodimerComplexREACT_20182 (Reactome)
Necl-1:Nectin-1 trans heterodimerComplexREACT_19689 (Reactome)
Necl-1:Nectin-3 trans heterodimerComplexREACT_19782 (Reactome)
Nectin cis-homodimerComplexREACT_19521 (Reactome)
Nectin trans homodimerComplexREACT_19779 (Reactome)
Nectin-1 cis homodimerComplexREACT_19460 (Reactome)
Nectin-1:Nectin-4 trans heterodimerComplexREACT_20421 (Reactome)
Nectin-1:PVRL3 trans heterodimerComplexREACT_20025 (Reactome)
Nectin-2 cis homodimerComplexREACT_20053 (Reactome)
Nectin-2:PVRL3 transheterodimerComplexREACT_20370 (Reactome)
Nectin-3:Necl-2 trans heterodimerComplexREACT_19977 (Reactome)
Nectin-4 cis homodimerComplexREACT_20206 (Reactome)
Nectin:afadin complexComplexREACT_20350 (Reactome)
NectinProteinREACT_20136 (Reactome)
PARD3 [cytosol]ProteinQ8TEW0 (Uniprot-TrEMBL)
PARD3 [plasma membrane]ProteinQ8TEW0 (Uniprot-TrEMBL)
PARD6A [cytosol]ProteinQ9NPB6 (Uniprot-TrEMBL)
PARD6A [plasma membrane]ProteinQ9NPB6 (Uniprot-TrEMBL)
PARD6B [cytosol]ProteinQ9BYG5 (Uniprot-TrEMBL)
PARD6B [plasma membrane]ProteinQ9BYG5 (Uniprot-TrEMBL)
PARD6G [cytosol]ProteinQ9BYG4 (Uniprot-TrEMBL)
PARD6G [plasma membrane]ProteinQ9BYG4 (Uniprot-TrEMBL)
PARVA [cytosol]ProteinQ9NVD7 (Uniprot-TrEMBL)
PARVA:PaxillinComplexREACT_21170 (Reactome)
PARVA:TESK1ComplexREACT_21038 (Reactome)
PARVAProteinQ9NVD7 (Uniprot-TrEMBL)
PARVB [cytosol]ProteinQ9HBI1 (Uniprot-TrEMBL)
PARVB:alpha actininComplexREACT_21104 (Reactome)
PARVBProteinQ9HBI1 (Uniprot-TrEMBL)
PINCH-ILK-parvin complexComplexREACT_20853 (Reactome)
PINCHProteinREACT_20717 (Reactome)
PLEC [cytosol]ProteinQ15149 (Uniprot-TrEMBL)
PLECProteinQ15149 (Uniprot-TrEMBL)
PRKCI(1-587) [cytosol]ProteinP41743 (Uniprot-TrEMBL)
PRKCI(1-587) [plasma membrane]ProteinP41743 (Uniprot-TrEMBL)
PRV:PVRL3 trans heterodimerComplexREACT_19715 (Reactome)
PVR [plasma membrane]ProteinP15151 (Uniprot-TrEMBL)
PVRL1 [plasma membrane]ProteinQ15223 (Uniprot-TrEMBL)
PVRL1ProteinQ15223 (Uniprot-TrEMBL)
PVRL2 [plasma membrane]ProteinQ92692 (Uniprot-TrEMBL)
PVRL3 [plasma membrane]ProteinQ9NQS3 (Uniprot-TrEMBL)
PVRL3 dimerComplexREACT_19940 (Reactome)
PVRL3ProteinQ9NQS3 (Uniprot-TrEMBL)
PVRL4 [plasma membrane]ProteinQ96NY8 (Uniprot-TrEMBL)
PVRProteinP15151 (Uniprot-TrEMBL)
PXN [plasma membrane]ProteinP49023 (Uniprot-TrEMBL)
PXNProteinP49023 (Uniprot-TrEMBL)
Par3:Par6:aPKC complexComplexREACT_19423 (Reactome)
ParvB/Affixin:Alpha-PixComplexREACT_20814 (Reactome)
RSU1 [cytosol]ProteinQ15404 (Uniprot-TrEMBL)
RSU1ProteinQ15404 (Uniprot-TrEMBL)
Rsu-1:Pinch1 complexComplexREACT_20937 (Reactome)
TESK1 [cytosol]ProteinQ15569 (Uniprot-TrEMBL)
TESK1ProteinQ15569 (Uniprot-TrEMBL)
Type II hemidesmosomeComplexREACT_20848 (Reactome)
VASP [cytosol]ProteinP50552 (Uniprot-TrEMBL)
VASPProteinP50552 (Uniprot-TrEMBL)
alpha/beta parvinProteinREACT_20989 (Reactome)
claudin trans-homodimerComplexREACT_20391 (Reactome)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
ACTN1REACT_20671 (Reactome)
ARHGEF6REACT_20672 (Reactome)
Afadin:F-actinArrowREACT_19163 (Reactome)
BP230:BP180:Plectin:integrin

