Androgen receptor signaling pathway (Mus musculus)

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1-7PMMitochondrionEndosomeDeSumoylationGOCY->NUDCY->NUPDNucleusAndrogen (T/DHT)DeubiquitinationMolecular associationECDInhibitionLigandProteolytic CleavageReceptorDProteins in a complex interactionActivationPalmitoylationDemethylationAcetylationCY->NUUbiquitination(Protein-protein interaction)Androgen IndependentRecruitmentGlycosylationAutophosphorylationPNUSumoylationMethylationDephosphorylationGolgi appparatusDeacetylationCY->NUMTCYENEnzyme complexPPlasma membraneExtracellularAndrogen IndependentPhosphorylationERReactions through unknown mechanisms/moleculesTranslocationDEndoplasmic reticulumCytoplasmGene SymbolAccession Number: NetPath 2; cellmap:2ControlMolecule in the pathwayPPSin3aTgfb1i1Hmgb2SrcHdac1Pa2g4Tgif1Cdk7JunNr3c1Psmc3ipCdk9Gtf2h1FlnaCasp8Pnrc1Ctdp1Il6PLAGL1Ncoa3Ncoa1Patz1YwhahArMmp1aMapk1CrebbpCav1Casp1Mapk1Pias4Pias1Bag1CcnhHSPA1ANr3c1Nsd1RUNX1Igf1Smad4RanPxnCcnd1Brca1Hmg1l1Cdc37Gtf2f2Rb1Rchy1COX5BArRchy1Nr2c2Smad3Gm13882Ep300Rnf14Myst2Kat5Stat3Ncoa2Fhl2Tmf1Cdc2aCasp3EgfrAkt1Stub1Pou2f2Ncor2Esr2Ccne1Nr0b2Hipk3Pias2Il6stArJunPrmt1Rac3Prmt1Gstt2Raf1Gtf2f1Map2k1NCOA4ArSlc25a4UxtUbe3aCasp7Atf2Etv5Trp53AesRASSpdefSp1Esr1Runx2Pou2f1Rb1Nr5a1Esr1Appl1Cdc25bArRnf4SRYPnrc1PtenRelaNr0b1PCAFRad54l2Pak6SvilFlnaUbe2iRanbp9GhrMdm2Pias3CalrSenp1Ctnnb1Nrip1Akt1


Description

The androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among others, dimerize and bind to DNA. Its ligands include testosterone, dehydroepiandrosterone and androstenedione. Stimulation of the receptor activates the SMAD signaling module. Source: http://www.netpath.org/pathways?path_id=NetPath_2

Comments

GenMAPP notes 
NetPath:2; cellmap:2 - Androgen Receptor Signaling Pathway. The Androgen Receptor signaling pathway was kindly reviewed by Liying Zhang and William Gerald. This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP138(r20973) with a 93% conversion rate.

