Glucocorticoid receptor pathway (Homo sapiens)

From WikiPathways

Revision as of 11:37, 2 December 2014 by Riannefijten (Talk | contribs)
(diff) ←Older revision | Current revision (diff) | Newer revision→ (diff)
Jump to: navigation, search
JUNNR3C1NFKB214GenesTATA boxNR3C1NR3C1HSP90AA1GR ligandHSP90AA1NR3C1HSP90AA111, 14NR3C114LigandNR3C1Ligand14LigandLigandNR3C1NR3C1LigandLigandGREGenesTATA boxNR3C1NR3C1LigandLigandnGREPTGES3PTGES3PTGES3BHLHE40NAV3IL11AMIGO2SERTAD2ARL5BCXCR7CUL1FGFBP1KTN1SERPINB9CCL2ENC1PTGS2ZIC2PMP2PDE4BPLK2GR inhibitorytarget genesInflammation45Growth andapoptosis45Signaltransduction45Other45CCL20EDN2MGAMRGS2ALOX5APTSC22D3CDC42EP3SNAI2BIRC3SPINK13SPRY1GADD45BPRRG4FGD4SLC26A2EPB41L4BGPR115PPP1R14CBIRC2GPR153TGFBR3ANGPTL4LRRC8AANKRD1THBDCDKN1CSCNN1ASLC19A2TNFAIP3SRGNSTOMSEC14L1DNAJC15DNERMFGE8ABHD2CPEB4SDPRMT1IPETNK2B3GNT5AKAP13POU5F1TNS4S100PNR1I3NR1I22727RXRA4, 7, 27InflammationGrowth andapoptosis45Signaltransduction45Metabolism4545TransportOther4545NuclearreceptorsGR stimulatorytarget genes


Description

No description

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. Handschin C, Meyer UA; ''''; , PubMed Europe PMC Scholia
  2. ''''; , PubMed Europe PMC Scholia
  3. Weiss C, Faust D, Schreck I, Ruff A, Farwerck T, Melenberg A, Schneider S, Oesch-Bartlomowicz B, Zatloukalová J, Vondrácek J, Oesch F, Dietrich C; ''TCDD deregulates contact inhibition in rat liver oval cells via Ah receptor, JunD and cyclin A.''; Oncogene, 2008 PubMed Europe PMC Scholia
  4. Weiss C, Faust D, Dürk H, Kolluri SK, Pelzer A, Schneider S, Dietrich C, Oesch F, Göttlicher M; ''TCDD induces c-jun expression via a novel Ah (dioxin) receptor-mediated p38-MAPK-dependent pathway.''; Oncogene, 2005 PubMed Europe PMC Scholia
  5. Fijten RR, Jennen DG, van Delft JH; ''Pathways for ligand activated nuclear receptors to unravel the genomic responses induced by hepatotoxicants.''; Curr Drug Metab, 2013 PubMed Europe PMC Scholia
  6. Gadaleta RM, van Mil SW, Oldenburg B, Siersema PD, Klomp LW, van Erpecum KJ; ''Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease.''; Biochim Biophys Acta, 2010 PubMed Europe PMC Scholia
  7. Drocourt L, Ourlin JC, Pascussi JM, Maurel P, Vilarem MJ; ''Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  8. Jeon MS, Esser C; ''The murine IL-2 promoter contains distal regulatory elements responsive to the Ah receptor, a member of the evolutionarily conserved bHLH-PAS transcription factor family.''; J Immunol, 2000 PubMed Europe PMC Scholia
  9. Maglich JM, Watson J, McMillen PJ, Goodwin B, Willson TM, Moore JT; ''The nuclear receptor CAR is a regulator of thyroid hormone metabolism during caloric restriction.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  10. Wang JC, Derynck MK, Nonaka DF, Khodabakhsh DB, Haqq C, Yamamoto KR; ''''; , PubMed Europe PMC Scholia
  11. Echchgadda I, Song CS, Oh T, Ahmed M, De La Cruz IJ, Chatterjee B; ''The xenobiotic-sensing nuclear receptors pregnane X receptor, constitutive androstane receptor, and orphan nuclear receptor hepatocyte nuclear factor 4alpha in the regulation of human steroid-/bile acid-sulfotransferase.''; Mol Endocrinol, 2007 PubMed Europe PMC Scholia
  12. Tachibana K, Kobayashi Y, Tanaka T, Tagami M, Sugiyama A, Katayama T, Ueda C, Yamasaki D, Ishimoto K, Sumitomo M, Uchiyama Y, Kohro T, Sakai J, Hamakubo T, Kodama T, Doi T; ''''; , PubMed Europe PMC Scholia
  13. Pascussi JM, Gerbal-Chaloin S, Drocourt L, Maurel P, Vilarem MJ; ''The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors.''; Biochim Biophys Acta, 2003 PubMed Europe PMC Scholia
