RNA Polymerase II Transcription (Homo sapiens)

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422244, 6-12415, 17-19227, 13237, 14-1644, 520, 214237, 152223237, 13nucleoplasmTFIIHRD proteinPol II transcription complex containing transcript to +30NTPMature Intronless transcript derived Histone mRNA:SLBP:CBP80:CBP20TFIIHNTPRNA Polymerase II (unphosphorylated):TFIIF complexNTPOrthophosphateFACT 80 kDa subunitRNA (guanine-7-) methyltransferaseupstream mRNA fragment:CPSF:PAP:PABPN1 complexAborted elongation complex after arrestNTPpol II closed pre-initiation complexElongin B:C complexTFIIS proteinPol II Promoter Escape Complexpol II transcription complex containing 4 nucleotide long transcriptpyrophosphatepol II open pre-initiation complexCyclin T2TFIIDpol II transcription complex containing 3 Nucleotide long transcriptFCP1P proteinpyrophosphateNELF-B proteinpyrophosphateRNA Polymerase II holoenzyme complex (hyperphosphorylated)RNA polymerase II elongation factor ELLpol II promoter:TFIID:TFIIA:TFIIB complexPaused processive elongation complexpol II transcription complex containing 9 nucleotide long transcriptpol II transcription complexNTPLigated exon containing complexCap Binding Complex (CBC)Pol II transcription complex containing extruded transcript to +30TFIIECstFElongin C proteinTFIIANELF-A proteintemplate DNA:4-9 nucleotide transcript hybridMature intronless transcript derived Histone pre-mRNA:CBC complexATPNTPTFIIBphospho-Spt5pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF:TFIIE complexdamaged DNA substrate:nascent mRNA hybridNTPNTPTFIIBRNA Pol II with phosphorylated CTD: CE complex with activated GTRNA Pol II (hypophosphorylated) complex bound to DSIF proteinElongation complexpyrophosphatepol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF complexCyclin T1RNA Pol II (hypophosphorylated):capped pre-mRNA complexElongation complex with separated and uncleaved transcript3' end cleaved, ligated exon containing complexProcessive elongation complextemplate DNA with first transcript dinucleotide, opened to +8 positionTFIIHmRNA 3'-end cleavage factorPol II initiation complexTFIIHADPCdk 9 proteinCF IISPT4H1 proteinNTPNELF complexRNA Pol II with phosphorylated CTD: CE complexDNA containing Pol II promoter with transcript with 2 or 3 nucleotidesPol II transcription complex with (ser5) phosphorylated CTD containing extruded transcript to +30P-TEFb complexdownstream intronless mRNA fragmentFACT complexElongin B proteinEarly elongation complex with hyperphosphorylated Pol II CTDTFIIHpyrophosphateElongation complex prior to separationintronless pre-mRNA cleavage complexFACT 140 kDa subunitCF ICE:Pol II CTD:Spt5 complexDSIF:NELF:early elongation complexDSIF complexArrested processive elongation complexElongin A1 proteinPol II Initiation complex with phosphodiester-PPi intermediatemRNA capping enzymeDNA containing RNA Polymerase II promoterTFIIEpol II transcription complex containing 11 nucleotide long transcriptpol II transcription complex containing 4-9 nucleotide long transcriptcapped pre-mRNA:CBC:RNA Pol II (phosphorylated) complexCapped Intronless Histone pre-mRNA:CBC:ZFP100 Complexpol II promoter:TFIID complexNTPCapped Intronless Histone pre-mRNA:CBP80:CBP20:SLBP:ZFP100 ComplexTFIIFElongin ComplexAborted early elongation complexNTPpyrophosphateTFIIAU7 snRNP:ZFP100 ComplexNELF-C/D proteinTFIID123