alpha 6 beta

4:Laminin 332		ArrowREACT_20561 (Reactome)
BP230:BP180:Plectin:integrin

alpha 6 beta

4:Laminin 332		REACT_20665 (Reactome)
BP230REACT_20561 (Reactome)
Beta-catenin/gamma cateninREACT_19131 (Reactome)
CADM1REACT_19130 (Reactome)
CADM1REACT_19220 (Reactome)
CADM3REACT_19130 (Reactome)
CADM3REACT_19202 (Reactome)
CADM3REACT_19267 (Reactome)
CD151:BP230:BP180:Plectin:Integrin

alpha 6 beta 4:

Laminin		ArrowREACT_20665 (Reactome)
CD151:BP230:BP180:Plectin:Integrin

alpha 6 beta 4:

Laminin		REACT_20615 (Reactome)
CD151REACT_20665 (Reactome)
COL17A1(1-1497)REACT_20589 (Reactome)
CRB3:PALS1:PATJ complexArrowREACT_19144 (Reactome)
CRB3REACT_19144 (Reactome)
CTNNA1REACT_19131 (Reactome)
CTNND1REACT_19131 (Reactome)
Ca2+REACT_19416 (Reactome)
Cadherin trans-homodimerArrowREACT_19416 (Reactome)
Cadherin:Catenin complexArrowREACT_19131 (Reactome)
Classic CadherinREACT_19131 (Reactome)
Classic CadherinREACT_19416 (Reactome)
ClaudinREACT_19338 (Reactome)
F-actinREACT_19163 (Reactome)
F-actinREACT_20513 (Reactome)
F11RREACT_19353 (Reactome)
FBLIM1REACT_20513 (Reactome)
FBLIM1REACT_20555 (Reactome)
FBLIM1REACT_20572 (Reactome)
FERMT2REACT_20555 (Reactome)
FilaminREACT_20513 (Reactome)
ILK:Integrin beta-1ArrowREACT_20656 (Reactome)
ILKREACT_20645 (Reactome)
ILKREACT_20656 (Reactome)
INADLREACT_19144 (Reactome)
ITGB1REACT_20656 (Reactome)
Integrin

