Initiation of transcription and translation elongation at the HIV-1 LTR (Homo sapiens)

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NFATC4PNFATC3PNFATC2P1HIV-1 LTRDSIF5'DegradationNucleusCycT1SP1SUPT5HCDK9TatNELFBCBPNELFAHDACHEXIM1RNA Pol IIp300HistonesHMBACalcineurin complexSUPT4H1AcIKBANFATC1PRELANFATC4ProstratinNFATC3UbiquitinNFATC2NFATC1p50NFATC4NFATC3NFATC2NFATC13'CytoplasmIKBAPPRELAp50RELAp50RELAp50RELAp50NFATC4NFATC3NFATC2NFATC1p50p50CBPp300HistonesAcCDK9CycT1TatTatNELFCDNELFECDK9CycT1TatSP1SP1


Description

Following cellular activation or drug treatment, NFAT and NF-kB translocate to the nucleus and bind sites at the HIV-1 LTR. NFAT and NF-kB recruit p300/CBP to the LTR, resulting in acetylation of histone tails and transcriptional activation. In the case of NF-kB, proteosomal degradation of IkBa permits NF-kB translocation and displacement of the p50 homodimers. This is followed by Tat- dependent elongation in which Tat recruits the P-TEFb complex to TAR. Cdk9 phosphorylates the CTD of RNA Pol II, resulting in increased processivity. P-TEFb phosphorylates DSIF and NELF, resulting in removal of NELF from Pol II and converting DSIF into a positive elongation factor, thereby promoting productive elongation. Data nodes in blue represent HIV proteins.

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Bibliography

  1. Ruelas DS, Greene WC; ''An integrated overview of HIV-1 latency.''; Cell, 2013 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129351view09:27, 27 March 2024MkutmonOntology Term : 'infectious disease pathway' added !
129350view09:27, 27 March 2024MkutmonOntology Term : 'disease pathway' added !
106735view13:21, 17 September 2019MaintBotHMDB identifier normalization
106616view20:44, 12 September 2019KhanspersModified description
105625view05:01, 10 August 2019KhanspersModified description
97633view12:33, 31 May 2018AMTanOntology Term : 'human immunodeficiency virus infectious disease' added !
87386view11:05, 22 July 2016MaintBotadded missing graphids
82252view23:18, 16 September 2015Khanspersnew version
81816view06:09, 1 September 2015KhanspersModified description
81815view06:06, 1 September 2015KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CBPGeneProductENSG00000005339 (Ensembl)
CDK9GeneProductENSG00000136807 (Ensembl)
Calcineurin complexGeneProduct
CycT1GeneProductENSG00000129315 (Ensembl)
HDACGeneProduct
HEXIM1GeneProductENSG00000186834 (Ensembl)
HMBAMetaboliteHMDB41901 (HMDB)
HistonesGeneProduct
IKBAGeneProductENSG00000100906 (Ensembl)
NELFAGeneProductENSG00000185049 (Ensembl)
NELFBGeneProductENSG00000188986 (Ensembl)
NELFCDGeneProductENSG00000101158 (Ensembl)
NELFEGeneProduct7936 (Entrez Gene)
NFATC1GeneProductENSG00000131196 (Ensembl)
NFATC2GeneProductENSG00000101096 (Ensembl)
NFATC3GeneProductENSG00000072736 (Ensembl)
NFATC4GeneProductENSG00000100968 (Ensembl)
ProstratinMetabolite399975 (Chemspider)
RELAGeneProductENSG00000173039 (Ensembl)
RNA Pol IIGeneProduct
SP1GeneProductENSG00000185591 (Ensembl)
SUPT4H1GeneProductENSG00000213246 (Ensembl)
SUPT5HGeneProductENSG00000196235 (Ensembl)
TatGeneProduct
UbiquitinGeneProduct
p300GeneProductENSG00000100393 (Ensembl)
p50GeneProductENSG00000109320 (Ensembl)

Annotated Interactions

No annotated interactions

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