Corticotropin-releasing hormone signaling pathway (Homo sapiens)

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PRKCQP390NOcGMPActivated inkeratinocytesthymocytesCYNUCYGuanylateRegulation of CRHCyclaseCorticotropin-Releasing Hormone Signaling PathwayNUENPlacentalvesselvasodilationProinflammatory effect in leukocutesInhibited inmelanocytespituitary corticotrophspituitary tumor cellsFatty acidoxidationNUAdenylateNUCYENDesensitizationIncreased gap junctionsNeuroprotectionVEGF releasein mast cellsFASL releasein PC12 cellsCYPMRecycling of receptorsApoptosis inMicroglial cellsHippocampal neuronsProstate cancer cellsNUCYDehydroepiandrosterone sulfate and cortisol productionKeratinocytedifferentiationand proliferationCell survivalNUCYNUPMCYNeuronalsurvivalInhibits Cell proliferationJUNDTLR4FOSL2PTK2FOSNCOA2PRKAA2IL18CACNA1HFOSBNR4A1FOSL1JUNBTRIM28IL8RHOANOS3PRKACRHBPNR4A1SP1ACACAJUNCRHS80PT172PRKCIPPRKCDPHSD3B1TCF4TFAP2ACTNNB1ACTH productionMAPK3T204T202IL2KRT1MAPK9T183Y185NR4A2CRHR2MAPK1CRHY187Y185SP1CYP11A1HSP90AA1IVLCRHR1S386S301NR4A1S412CRHTFAP2ACRHR1EPACCTNNB1KRT14Enzyme complexTranslocation DeubiquitinationActivationInhibitionAcetylationNegative regulation of gene expressionLEGENDLeads to through unknown mechanismPhosphorylationProtein-protein interactionTransportUbiquitinationDephosphorylationInduced catalysisAuto catalysisSumoylationPositive regulation of gene expressionReceptorLigandmRNAProteinProteinDeacetylationGolgi apparatusEndosomeNucleusMitochondrionDesumoylationMethylationDemethylationPalmitoylationCytoplasmECPlasma membraneMTEndoplasmic reticulumCYPMGONUExtracellularERENProteolytic cleavageRELAPRKCBPPRKCAPGNAQCREB1S133PRKAcAMPGNB5GNB3GNB2GNB1ADRBK2GNA11GNAO1GNASGNAI2GNAI1DAGIP3PIP2MAP2K1BRAFRAP1BPLCB3PLCG2S537PPLCG1PGSK3BS9PARP1PCCASP9PCCASP3PCCASP12PCMAPK8Y185T183MAP3K5PERNPCYP21A2CYP17A1STARCYP11B1CYP11A1CAMK2AHSD3B2GRK6ADRBK2ECE1NFKBIAPCGJA1CRHR2ARRB1SULT2A1ADRBK2CRHARRB2RELABCL2PI3KAKT1S473POMCNR4A2FOSCalciumPMCYARRB1ARRB2PMCYECE1CRHCRHR1CRHR2CRHCRHR1T399CRHCyclaseGNAZELK1TBX19FOSG-gammaInhibits Progesterone synthesis in Placental trophoblastspathwayDegradationand dissociationof NFKBsNFKB1NFKB1NFKB1MAPK14Y182T180NR4A1AP-1 complexClathrin and arrestin mediated endocytosisENPMPro-inflammatorycytokine productionCRHCRHBP


Description

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Comments

 
NetPath - Corticotropin-releasing hormone. NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.

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Quality Tags

Ontology Terms

 

