Overview of nanoparticle effects (Homo sapiens)

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1, 14DNA damageGenotoxicity / CancerCell migrationAcute lung effects: hypercoagulation, hypofibrinolysis, etc.EndocytosisExocytosisPhagocytosisCoronary heart disease, plaques, DICCell deathAstrocytesMitochondrial potentialdepletion in hepatocytes12, 13, 165, 172Prostaglandin COX2 (PTGS2)DifferentiationCell adhesionActinP-cadherinOxidative stressC-reactive proteinProstaglandin pathwayAKTImmune systemup or down regulationMetallothioneinInflammationCOX1 (PTGS1)PI3KTNF-a SignalingIntegrinAngiogenesisCytoskeletonferritinIl-6 signalingDNA damage responseNanoparticleCell cycleApoptosisFAK (PTK2)Autophagic cell deathHMOX1NecrosisNecroptosisGlutathione Blood coagulation3, 46, 1611141181, 15116187, 10911fibronectincollagen IVNF-kBBaxIL-6Il-8Bcl-2TNF-acyclin D318laminin


Description

This pathway is giving a summary of currently known nanoparticle effects on cells and organisms. Although there is currently no nanoparticle-specific effect known, there is a cascade of effects triggered if cells or organisms are exposed to nanoparticles: The most abundantly observed event is oxidative stress which causes DNA damage, protein and lipid oxidation, and cell death. The mere overload of nanoparticles in the vesicular system leads to cytoskeleton and cell adhesion problems and interfere with the cell's autophagic system. Some specific nanoparticles are reported to interfere with the cell membrane, others stimulate the blood coagulation system. The release of metal ions from specific nanoparticles challenges the metal disposal system of the cell.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
121705view04:38, 26 February 2022EweitzUse gene symbol
118405view14:13, 27 May 2021Mkutmonfix publication refs
113822view16:55, 28 November 2020EgonwChanged to use rounded rectangles
110681view13:07, 28 May 2020Fehrhartgave nanoparticle a class and ID
107141view14:22, 17 September 2019MaintBotChEBI identifier normalization
89371view06:15, 10 September 2016EgonwConnected lines.
88835view13:18, 15 August 2016Fehrhartconnecting unconnected lines
88266view14:32, 1 August 2016FehrhartOntology Term : 'nanomaterial response pathway' added !
87252view13:14, 20 July 2016LindarieswijkChanged necroptosis instead of necrotopsis
84570view12:23, 3 March 2016Mkutmonfix literature references
84569view12:18, 3 March 2016Mkutmonadded missing graph ids
82926view12:57, 13 November 2015FehrhartAdded identifiers (now complete, except nanoparticle)
82925view12:51, 13 November 2015FehrhartAdded identifiers
82924view10:27, 13 November 2015FehrhartAdded identifiers
80967view11:41, 6 July 2015MkutmonModified title
80961view12:25, 2 July 2015FehrhartModified description
80960view12:20, 2 July 2015FehrhartNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKTGeneProductENSG00000117020 (Ensembl)
ActinGeneProductPF00022 (Pfam)
AngiogenesisPathwayWP1539 (WikiPathways)
ApoptosisPathwayWP2507 (WikiPathways)
Autophagic cell deathPathwayWP2509 (WikiPathways)
BaxGeneProductENSG00000087088 (Ensembl)
Bcl-2GeneProductENSG00000171791 (Ensembl)
Blood coagulationPathwayWP558 (WikiPathways)
C-reactive proteinGeneProductENSG00000132693 (Ensembl)
COX1 (PTGS1)GeneProductENSG00000095303 (Ensembl)
COX2 (PTGS2)GeneProductENSG00000073756 (Ensembl)
Cell adhesionPathwayWP306 (WikiPathways)
Cell cyclePathwayWP179 (WikiPathways)
CytoskeletonPathwayWP51 (WikiPathways)
DNA damage responsePathwayWP707 (WikiPathways)
DifferentiationPathwayWP2848 (WikiPathways)
FAK (PTK2)GeneProductENSG00000169398 (Ensembl)
Glutathione MetaboliteCHEBI:16856 (ChEBI)
HMOX1GeneProductENSG00000100292 (Ensembl)
IL-6GeneProductENSG00000136244 (Ensembl)
Il-6 signalingPathwayWP364 (WikiPathways)
Il-8GeneProductENSG00000169429 (Ensembl)
Immune system up or down regulationPathwayWP2783 (WikiPathways)
InflammationPathwayWP453 (WikiPathways)
IntegrinGeneProductENSG00000156886 (Ensembl)
MetallothioneinGeneProductPF00131 (Pfam)
NF-kBGeneProductENSG00000170322 (Ensembl)
NanoparticleMetabolite50803 (ChEBI)
NecroptosisPathwayWP2513 (WikiPathways)
NecrosisPathwayWP2513 (WikiPathways)
Oxidative stressPathwayWP408 (WikiPathways)
P-cadherinGeneProductENSG00000062038 (Ensembl)
PI3KGeneProductENSG00000171608 (Ensembl)
Prostaglandin MetaboliteCHEBI:26333 (ChEBI)
Prostaglandin pathwayPathwayWP98 (WikiPathways)
TNF-a SignalingPathwayWP231 (WikiPathways)
TNF-aGeneProductENSG00000232810 (Ensembl)
collagen IVGeneProductENSG00000187498 (Ensembl)
cyclin D3GeneProductENSG00000112576 (Ensembl)
ferritinGeneProductPF00210 (Pfam)
fibronectinGeneProductENSG00000115414 (Ensembl)
lamininGeneProductENSG00000053747 (Ensembl)

Annotated Interactions

No annotated interactions

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