Hematopoietic stem cell differentiation (Homo sapiens)

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3ZFP37RUN1T1PBX1LMO2THOP1VEGFAIL11BMP4SCFIGF1HLFTOPPRDM5TOPSCFSCFTPOIL3EPOErythrocyteHemocytoblastMyeloblastMegakaryocyteCommon MyeloidProgenitorIL6IL1ACSF2IL1BSCFIL3CSF2CSF2CXCR4MXI12RIOK3ALK4MIR15A2VEGFABMP4FLT3bFGFSCFEPOIL3MIR223MIR17MIR24AMIR155MIR181AMIR128AMIR10AMIR130AiHSC ReprogrammingFactorsErythrocyte-MegakaryocytePrecursorMIR16-11MIR4511MIR221MIR2221MIR15011


Description

Growth factors and miRNA regulating differentiation of hemocytoblasts to various blood-related cell types. Note that myeloblasts branch off separately from erythrocytes and megakaryocytes. Adapted from an open access image attributed to ZooFari and Mikael Häggström (http://en.wikipedia.org/wiki/User:Mikael_H%C3%A4ggstr%C3%B6m/Gallery#Medical_collaborations) and augmented from literature.

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Ontology Terms

 

Bibliography

  1. Zhang L, Sankaran VG, Lodish HF; ''MicroRNAs in erythroid and megakaryocytic differentiation and megakaryocyte-erythroid progenitor lineage commitment.''; Leukemia, 2012 PubMed Europe PMC Scholia
  2. Riddell J, Gazit R, Garrison BS, Guo G, Saadatpour A, Mandal PK, Ebina W, Volchkov P, Yuan GC, Orkin SH, Rossi DJ; ''Reprogramming committed murine blood cells to induced hematopoietic stem cells with defined factors.''; Cell, 2014 PubMed Europe PMC Scholia
  3. Slavov SN, Gimenes Teixeira HL, Rego EM; ''The role of micro-ribonucleic acids in normal hematopoiesis and leukemic T-lymphogenesis.''; Braz J Med Biol Res, 2010 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129244view02:36, 16 March 2024EweitzOntology Term : 'platelet' added !
129243view02:35, 16 March 2024EweitzOntology Term : 'megakaryocyte' added !
129242view02:34, 16 March 2024EweitzOntology Term : 'erythrocyte' added !
129241view02:33, 16 March 2024EweitzOntology Term : 'monocyte' added !
129240view02:33, 16 March 2024EweitzOntology Term : 'eosinophil' added !
129239view02:33, 16 March 2024EweitzOntology Term : 'neutrophil' added !
129238view02:33, 16 March 2024EweitzOntology Term : 'basophil' added !
129237view02:31, 16 March 2024EweitzOntology Term : 'myeloblast' added !
129236view02:30, 16 March 2024EweitzOntology Term : 'common myeloid progenitor' added !
129235view02:29, 16 March 2024EweitzOntology Term : 'hematopoietic stem cell' added !
117150view09:43, 18 May 2021EweitzModified title
103039view11:57, 2 February 2019MaintBotReplaced an outdated Ensembl identifiers with the new one.
102164view22:12, 4 December 2018Khanspersupdated xrefs for miRNAs
97552view14:50, 24 May 2018Mkutmonfix some of the uniprot identifiers
89818view11:53, 6 October 2016MkutmonModified description
84764view18:34, 16 March 2016KhanspersReverted to version '04:17, 18 November 2015' by Khanspers
84763view18:14, 16 March 2016WRothReverted to version '20:29, 28 September 2014' by WRoth
84762view18:14, 16 March 2016WRothReverted to version '22:37, 29 September 2014' by WRoth
84761view18:14, 16 March 2016WRothReverted to version '20:25, 28 September 2014' by WRoth
84760view18:14, 16 March 2016WRothReverted to version '20:28, 28 September 2014' by WRoth
84759view18:14, 16 March 2016WRothReverted to version '22:53, 29 September 2014' by WRoth
84758view18:14, 16 March 2016WRothReverted to version '20:39, 29 September 2014' by WRoth
84757view18:14, 16 March 2016WRothReverted to version '20:30, 28 September 2014' by WRoth
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84740view18:12, 16 March 2016WRothReverted to version '00:50, 30 September 2014' by WRoth
84739view18:12, 16 March 2016WRothReverted to version '00:41, 30 September 2014' by WRoth
84738view18:12, 16 March 2016WRothReverted to version '18:09, 30 September 2014' by WRoth
84737view18:12, 16 March 2016WRothReverted to version '02:09, 30 September 2014' by WRoth
84736view18:12, 16 March 2016WRothReverted to version '17:58, 30 September 2014' by WRoth
84735view18:12, 16 March 2016WRothReverted to version '18:47, 30 September 2014' by WRoth
84734view18:12, 16 March 2016WRothReverted to version '19:13, 30 September 2014' by WRoth
84733view18:12, 16 March 2016WRothReverted to version '18:11, 30 September 2014' by WRoth
84732view18:12, 16 March 2016WRothReverted to version '18:53, 30 September 2014' by WRoth
84731view18:12, 16 March 2016WRothReverted to version '20:06, 30 September 2014' by WRoth
84730view18:11, 16 March 2016WRothReverted to version '19:45, 30 September 2014' by WRoth

