Eicosanoid synthesis (Mus musculus)

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1Prostaglandin E26-Keto-Prostaglandin F2-alpha12-Hydroperoxy Eicosatetraenoic AcidCell Membrane15-Hydroperoxy Eicosatetraenoic AcidThromboxane A3Thromboxane B2Pla2g6Lta4hAlox5ap5-HPETE12-HETE15-HETEPeroxidase?Leukotriene A4Pla2g6Pnpla8Prostaglandin D2Alox8Peroxidase?Leukotriene C45-HETEAlox12Prostaglandin F2aArachidonic acidLeukotriene B4Ggt1Ptges2Prostaglandin H2Alox5Ptgs2Prostaglandin I2PtgisPGE2 9-ketoreducPeroxidase?PtgdsLtc4sLeukotriene E4Tbxas1Alox15Leukotriene D4PtgesPtgs1Alox15Pla2g2aAlox5apDpep1PGD2 11-ketoreducThromboxane A2Alox5


Description

In biochemistry, eicosanoids are signaling molecules made by oxidation of twenty-carbon essential fatty acids, (EFAs). They exert complex control over many bodily systems, mainly in inflammation or immunity, and as messengers in the central nervous system. Source: Wikipedia

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP167(r21031) with a 70% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Funk CD; ''Prostaglandins and leukotrienes: advances in eicosanoid biology.''; Science, 2001 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117878view10:20, 23 May 2021EweitzModified title
106877view13:35, 17 September 2019MaintBotHMDB identifier normalization
89525view11:03, 16 September 2016Mkutmonontology tag fix
89477view13:39, 15 September 2016Mkutmonremove space from ontology term id
71719view20:16, 17 October 2013MaintBotAutomated update of data sources
71313view17:15, 17 October 2013MaintBotAutomated update of data sources
69076view18:09, 8 July 2013MaintBotUpdated to 2013 gpml schema
67186view10:18, 26 June 2013Christine ChichesterOntology Term : 'eicosanoid biosynthetic pathway' added !
62829view04:44, 3 May 2013MaintBotUpdated UniProt data source
41263view00:21, 2 March 2011MaintBotRemoved redundant pathway information and comments
35469view12:08, 12 February 2010ThomasModified description
35468view12:08, 12 February 2010Thomasadded literature
34376view22:44, 9 December 2009MaintBotAutomatic update of empty xrefs
32690view23:04, 31 August 2009Khanspersupdated xrefs
32047view13:30, 14 August 2009MaintBotFixed group labels
30816view23:56, 29 July 2009MaintBotConverted from Homo sapiens
21349view11:31, 14 November 2008MaintBot[[Pathway:Mus musculus:Eicosanoid Synthesis]] moved to [[Pathway:WP318]]: Moved to stable identifier
8004view13:46, 7 January 2008MaintBot[[Pathway:Mouse:Eicosanoid Synthesis]] moved to [[Pathway:Mus musculus:Eicosanoid Synthesis]]: Renaming species
7625view16:05, 18 December 2007MaintBotfixed category names
7338view12:42, 4 November 2007MaintBotAdded categories to GPML
6434view22:18, 22 May 2007A.Kwagpml file for [[Mouse:Eicosanoid_Synthesis]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
12-HETEMetabolite
15-HETEMetabolite
5-HETEMetabolite70608-72-9 (CAS)
5-HPETEMetaboliteHMDB01193 (HMDB)
Alox12GeneProduct11684 (Entrez Gene)
Alox15GeneProduct11687 (Entrez Gene)
Alox5GeneProduct11689 (Entrez Gene)
Alox5apGeneProduct11690 (Entrez Gene)
Alox8GeneProduct11688 (Entrez Gene)
Arachidonic acidMetaboliteHMDB01043 (HMDB)
Dpep1GeneProduct13479 (Entrez Gene)
Ggt1GeneProduct14598 (Entrez Gene)
Leukotriene A4MetaboliteHMDB01337 (HMDB)
Leukotriene B4MetaboliteHMDB01085 (HMDB)
Leukotriene C4MetaboliteHMDB01198 (HMDB)
Leukotriene D4MetaboliteHMDB03080 (HMDB)
Leukotriene E4MetaboliteHMDB02200 (HMDB)
Lta4hGeneProduct16993 (Entrez Gene)
Ltc4sGeneProduct17001 (Entrez Gene)
PGD2 11-ketoreducGeneProduct
PGE2 9-ketoreducGeneProduct
Peroxidase?GeneProduct
Pla2g2aGeneProduct18780 (Entrez Gene)
Pla2g6GeneProduct53357 (Entrez Gene)
Pnpla8GeneProduct67452 (Entrez Gene)
Prostaglandin D2MetaboliteHMDB01403 (HMDB)
Prostaglandin F2aMetaboliteHMDB01139 (HMDB)
Prostaglandin H2MetaboliteHMDB01381 (HMDB)
Prostaglandin I2MetaboliteHMDB01335 (HMDB)
PtgdsGeneProduct19215 (Entrez Gene)
Ptges2GeneProduct96979 (Entrez Gene)
PtgesGeneProduct64292 (Entrez Gene)
PtgisGeneProduct19223 (Entrez Gene)
Ptgs1GeneProduct19224 (Entrez Gene)
Ptgs2GeneProduct19225 (Entrez Gene)
Tbxas1GeneProduct21391 (Entrez Gene)
Thromboxane A2MetaboliteHMDB01452 (HMDB)
Thromboxane B2MetaboliteHMDB03252 (HMDB)

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP318"