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Bibliography

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  30. Kamakaka RT, Bulger M, Kadonaga JT.; ''Potentiation of RNA polymerase II transcription by Gal4-VP16 during but not after DNA replication and chromatin assembly.''; PubMed Europe PMC Scholia
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  71. Dominski Z, Erkmann JA, Yang X, Sànchez R, Marzluff WF.; ''A novel zinc finger protein is associated with U7 snRNP and interacts with the stem-loop binding protein in the histone pre-mRNP to stimulate 3'-end processing.''; PubMed Europe PMC Scholia
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  73. Buratowski S.; ''Progression through the RNA polymerase II CTD cycle.''; PubMed Europe PMC Scholia
  74. Schweisguth F.; ''Regulation of notch signaling activity.''; PubMed Europe PMC Scholia
  75. Aso T, Yamazaki K, Amimoto K, Kuroiwa A, Higashi H, Matsuda Y, Kitajima S, Hatakeyama M.; ''Identification and characterization of Elongin A2, a new member of the Elongin family of transcription elongation factors, specifically expressed in the testis.''; PubMed Europe PMC Scholia
  76. Pal M, Luse DS.; ''Strong natural pausing by RNA polymerase II within 10 bases of transcription start may result in repeated slippage and reextension of the nascent RNA.''; PubMed Europe PMC Scholia
  77. Parvin JD, Sharp PA.; ''DNA topology and a minimal set of basal factors for transcription by RNA polymerase II.''; PubMed Europe PMC Scholia
  78. Fiedler U, Timmers HT.; ''Analysis of the open region of RNA polymerase II transcription complexes in the early phase of elongation.''; PubMed Europe PMC Scholia
  79. Lin C, Smith ER, Takahashi H, Lai KC, Martin-Brown S, Florens L, Washburn MP, Conaway JW, Conaway RC, Shilatifard A.; ''AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia.''; PubMed Europe PMC Scholia
  80. Bernstein LB, Manser T, Weiner AM.; ''Human U1 small nuclear RNA genes: extensive conservation of flanking sequences suggests cycles of gene amplification and transposition.''; PubMed Europe PMC Scholia
  81. Kugel JF, Goodrich JA.; ''Translocation after synthesis of a four-nucleotide RNA commits RNA polymerase II to promoter escape.''; PubMed Europe PMC Scholia
  82. Hernandez N.; ''TBP, a universal eukaryotic transcription factor?''; PubMed Europe PMC Scholia
  83. Näär AM, Lemon BD, Tjian R.; ''Transcriptional coactivator complexes.''; PubMed Europe PMC Scholia
  84. Zawel L, Kumar KP, Reinberg D.; ''Recycling of the general transcription factors during RNA polymerase II transcription.''; PubMed Europe PMC Scholia
  85. Cramer P, Bushnell DA, Kornberg RD.; ''Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution.''; PubMed Europe PMC Scholia
  86. Schaeffer L, Roy R, Humbert S, Moncollin V, Vermeulen W, Hoeijmakers JH, Chambon P, Egly JM.; ''DNA repair helicase: a component of BTF2 (TFIIH) basic transcription factor.''; PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
115030view16:57, 25 January 2021ReactomeTeamReactome version 75
113475view11:55, 2 November 2020ReactomeTeamReactome version 74
112674view16:06, 9 October 2020ReactomeTeamReactome version 73
101591view11:46, 1 November 2018ReactomeTeamreactome version 66
101127view21:31, 31 October 2018ReactomeTeamreactome version 65
100655view20:04, 31 October 2018ReactomeTeamreactome version 64
100205view16:49, 31 October 2018ReactomeTeamreactome version 63
99756view15:15, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99318view12:47, 31 October 2018ReactomeTeamreactome version 62
93793view13:36, 16 August 2017ReactomeTeamreactome version 61
93329view11:20, 9 August 2017ReactomeTeamreactome version 61
86414view09:17, 11 July 2016ReactomeTeamreactome version 56
83471view13:23, 18 November 2015ReactomeTeamVersion54
81416view12:56, 21 August 2015ReactomeTeamVersion53
76887view08:16, 17 July 2014ReactomeTeamFixed remaining interactions
76592view11:57, 16 July 2014ReactomeTeamFixed remaining interactions
75625view10:49, 10 June 2014ReactomeTeamReactome 48 Update
74980view13:50, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74624view08:40, 30 April 2014ReactomeTeamReactome46
45042view18:59, 6 October 2011ThomasOntology Term : 'RNA Polymerase II transcription pathway' added !
42122view21:58, 4 March 2011MaintBotAutomatic update
39932view05:57, 21 January 2011MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
3' end cleaved,

