Oncostatin M signaling pathway (Homo sapiens)

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JUNDKRASGTPMAPK9MAPK8T183Y185MAP2K1S218LIFRPJAK2Y1007Y1007PRKCHPPRKCEPPRKCBPPRKCAPIL6STY759MAP2K2S222S226STAT3Y705STAT1Y701IL6STY782DissociationAdrenocortical Y-1 cells Mammary epithelial cells In astrocytes,adipose tissues,VSMCs, and inlung carcinomaSensitization of osteosarcoma cellsto apoptosisMEKdependentOncostatin M Signaling PathwayApoptosis in VEGFAHIF1AJAK1Y1022Y1023MAPK14Y180Y182JAK3Y980TYK2Y1055Y1054RELAPMAPK3Y202Y204SOCS3OSMRY861PTPN11Y542Y580MAPK1Y185Y187STAT1Y701PIAS3STAT5BSTAT5BY699CASP3OSMSOS1GRB2SHC1PIRS1PSRCY419STAT3S727Y705RAF1S338HRASGTPPIK3R1AKT1T308S473OSMSTAT3Y705STAT1Y701FOSPXNPTK2BPCDK2CDKN1BCEBPBPRPS6S235S236JUNBPSTAT3PRKCDPMTORMMP13TP53STAT1STAT5BRICTORCREB1S133CYR61EGR1LDLREGR1CCL2MMP1MMP3NFKB1NFKBIAPUbRELANFKB1SERPINE1TIMP3CYNUCYNUCYNUCYNUCYNUCYNUCYNUIncrease in proliferationRegulation ofblood cholesterolIncrease in proliferationRegulation of osteoblastdifferentiationand activityCytoskeletonreorganizationSTAT5BY699STAT3Y705STAT1Y701MAPK3Y202Y204MAPK1Y187Y185Plaqueangiogenesis and destabilization incoronary arteryand arotic smoothmuscle cellsIn humanosteoblasts andU2OS cellsCartilagedegradationGrowthinhibitionin MCF-7cellsCASP7ProteinReceptorProteinProteinmRNALigandInduced activationEnzyme complexInhibitionTransportPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionTranslocation Induced catalysisProtein-protein interaction (PPI)LEGENDPhosphorylationNucleusCytoplasmCYNUActivationCASP9Dissociation of PPI


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Bibliography

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  1. O'Hara KA, Kedda MA, Thompson PJ, Knight DA; ''Oncostatin M: an interleukin-6-like cytokine relevant to airway remodelling and the pathogenesis of asthma.''; Clin Exp Allergy, 2003 PubMed Europe PMC Scholia
  2. Halfter H, Friedrich M, Postert C, Ringelstein EB, Stögbauer F; ''Activation of Jak-Stat and MAPK2 pathways by oncostatin M leads to growth inhibition of human glioma cells.''; Mol Cell Biol Res Commun, 1999 PubMed Europe PMC Scholia
  3. Halfter H, Postert C, Friedrich M, Ringelstein EB, Stögbauer F; ''Activation of the Jak-Stat- and MAPK-pathways by oncostatin M is not sufficient to cause growth inhibition of human glioma cells.''; Brain Res Mol Brain Res, 2000 PubMed Europe PMC Scholia
  4. Stross C, Radtke S, Clahsen T, Gerlach C, Volkmer-Engert R, Schaper F, Heinrich PC, Hermanns HM; ''Oncostatin M receptor-mediated signal transduction is negatively regulated by SOCS3 through a receptor tyrosine-independent mechanism.''; J Biol Chem, 2006 PubMed Europe PMC Scholia
  5. Brantley EC, Benveniste EN; ''Signal transducer and activator of transcription-3: a molecular hub for signaling pathways in gliomas.''; Mol Cancer Res, 2008 PubMed Europe PMC Scholia
  6. Fritz DK, Kerr C, Tong L, Smyth D, Richards CD; ''Oncostatin-M up-regulates VCAM-1 and synergizes with IL-4 in eotaxin expression: involvement of STAT6.''; J Immunol, 2006 PubMed Europe PMC Scholia
