Vascular smooth muscle contraction (Bos taurus)

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HyperpolarizationCrossbreidge+pReduction of contractile system Ca2+ sensitivityRELAXCATIONIntravasal pressure/stretchMyofilaments+pDepolarizationContractionVasoconstrictorsReduction of intracellular Ca2+ concentration-pPLA2G12ARAMP2EETCa2+CaDKCNMB3CALM2BNPIRAGAVPR1BPGI2ITPR220-HETECACNA1SPLA2G2FADORA2AGNA11ADCY9KCNMB4ADCY5Arachidonic acid metabolismMHCPLCB3PLA2G4DADCY4PRKCQARAFNorepinephrineK+ArachidonateADCY7ADCY1PLCB2PLCB4PRKACAPLA2G12BcGMPAdenosineAVPR1AMYL9Ca2+GsMYL6BNPR-BPPP1R12BvasopressinPLA2G2ECa2+CALML6MYLK3GNAQGNA12KCNMA1GUCY1A3PLA2G6PLA2G10CYP4A22Calcium signal PathwayCALCRLPRKCEPLA2G4Fphospholipase A2PTGIREndothelinITPR1CNPPRKCAPRKCBCACNA1DGUCY1B3ADRA1AAdrenomedullinPRKXADRA1DCALM3GNA13ADRA1BPPP1R12CAngiotensin IIEDNRAPLA2G2AGUCY1A2PLCB1ADCY8PLA2G2D4ACTG2KCNMB2ADCY2MYLK4IP3ITPR3DAGKCNU1RAMP1PRKCGADCY6MAPK1KCNMB1CYP4A11RhOAPLA2G3CALMPPP1CCADCY3PPP1R12AACTA2CACNA1FPLA2G2CRAF1CALM1PLA2G5MYLK2MAPK3PPP1CANOK+ROCK1ARHGEF11CPI-17MYL6phospholipase A2ARHGEF1PLA2G4ERAMP3CALML5ROCK2CAMPCACNA1CPRKCHARHGEF12PLA2G4BMAP2K1MAP2K2ADORA2BPLA2G1BCGRPPLA2G2D1PRKACBPRKCDPLA2G2AMYLKPKGANPPLA2G4ANPR-AAGTR1BRAFPPP1CBCACNA1FCACNA1DCACNA1SCACNA1CKCNMB2KCNU1KCNMB3KCNMB4KCNMB1KCNMA1ITPR2ITPR1ITPR3MYLK2MYLKMYLK4MYLK3MyosinACTG2MYL6MHCMYL9ACTA2MYL6BMyosinPPP1CCPPP1CBPPP1R12CPPP1CAPPP1R12BPPP1R12AVasodilators+p+p+p+p+p+p+p+p-p


Description

Vascular smooth muscle refers to the particular type of smooth muscle found within, and composing the majority of the wall of blood vessels. The main function of vascular smooth muscle tonus is to regulate the caliber of the blood vessels in the body. Excessive vasoconstriction leads to high blood pressure, while excessive vasodilation as in shock leads to low blood pressure (http://en.wikipedia.org/wiki/Vascular_smooth_muscle).