ligated exon containing complex

ComplexREACT_3092 (Reactome)
ADP Metabolite16761 (ChEBI)
ATP Metabolite15422 (ChEBI)
Aborted early

elongation complex

ComplexREACT_3362 (Reactome)
Aborted elongation

complex after arrest

ComplexREACT_6654 (Reactome)
Arrested processive

elongation complex

ComplexREACT_4675 (Reactome)
CE:Pol II CTD:Spt5

complex

ComplexREACT_2332 (Reactome) Spt5 reacts with Guanyl Transferase (GT) of the capping enzyme (CE).
CF I ComplexREACT_4896 (Reactome)
CF II ComplexREACT_3772 (Reactome)
Cap Binding

Complex (CBC)

ComplexREACT_3884 (Reactome)
Capped Intronless

Histone pre-mRNA: CBC:ZFP100 Complex

ComplexREACT_5338 (Reactome)
Capped Intronless

Histone pre-mRNA: CBP80:CBP20:SLBP: ZFP100 Complex

ComplexREACT_3667 (Reactome)
Cdk 9 protein ProteinP50750 (UniProt)
CstF ComplexREACT_3503 (Reactome)
Cyclin T1 ProteinO60563 (UniProt)
Cyclin T2 ProteinO60583 (UniProt)
DNA containing Pol II

promoter with transcript with 2 or 3 nucleotides

UnknownREACT_3936 (Reactome)
DNA containing RNA

Polymerase II promoter

UnknownREACT_2835 (Reactome)
DSIF complex ComplexREACT_2797 (Reactome)
DSIF:NELF:early

elongation complex

ComplexREACT_4575 (Reactome)
Early elongation

complex with hyperphosphorylated Pol II CTD

ComplexREACT_2481 (Reactome)
Elongation complex ComplexREACT_3511 (Reactome)
Elongation complex

prior to separation

ComplexREACT_5853 (Reactome)
Elongation complex

with separated and uncleaved transcript

ComplexREACT_5512 (Reactome)
Elongin A1 protein ProteinQ14241 (UniProt)
Elongin B protein ProteinQ15369 (UniProt)
Elongin B:C complex ComplexREACT_2434 (Reactome)
Elongin C protein ProteinQ15370 (UniProt)
Elongin Complex ComplexREACT_5616 (Reactome)
FACT 140 kDa

subunit

ProteinQ9Y5B9 (UniProt) DSIF is a heterodimer consisting of hSPT4 (human homolog of yeast Spt4- p14) and hSPT5 (human homolog of yeast Spt5-p160). DSIF association with Pol II may be enabled by Spt5 binding to Pol II creating a scaffold for NELF binding (Wada et al.,1998). Spt5 subunit of DSIF can be phosphorylated by P-TEFb.
FACT 80 kDa

subunit

ProteinQ08945 (UniProt)
FACT complex ComplexREACT_4314 (Reactome)
FCP1P protein ProteinQ9Y5B0 (UniProt)
Ligated exon

containing complex

ComplexREACT_5472 (Reactome)
Mature Intronless

transcript derived Histone mRNA:SLBP: CBP80:CBP20

ComplexREACT_3802 (Reactome)
Mature intronless

transcript derived Histone pre-mRNA: CBC complex

ComplexREACT_5592 (Reactome)
NELF complex ComplexREACT_2737 (Reactome)
NELF-A protein ProteinQ9H3P2 (UniProt)
NELF-B protein ProteinQ8WX92 (UniProt)
NELF-C/D protein ProteinQ8IXH7 (UniProt)
NTP MetaboliteREACT_4491 (Reactome)
Orthophosphate Metabolite18367 (ChEBI)
P-TEFb complex ComplexREACT_3433 (Reactome)
Paused processive