alpha6:beta4:Plectin:BP180

complex		ArrowREACT_20589 (Reactome)
Integrin

alpha6:beta4:Plectin:BP180

complex		REACT_20660 (Reactome)
Integrin alpha

6:beta 4:Plectin:BP180:Laminin-322

complex		ArrowREACT_20660 (Reactome)
Integrin alpha

6:beta 4:Plectin:BP180:Laminin-322

complex		REACT_20561 (Reactome)
Integrin alpha

6:beta 4:Plectin

complex		ArrowREACT_20528 (Reactome)
Integrin alpha

6:beta 4:Plectin

complex		REACT_20589 (Reactome)
Integrin alpha6beta4REACT_20528 (Reactome)
JAM-A:PAR-aPKC complexArrowREACT_19353 (Reactome)
Keratin 5/14REACT_20615 (Reactome)
LIMS1REACT_20616 (Reactome)
Laminin-332REACT_20660 (Reactome)
MIG-2:MIGFILINArrowREACT_20555 (Reactome)
MIGFILIN:VASPArrowREACT_20572 (Reactome)
MLLT4-2REACT_19163 (Reactome)
MLLT4-2REACT_19214 (Reactome)
MPP5REACT_19144 (Reactome)
Migfilin:Filamin A:F-actinArrowREACT_20513 (Reactome)
Necl-1/Necl-2/Necl-3 homodimerREACT_19179 (Reactome)
Necl-1/Necl-2/Necl-3 trans homodimerArrowREACT_19179 (Reactome)
Necl-1:Necl-2 trans heterodimerArrowREACT_19130 (Reactome)
Necl-1:Nectin-1 trans heterodimerArrowREACT_19202 (Reactome)
Necl-1:Nectin-3 trans heterodimerArrowREACT_19267 (Reactome)
Nectin cis-homodimerArrowREACT_19169 (Reactome)
Nectin cis-homodimerREACT_19364 (Reactome)
Nectin trans homodimerArrowREACT_19364 (Reactome)
Nectin-1 cis homodimerREACT_19201 (Reactome)
Nectin-1 cis homodimerREACT_19302 (Reactome)
Nectin-1:Nectin-4 trans heterodimerArrowREACT_19201 (Reactome)
Nectin-1:PVRL3 trans heterodimerArrowREACT_19302 (Reactome)
Nectin-2 cis homodimerREACT_19176 (Reactome)
Nectin-2:PVRL3 transheterodimerArrowREACT_19176 (Reactome)
Nectin-3:Necl-2 trans heterodimerArrowREACT_19220 (Reactome)
Nectin-4 cis homodimerREACT_19201 (Reactome)
Nectin:afadin complexArrowREACT_19214 (Reactome)
NectinREACT_19169 (Reactome)
NectinREACT_19214 (Reactome)
PARVA:PaxillinArrowREACT_20542 (Reactome)
PARVA:TESK1ArrowREACT_20609 (Reactome)
PARVAREACT_20542 (Reactome)
PARVAREACT_20609 (Reactome)
PARVB:alpha actininArrowREACT_20671 (Reactome)
PARVBREACT_20671 (Reactome)
PARVBREACT_20672 (Reactome)
PINCH-ILK-parvin complexArrowREACT_20645 (Reactome)
PINCHREACT_20645 (Reactome)
PLECREACT_20528 (Reactome)
PRV:PVRL3 trans heterodimerArrowREACT_19151 (Reactome)
PVRL1REACT_19202 (Reactome)
PVRL3 dimerREACT_19176 (Reactome)
PVRL3 dimerREACT_19302 (Reactome)
PVRL3REACT_19151 (Reactome)
PVRL3REACT_19220 (Reactome)
PVRL3REACT_19267 (Reactome)
PVRREACT_19151 (Reactome)
PXNREACT_20542 (Reactome)
Par3:Par6:aPKC complexREACT_19353 (Reactome)
ParvB/Affixin:Alpha-PixArrowREACT_20672 (Reactome)
REACT_19130 (Reactome) Necl-1 displays Ca2+-independent heterophilic cell-cell adhesion activity with Necl-2 (Kakunaga et al., 2005).
REACT_19131 (Reactome) The cytoplasmic tails of classical cadherins form a multiprotein complex with alpha-catenin, beta/gamma-catenins and p120 catenin (p120ctn) (Gumbiner, 2005). Beta-catenin and p120ctn directly interact with the cadherin molecule through highly conserved regions in the membrane-distal and membrane-proximal domains, respectively, of the cadherin. The interactions with beta-catenin and p120ctn regulate cadherin localization at cell-cell contacts as well as its adhesive activity (Halbleib and Nelson, 2006). The association of beta-catenin and alpha-catenin probably serves to link the cadherin-catenin complex to the F-actin cytoskeleton through the protein ELPIN (Abe and Takeichi, 2008). Independently of its association with the cadherin-catenin complex, alpha-catenin also regulates the bundling and growth of actin filaments at sites of cell-cell contact formation (Drees et al., 2005; Weis and Nelson, 2006).
REACT_19144 (Reactome) The CRB3–Pals1–PATJ complex is the second major cell polarity protein complex at Tight Junctions (TJs) (Shin et al., 2006). The integral membrane protein CRB3 localizes to the apical domain of epithelial cells and is concentrated at TJs. CRB3 directly associates with Pals1 which interacts with PATJ, a proteins consisting of 10 PDZ domains. The interaction with CRB3 might recruit the Pals1-PATJ complex to TJs (Lemmers et al., 2002; Roh et al., 2003). Although its precise functions of the individual components have not been established, the complex is required for TJ formation, in part through the stabilization of apical and lateral components of tight junctions (Michel et al., 2005; Shin et al., 2005).