  7. Migita K, Komori A, Torigoshi T, Maeda Y, Izumi Y, Jiuchi Y, Miyashita T, Nakamura M, Motokawa S, Ishibashi H; ''CP690,550 inhibits oncostatin M-induced JAK/STAT signaling pathway in rheumatoid synoviocytes.''; Arthritis Res Ther, 2011 PubMed Europe PMC Scholia
  8. Hintzen C, Evers C, Lippok BE, Volkmer R, Heinrich PC, Radtke S, Hermanns HM; ''Box 2 region of the oncostatin M receptor determines specificity for recruitment of Janus kinases and STAT5 activation.''; J Biol Chem, 2008 PubMed Europe PMC Scholia
  9. Zhang F, Lin M, Abidi P, Thiel G, Liu J; ''Specific interaction of Egr1 and c/EBPbeta leads to the transcriptional activation of the human low density lipoprotein receptor gene.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  10. Chung CD, Liao J, Liu B, Rao X, Jay P, Berta P, Shuai K; ''Specific inhibition of Stat3 signal transduction by PIAS3.''; Science, 1997 PubMed Europe PMC Scholia
  11. Li WQ, Dehnade F, Zafarullah M; ''Oncostatin M-induced matrix metalloproteinase and tissue inhibitor of metalloproteinase-3 genes expression in chondrocytes requires Janus kinase/STAT signaling pathway.''; J Immunol, 2001 PubMed Europe PMC Scholia
  12. Auernhammer CJ, Dorn F, Vlotides G, Hengge S, Kopp FB, Spoettl G, Cengic N, Engelhardt D, Weber MM; ''The oncostatin M receptor/gp130 ligand murine oncostatin M induces apoptosis in adrenocortical Y-1 tumor cells.''; J Endocrinol, 2004 PubMed Europe PMC Scholia
  13. Tiffen PG, Omidvar N, Marquez-Almuina N, Croston D, Watson CJ, Clarkson RW; ''A dual role for oncostatin M signaling in the differentiation and death of mammary epithelial cells in vivo.''; Mol Endocrinol, 2008 PubMed Europe PMC Scholia
  14. Chipoy C, Brounais B, Trichet V, Battaglia S, Berreur M, Oliver L, Juin P, Rédini F, Heymann D, Blanchard F; ''Sensitization of osteosarcoma cells to apoptosis by oncostatin M depends on STAT5 and p53.''; Oncogene, 2007 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
126376view17:54, 25 April 2023EgonwLicense is CCZero
120781view22:39, 4 January 2022KhanspersModified description
120780view22:34, 4 January 2022Khanspersadded lit refs, fixed interactions, updated legend to graphical objects
120726view01:39, 24 December 2021EweitzStandardize font, weight, case
116728view10:26, 11 May 2021EweitzModified title
106575view21:21, 6 September 2019KhanspersModified description
105763view19:34, 15 August 2019KhanspersModified description
98073view17:40, 16 July 2018AlexanderPicoReverted edits by [[Special:Contributions/Mechebek maghnaui|Mechebek maghnaui]] ([[User talk:Mechebek maghnaui|Talk]]) to last version by [[User:AlexanderPico|AlexanderPico]]
98061view15:16, 13 July 2018Mechebek maghnauiModified title
92557view00:09, 16 June 2017AlexanderPicoFixed 0 widths and heights by removing "hidden" elements
92556view00:08, 16 June 2017AlexanderPicoFixed 0 widths and heights
73668view20:34, 13 February 2014MaintBotFixing labels with red fill color
72050view17:00, 24 October 2013Mkutmonupdated annotations for HIF1A and VEGFA
71378view18:39, 17 October 2013MaintBotAutomated update of data sources
67549view11:24, 26 June 2013DdiglesOntology Term : 'oncostatin M signaling pathway' added !