elongation complex

ComplexREACT_3066 (Reactome)
Pol II Initiation

complex with phosphodiester-PPi intermediate

ComplexREACT_2410 (Reactome)
Pol II Promoter

Escape Complex

ComplexREACT_3851 (Reactome)
Pol II initiation

complex

ComplexREACT_5487 (Reactome)
Pol II transcription

complex containing extruded transcript to +30

ComplexREACT_4335 (Reactome)
Pol II transcription

complex containing transcript to +30

ComplexREACT_4399 (Reactome)
Pol II transcription

complex with (ser5) phosphorylated CTD containing extruded transcript to +30

ComplexREACT_2595 (Reactome)
Processive

elongation complex

ComplexREACT_3018 (Reactome)
RD protein ProteinP18615 (UniProt)
RNA (guanine-7-)

methyltransferase

ProteinO43148 (UniProt)
RNA Pol II

(hypophosphorylated) complex bound to DSIF protein

ComplexREACT_4417 (Reactome)
RNA Pol II

(hypophosphorylated): capped pre-mRNA complex

ComplexREACT_5658 (Reactome)
RNA Pol II with

phosphorylated CTD: CE complex

ComplexREACT_2371 (Reactome)
RNA Pol II with

phosphorylated CTD: CE complex with activated GT

ComplexREACT_3171 (Reactome)
RNA Polymerase II

(unphosphorylated): TFIIF complex

ComplexREACT_2692 (Reactome)
RNA Polymerase II

holoenzyme complex (hyperphosphorylated)

ComplexREACT_4889 (Reactome)
RNA polymerase II

elongation factor ELL

ProteinP55199 (UniProt)
SPT4H1 protein ProteinP63272 (UniProt)
TFIIA ComplexREACT_5743 (Reactome)
TFIIB ProteinQ00403 (UniProt)
TFIID ComplexREACT_5886 (Reactome)
TFIIE ComplexREACT_2368 (Reactome)
TFIIF ComplexREACT_4708 (Reactome)
TFIIH ComplexREACT_3832 (Reactome)
TFIIS protein ProteinP23193 (UniProt)
U7 snRNP:ZFP100

Complex

ComplexREACT_5001 (Reactome)
capped pre-mRNA:

CBC:RNA Pol II (phosphorylated) complex

ComplexREACT_3243 (Reactome)
damaged DNA

substrate:nascent mRNA hybrid

UnknownREACT_3022 (Reactome)
downstream

intronless mRNA fragment

UnknownREACT_3064 (Reactome)
intronless pre-mRNA

cleavage complex

ComplexREACT_3895 (Reactome)
mRNA 3'-end

cleavage factor

ComplexREACT_2642 (Reactome)
mRNA capping

enzyme

ProteinO60942 (UniProt)
phospho-Spt5 ProteinREACT_14075 (Reactome)
pol II closed pre-

initiation complex

ComplexREACT_5734 (Reactome)
pol II open pre-

initiation complex

ComplexREACT_4930 (Reactome)
pol II promoter:

TFIID:TFIIA:TFIIB complex

ComplexREACT_2339 (Reactome)
pol II promoter:TFIID

complex

ComplexREACT_5906 (Reactome)
pol II promoter:TFIID:

TFIIA:TFIIB:Pol II:TFIIF complex

ComplexREACT_2469 (Reactome)
pol II promoter:TFIID:

TFIIA:TFIIB:Pol II:TFIIF: TFIIE complex

ComplexREACT_4404 (Reactome)
pol II transcription

complex

ComplexREACT_2954 (Reactome)
pol II transcription

complex containing 11 nucleotide long transcript

ComplexREACT_3183 (Reactome)
pol II transcription

complex containing 4-9 nucleotide long transcript

ComplexREACT_3928 (Reactome)
pol II transcription

complex containing 3 Nucleotide long transcript

ComplexREACT_3251 (Reactome)
pol II transcription

complex containing 4 nucleotide long transcript

ComplexREACT_4148 (Reactome)
pol II transcription

complex containing 9 nucleotide long transcript

ComplexREACT_5212 (Reactome)
pyrophosphate Metabolite29888 (ChEBI)
template DNA with first

transcript dinucleotide, opened to +8 position

UnknownREACT_3318 (Reactome)
template DNA:4-9

nucleotide transcript hybrid

UnknownREACT_3607 (Reactome)
upstream mRNA

fragment:CPSF:PAP: PABPN1 complex

ComplexREACT_3436 (Reactome)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1906"