Alpha 6 beta 4 signaling pathway (Homo sapiens)

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122, 234, 23623423423410229440, 45, 15647, 41475, 221, 25893, 125267, 37245, 15619, 414406303, 41443647, 104, 294, 414264, 406125, 162116, 432cytoskeletalAlpha 6 Beta 4 Signal Transduction PathwayCofilinorganisationRegulation of LAMB1PIK3R1LAMA2LAMA2ITGB4RHOAPRKCALAMC1MTORMAPK1ITGA6RAC1HRASLAMB2PIK3R2LAMA1GAB1GRB2LAMB2LAMB1MAPK14ITGA6ITGA6SHC1SRCITGA6ITGB4IRS1LAMB1PTPN11LAMC1AKT1PRKCDITGB4LAMC2LAMA5ITGB4ITGB4ITGB4LAMC1MAPK3IRS2EIF4EBP1LAMA5LAMB3LAMC1SOS1LAMA3LAMC1ITGA6PTK2ITGA6PP122, 162, 311, 4054064515642143693125, 267227125, 21993Enzyme complexAcetylationDephosphorylationInhibitionLEGENDSumoylationUbiquitinationNegative regulation of gene expressionDeubiquitinationAuto catalysisPositive regulation of gene expressionPhosphorylationInduced catalysisTranslocation TransportActivationProtein-protein interactionLeads to through unknown mechanismReceptorProteinProteinLigandmRNADeacetylationGolgi apparatusEndosomeNucleusMitochondrionDesumoylationMethylationDemethylationPalmitoylationCytoplasmECPlasma membraneMTEndoplasmic reticulumCYPMGONUExtracellularERENProteolytic cleavage


Description

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Ontology Terms

 

Bibliography

  1. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A; ''NetPath: a public resource of curated signal transduction pathways.''; Genome Biol, 2010 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
126340view09:03, 23 April 2023EgonwLicense is CCZero
120686view12:26, 23 December 2021EweitzStandardize font, weight, case
117645view11:42, 22 May 2021EweitzModified title
115920view16:59, 20 March 2021EgonwCopied the NetPath paper into the literature list
115915view14:44, 20 March 2021EgonwModified description
108319view20:44, 6 December 2019L DupuisConnected line
108318view20:44, 6 December 2019L DupuisConverted interactions to graphical lines in legend
85199view08:27, 25 April 2016EgonwReplaced a mim-conversion with Arrow.
78506view10:29, 7 January 2015MaintBotadded missing graphIds
72056view17:13, 24 October 2013Mkutmonupdated annotations for SOS1 and GRB2
71703view19:54, 17 October 2013MaintBotremoved data source from nodes without identifier
63141view19:17, 8 May 2013MaintBotUpdating GPML version
44947view12:32, 6 October 2011MartijnVanIerselOntology Term : 'integrin mediated signaling pathway' added !
44577view20:33, 20 September 2011MaintBotModified categories
44576view20:32, 20 September 2011MaintBot
44575view20:32, 20 September 2011MaintBotUpdating content to NetSlim
44117view20:47, 24 August 2011KhanspersReverted to version '23:41, 1 March 2011' by Khanspers
44044view23:33, 22 August 2011KhanspersModified description
44043view23:32, 22 August 2011KhanspersUpdating pathway from NetSlim
41155view23:41, 1 March 2011MaintBotRemoved redundant pathway information and comments
35307view00:07, 12 February 2010Nsalomonisconnected some lines
35298view23:12, 11 February 2010NsalomonisModified description
35283view22:44, 11 February 2010Nsalomonisin progress
35242view19:49, 11 February 2010NsalomonisModified description
21193view11:31, 14 November 2008MaintBot[[Pathway:Homo sapiens:Alpha6-Beta4-Integrin NetPath 1]] moved to [[Pathway:WP244]]: Moved to stable identifier
7896view13:46, 7 January 2008MaintBot[[Pathway:Human:Alpha6-Beta4-Integrin NetPath 1]] moved to [[Pathway:Homo sapiens:Alpha6-Beta4-Integrin NetPath 1]]: Renaming species
7573view16:00, 18 December 2007MaintBotfixed category names
7192view12:33, 4 November 2007MaintBotAdded categories to GPML
6896view12:04, 23 July 2007212.48.140.65
6293view22:17, 22 May 2007A.Pandeygpml file for [[Human:Alpha6-Beta4-Integrin_NetPath_1]]

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1GeneProduct207 (Entrez Gene)
EIF4EBP1GeneProduct1978 (Entrez Gene)
GAB1GeneProduct2549 (Entrez Gene)
GRB2GeneProduct2885
HRASGeneProduct3265 (Entrez Gene)
IRS1GeneProduct3667 (Entrez Gene)
IRS2GeneProduct8660 (Entrez Gene)
ITGA6GeneProduct3655 (Entrez Gene) ITGB4 interacts with ITGA6 in PA-JEB keratinocytes, 804G cells,MDA-MB-435 cells and HUVECs.
ITGB4GeneProduct3691 (Entrez Gene)
LAMA1GeneProduct284217 (Entrez Gene)
LAMA2GeneProduct3908 (Entrez Gene)
LAMA3GeneProduct3909 (Entrez Gene)
LAMA5GeneProduct3911 (Entrez Gene)
LAMB1GeneProduct3912 (Entrez Gene)
LAMB2GeneProduct3913 (Entrez Gene)
LAMB3GeneProduct3914 (Entrez Gene)
LAMC1GeneProduct3915 (Entrez Gene)
LAMC2GeneProduct3918 (Entrez Gene)
LigandGeneProduct7040 (Entrez Gene)
MAPK14GeneProduct1432 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
MTORGeneProduct2475 (Entrez Gene)
PIK3R1GeneProduct5295 (Entrez Gene)
PIK3R2GeneProduct5296 (Entrez Gene)
PRKCAGeneProduct5578 (Entrez Gene)
PRKCDGeneProduct5580 (Entrez Gene)
PTK2GeneProduct5747 (Entrez Gene)
PTPN11GeneProduct5781 (Entrez Gene)
ProteinProtein5894 (Entrez Gene)
ProteinProtein
RAC1GeneProduct5879 (Entrez Gene)
RHOAGeneProduct387 (Entrez Gene)
ReceptorGeneProduct7040 (Entrez Gene)
SHC1GeneProduct6464 (Entrez Gene)
SOS1GeneProduct
SRCGeneProduct6714 (Entrez Gene)
mRNAProtein

Annotated Interactions

No annotated interactions

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