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History

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CompareRevisionActionTimeUserComment
107057view14:14, 17 September 2019MaintBotChEBI identifier normalization
87857view11:54, 25 July 2016MirellaKalafatiOntology Term : 'regulatory pathway' added !
82870view16:22, 10 November 2015JmeliusCorrect outdated id
80970view12:08, 6 July 2015Mkutmonfixed graphid problem
80968view12:00, 6 July 2015Mkutmonfixed unconnected lines
79750view08:51, 9 April 2015Zarichanged identyfier for CACNA1C
79732view11:42, 7 April 2015ZariModified description
79731view11:34, 7 April 2015ZariNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
20-HETEMetabolite34306 (ChEBI)
ACTA2GeneProduct515610 (Entrez Gene)
ACTG2GeneProduct281595 (Entrez Gene)
ADCY1GeneProduct281601 (Entrez Gene)
ADCY2GeneProduct510708 (Entrez Gene)
ADCY3GeneProduct535603 (Entrez Gene)
ADCY4GeneProduct788151 (Entrez Gene)
ADCY5GeneProduct505740 (Entrez Gene)
ADCY6GeneProduct509936 (Entrez Gene)
ADCY7GeneProduct281603 (Entrez Gene)
ADCY8GeneProduct535017 (Entrez Gene)
ADCY9GeneProduct525482 (Entrez Gene)
ADORA2AGeneProduct617828 (Entrez Gene)
ADORA2BGeneProduct529760 (Entrez Gene)
ADRA1AGeneProduct282134 (Entrez Gene)
ADRA1BGeneProduct407140 (Entrez Gene)
ADRA1DGeneProduct539543 (Entrez Gene)
AGTR1GeneProduct281607 (Entrez Gene)
ANPMetabolite80233 (ChEBI)
ARAFGeneProduct540421 (Entrez Gene)
ARHGEF11GeneProduct511220 (Entrez Gene)
ARHGEF12GeneProduct503575 (Entrez Gene)
ARHGEF1GeneProduct513377 (Entrez Gene)
AVPR1AGeneProduct538439 (Entrez Gene)
AVPR1BGeneProduct282861 (Entrez Gene)
AdenosineMetabolite
AdrenomedullinMetabolite80339 (ChEBI)
Angiotensin IIMetabolite2719 (ChEBI)
ArachidonateMetabolite15843 (ChEBI)
Arachidonic acid metabolismPathway
BNPMetabolite80234 (ChEBI)
BRAFGeneProduct536051 (Entrez Gene)
CACNA1CGeneProduct408015 (Entrez Gene)
CACNA1CGeneProductENSBTAG00000010660 (Ensembl)
CACNA1DGeneProduct408013 (Entrez Gene)
CACNA1FGeneProduct509779 (Entrez Gene)
CACNA1SGeneProduct100337204 (Entrez Gene)
CALCRLGeneProduct527140 (Entrez Gene)
CALM1GeneProduct617095 (Entrez Gene)
CALM2GeneProduct100297344 (Entrez Gene)
CALMGeneProduct326597 (Entrez Gene)
CALM3GeneProduct520277 (Entrez Gene)
CALML5GeneProduct520404 (Entrez Gene)
CALML6GeneProduct617412 (Entrez Gene)
CAMPMetabolite17489 (ChEBI)
CGRPMetabolite80337 (ChEBI)
CNPMetabolite80235 (ChEBI)
CPI-17GeneProduct615348 (Entrez Gene)
CYP4A11GeneProduct511890 (Entrez Gene)
CYP4A22GeneProduct516085 (Entrez Gene)
Ca2+Metabolite29108 (ChEBI)
CaDGeneProduct281660 (Entrez Gene)
Calcium signal PathwayPathway
DAGMetabolite18035 (ChEBI)
EDNRAGeneProduct281749 (Entrez Gene)
EETMetabolite34157 (ChEBI)
EndothelinMetabolite80240 (ChEBI)
GNA11GeneProduct281788 (Entrez Gene)
GNA12GeneProduct515159 (Entrez Gene)
GNA13GeneProduct505611 (Entrez Gene)
GNAQGeneProduct536654 (Entrez Gene)
GUCY1A2GeneProduct613600 (Entrez Gene)
GUCY1A3GeneProduct281216 (Entrez Gene)
GUCY1B3GeneProduct282433 (Entrez Gene)
GsGeneProduct281793 (Entrez Gene)
IP3Metabolite16595 (ChEBI)