Bibliography

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History

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CompareRevisionActionTimeUserComment
126374view17:53, 25 April 2023EgonwLicense is CCZero (more specific)
120664view00:03, 23 December 2021EweitzStandardize font weight
120662view21:46, 22 December 2021EweitzUse standard font, refine graphics
108254view14:14, 3 December 2019L DupuisConverted interactions to graphical lines in legend
108206view11:02, 29 November 2019FehrhartOntology Term : 'Alzheimer's disease' added !
108205view11:02, 29 November 2019FehrhartOntology Term : 'Parkinson's disease' added !
108204view11:01, 29 November 2019FehrhartOntology Term : 'major depressive disorder' added !
108203view11:01, 29 November 2019FehrhartOntology Term : 'anorexia nervosa' added !
106369view00:54, 23 August 2019KhanspersModified description
105563view06:19, 9 August 2019KhanspersModified description
97622view07:46, 31 May 2018AMTanModified description
94191view14:21, 25 August 2017Mkutmonadded missing metabolite identifier
94190view14:16, 25 August 2017Mkutmonadded missing metabolite identifiers
90017view19:26, 8 October 2016AlexanderPicoModified description
89805view11:41, 6 October 2016Mkutmonfixed special characters in description
88987view11:26, 18 August 2016MirellaKalafatiModified title
79973view07:00, 29 April 2015Zariannotated IL8,CYP11A1 and changed box for protein and mRNA
79562view15:34, 25 March 2015Zariadded ID for EPAC gene
78490view10:28, 7 January 2015MaintBotadded missing graphIds
71393view18:58, 17 October 2013MaintBotRemoved source from datanodes with empty id
67947view09:32, 28 June 2013DdiglesOntology Term : 'corticotropin-releasing hormone signaling pathway' added !
63171view20:28, 8 May 2013MaintBotUpdating gpml version
61292view21:59, 6 April 2013MaintBot
61291view21:58, 6 April 2013MaintBot
61290view21:56, 6 April 2013MaintBotremoved old publication references
61233view17:33, 5 April 2013MaintBotupdated pathway elements from provided gpml
57669view20:15, 31 January 2013KhanspersModified categories
57322view15:26, 25 January 2013NetPathSpecify description
53380view04:50, 6 November 2012NetPathModified description
53379view04:46, 6 November 2012NetPathModified description
53378view04:41, 6 November 2012NetPathNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACACAGeneProduct31 (Entrez Gene)
ACTH production
ADRBK2GeneProduct157 (Entrez Gene)
AKT1GeneProduct207 (Entrez Gene)
ARRB1GeneProduct408 (Entrez Gene)
ARRB2GeneProduct409 (Entrez Gene)
BCL2GeneProduct596 (Entrez Gene)
BRAFGeneProduct673 (Entrez Gene)
CACNA1HGeneProduct8912 (Entrez Gene)
CAMK2AGeneProduct815 (Entrez Gene)
CASP12GeneProduct100506742 (Entrez Gene)
CASP3GeneProduct836 (Entrez Gene)
CASP9GeneProduct842 (Entrez Gene)
CREB1GeneProduct1385 (Entrez Gene)
CRHGeneProduct1392 (Entrez Gene)
CRHBPGeneProduct1393 (Entrez Gene)
CRHR1GeneProduct1394 (Entrez Gene)
CRHR2GeneProduct1395 (Entrez Gene)
CTNNB1GeneProduct1499 (Entrez Gene)
CYP11A1GeneProduct1583 (Entrez Gene)
CYP11A1GeneProduct
CYP11B1GeneProduct1584 (Entrez Gene)
CYP17A1GeneProduct1584 (Entrez Gene)
CYP21A2GeneProduct1589 (Entrez Gene)
CalciumMetabolite
DAGMetabolite
ECE1GeneProduct1889 (Entrez Gene)
ELK1GeneProduct2002 (Entrez Gene)
EPACGeneProduct
ERNGeneProduct2081 (Entrez Gene)
FOSGeneProduct2353 (Entrez Gene)
FOSBGeneProduct2354 (Entrez Gene)
FOSL1GeneProduct8061 (Entrez Gene)
FOSL2GeneProduct2355 (Entrez Gene)
G-gamma
GJA1GeneProduct2697 (Entrez Gene)
GNA11GeneProduct2767 (Entrez Gene)
GNAI1GeneProduct2770 (Entrez Gene)
GNAI2GeneProduct2771 (Entrez Gene)
GNAO1GeneProduct2775 (Entrez Gene)
GNAQGeneProduct2776 (Entrez Gene)
GNASGeneProduct2778 (Entrez Gene)
GNAZGeneProduct2781 (Entrez Gene)
GNB1GeneProduct2782 (Entrez Gene)
GNB2GeneProduct2783 (Entrez Gene)
GNB3GeneProduct2784 (Entrez Gene)
GNB5GeneProduct10681 (Entrez Gene)
GRK6GeneProduct2870 (Entrez Gene)
GSK3BGeneProduct2932 (Entrez Gene)
HSD3B1GeneProduct3283 (Entrez Gene)
HSD3B2GeneProduct3284 (Entrez Gene)
HSP90AA1GeneProduct3320 (Entrez Gene)
IL18GeneProduct3606 (Entrez Gene)
IL2GeneProduct3558 (Entrez Gene)
IL8GeneProduct
IP3Metabolite
IVLGeneProduct3713 (Entrez Gene)
JUNGeneProduct3726 (Entrez Gene)
JUNBGeneProduct3727 (Entrez Gene)
JUNDGeneProduct3728 (Entrez Gene)
KRT1GeneProduct3848 (Entrez Gene)
KRT14GeneProduct3861 (Entrez Gene)
LigandGeneProduct7040 (Entrez Gene)
MAP2K1GeneProduct5604 (Entrez Gene)
MAP3K5GeneProduct4217 (Entrez Gene)
MAPK14GeneProduct1432 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
MAPK8GeneProduct5599 (Entrez Gene)
MAPK9GeneProduct5601 (Entrez Gene)
NCOA2GeneProduct10499 (Entrez Gene)
NFKB1GeneProduct4790 (Entrez Gene)
NFKBIAGeneProduct4792 (Entrez Gene)
NOS3GeneProduct4846 (Entrez Gene)
NR4A1GeneProduct3164 (Entrez Gene)
NR4A2GeneProduct4929 (Entrez Gene)
PARP1GeneProduct142 (Entrez Gene)
PI3K
PIP2Metabolite
PLCB3GeneProduct1394 (Entrez Gene)
PLCG1GeneProduct5335 (Entrez Gene)
PLCG2GeneProduct5336 (Entrez Gene)
POMCGeneProduct5443 (Entrez Gene)
PRKAA2GeneProduct5563 (Entrez Gene)
PRKAGeneProduct
PRKCAGeneProduct5578 (Entrez Gene)
PRKCBGeneProduct5579 (Entrez Gene)
PRKCDGeneProduct5580 (Entrez Gene)
PRKCIGeneProduct5584 (Entrez Gene)
PRKCQGeneProduct5588 (Entrez Gene)
PTK2GeneProduct5747 (Entrez Gene)
ProteinProtein5894 (Entrez Gene)
ProteinProtein
RAP1BGeneProduct5908 (Entrez Gene)
RELAGeneProduct5970 (Entrez Gene)
RHOAGeneProduct387 (Entrez Gene)
ReceptorGeneProduct7040 (Entrez Gene)
SP1GeneProduct6667 (Entrez Gene)
STARGeneProduct6770 (Entrez Gene)
SULT2A1GeneProduct6822 (Entrez Gene)
TBX19GeneProduct9095 (Entrez Gene)
TCF4GeneProduct6925 (Entrez Gene)
TFAP2AGeneProduct7020 (Entrez Gene)
TLR4GeneProduct7099 (Entrez Gene)
TRIM28GeneProduct10155 (Entrez Gene)
cAMPMetabolite
mRNAProtein

Annotated Interactions

No annotated interactions
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