ATM signaling in development and disease (Homo sapiens)

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1CSRHypotonic Stress DNA Damage V(D)JOxidative StressAutophagyATMINNEMOLKB1KAP1CDKRNF40Mre11Cell CycleTSC2NF-KBATRBub1H2AXRad50PP2ACTIPMDC1Nbs1mTORC1WIP1XLFAurora BHMGN1Lamin-BRIF1Reactive Oxygen Species ArtemisCHK1uH2ACdc25ATMTIP60p38MAPKHSP27ATF2AMPKCHK2G6PDDNAPKcsHMGN1p38SMC1RNF8PP5RNF168RNF20CEP63uH2B53BP1ATMATMATMMre11Rad50Nbs1ATMNbs1Mre11Rad50ATMATM


Description

This pathway is modeled after Figure 4 in the article "The ATM signaling network in development and disease" (See Bibliography). When DNA is damaged, DDR begins to work on recuperating the damage through the appropriate cellular programs such as transcription, translation, etc etc. The ataxia-telangiectasia mutated (ATM) kinase acts as the main core of this pathway acting upon or receiving a lot of the reactions towards other gene products.

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Ontology Terms

 

Bibliography

  1. Stracker TH, Roig I, Knobel PA, Marjanović M; ''The ATM signaling network in development and disease.''; Front Genet, 2013 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
128977view18:05, 26 February 2024Khanspersclarify connection to checkpoint activation
128958view14:50, 25 February 2024EgonwFixed a datasource
128600view02:05, 15 February 2024EweitzTweak placement
128599view02:04, 15 February 2024EweitzTuck straggling node
128598view02:01, 15 February 2024EweitzEconomize layout, standardize case
127927view19:35, 17 January 2024Khanspersupdated xrefs, lables
127911view07:10, 13 January 2024Khanspersupdated and xrefs and cleaned up pathway nodes
127910view06:34, 13 January 2024Khanspersupdated xrefs
123399view06:26, 23 July 2022EgonwMade a pathway clickable
117656view11:51, 22 May 2021EweitzModified title
106756view13:23, 17 September 2019MaintBotHMDB identifier normalization
105871view04:47, 16 August 2019KhanspersModified description
105432view04:33, 8 August 2019KhanspersModified description
89745view23:52, 29 September 2016KhanspersModified title
89623view19:41, 21 September 2016Khanspersupdated labels, some xrefs, added legend and coloring
88965view22:23, 17 August 2016AAR&CoModified description
88964view22:20, 17 August 2016AAR&CoModified description
88962view22:15, 17 August 2016AAR&CoModified description
88856view15:59, 16 August 2016AAR&CoModified description
88849view22:17, 15 August 2016AAR&CoOntology Term : 'G1 phase pathway' added !
88848view22:16, 15 August 2016AAR&CoOntology Term : 'DNA repair pathway' added !
88847view22:15, 15 August 2016AAR&CoAdded Literature Reference
88846view22:13, 15 August 2016AAR&CoNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
53BP1GeneProductENSG00000067369 (Ensembl)
AMPKGeneProductENSG00000132356 (Ensembl)
ATF2GeneProductENSG00000115966 (Ensembl)
ATMGeneProductENSG00000149311 (Ensembl)
ATMINGeneProductENSG00000166454 (Ensembl)
ATRGeneProductENSG00000175054 (Ensembl)
ArtemisGeneProductENSG00000152457 (Ensembl)
Aurora BGeneProductENSG00000178999 (Ensembl)
Bub1GeneProductENSG00000169679 (Ensembl)
CDKGeneProductENSG00000170312 (Ensembl)
CEP63GeneProductENSG00000182923 (Ensembl)
CHK1GeneProductENSG00000149554 (Ensembl)
CHK2GeneProductENSG00000183765 (Ensembl)
CTIPGeneProductENSG00000101773 (Ensembl)
Cdc25GeneProductENSG00000058335 (Ensembl)
Cell CyclePathwayWP45 (WikiPathways)
DNAPKcsGeneProductENSG00000253729 (Ensembl)
G6PDGeneProductENSG00000160211 (Ensembl)
H2AXGeneProductENSG00000188486 (Ensembl)
HMGN1GeneProductENSG00000205581 (Ensembl)
HSP27GeneProductENSG00000106211 (Ensembl)
KAP1GeneProductENSG00000130726 (Ensembl)
LKB1GeneProductENSG00000118046 (Ensembl)
Lamin-BGeneProductENSG00000143815 (Ensembl)
MDC1GeneProductENSG00000137337 (Ensembl)
Mre11GeneProductENSG00000242537 (Ensembl)
NEMOGeneProductENSG00000269335 (Ensembl)
NF-KBGeneProductENSG00000109320 (Ensembl)
Nbs1GeneProductENSG00000104320 (Ensembl)
PP2AGeneProductENSG00000113575 (Ensembl)
PP5GeneProductENSG00000011485 (Ensembl)
RIF1GeneProductENSG00000080345 (Ensembl)
RNF168GeneProductENSG00000163961 (Ensembl)
RNF20GeneProductENSG00000155827 (Ensembl)
RNF40GeneProductENSG00000103549 (Ensembl)
RNF8GeneProductENSG00000112130 (Ensembl)
Rad50GeneProductENSG00000113522 (Ensembl)
Reactive Oxygen Species MetaboliteHMDB03125 (HMDB)
SMC1GeneProductENSG00000072501 (Ensembl)
TIP60GeneProductENSG00000172977 (Ensembl)
TSC2GeneProductENSG00000103197 (Ensembl)
WIP1GeneProductENSG00000170836 (Ensembl)
XLFGeneProductENSG00000152457 (Ensembl)
mTORC1GeneProductENSG00000198793 (Ensembl)
p38GeneProductENSG00000176749 (Ensembl)
p38MAPKGeneProductENSG00000197442 (Ensembl)
uH2AGeneProductIdentifier not Found
uH2BGeneProductIdentifier not Found

Annotated Interactions

No annotated interactions

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