IRAGGeneProduct281918 (Entrez Gene)
ITPR1GeneProduct317697 (Entrez Gene)
ITPR2GeneProduct281878 (Entrez Gene)
ITPR3GeneProduct281879 (Entrez Gene)
K+Metabolite29103 (ChEBI)
KCNMA1GeneProduct282573 (Entrez Gene)
KCNMB1GeneProduct407176 (Entrez Gene)
KCNMB2GeneProduct534568 (Entrez Gene)
KCNMB3GeneProduct539609 (Entrez Gene)
KCNMB4GeneProduct520448 (Entrez Gene)
KCNU1GeneProduct524144 (Entrez Gene)
MAP2K1GeneProduct533199 (Entrez Gene)
MAP2K2GeneProduct510434 (Entrez Gene)
MAPK1GeneProduct327672 (Entrez Gene)
MAPK3GeneProduct531391 (Entrez Gene)
MHCGeneProduct
MYL6GeneProduct281341 (Entrez Gene)
MYL6BGeneProduct515421 (Entrez Gene)
MYL9GeneProduct505964 (Entrez Gene)
MYLK2GeneProduct533378 (Entrez Gene)
MYLKGeneProduct338037 (Entrez Gene)
MYLK3GeneProduct526379 (Entrez Gene)
MYLK4GeneProduct518025 (Entrez Gene)
NOMetabolite16480 (ChEBI)
NPR-AGeneProduct533048 (Entrez Gene)
NPR-BGeneProduct281357 (Entrez Gene)
NorepinephrineMetabolite18357 (ChEBI)
PGI2Metabolite15552 (ChEBI)
PKGGeneProduct
PLA2G10GeneProduct613966 (Entrez Gene)
PLA2G12AGeneProduct527214 (Entrez Gene)
PLA2G12BGeneProduct100337447 (Entrez Gene)
PLA2G1BGeneProduct282457 (Entrez Gene)
PLA2G2AGeneProduct507201 (Entrez Gene)
PLA2G2AGeneProduct521383 (Entrez Gene)
PLA2G2CGeneProduct504978 (Entrez Gene)
PLA2G2D1GeneProduct494318 (Entrez Gene)
PLA2G2D4GeneProduct503625 (Entrez Gene)
PLA2G2EGeneProduct506243 (Entrez Gene)
PLA2G2FGeneProduct541294 (Entrez Gene)
PLA2G3GeneProduct527631 (Entrez Gene)
PLA2G4AGeneProduct525072 (Entrez Gene)
PLA2G4BGeneProduct505485 (Entrez Gene)
PLA2G4DGeneProduct531209 (Entrez Gene)
PLA2G4EGeneProduct526364 (Entrez Gene)
PLA2G4FGeneProduct522866 (Entrez Gene)
PLA2G5GeneProduct614911 (Entrez Gene)
PLA2G6GeneProduct535381 (Entrez Gene)
PLCB1GeneProduct287026 (Entrez Gene)
PLCB2GeneProduct508888 (Entrez Gene)
PLCB3GeneProduct515669 (Entrez Gene)
PLCB4GeneProduct281985 (Entrez Gene)
PPP1CAGeneProduct516175 (Entrez Gene)
PPP1CBGeneProduct538829 (Entrez Gene)
PPP1CCGeneProduct282318 (Entrez Gene)
PPP1R12AGeneProduct538606 (Entrez Gene)
PPP1R12BGeneProduct100337338 (Entrez Gene)
PPP1R12BGeneProductENSBTAG00000011772 (Ensembl)
PPP1R12CGeneProduct512431 (Entrez Gene)
PRKACAGeneProduct282322 (Entrez Gene)
PRKACBGeneProduct282323 (Entrez Gene)
PRKCAGeneProduct282001 (Entrez Gene)
PRKCBGeneProduct282325 (Entrez Gene)
PRKCDGeneProduct505708 (Entrez Gene)
PRKCEGeneProduct507041 (Entrez Gene)
PRKCGGeneProduct282002 (Entrez Gene)
PRKCHGeneProduct518542 (Entrez Gene)
PRKCQGeneProduct505901 (Entrez Gene)
PRKXGeneProduct505773 (Entrez Gene)
PTGIRGeneProduct520278 (Entrez Gene)
RAF1GeneProduct521196 (Entrez Gene)
RAMP1GeneProduct617017 (Entrez Gene)
RAMP2GeneProduct504230 (Entrez Gene)
RAMP3GeneProduct613547 (Entrez Gene)
ROCK1GeneProduct785911 (Entrez Gene)
ROCK2GeneProduct282041 (Entrez Gene)
RhOAGeneProduct338049 (Entrez Gene)
cGMPMetabolite16356 (ChEBI)
phospholipase A2GeneProduct104974671 (Entrez Gene)
phospholipase A2GeneProduct615045 (Entrez Gene)
vasopressinMetabolite34543 (ChEBI)

Annotated Interactions

No annotated interactions