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ALK4GeneProductENSG00000135503 (Ensembl)
BMP4GeneProductENSG00000125378 (Ensembl)
CSF2GeneProductENSG00000164400 (Ensembl)
CXCR4GeneProductENSG00000121966 (Ensembl)
EPOGeneProductENSG00000130427 (Ensembl Human)
FLT3GeneProductENSG00000122025 (Ensembl)
HLFGeneProductHLF (Uniprot-TrEMBL)
IGF1GeneProductENSG00000017427 (Ensembl)
IL11GeneProductENSG00000095752 (Ensembl)
IL1AGeneProductENSG00000115008 (Ensembl)
IL1BGeneProductENSG00000125538 (Ensembl)
IL3GeneProductENSG00000164399 (Ensembl Human)
IL6GeneProductENSG00000136244 (Ensembl)
LMO2GeneProductLMO2 (Uniprot-TrEMBL)
MIR10AGeneProductENSG00000207777 (Ensembl)
MIR128AGeneProductENSG00000207654 (Ensembl)
MIR130AGeneProductENSG00000208009 (Ensembl)
MIR150GeneProductENSG00000207782 (Ensembl)
MIR155GeneProductENSG00000207795 (Ensembl)
MIR15AGeneProductENSG00000207718 (Ensembl)
MIR16-1GeneProductENSG00000208006 (Ensembl)
MIR17GeneProductENSG00000207745 (Ensembl)
MIR181AGeneProductENSG00000207759 (Ensembl)
MIR221GeneProductENSG00000207870 (Ensembl)
MIR222GeneProductENSG00000207870 (Ensembl)
MIR223GeneProductENSG00000207939 (Ensembl)
MIR24AGeneProductENSG00000207617 (Ensembl)
MIR451GeneProductENSG00000207794 (Ensembl)
MXI1GeneProductENSG00000119950 (Ensembl)
PBX1GeneProductPBX1 (Uniprot-TrEMBL)
PRDM5GeneProductPRDM5 (Uniprot-TrEMBL)
RIOK3GeneProductENSG00000101782 (Ensembl)
RUN1T1GeneProductRUN1T1 (Uniprot-TrEMBL)
SCFGeneProductENSG00000049130 (Ensembl)
SCFGeneProductSCF (Uniprot-TrEMBL)
THOP1GeneProductENSG00000172009 (Ensembl)
TOPGeneProductTOP (Uniprot-TrEMBL)
TPOGeneProductENSG00000115705 (Ensembl Human)
VEGFAGeneProductENSG00000112715 (Ensembl)
ZFP37GeneProductZFP37 (Uniprot-TrEMBL)
bFGFGeneProductENSG00000138685 (Ensembl)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP2849"