ApoE and miR-146 in inflammation and atherosclerosis (Mus musculus)

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LipopolysaccharideTraf4p65Mir146Nfkb2PU.1ApoEMir146Tlr2Tlr4Irak1ox-LDLPp65Nfkb2PMonocyte and macrophage activationpri-miR-146apre-miR-146apre-miR-146aMir146Nfkb2p65Pcytokine genes


Description

Apolipoprotein E (ApoE) enhances purine-rich PU-box–binding protein 1 (PU.1)-dependent miR-146a transcription to suppress nuclear factor-κB (NF-κB)−driven monocyte and macrophage activation and thereby inflammation and atherosclerosis.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Li K, Ching D, Luk FS, Raffai RL; ''Apolipoprotein E enhances microRNA-146a in monocytes and macrophages to suppress nuclear factor-κB-driven inflammation and atherosclerosis.''; Circ Res, 2015 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
94329view20:54, 1 September 2017Khanspersupdated xref
89801view11:31, 6 October 2016Mkutmonfixed special characters in description
89132view21:48, 22 August 2016AriuttaOntology Term : 'disease pathway' added !
87398view11:05, 22 July 2016MaintBotadded missing graphids
84852view21:41, 28 March 2016Khanspersupdated interactions
84084view10:36, 13 January 2016EgonwAdded IDs for two metabolites.
84081view00:04, 13 January 2016Khansperschanged interaction types
83897view00:39, 23 December 2015Khansperschanged interaction types
83896view00:36, 23 December 2015KhanspersModified description
83895view00:35, 23 December 2015Khanspersremoved miR locus
83866view00:19, 18 December 2015KhanspersAdjusted state position
83865view00:18, 18 December 2015KhanspersAdded literature reference
83864view00:15, 18 December 2015KhanspersModified description
83862view21:13, 17 December 2015KhanspersNew pathway
83863view21:13, 17 December 2015KhanspersModified title

External references

DataNodes

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NameTypeDatabase referenceComment
ApoEGeneProductENSMUSG00000002985 (Ensembl)
Irak1GeneProductENSMUSG00000031392 (Ensembl)
Mir146GeneProductENSMUSG00000065601 (Ensembl)
Mir146GeneProductMI0000170 (miRBase Sequence)
Nfkb2GeneProductENSMUSG00000025225 (Ensembl)
PU.1GeneProduct20375 (Entrez Gene)
Tlr2GeneProductENSMUSG00000027995 (Ensembl)
Tlr4GeneProductENSMUSG00000039005 (Ensembl)
Traf4GeneProductENSMUSG00000017386 (Ensembl)
p65GeneProductENSMUSG00000024927 (Ensembl)

Annotated Interactions

No annotated interactions

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