Pregnane X receptor pathway (Homo sapiens)

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9, 39LigandPPARGC1ASRCHSP90AA1NCOA3SRPX2RXRANCOA2PSMC5UnknownNR1I2NRIP142NR1I2LigandHSP90AA1CoregulatorsGenesTATA boxXRERXRANR1I2LigandDNAJC7DNAJC7CYP3A731UGT1A65UGT1A3UGT1A955CYP2A631UGT1A4PXR target genes517, 23SLCO1B117SRPX2NCOA3FOXO1CYP4F1220CYP3A41731UGT1A1ABCC41717NRIP1CYP2B631GSTA2PSMC517PPARGC1ANCOA1NCOA2ABCB117CoregulatorsCYP2C931CYP3A5CYP2C193131SULT2A127ABCC2ABCC344Drug and steroidmetabolism44Phase 2metabolismMulti-drugresistanceOther


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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
124933view13:31, 1 January 2023EgonwRemoved biopax duplication
124932view13:30, 1 January 2023EgonwOntology Term : 'signaling pathway' added !
124931view13:30, 1 January 2023EgonwOntology Term : 'PW:0001229' removed !
116466view10:07, 7 May 2021EweitzModified title
110712view14:51, 28 May 2020Fehrhartremoved unknown node
106535view00:00, 6 September 2019KhanspersModified description
105789view19:47, 15 August 2019KhanspersModified description
94905view23:29, 12 October 2017Khanspersremoving empty comment
94792view23:02, 5 October 2017AlexanderPicoConverted lines
94782view22:31, 5 October 2017AlexanderPicoConverted lines
88344view16:04, 1 August 2016FehrhartOntology Term : 'xenobiotic metabolic pathway' added !
79556view12:58, 25 March 2015FehrhartReplace Ensembl Human with Ensembl datasource
79537view14:56, 24 March 2015RiannefijtenModified description
79536view14:54, 24 March 2015Riannefijtenchanged pathway nodes to labels
79535view14:52, 24 March 2015Riannefijtenadded reference, fixed unconnected lines
79479view12:49, 23 March 2015EgonwAnnotated "ligand" with the ChEBI identifier for pregnane X receptor agonist.
78484view10:28, 7 January 2015MaintBotadded missing graphIds
78257view22:19, 17 December 2014KhanspersModified title
78218view15:07, 14 December 2014MaintBotUpdated the GPML schema.
78217view15:06, 14 December 2014MaintBotModified title
78089view11:37, 2 December 2014RiannefijtenNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ABCB1GeneProductENSG00000085563 (Ensembl Human)
ABCC2GeneProductENSG00000023839 (Ensembl Human)
ABCC3GeneProductENSG00000108846 (Ensembl Human)
ABCC4GeneProductENSG00000125257 (Ensembl Human)
CYP2A6GeneProductENSG00000255974 (Ensembl Human)
CYP2B6GeneProductENSG00000197408 (Ensembl Human)
CYP2C19GeneProductENSG00000165841 (Ensembl Human)
CYP2C9GeneProductENSG00000138109 (Ensembl Human)
CYP3A4GeneProductENSG00000160868 (Ensembl Human)
CYP3A5GeneProductENSG00000106258 (Ensembl Human)
CYP3A7GeneProductENSG00000160870 (Ensembl Human)
CYP4F12GeneProductENSG00000186204 (Ensembl Human)
DNAJC7GeneProductENSG00000168259 (Ensembl Human)
Drug and steroid metabolismPathway
FOXO1GeneProductENSG00000150907 (Ensembl Human)
GSTA2GeneProductENSG00000244067 (Ensembl Human)
HSP90AA1GeneProductENSG00000080824 (Ensembl Human)
Multi-drug resistancePathway
NCOA1GeneProductENSG00000084676 (Ensembl Human)
NCOA2GeneProductENSG00000140396 (Ensembl Human)
NCOA3GeneProductENSG00000124151 (Ensembl Human)
NR1I2GeneProductENSG00000144852 (Ensembl Human)
NRIP1GeneProductENSG00000180530 (Ensembl Human)
OtherPathway
PPARGC1AGeneProductENSG00000109819 (Ensembl Human)
PSMC5GeneProductENSG00000087191 (Ensembl Human)
Phase 2 metabolismPathway
RXRAGeneProductENSG00000186350 (Ensembl Human)
SLCO1B1GeneProductENSG00000134538 (Ensembl Human)
SRCGeneProductENSG00000197122 (Ensembl Human)
SRPX2GeneProductENSG00000102359 (Ensembl Human)
SULT2A1GeneProductENSG00000105398 (Ensembl Human)
UGT1A1GeneProductENSG00000241635 (Ensembl Human)
UGT1A3GeneProductENSG00000243135 (Ensembl Human)
UGT1A4GeneProductENSG00000244474 (Ensembl Human)
UGT1A6GeneProductENSG00000167165 (Ensembl Human)
UGT1A9GeneProductENSG00000241119 (Ensembl Human)
Unknown

Annotated Interactions

No annotated interactions
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