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Bibliography

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  1. Mooradian AD, Morley JE, Korenman SG; ''Biological actions of androgens.''; Endocr Rev, 1987 PubMed Europe PMC Scholia
  2. Bardin CW, Brown T, Isomaa VV, Jänne OA; ''Progestins can mimic, inhibit and potentiate the actions of androgens.''; Pharmacol Ther, 1983 PubMed Europe PMC Scholia
  3. Holterhus PM, Piefke S, Hiort O; ''Anabolic steroids, testosterone-precursors and virilizing androgens induce distinct activation profiles of androgen responsive promoter constructs.''; J Steroid Biochem Mol Biol, 2002 PubMed Europe PMC Scholia
  4. Heinlein CA, Chang C; ''The roles of androgen receptors and androgen-binding proteins in nongenomic androgen actions.''; Mol Endocrinol, 2002 PubMed Europe PMC Scholia
  5. Roy AK, Lavrovsky Y, Song CS, Chen S, Jung MH, Velu NK, Bi BY, Chatterjee B; ''Regulation of androgen action.''; Vitam Horm, 1999 PubMed Europe PMC Scholia
  6. Raudrant D, Rabe T; ''Progestogens with antiandrogenic properties.''; Drugs, 2003 PubMed Europe PMC Scholia
  7. Davison SL, Bell R; ''Androgen physiology.''; Semin Reprod Med, 2006 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
117994view11:24, 23 May 2021EweitzModified title
108334view11:43, 7 December 2019L DupuisConverted interactions to graphical lines in legend
73768view00:54, 22 February 2014MaintBotupdated schema
71763view20:28, 17 October 2013MaintBotremoved data source from nodes without identifier
67044view09:58, 26 June 2013Christine ChichesterOntology Term : 'androgen signaling pathway' added !
47768view05:26, 6 April 2012Khanspersupdated xref
41267view00:21, 2 March 2011MaintBotRemoved redundant pathway information and comments
35669view22:44, 12 February 2010AlexanderPico
35668view22:41, 12 February 2010AlexanderPicodescription and refs
34378view22:45, 9 December 2009MaintBotAutomatic update of empty xrefs
31414view20:55, 13 August 2009MaintBotFixed text labels
30854view00:08, 30 July 2009MaintBotConverted from Homo sapiens
21209view11:31, 14 November 2008MaintBot[[Pathway:Mus musculus:Androgen-Receptor NetPath 2]] moved to [[Pathway:WP252]]: Moved to stable identifier
7904view13:46, 7 January 2008MaintBot[[Pathway:Mouse:Androgen-Receptor NetPath 2]] moved to [[Pathway:Mus musculus:Androgen-Receptor NetPath 2]]: Renaming species
7577view16:01, 18 December 2007MaintBotfixed category names
7196view12:33, 4 November 2007MaintBotAdded categories to GPML
6414view22:18, 22 May 2007A.Pandeygpml file for [[Mouse:Androgen-Receptor_NetPath_2]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AesGeneProduct14797 (Entrez Gene)
Akt1GeneProduct11651 (Entrez Gene)
Appl1GeneProduct72993 (Entrez Gene)
ArGeneProduct11835 (Entrez Gene)
Atf2GeneProduct11909 (Entrez Gene)
Bag1GeneProduct12017 (Entrez Gene)
Brca1GeneProduct12189 (Entrez Gene)
COX5BGeneProduct12859 (Entrez Gene)
CalrGeneProduct12317 (Entrez Gene)
Casp1GeneProduct12362 (Entrez Gene)
Casp3GeneProduct12367 (Entrez Gene)
Casp7GeneProduct12369 (Entrez Gene)
Casp8GeneProduct12370 (Entrez Gene)
Cav1GeneProduct12389 (Entrez Gene)
Ccnd1GeneProduct12443 (Entrez Gene)
Ccne1GeneProduct12447 (Entrez Gene)
CcnhGeneProduct66671 (Entrez Gene)
Cdc25bGeneProduct12531 (Entrez Gene)
Cdc2aGeneProduct12534 (Entrez Gene)
Cdc37GeneProduct12539 (Entrez Gene)
Cdk7GeneProduct12572 (Entrez Gene)
Cdk9GeneProduct107951 (Entrez Gene)