REACT_19151 (Reactome) Necl-5/PVR and Nectin-3/PVRL3 interact forming a trans heterodimer.
REACT_19163 (Reactome) Afadin serves as a linker of the actin cytoskeleton to the plasma membrane at cell-to-cell Adherens Junctions (Mandai et al., 1997).
REACT_19169 (Reactome) The Nectin family of Ca2+-independent cell adhesion molecules (CAMs) is comprised of four members, nectin-1, nectin-2, nectin-3, and nectin-4 (reviewed in Sakisaka et al., 2007). Each nectin first forms homophilic cis-dimers and then forms homophilic or heterophilic trans-dimers involved in cell–cell adhesion. Heterophilic trans-interactions are stronger than homophilic trans-interactions.
REACT_19176 (Reactome) Nectin-2 and Nectin-3 interact forming a trans heterodimer.
REACT_19179 (Reactome) The nectin-like (Necl) family comprises five members, called Necl-1 to -5. Necl have an overall organization like that of nectins with three Ig-like domains, a transmembrane region and a cytoplasmic domain. Necls have a greater variety of functions than nectins and are ubiquitously expressed. In contrast to nectins, Necls do not interact with afadin. Transhomodimerization has been described for Necl-1, -2 and -3 but not for Necl-4 and -5. (Sakisaka et al., 2007; Sakisaka and Takai, 2004; Takai et al., 2008).
REACT_19201 (Reactome) Nectin-1 and Nectin-4 interact forming a trans heterodimer.
REACT_19202 (Reactome) Necl-1 displays Ca2+-independent heterophilic cell-cell adhesion activity with Nectin-1 (Kakunaga et al., 2005).
REACT_19214 (Reactome) Nectins are immunoglobulin-like cell adhesion molecules comprising a family of four members, nectin 1 - 4 (Takai and Nakanishi, 2003). In contrast to classical cadherins which interact only homophilically, nectins undergo trans-homophilic and trans-heterophilic interactions with nectins and nectin-like molecules (Takai et al., 2008b). Nectins cooperate with cadherins in regulating the formation of adherens junctions (AJs) and the strength of cell-cell adhesion. Nectins are linked to the underlying actin cytoskeleton through their interaction with the actin-binding protein Afadin (Takai et al., 2008a). Nectin-based cell–cell adhesions contribute to formation of many types of cell-cell junctions including AJs, tight junctions, and synaptic junctions.
REACT_19220 (Reactome) Necl-2 and Nectin 3 form a trans heterodimer.
REACT_19267 (Reactome) Necl-1 displays Ca2+-independent heterophilic cell-cell adhesion activity with Nectin-3 (Kakunaga et al., 2005).
REACT_19302 (Reactome) Nectin-1 and Nectin 3 interact forming a trans heterodimer.
REACT_19338 (Reactome) Claudins are the major cell adhesion molecules in tight junctions and are involved in regulating the paracellular flux of water-soluble molecules between adjacent cells (reviewed in (Furuse and Tsukita, 2006). Claudins create paired strands through homophilic and heterophilic cis and trans interactions. A strand of one cell associates laterally with a strand in the apposing membrane of an adjacent cell creating a paired TJ strand (Tsukita et al., 2001). The TJ strands contain aqueous pores with size and charge selectivity that are permeable to water-soluble molecules. Differences in the barrier properties in epithelia of different tissues have been explained by the expression of a unique set of claudins in a given tissue (Van Itallie and Anderson, 2006). 24 claudins were identified in humans, which allows a large number of possible combinations and specific barrier properties.
