IL1 and megakaryocytes in obesity (Homo sapiens)

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Increased ploidyHigh Fat DietIncreased adhesionPlatelets with increased inflammatoryand thrombotic transcriptsPlateletHBEGFS100A9ThrombinICAM1PIK3CASELENBP1ERKpathwayMYD88MYD88FCER1ACCL2PLA2G7TIMP1MMP9PAR1MMP9TIMP2IRAK1IL1BIL18CCR3TLR2IFNGIL1R1TLR1NLRP3p38/MAPK pathwayActive integrinsPlateletWhite Blood CellAdhesionAggregationHeterotypic AggregateFormationMegakaryocyteIL1R1NFKB1IL1BIL1R1


Description

No description

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Quality Tags

Ontology Terms

 

Bibliography

  1. Beaulieu LM, Lin E, Mick E, Koupenova M, Weinberg EO, Kramer CD, Genco CA, Tanriverdi K, Larson MG, Benjamin EJ, Freedman JE; ''Interleukin 1 receptor 1 and interleukin 1β regulate megakaryocyte maturation, platelet activation, and transcript profile during inflammation in mice and humans.''; Arterioscler Thromb Vasc Biol, 2014 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
123108view14:57, 3 July 2022EgonwMade a pathway clickable
120807view11:03, 11 January 2022SusanOntology Term : 'interleukin-1 signaling pathway' added !
106600view19:38, 10 September 2019KhanspersModified description
105623view05:00, 10 August 2019KhanspersModified description
97642view14:34, 31 May 2018AMTanOntology Term : 'obesity' added !
88662view15:21, 12 August 2016JmeliusOntology Term : 'obesity disease pathway' added !
86165view13:42, 3 July 2016MirellaKalafatiModified title
81650view18:48, 21 August 2015Khanspersfixed unconnected interactions
78483view10:28, 7 January 2015MaintBotadded missing graphIds
78080view00:07, 1 December 2014Khanspersfixed unconnected interactions
77990view18:31, 4 November 2014KhanspersModified description
77989view18:22, 4 November 2014KhanspersOntology Term : 'overnutrition' added !
77988view18:21, 4 November 2014KhanspersModified description
77987view18:19, 4 November 2014Khanspersminor edits
77855view20:52, 22 October 2014Khansperschanged layout and added info on transcript data
77779view18:31, 17 October 2014KhanspersModified description
77778view18:29, 17 October 2014KhanspersAdded lit ref
77777view18:27, 17 October 2014KhanspersNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
CCL2GeneProduct6347 (Entrez Gene)
CCR3GeneProduct1232 (Entrez Gene)
ERK pathwayPathway
FCER1AGeneProduct2205 (Entrez Gene)
HBEGFGeneProduct1839 (Entrez Gene)
ICAM1GeneProduct3383 (Entrez Gene)
IFNGGeneProduct3458 (Entrez Gene)
IL18GeneProduct3606 (Entrez Gene)
IL1BGeneProduct3553 (Entrez Gene)
IL1R1GeneProduct3554 (Entrez Gene)
IRAK1GeneProduct3654 (Entrez Gene)
MMP9GeneProduct4318 (Entrez Gene)
MYD88GeneProduct4615 (Entrez Gene)
NFKB1GeneProduct4790 (Entrez Gene)
NLRP3GeneProduct114548 (Entrez Gene)
PAR1GeneProduct2149 (Entrez Gene)
PIK3CAGeneProduct5290 (Entrez Gene)
PLA2G7GeneProduct7941 (Entrez Gene)
S100A9GeneProduct6280 (Entrez Gene)
SELENBP1GeneProduct8991 (Entrez Gene)
TIMP1GeneProduct7076 (Entrez Gene)
TIMP2GeneProduct7077 (Entrez Gene)
TLR1GeneProduct7096 (Entrez Gene)
TLR2GeneProduct7097 (Entrez Gene)
ThrombinGeneProduct2147 (Entrez Gene)
p38/MAPK pathwayPathwayWP400 (WikiPathways)

Annotated Interactions

No annotated interactions

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