  14. Han S, Chiang JY; ''Mechanism of vitamin D receptor inhibition of cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes.''; Drug Metab Dispos, 2009 PubMed Europe PMC Scholia
  15. Timsit YE, Negishi M; ''CAR and PXR: the xenobiotic-sensing receptors.''; Steroids, 2007 PubMed Europe PMC Scholia
  16. Rochette-Egly C, Germain P; ''Dynamic and combinatorial control of gene expression by nuclear retinoic acid receptors (RARs).''; Nucl Recept Signal, 2009 PubMed Europe PMC Scholia
  17. Maglich JM, Parks DJ, Moore LB, Collins JL, Goodwin B, Billin AN, Stoltz CA, Kliewer SA, Lambert MH, Willson TM, Moore JT; ''Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  18. Li AC, Glass CK; ''''; , PubMed Europe PMC Scholia
  19. Maglich JM, Parks DJ, Moore LB, Collins JL, Goodwin B, Billin AN, Stoltz CA, Kliewer SA, Lambert MH, Willson TM, Moore JT; ''Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  20. Gao H, Fält S, Sandelin A, Gustafsson JA, Dahlman-Wright K; ''Genome-wide identification of estrogen receptor alpha-binding sites in mouse liver.''; Mol Endocrinol, 2008 PubMed Europe PMC Scholia
  21. Bock KW; ''''; , PubMed Europe PMC Scholia
  22. Willson TM, Kliewer SA; ''PXR, CAR and drug metabolism.''; Nat Rev Drug Discov, 2002 PubMed Europe PMC Scholia
  23. Rowlands JC, Gustafsson JA; ''Aryl hydrocarbon receptor-mediated signal transduction.''; Crit Rev Toxicol, 1997 PubMed Europe PMC Scholia
  24. Krogsdam AM, Nielsen CA, Neve S, Holst D, Helledie T, Thomsen B, Bendixen C, Mandrup S, Kristiansen K; ''Nuclear receptor corepressor-dependent repression of peroxisome-proliferator-activated receptor delta-mediated transactivation.''; Biochem J, 2002 PubMed Europe PMC Scholia
  25. Cai Y, Konishi T, Han G, Campwala KH, French SW, Wan YJ; ''The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways.''; Eur J Pharm Sci, 2002 PubMed Europe PMC Scholia
  26. Drocourt L, Ourlin JC, Pascussi JM, Maurel P, Vilarem MJ; ''Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  27. Handschin C, Meyer UA; ''''; , PubMed Europe PMC Scholia
  28. Mandard S, Müller M, Kersten S; ''Peroxisome proliferator-activated receptor alpha target genes.''; Cell Mol Life Sci, 2004 PubMed Europe PMC Scholia
  29. Le Vee M, Jouan E, Fardel O; ''Involvement of aryl hydrocarbon receptor in basal and 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced expression of target genes in primary human hepatocytes.''; Toxicol In Vitro, 2010 PubMed Europe PMC Scholia
  30. Haarmann-Stemmann T, Bothe H, Abel J; ''Growth factors, cytokines and their receptors as downstream targets of arylhydrocarbon receptor (AhR) signaling pathways.''; Biochem Pharmacol, 2009 PubMed Europe PMC Scholia
  31. Marchand A, Tomkiewicz C, Marchandeau JP, Boitier E, Barouki R, Garlatti M; ''2,3,7,8-Tetrachlorodibenzo-p-dioxin induces insulin-like growth factor binding protein-1 gene expression and counteracts the negative effect of insulin.''; Mol Pharmacol, 2005 PubMed Europe PMC Scholia
  32. Mimura J, Fujii-Kuriyama Y; ''Functional role of AhR in the expression of toxic effects by TCDD.''; Biochim Biophys Acta, 2003 PubMed Europe PMC Scholia
  33. Pavek P, Dvorak Z; ''Xenobiotic-induced transcriptional regulation of xenobiotic metabolizing enzymes of the cytochrome P450 superfamily in human extrahepatic tissues.''; Curr Drug Metab, 2008 PubMed Europe PMC Scholia
  34. Sugatani J, Kojima H, Ueda A, Kakizaki S, Yoshinari K, Gong QH, Owens IS, Negishi M, Sueyoshi T; ''''; , PubMed Europe PMC Scholia
