Kit receptor signaling pathway (Homo sapiens)

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RPS6KA1RPS6KA3PAKT1P39, 245, 459, 472, 499...9, 542, 3825452, 382175, 331, 5113132, 38254152, 159169, 206, 26288, 155, 480210, 382139, 315, 32785, 265, 472139, 140, 387, 416, 44385, 47216930415, 139134, 552163, 31998, 403, 407, 443, 490117, 344153, 320, 443341, 407, 443, 522, 552313, 556382134, 5527, 31923, 20668, 240, 407141, 407, 443, 490, 552116, 153, 403, 443, 490...116, 472382, 430382, 43073, 156343, 382134, 31957, 139, 206, 227153, 163, 382, 443472490, 516187, 415153, 406, 443132, 134, 206, 407, 443...125, 153, 209292, 490, 504153, 443, 468, 490, 552...179, 265104, 139, 206, 319, 407...1, 41, 490Kit Receptor Signal Transduction PathwayPhospholipase DCYNUDOK1PCRK85, 139, 203, 443PEP300179, 265KITLGKITVAV1P56, 159FOSGAB2PTEC343, 513MAP2K2BCL2PGRB71, 6, 140SHC1PSH2B2159, 313, 341FYNKITUbCRKLSNAI2JAK2PTBX2550PIK3R2STAT5BSOCS1PLCG1PSNAI1187, 264, 319, 443, 499BTKPGRB10187, 196LYNMATKPTPN6KITCBLP159, 255, 447SOCS6KITLGRPS6MTORP358SOS1RAF1P139, 283MAP2K1P1, 39, 140INPP5DSTAT3STAT3P256, 515STAT1MAPK1P1, 39, 236, 245, 264...FOXO3ASTAT1P159, 169, 457GRB2MAPK3P1, 39, 236, 245, 264...PTPN11P513RPS6KB1P358, 457, 573STAT5ASTAT5BSTAT5APJUNB117, 251PRKCABADPRKCB1MAPK8MAPK8PMAPK14236, 358, 513PIK3R1PSRC53, 125, 245, 358, 499...P1, 556P108, 140, 443MITFSTAT5AHRASGTP73, 344262RPS6KA1RPS6KA3RPS6KB1304MAPK1MAPK3CYNUCYNUCYNUCYNUEnzyme complexInhibitionAuto catalysisTransportPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionTranslocation UbiquitinationDeubiquitinationSumoylationInduced catalysisProtein-protein interactionAcetylationDephosphorylationLEGENDPhosphorylationProteinmRNAProteinReceptorLigandDeacetylationGolgi apparatusEndosomeNucleusMitochondrionDesumoylationMethylationDemethylationPalmitoylationCytoplasmECPlasma membraneMTEndoplasmic reticulumCYPMGONUExtracellularERENProteolytic cleavage


Description

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Quality Tags

Ontology Terms

 