CrebbpGeneProduct12914 (Entrez Gene)
Ctdp1GeneProduct67655 (Entrez Gene)
Ctnnb1GeneProduct12387 (Entrez Gene)
EgfrGeneProduct13649 (Entrez Gene)
Ep300GeneProduct328572 (Entrez Gene)
Esr1GeneProduct13982 (Entrez Gene)
Esr2GeneProduct13983 (Entrez Gene)
Etv5GeneProduct104156 (Entrez Gene)
Fhl2GeneProduct14200 (Entrez Gene)
FlnaGeneProduct192176 (Entrez Gene)
GhrGeneProduct14600 (Entrez Gene)
Gm13882GeneProduct100043349 (Entrez Gene)
Gstt2GeneProduct14872 (Entrez Gene)
Gtf2f1GeneProduct98053 (Entrez Gene)
Gtf2f2GeneProduct68705 (Entrez Gene)
Gtf2h1GeneProduct14884 (Entrez Gene)
HSPA1AGeneProduct193740 (Entrez Gene)
Hdac1GeneProduct433759 (Entrez Gene)
Hipk3GeneProduct15259 (Entrez Gene)
Hmg1l1GeneProduct434174 (Entrez Gene)
Hmgb2GeneProduct97165 (Entrez Gene)
Igf1GeneProduct16000 (Entrez Gene)
Il6GeneProduct16193 (Entrez Gene)
Il6stGeneProduct16195 (Entrez Gene)
JunGeneProduct16476 (Entrez Gene)
Kat5GeneProduct81601 (Entrez Gene)
Map2k1GeneProduct26395 (Entrez Gene)
Mapk1GeneProduct26413 (Entrez Gene)
Mdm2GeneProduct17246 (Entrez Gene)
Mmp1aGeneProduct83995 (Entrez Gene)
Myst2GeneProduct217127 (Entrez Gene)
NCOA4GeneProduct27057 (Entrez Gene)
Ncoa1GeneProduct17977 (Entrez Gene)
Ncoa2GeneProduct17978 (Entrez Gene)
Ncoa3GeneProduct17979 (Entrez Gene)
Ncor2GeneProduct20602 (Entrez Gene)
Nr0b1GeneProduct11614 (Entrez Gene)
Nr0b2GeneProduct23957 (Entrez Gene)
Nr2c2GeneProduct22026 (Entrez Gene)
Nr3c1GeneProduct14815 (Entrez Gene)
Nr5a1GeneProduct26423 (Entrez Gene)
Nrip1GeneProduct268903 (Entrez Gene)
Nsd1GeneProduct18193 (Entrez Gene)
PCAFGeneProduct
PLAGL1GeneProduct22634 (Entrez Gene)
Pa2g4GeneProduct18813 (Entrez Gene)
Pak6GeneProduct214230 (Entrez Gene)
Patz1GeneProduct56218 (Entrez Gene)
Pias1GeneProduct56469 (Entrez Gene)
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Pias3GeneProduct229615 (Entrez Gene)
Pias4GeneProduct59004 (Entrez Gene)
Pnrc1GeneProduct108767 (Entrez Gene)
Pou2f1GeneProduct18986 (Entrez Gene)
Pou2f2GeneProduct18987 (Entrez Gene)
Prmt1GeneProduct15469 (Entrez Gene)
Psmc3ipGeneProduct19183 (Entrez Gene)
PtenGeneProduct19211 (Entrez Gene)
PxnGeneProduct19303 (Entrez Gene)
RASGeneProduct19412 (Entrez Gene)
RUNX1GeneProduct12394 (Entrez Gene)
Rac3GeneProduct170758 (Entrez Gene)
Rad54l2GeneProduct81000 (Entrez Gene)
Raf1GeneProduct110157 (Entrez Gene)
RanGeneProduct19384 (Entrez Gene)
Ranbp9GeneProduct56705 (Entrez Gene)
Rb1GeneProduct19645 (Entrez Gene)
Rchy1GeneProduct68098 (Entrez Gene)
RelaGeneProduct19697 (Entrez Gene)
Rnf14GeneProduct56736 (Entrez Gene)
Rnf4GeneProduct19822 (Entrez Gene)
Runx2GeneProduct12393 (Entrez Gene)
SRYGeneProduct21674 (Entrez Gene)
Senp1GeneProduct223870 (Entrez Gene)
Sin3aGeneProduct20466 (Entrez Gene)
Slc25a4GeneProduct11739 (Entrez Gene)
Smad3GeneProduct17127 (Entrez Gene)
Smad4GeneProduct17128 (Entrez Gene)
Sp1GeneProduct20683 (Entrez Gene)
SpdefGeneProduct30051 (Entrez Gene)
SrcGeneProduct20779 (Entrez Gene)
Stat3GeneProduct20848 (Entrez Gene)
Stub1GeneProduct56424 (Entrez Gene)
SvilGeneProduct225115 (Entrez Gene)
Tgfb1i1GeneProduct21804 (Entrez Gene)
Tgif1GeneProduct21815 (Entrez Gene)
Tmf1GeneProduct232286 (Entrez Gene)
Trp53GeneProduct22059 (Entrez Gene)
Ube2iGeneProduct22196 (Entrez Gene)
Ube3aGeneProduct22215 (Entrez Gene)
UxtGeneProduct22294 (Entrez Gene)
YwhahGeneProduct22629 (Entrez Gene)

Annotated Interactions

No annotated interactions
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