  35. Hashimoto K, Mori M; ''''; , PubMed Europe PMC Scholia
  36. Handschin C, Meyer UA; ''Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR.''; Arch Biochem Biophys, 2005 PubMed Europe PMC Scholia
  37. Köhle C, Bock KW; ''Coordinate regulation of Phase I and II xenobiotic metabolisms by the Ah receptor and Nrf2.''; Biochem Pharmacol, 2007 PubMed Europe PMC Scholia
  38. Hockley SL, Arlt VM, Brewer D, Te Poele R, Workman P, Giddings I, Phillips DH; ''AHR- and DNA-damage-mediated gene expression responses induced by benzo(a)pyrene in human cell lines.''; Chem Res Toxicol, 2007 PubMed Europe PMC Scholia
  39. Echchgadda I, Song CS, Roy AK, Chatterjee B; ''Dehydroepiandrosterone sulfotransferase is a target for transcriptional induction by the vitamin D receptor.''; Mol Pharmacol, 2004 PubMed Europe PMC Scholia
  40. Nilsson S, Gustafsson JÃ…; ''''; , PubMed Europe PMC Scholia
  41. Smoak KA, Cidlowski JA; ''Mechanisms of glucocorticoid receptor signaling during inflammation.''; Mech Ageing Dev, 2004 PubMed Europe PMC Scholia
  42. Mandard S, Müller M, Kersten S; ''Peroxisome proliferator-activated receptor alpha target genes.''; Cell Mol Life Sci, 2004 PubMed Europe PMC Scholia
  43. Hariparsad N, Chu X, Yabut J, Labhart P, Hartley DP, Dai X, Evers R; ''Identification of pregnane-X receptor target genes and coactivator and corepressor binding to promoter elements in human hepatocytes.''; Nucleic Acids Res, 2009 PubMed Europe PMC Scholia
  44. ''''; , PubMed Europe PMC Scholia
  45. Cai Y, Konishi T, Han G, Campwala KH, French SW, Wan YJ; ''The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways.''; Eur J Pharm Sci, 2002 PubMed Europe PMC Scholia
  46. Lindsey S, Papoutsakis ET; ''''; , PubMed Europe PMC Scholia
  47. Xu RX, Lambert MH, Wisely BB, Warren EN, Weinert EE, Waitt GM, Williams JD, Collins JL, Moore LB, Willson TM, Moore JT; ''A structural basis for constitutive activity in the human CAR/RXRalpha heterodimer.''; Mol Cell, 2004 PubMed Europe PMC Scholia
  48. Gadaleta RM, van Mil SW, Oldenburg B, Siersema PD, Klomp LW, van Erpecum KJ; ''Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease.''; Biochim Biophys Acta, 2010 PubMed Europe PMC Scholia
  49. Vezina CM, Walker NJ, Olson JR; ''Subchronic exposure to TCDD, PeCDF, PCB126, and PCB153: effect on hepatic gene expression.''; Environ Health Perspect, 2004 PubMed Europe PMC Scholia
  50. Rodríguez-Sosa M, Elizondo G, López-Durán RM, Rivera I, Gonzalez FJ, Vega L; ''''; , PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117734view12:38, 22 May 2021EweitzModified title
112288view13:15, 9 October 2020Fehrhart
112287view13:14, 9 October 2020Fehrhart
87558view02:13, 25 July 2016AlexanderPicoOntology Term : 'signaling pathway' added !
87557view02:13, 25 July 2016AlexanderPicoOntology Term : 'glucocorticoid signaling pathway' added !
79615view10:14, 29 March 2015EgonwConverted the 'ligand' labels to DataNode's and gave them ChEBI IDs.
79548view09:53, 25 March 2015FehrhartUpdate of GenIDs and comments
79522view09:45, 24 March 2015Riannefijtenadded reference and changed interaction lines (for X) to graphical elements
79521view09:43, 24 March 2015RiannefijtenModified description
79494view13:39, 23 March 2015RiannefijtenUpdated connections and annotations
78505view10:29, 7 January 2015MaintBotadded missing graphIds
78258view22:21, 17 December 2014KhanspersModified title
78227view15:34, 14 December 2014MaintBotUpdated the GPML schema.