61293view22:00, 6 April 2013MaintBotremoved old publication references
61234view17:35, 5 April 2013MaintBotupdated pathway elements from provided gpml
57683view20:52, 31 January 2013KhanspersModified categories
54418view11:10, 29 November 2012MaintBotOntology Term : 'osteosarcoma' added !
54417view11:09, 29 November 2012MaintBotOntology Term : 'lymphocyte' added !
54416view11:08, 29 November 2012MaintBotOntology Term : 'cytokine mediated signaling pathway' added !
54197view13:32, 23 November 2012NetPathModified description
54196view13:30, 23 November 2012NetPathModified description
54195view13:29, 23 November 2012NetPathNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1Protein207 (Entrez Gene)
CASP3Protein836 (Entrez Gene)
CASP7Protein840 (Entrez Gene)
CASP9Protein840 (Entrez Gene)
CCL2Rna6347 (Entrez Gene)
CDK2Protein1017 (Entrez Gene)
CDKN1BProtein1027 (Entrez Gene)
CEBPBProtein1051 (Entrez Gene)
CREB1Protein1385 (Entrez Gene)
CYR61Rna3491 (Entrez Gene)
EGR1Rna1958 (Entrez Gene)
FOSProtein2353 (Entrez Gene)
GRB2Protein2885 (Entrez Gene)
HIF1ARna
HRASProtein3265 (Entrez Gene)
IL6STProtein3572 (Entrez Gene)
IRS1Protein3667 (Entrez Gene)
JAK1Protein3716 (Entrez Gene)
JAK2Protein3717 (Entrez Gene)
JAK3Protein3718 (Entrez Gene)
JUNBProtein3726 (Entrez Gene)
JUNDProtein3727 (Entrez Gene)
KRASProtein3845 (Entrez Gene)
LDLRRna3949 (Entrez Gene)
LIFRProtein3977 (Entrez Gene)
MAP2K1Protein5604 (Entrez Gene)
MAP2K2Protein5605 (Entrez Gene)
MAPK14Protein1432 (Entrez Gene)
MAPK1Protein5594 (Entrez Gene)
MAPK3Protein5595 (Entrez Gene)
MAPK8Protein5599 (Entrez Gene)
MAPK9Protein5601 (Entrez Gene)
MMP13Rna4322 (Entrez Gene)
MMP1Rna4312 (Entrez Gene)
MMP3Rna4314 (Entrez Gene)
MTORProtein2475 (Entrez Gene)
NFKB1Protein4790 (Entrez Gene)
NFKBIAProtein4792 (Entrez Gene)
OSMProtein5008 (Entrez Gene)
OSMRProtein9180 (Entrez Gene)
PIAS3Protein10401 (Entrez Gene)
PIK3R1Protein5295 (Entrez Gene)
PRKCAProtein5578 (Entrez Gene)
PRKCBProtein5579 (Entrez Gene)
PRKCDProtein5580 (Entrez Gene)
PRKCEProtein5581 (Entrez Gene)
PRKCHProtein5583 (Entrez Gene)
PTK2BProtein2185 (Entrez Gene)
PTPN11Protein5781 (Entrez Gene)
PXNProtein5829 (Entrez Gene)
RAF1Protein5894 (Entrez Gene)
RELAProtein5970 (Entrez Gene)
RICTORProtein253260 (Entrez Gene)
RPS6Protein6194 (Entrez Gene)
SERPINE1Rna5054 (Entrez Gene)
SHC1Protein6464 (Entrez Gene)
SOCS3Protein9021 (Entrez Gene)
SOS1Protein6654 (Entrez Gene)
SRCProtein6714 (Entrez Gene)
STAT1Protein6772 (Entrez Gene)
STAT3Protein6774 (Entrez Gene)
STAT5BProtein6777 (Entrez Gene)
TIMP3Rna7078 (Entrez Gene)
TP53Rna7157 (Entrez Gene)
TYK2Protein7297 (Entrez Gene)
VEGFARna

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP2374"