REACT_19353 (Reactome) PAR-3 exists in a ternary complex with aPKC and PAR-6 to form the PAR-aPKC complex (Macara, 2004; Suzuki and Ohno, 2006). This complex is critically involved in the development of Tight Junctions (TJs) from primordial spot-like Adherens Junctions (AJs) (Suzuki et al., 2002). PAR-3 directly interacts with Junctional Adhesion Molecules (JAM)-A, -B, and -C (Ebnet et al., 2001; Ebnet et al., 2004).The interaction with JAM-A might anchor the PAR-aPKC complex to TJs but might also be necessary to recruit the PAR-aPKC complex to primordial spot-like AJs where it becomes activated in response to cell-cell adhesion (reviewed in (Ebnet et al., 2008). The PAR-aPKC complex might also be physically linked to the second polarity protein complex at TJs, the CRB3-Pals1-PATJ complex through a direct interaction between PAR-6 and Pals1 (Hurd et al., 2003).
REACT_19364 (Reactome) Nectins are Ca(2+)-independent cell adhesion molecules which interact homophilically and heterophilically in trans to form cell-cell adhesions (reviewed in (Sakisaka et al., 2007; Takai et al., 2008). Each nectin first forms homo-cis-dimers and then homo- or hetero-trans-dimers through the extracellular region, causing cell–cell adhesion. The Nectin protein family is made up of four members, nectin-1, -2, -3, and -4, all of which have an extracellular region with three Ig-like loops, a single transmembrane region, and a cytoplasmic tail region.
REACT_19416 (Reactome) Cadherins are the major cell adhesion molecules at adherens junctions (AJs). Classical cadherins are Ca2+-dependent, homophilic adhesion molecules that link adjacent cells (Gumbiner, 2005; Halbleib and Nelson, 2006; Pokutta and Weis, 2007). The extracellular domain of classical cadherins consists of five cadherin-type repeats (called "extracellular cadherin" (EC) -domains). In the presence of Ca2+, the monomers form parallel cis-dimers resulting in a rod-like structure (Gumbiner, 2005). The cis-dimers undergo trans homophilic interactions to mediate homotypic cell-cell interactions. The cytoplasmic tails of classical cadherins interact with different proteins (primarily catenins) to regulate cell surface expression levels, linkage to the actin cytoskeleton, and cell signaling. Non-classical cadherins (Atypical cadherins, Proto-cadherins, cadherin-related proteins) have a variable number of cadherin-type repeats, do not associate with catenins, and are not associated with AJs (Halbleib and Nelson, 2006).
REACT_20513 (Reactome) Migfilin associates with actin filaments as a result of its interaction with filamin (Tu et al., 2003). Migfilin associates with actin filaments and loss of migfilin decreases the level of F-actin suggesting that, in addition to providing an anchoring site for actin filaments at cell-ECM adhesions, migfilin also functions in the regulation of filamin-mediated cross-linking and stabilization of actin filaments (Tu et al., 2003).
REACT_20528 (Reactome) The actin-binding domain of plectin interacts with the first pair of FNIII repeats and the N-terminal 35 amino acids of the connecting segment of integrin b4 ( Geerts et al., 1999; Niessen et al., 1997; Koster et al., 2004). This interaction is thought to be the initial step in hemidesmosome (HD) assembly and is critical for the mechanical stability of the HD. This interaction is destabilized when HD disassembly is required, for example, to allow cell migration during wound healing. The Integrin a6b4 also associates extracellularly with laminin-332 (See Koster et al., 2003).
REACT_20542 (Reactome) The focal adhesion protein alpha-parvin, interacts with paxillin, through the C-terminal CH-containing fragment of the alpha-parvin and paxillin LD motif (Wang et al., 2008; Lorenz et al., 2008). This interaction likely contributes to the localization of the PINCH-ILK-parvin complexes to focal adhesions.
REACT_20555 (Reactome) Migfilin functions in cell shape modulation regulating filamin-mediated cross-linking and stabilization of actin filaments. Migfilin is recruited to cell–Extra Cellular Matrix adhesion sites in a variety of fibroblasts, epithelial, and endothelial cells by interaction with Mig-2 (Tu et al., 2003).
REACT_20561 (Reactome) Following the association of BP180 with the forming hemidesmosome, BP230 is recruited through associations with BP180 and a region on beta 4 integrin that includes the C-terminal 21 amino acids of the connecting segment and the second pair of FNIII repeats (Hopkinson et al.,2000).
