Male mating (Caenorhabditis elegans)

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225555682, 9466ciliummale sensory neuronPKD-2KIN-3UNC-10110107STAM-1/STAM5RAB-55HGSRS-1/Hrs5PKD-2/PC-27CIL-1UnknownCWP-52ASB-14OSM-1PI(3,5)P2DAF-10ATP-24PI3POSM-58LOV-1/PC-13, 6, 9LOV-1/PC-13, 4, 6, 9PKD-2/PC-23, 6, 7, 9CHE-11OSM-68KAP-18LOV-1/PC-13PKD-2/PC-23, 9CWP-52PKD-2/PC-23, 6, 7, 9, 1024ATP-24ASG-14ASG-14ASB-1488ciliary transition zone96STAM-1/STAM5PKD-2/PC-27PKD-2/PC-27UNC-101KIN-10/CK27KIN-31010KIN-10/CK210KIN-3KIN-10/CK21010KIN-3KIN-10/CK210TAX-6/Calcineurin10PKD-2101010


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Bibliography

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  1. Qin H, Rosenbaum JL, Barr MM; ''An autosomal recessive polycystic kidney disease gene homolog is involved in intraflagellar transport in C. elegans ciliated sensory neurons.''; Curr Biol, 2001 PubMed Europe PMC Scholia
  2. Miller RM, Portman DS; ''A latent capacity of the C. elegans polycystins to disrupt sensory transduction is repressed by the single-pass ciliary membrane protein CWP-5.''; Dis Model Mech, 2010 PubMed Europe PMC Scholia
  3. Bae YK, Qin H, Knobel KM, Hu J, Rosenbaum JL, Barr MM; ''General and cell-type specific mechanisms target TRPP2/PKD-2 to cilia.''; Development, 2006 PubMed Europe PMC Scholia
  4. Barr MM, Garcia LR; ''Male mating behavior.''; WormBook, 2006 PubMed Europe PMC Scholia
  5. Bae YK, Kim E, L'hernault SW, Barr MM; ''''; ,
  6. Hu J, Bae YK, Knobel KM, Barr MM; ''Casein kinase II and calcineurin modulate TRPP function and ciliary localization.''; Mol Biol Cell, 2006 PubMed Europe PMC Scholia
  7. Winyard P, Jenkins D; ''Putative roles of cilia in polycystic kidney disease.''; Biochim Biophys Acta, 2011 PubMed Europe PMC Scholia
  8. Hu J, Barr MM; ''ATP-2 interacts with the PLAT domain of LOV-1 and is involved in Caenorhabditis elegans polycystin signaling.''; Mol Biol Cell, 2005 PubMed Europe PMC Scholia
  9. Barr MM, Sternberg PW; ''A polycystic kidney-disease gene homologue required for male mating behaviour in C. elegans.''; Nature, 1999 PubMed Europe PMC Scholia
  10. Lipton J; ''Mating worms and the cystic kidney: Caenorhabditis elegans as a model for renal disease.''; Pediatr Nephrol, 2005 PubMed Europe PMC Scholia
  11. Müller RU, Zank S, Fabretti F, Benzing T; ''Caenorhabditis elegans, a model organism for kidney research: from cilia to mechanosensation and longevity.''; Curr Opin Nephrol Hypertens, 2011 PubMed Europe PMC Scholia
  12. Bae YK, Kim E, L'hernault SW, Barr MM; ''The CIL-1 PI 5-phosphatase localizes TRP Polycystins to cilia and activates sperm in C. elegans.''; Curr Biol, 2009 PubMed Europe PMC Scholia
  13. Hu J, Wittekind SG, Barr MM; ''STAM and Hrs down-regulate ciliary TRP receptors.''; Mol Biol Cell, 2007 PubMed Europe PMC Scholia
  14. Barr MM, DeModena J, Braun D, Nguyen CQ, Hall DH, Sternberg PW; ''The Caenorhabditis elegans autosomal dominant polycystic kidney disease gene homologs lov-1 and pkd-2 act in the same pathway.''; Curr Biol, 2001 PubMed Europe PMC Scholia