78222view15:26, 14 December 2014MaintBotModified title
78093view11:37, 2 December 2014RiannefijtenNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABHD2GeneProductENSG00000140526 (Ensembl Human)
AKAP13GeneProductENSG00000170776 (Ensembl Human)
ALOX5APGeneProductENSG00000132965 (Ensembl Human)
AMIGO2GeneProductENSG00000139211 (Ensembl Human)
ANGPTL4GeneProductENSG00000167772 (Ensembl Human)
ANKRD1GeneProductENSG00000148677 (Ensembl Human)
ARL5BGeneProductENSG00000165997 (Ensembl Human)
B3GNT5GeneProductENSG00000176597 (Ensembl Human)
BHLHE40GeneProductENSG00000134107 (Ensembl Human)
BIRC2GeneProductENSG00000110330 (Ensembl Human)
BIRC3GeneProductENSG00000023445 (Ensembl Human)
CCL20GeneProductENSG00000115009 (Ensembl Human)
CCL2GeneProductENSG00000108691 (Ensembl Human)
CDC42EP3GeneProductENSG00000163171 (Ensembl Human)
CDKN1CGeneProductENSG00000129757 (Ensembl Human)
CPEB4GeneProductENSG00000113742 (Ensembl Human)
CUL1GeneProductENSG00000055130 (Ensembl Human)
CXCR7GeneProductENSG00000144476 (Ensembl Human)
DNAJC15GeneProductENSG00000120675 (Ensembl Human)
DNERGeneProductENSG00000187957 (Ensembl Human)
EDN2GeneProductENSG00000127129 (Ensembl Human)
ENC1GeneProductENSG00000171617 (Ensembl Human)
EPB41L4BGeneProductENSG00000095203 (Ensembl Human)
ETNK2GeneProductENSG00000143845 (Ensembl Human)
FGD4GeneProductENSG00000139132 (Ensembl Human)
FGFBP1GeneProductENSG00000137440 (Ensembl Human)
GADD45BGeneProductENSG00000099860 (Ensembl Human)
GPR115GeneProductENSG00000153294 (Ensembl Human)
GPR153GeneProductENSG00000158292 (Ensembl Human)
Growth and apoptosisPathway
HSP90AA1GeneProductENSG00000080824 (Ensembl Human)
IL11GeneProductENSG00000095752 (Ensembl Human)
InflammationPathway
JUNGeneProductENSG00000177606 (Ensembl Human)
KTN1GeneProductENSG00000126777 (Ensembl Human)
LRRC8AGeneProductENSG00000136802 (Ensembl Human)
MFGE8GeneProductENSG00000140545 (Ensembl Human)
MGAMGeneProductENSG00000179087 (Ensembl Human)
MT1IPGeneProduct644314 (Entrez Gene)
MetabolismPathway
NAV3GeneProductENSG00000067798 (Ensembl Human)
NFKB2GeneProductENSG00000077150 (Ensembl Human)
NR1I2GeneProductENSG00000144852 (Ensembl Human)
NR1I3GeneProductENSG00000143257 (Ensembl Human)
NR3C1GeneProductENSG00000113580 (Ensembl Human)
Nuclear receptorsPathway
OtherPathway
PDE4BGeneProductENSG00000184588 (Ensembl Human)
PLK2GeneProductENSG00000145632 (Ensembl Human)
PMP2GeneProductENSG00000147588 (Ensembl Human)
POU5F1GeneProductENSG00000204531 (Ensembl Human)
PPP1R14CGeneProductENSG00000198729 (Ensembl Human)
PRRG4GeneProductENSG00000135378 (Ensembl Human)
PTGES3GeneProductENSG00000110958 (Ensembl Human)
PTGS2GeneProductENSG00000073756 (Ensembl Human)
RGS2GeneProductENSG00000116741 (Ensembl Human)
RXRAGeneProductENSG00000186350 (Ensembl Human)
S100PGeneProductENSG00000163993 (Ensembl Human)
SCNN1AGeneProductENSG00000111319 (Ensembl Human)
SDPRGeneProductENSG00000168497 (Ensembl Human)
SEC14L1GeneProductENSG00000129657 (Ensembl Human)
SERPINB9GeneProductENSG00000170542 (Ensembl Human)
SERTAD2GeneProductENSG00000179833 (Ensembl Human)
SLC19A2GeneProductENSG00000117479 (Ensembl Human)
SLC26A2GeneProductENSG00000155850 (Ensembl Human)
SNAI2GeneProductENSG00000019549 (Ensembl Human)
SPINK13GeneProductENSG00000214510 (Ensembl Human)
SPRY1GeneProductENSG00000164056 (Ensembl Human)
SRGNGeneProductENSG00000122862 (Ensembl Human)
STOMGeneProductENSG00000148175 (Ensembl Human)
Signal transductionPathway
TGFBR3GeneProductENSG00000069702 (Ensembl Human)
THBDGeneProductENSG00000178726 (Ensembl Human)
TNFAIP3GeneProductENSG00000118503 (Ensembl Human)
TNS4GeneProductENSG00000131746 (Ensembl Human)
TSC22D3GeneProductENSG00000157514 (Ensembl Human)
TransportPathway
ZIC2GeneProductENSG00000043355 (Ensembl Human)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP2880"
Personal tools