Bibliography

  1. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A; ''NetPath: a public resource of curated signal transduction pathways.''; Genome Biol, 2010 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
126285view04:36, 20 April 2023EgonwLicense is CCZero
120696view12:59, 23 December 2021EweitzStandardize font, weight, case
115942view08:19, 21 March 2021EgonwCopied the NetPath paper into the literature list
115928view08:06, 21 March 2021EgonwModified description
108331view21:17, 6 December 2019L DupuisConverted interactions to graphical lines in legend
78799view18:30, 30 January 2015EgonwCopied Entrez IDs for STAT5B and STAT5A from nodes elsewhere in the pathway.
78539view10:30, 7 January 2015MaintBotadded missing graphIds
72102view21:45, 24 October 2013Mkutmonadded datasource for "GAB2", "FYN", "CRKL" and "GRB2"
68995view17:44, 8 July 2013MaintBotUpdated to 2013 gpml schema
67427view11:00, 26 June 2013DdiglesOntology Term : 'Stem Cell Factor signaling pathway' added !
47975view14:28, 23 April 2012NetPathModified description
44883view10:10, 6 October 2011MartijnVanIerselOntology Term : 'cytokine mediated signaling pathway' added !
44603view21:15, 21 September 2011KhanspersUpdating content to NetSlim
44112view20:36, 24 August 2011KhanspersReverted to version '23:42, 1 March 2011' by Khanspers
44033view23:13, 22 August 2011KhanspersModified description
44032view23:12, 22 August 2011KhanspersUpdating pathway from NetSlim
41172view23:42, 1 March 2011MaintBotRemoved redundant pathway information and comments
35649view21:40, 12 February 2010KhanspersModified description
21319view11:31, 14 November 2008MaintBot[[Pathway:Homo sapiens:Kit-Receptor NetPath 6]] moved to [[Pathway:WP304]]: Moved to stable identifier
13001view11:01, 17 May 2008MaintBotSticky edges patch by Sjoerd
8230view13:46, 7 January 2008MaintBot[[Pathway:Human:Kit-Receptor NetPath 6]] moved to [[Pathway:Homo sapiens:Kit-Receptor NetPath 6]]: Renaming species
7735view16:14, 18 December 2007MaintBotfixed category names
7271view12:41, 4 November 2007MaintBotAdded categories to GPML
6347view22:18, 22 May 2007A.Pandeygpml file for [[Human:Kit-Receptor_NetPath_6]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProduct207 (Entrez Gene)
BADGeneProduct572 (Entrez Gene)
BCL2Rna596 (Entrez Gene)
BTKGeneProduct695 (Entrez Gene)
CBLGeneProduct867 (Entrez Gene)
CRKGeneProduct1398 (Entrez Gene)
CRKLGeneProduct1399
DOK1GeneProduct1796 (Entrez Gene)
EP300GeneProduct2033 (Entrez Gene)
FOSRna2353 (Entrez Gene)
FOXO3AGeneProduct2309 (Entrez Gene)
FYNGeneProduct2534
GAB2GeneProduct9846
GRB10GeneProduct2887 (Entrez Gene)
GRB2GeneProduct2885
GRB7GeneProduct2886 (Entrez Gene)
HRASGeneProduct3265 (Entrez Gene)
INPP5DGeneProduct3635 (Entrez Gene)
JAK2GeneProduct3717 (Entrez Gene)
JUNBRna3726 (Entrez Gene)
KITGeneProduct3815 (Entrez Gene)
KITLGGeneProduct4254 (Entrez Gene)
LYNGeneProduct4067 (Entrez Gene)
LigandGeneProduct7040 (Entrez Gene)
MAP2K1GeneProduct5604 (Entrez Gene)
MAP2K2GeneProduct5605 (Entrez Gene)
MAPK14GeneProduct1432 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
MAPK8GeneProduct5599 (Entrez Gene)
MATKGeneProduct4145 (Entrez Gene)
MITFGeneProduct4286 (Entrez Gene)
MTORGeneProduct4137 (Entrez Gene)
PIK3R1GeneProduct5295 (Entrez Gene)
PIK3R2GeneProduct5296 (Entrez Gene)
PLCG1GeneProduct5335 (Entrez Gene)
PRKCAGeneProduct5578 (Entrez Gene)
PRKCB1GeneProduct5579 (Entrez Gene)
PTPN11GeneProduct5781 (Entrez Gene)
PTPN6GeneProduct5777 (Entrez Gene)
ProteinProtein5894 (Entrez Gene)
ProteinProtein
RAF1GeneProduct5894 (Entrez Gene)
RPS6GeneProduct6194 (Entrez Gene)
RPS6KA1GeneProduct6195 (Entrez Gene)
RPS6KA3GeneProduct6197 (Entrez Gene)
RPS6KB1GeneProduct6198 (Entrez Gene)
ReceptorGeneProduct7040 (Entrez Gene)
SH2B2GeneProduct10603 (Entrez Gene)
SHC1GeneProduct6464 (Entrez Gene)
SNAI1Rna6615 (Entrez Gene)
SNAI2Rna6591 (Entrez Gene)
SOCS1GeneProduct8651 (Entrez Gene)
SOCS6GeneProduct9306 (Entrez Gene)
SOS1GeneProduct6654 (Entrez Gene)
SRCGeneProduct6714 (Entrez Gene)
STAT1GeneProduct6772 (Entrez Gene)
STAT3GeneProduct6774 (Entrez Gene)
STAT5AGeneProduct6776 (Entrez Gene)
STAT5AGeneProductSTAT5A (Entrez Gene)
STAT5BGeneProduct6777 (Entrez Gene)
STAT5BGeneProductSTAT5B (Entrez Gene)
TBX2Rna6909 (Entrez Gene)
TECGeneProduct7006 (Entrez Gene)
VAV1GeneProduct7409 (Entrez Gene)
mRNAProtein

Annotated Interactions

No annotated interactions

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