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External references

DataNodes

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NameTypeDatabase referenceComment
ASB-1GeneProductF35G12.10 (WormBase) ASB-1 and ASG-2 localize to male-specific sensory cilia as well as mitochondria.
ASG-1GeneProductK07A12.3 (WormBase) ASB-1 and ASG-2 localize to male-specific sensory cilia as well as mitochondria.
ATP-2GeneProductC34E10.6 (WormBase)
  • ATP-2 is identified as one candidate that physically interacts with the PLAT domain of LOV-1
  • ATP-2 amd other ATP synthase components were found to localize to the cilia of male-specific sensory neurons.
  • ATP-2::GFP clearly colocalizes with PKD-2::DsRed2 in CEM cilia.
CHE-11GeneProductC27A7.4 (WormBase)
CIL-1GeneProductC50C3.7 (WormBase)
CWP-5GeneProductF48C11.2 (WormBase)
DAF-10GeneProductF23B2.4 (WormBase)
HGSRS-1/HrsGeneProductC07G1.5 (WormBase) STAM-1 and HGRS-1 expression completely overlaps in cell bodies and ciliary bases of polysystin-expressing neurons.
KAP-1GeneProductF08F8.3 (WormBase) IFT Complex A poly peptides , DAF-10 and CHE-11 move and that motility is at the same rate as IFT Complex B polypeptides, OSM-1, OSM-5 and OSM-6, and KAP (a subunit of the kinesin motor).
KIN-10/CK2GeneProductT01G9.6 (WormBase)
  • kin-3 and kin-10 are coexpressed with lov-1 and pkd-2 in the male-specific CEM head neurons and ray RnB and hook HOB tail neurons
  • KIN-3::GFP and KIN-10 GFP are enriched in cilia and also found in cell bodies (including nuclei), dendrites, and axons.
KIN-3GeneProductB0205.7 (WormBase)
  • kin-3 and kin-10 are coexpressed with lov-1 and pkd-2 in the male-specific CEM head neurons and ray RnB and hook HOB tail neurons
  • KIN-3::GFP and KIN-10 GFP are enriched in cilia and also found in cell bodies (including nuclei), dendrites, and axons.
LOV-1/PC-1GeneProductZK945.9 (WormBase) LOV-1 localizes to intracellular membranes
OSM-1GeneProductT27B1.1 (WormBase)
OSM-5GeneProductY41G9A.1 (WormBase) OSM-5 localizes to cilia through its TPR repeats through intraflagellar transport
OSM-6GeneProductR31.3 (WormBase)
PI(3,5)P2Metabolite
PI3PMetabolite
PKD-2/PC-2GeneProductY73F8A.1 (WormBase) PKD-2 is synthesized in the ER and packaged into vesicles that are transported to the ciliary base and inserted onto the ciliary membrane.
PKD-2GeneProductY73F8A.1 (WormBase)
  • PKD-2 phosphorylation state appears to modulate its function and ciliary localization, with S534A and S534D reflecting two extreme states.
  • CK2-phosphorylated PKD-2 is dephosphorylated by calcineurin.
RAB-5GeneProductF26H9.6 (WormBase) STAM-1 and RAB-5 collocate in the cell bodies and ciliary bases of polycystin-expressing neurons.
STAM-1/STAMGeneProductC34G6.7 (WormBase) GFP-tagged STAM-1 fusion protein localized to cytoplasmic and dendritic puncta resembling endosomes
TAX-6/CalcineurinGeneProductC02F4.2 (WormBase)
  • TAX-6::GFP also localizes to cilia of these polycystin-expressing neurons
  • CK and calcineurin/protein phosphatase 2B(PP2B) modulate PKD-2 function and ciliary localization
  • CK2 and calcineurin function antagonistically to regulate PKD-2 phosphorylation state
  • CK2 phosphorylated PKD-2 is dephosphorylated by calcineurin
  • In the male, we observed tax-6 expression in the CEM, HOB, and ray RnB neurons, with expression noticeably absent from ray 6, which is very similar to lov-1 and pkd-2 expression patterns
UNC-101GeneProductK11D2.3 (WormBase) UNC-101 acts at a somatodendritic sorting step to restrict PKFD-2, along with other ciliary receptors, to the dendritic compartment.
Unknown

Annotated Interactions

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