IL-9 signaling pathway (Homo sapiens)

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EndosomeDephosphorylationPhosphorylationSumoylationTranslocationGlycosylationDMTInhibitionDNucleusPalmitoylationDGene SymbolPMDeacetylationActivationCY->NUAcetylationAccession Number: NetPath 20ExtracellularNUControlReaction through unknown mechanisms/moleculesProteins in a complex interactionDesumoylationGolgi apparatusAutophosphorylationDemethylationGOProteins in a complex interactionCY(Protein-protein interaction)ReceptorDeubiquitinationDEndoplasmic reticulumENUbiquitinationCytoplasmMitochondrionLigandERECMethylationPlasma membraneMolecule in the pathwayProteolytic cleavageMolecular associationRecruitmentIRS2JAK3IL2RGMAP2K2GRB2IL9STAT3JAK1IRS1VCPTYK2STAT3PTPN11HTATIPMAPK1STAT5BIL9RSTAT1PIK3R1MAPK3SOCS3SHC1AKT1STAT5AMAP2K1


Description

Interleukin-9 belongs to a family of cytokines, which includes IL-2, IL-4, IL-7, IL-15 and IL-21. It signals through a receptor complex consisting of an IL-9 receptor (IL9R) and a common gamma chain that is shared between all members of this family. IL-9 activates Jak/STAT and MAPK signaling modules. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_20

Comments

GenMAPP notes 
NetPath 20 - IL-9 Signaling Pathway

NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.

GenMAPP remarks 
http://www.netpath.org

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Quality Tags

Ontology Terms

 

Bibliography

  1. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A; ''NetPath: a public resource of curated signal transduction pathways.''; Genome Biol, 2010 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
126261view05:49, 19 April 2023EgonwLicense is CCZero
120719view01:22, 24 December 2021EweitzStandardize font, weight, case
116635view11:22, 9 May 2021EweitzModified title
115880view12:32, 19 March 2021EgonwCopied the NetPath reference into the literature list
115878view12:15, 19 March 2021EgonwModified description
108329view21:13, 6 December 2019L DupuisConverted interactions to graphical lines in legend
97775view13:38, 7 June 2018AMTanModified description
79264view19:16, 19 March 2015Zarichanged Identifier for STAT5A
78534view10:30, 7 January 2015MaintBotadded missing graphIds
72098view21:39, 24 October 2013Mkutmonadded datasource for "STAT1"
70019view01:51, 12 July 2013AlexanderPicoModified title
67390view10:46, 26 June 2013Christine ChichesterOntology Term : 'interleukin-9 signaling pathway' added !
63215view20:59, 8 May 2013MaintBotUpdating gpml version
48441view14:46, 24 May 2012NetPathModified description
45370view21:00, 7 October 2011AlexanderPicoOntology Term : 'DOID:8406' removed !
45140view01:05, 7 October 2011AlexanderPicofixed db refs
44850view09:48, 6 October 2011MartijnVanIerselOntology Term : 'Interleukin mediated signaling pathway' added !
44629view18:12, 22 September 2011KhanspersUpdating content to NetSlim
44111view20:34, 24 August 2011KhanspersReverted to version '23:15, 1 March 2011' by Khanspers
44012view22:26, 22 August 2011KhanspersModified description
44011view22:23, 22 August 2011KhanspersUpdating pathway from NetSlim
41033view23:15, 1 March 2011MaintBotRemoved redundant pathway information and comments
35647view21:37, 12 February 2010KhanspersModified description
20723view11:29, 14 November 2008MaintBot[[Pathway:Homo sapiens:IL-9 NetPath 20]] moved to [[Pathway:WP22]]: Moved to stable identifier
8200view13:46, 7 January 2008MaintBot[[Pathway:Human:IL-9 NetPath 20]] moved to [[Pathway:Homo sapiens:IL-9 NetPath 20]]: Renaming species
7720view16:13, 18 December 2007MaintBotfixed category names
7259view12:41, 4 November 2007MaintBotAdded categories to GPML
6341view22:18, 22 May 2007A.Pandeygpml file for [[Human:IL-9_NetPath_20]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProduct207 (Entrez Gene)
GRB2GeneProduct2885 (Entrez Gene)
HTATIPGeneProduct10524 (Entrez Gene)
IL2RGGeneProduct3561 (Entrez Gene)
IL9GeneProduct3578 (Entrez Gene)
IL9RGeneProduct3581 (Entrez Gene)
IRS1GeneProduct3667 (Entrez Gene)
IRS2GeneProduct8660 (Entrez Gene)
JAK1GeneProduct3716 (Entrez Gene)
JAK3GeneProduct3718 (Entrez Gene)
MAP2K1GeneProduct5604 (Entrez Gene)
MAP2K2GeneProduct5605 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
PIK3R1GeneProduct5295 (Entrez Gene)
PTPN11GeneProduct5781 (Entrez Gene)
SHC1GeneProduct6464 (Entrez Gene)
SOCS3GeneProduct9021 (Entrez Gene)
STAT1GeneProduct6772 (Entrez Gene)
STAT3GeneProduct6774 (Entrez Gene)
STAT5AGeneProduct6776 (Entrez Gene)
STAT5BGeneProduct6777 (Entrez Gene)
TYK2GeneProduct7297 (Entrez Gene)
VCPGeneProduct7415 (Entrez Gene)

Annotated Interactions

No annotated interactions
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