REACT_20572 (Reactome) Migfilin interacts with VASP and regulates VASP localization to cell-matrix adhesions (Zhang et al., 2006). Interaction between migfilin and VASP is critical for migfilin-mediated regulation of cell migration (Zhang et al., 2006).
REACT_20589 (Reactome) BP180 interacts with Plectin following the association of Plectin with Integrin b4 (b4) (Koster et al., 2003). It is not clear whether the binding of BP180 to Plectin and b4 occurs sequentially or at the same time as the interaction between BP180 and Laminin?332.
REACT_20609 (Reactome) The association of PARVA with TESK1 appears to suppress cell spreading (Lalonde et al. 2005). TESK1 can phosphorylate cofilin and promote F-actin polymerization and cell spreading (Tsumura et al., 2005 ; Toshima et al., 2001; Leeksma et al., 2002). PARVA associates with testicular protein kinase 1 (TESK1) and inhibits its activity (Lalonde et al. 2005).
REACT_20615 (Reactome) BP230 interacts with cytokeratins K5/K14 (Fontao et al., 2003).
REACT_20616 (Reactome) The Ras suppressor, Rsu-1, interacts with the LIM 5 domain of PINCH1 (but not PINCH2) and may inhibit cell migration by stabilizing the Pinch-ILK-parvin adhesion complex (Dougherty et al., 2008; Kadrmas et al., 2004).
REACT_20645 (Reactome) The PINCH-ILK-parvin complex (Tu et al., 2001; Zhang et al., 2002; Li et al., 1999) localizes to focal adhesions and plays a critical role in the regulation of cell adhesion, cell shape modulation, motility and ECM deposition (Velyvis et al., 2001; Braun et al, 2003). ILK binds PINCH through its N-terminal domain and binds PARVA or PARVB through its C-terminal domain, resulting in formation of the ternary PINCH-ILK-parvin complex (Tu et al., 2001). These complexes form before they are localized to integrin-rich adhesion sites (Zhang et al., 2002). Formation of the ILK-PINCH-parvin complexes stabilizes these proteins by protecting them from degradation by the proteasome (Fukuda et al., 2003).
REACT_20656 (Reactome) ILK interacts with the cytoplasmic domain of beta1-integrin (Hannigan et al., 1996).
REACT_20660 (Reactome) BP180 interacts with Plectin following the association of Plectin with Integrin b4 (b4) (Koster et al., 2003). It is not clear whether the binding of BP180 to Plectin and b4 occurs sequentially or at the same time as the interaction between BP180 and Laminin?332.
REACT_20665 (Reactome) CD151 interacts with the extracellular domain of the integrin alpha 6 subunit. CD151 is thought to play a role in the formation and stability of hemidesmosomes by providing a framework for the spatial organization of the hemidesmosomal components (Sterk et al., 2000).
REACT_20671 (Reactome) PARVB interacts with the actin cross-linking protein Alpha-actinin (Yamaji et al. 2004). The ILK-PARVB complex may serve as an integrin-anchoring site for alpha-actinin and thereby mediate integrin signaling to alpha-actinin, which has been shown to play an important role in actin polymerization at focal adhesions (Yamaji et al., 2004).
REACT_20672 (Reactome) The Rho GTPases, Cdc42 and Rac1, play critical roles in cell migration by integrating cell-substrate adhesion and actin polymerization. PARVB/affixin appears to participate in the activation of Rac and Cdc42 by associating with alpha PIX through its CH1 domain (Mishima et al., 2004; Rosenberger et al., 2005). This activity of PARVB/affixin could promote the polymerization of actin through the activation of downstream effectors of Rac1/Cdc42, including WASP-Arp2/3 and Mena/VASP. Alpha-PIX, ILK and PARVB can be found at the leading edge of spreading cells (Rosenberger et al., 2005 ), and it is likely that activation of Rac1 and Cdc42 at the lamellipodia in some cells is stimulated by interactions of aPIX with PARVB and regulated by interaction of ILK and PARVB (see Sepulveda and Wu, 2005 ).
RSU1REACT_20616 (Reactome)
Rsu-1:Pinch1 complexArrowREACT_20616 (Reactome)
TESK1REACT_20609 (Reactome)
Type II hemidesmosomeArrowREACT_20615 (Reactome)
VASPREACT_20572 (Reactome)
alpha/beta parvinREACT_20645 (Reactome)
claudin trans-homodimerArrowREACT_19338 (Reactome)
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