IL-4 signaling pathway (Homo sapiens)

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MAPK3P281, 536, 537, 55240186169, 185216358518, 12243, 253293, 561116, 4373, 222, 236, 370169, 185315, 44843, 25354, 35233, 11654, 9554, 503116, 491117, 373352, 42214, 110, 173, 315116, 268256, 544155, 341315, 385116, 273248, 44093, 290272, 429110, 493162, 315155, 222, 254, 276, 29793, 290116, 491320, 389250, 276, 315213, 28456, 358483116, 491254, 293141, 253, 289141, 253396, 516358110, 216, 278, 375, 493...139, 146, 354139, 146, 354276, 315, 444gene expressionSTAT6 dependentIL-4 Signal Transduction PathwayBIRC5 STAT1 P216, 558HRH1 NFIL3PTPN11STAT6CEBPB RELA TYK2P54, 268FOS GATA3 MAPK11 p141, 253NCOA3FES JAK2p268, 281, 432SHC1 P54, 248NFKB1SOCS5RPS6KB1 p536, 544EP300CEBPA CBLP33, 54PTPN6ATF2STAT6p110, 149, 268, 276, 396...INPP5DIRS1P54, 102, 273, 536IRS2P102, 254, 276, 297, 483...PIK3R2BADP78, 143, 536SOCS1GAB2 MAPK14 p141, 253ELK1IL4JAK1STAT5BP216, 384IL2RG14, 315AKT1P110, 514, 536STAT6SOS1RELAIL4RP110, 276, 396STAT6STAT3P110, 444MAPK1P281, 537, 552MAPK3MAPK1pp281, 537, 552281, 536, 537, 552PIK3CAGRB2PIK3CD54, 540JAK3p76, 162, 396RASA1282, 448DOK2p39, 54, 448STAT5AP110, 384PIK3R1STAT6STAT6PRKCZ185, 396NFKB1P144, 306NFKBIAP144, 472IKBKBP185, 433CHUKP185, 433SOCS3113, 306216STAT1 P216, 558STAT5BP216, 384STAT3P110, 444STAT5AP110, 384216216Enzyme complexInhibitionAuto catalysisTransportPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionTranslocation UbiquitinationDeubiquitinationSumoylationInduced catalysisProtein-protein interactionAcetylationDephosphorylationLEGENDPhosphorylationProteinmRNAProteinReceptorLigandDeacetylationGolgi apparatusEndosomeNucleusMitochondrionDesumoylationMethylationDemethylationPalmitoylationCytoplasmECPlasma membraneMTEndoplasmic reticulumCYPMGONUExtracellularERENProteolytic cleavage


Description

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Ontology Terms

 

Bibliography

  1. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A; ''NetPath: a public resource of curated signal transduction pathways.''; Genome Biol, 2010 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
126335view06:06, 22 April 2023EgonwLicense is CCZero
120704view13:21, 23 December 2021EweitzStandardize font, weight, case
116636view11:22, 9 May 2021EweitzModified title
116002view15:59, 28 March 2021EgonwCopied the NetPath paper to the literature list.
115983view18:11, 23 March 2021EgonwModified description
110790view17:32, 5 June 2020Joops05Modified title
108325view21:04, 6 December 2019L DupuisConverted interactions to graphical lines in legend
89828view12:06, 6 October 2016MkutmonModified description
79978view13:37, 29 April 2015Zarirepalced NEW ID for NCOA3
78576view14:50, 7 January 2015MaintBotadded missing graphIds
78053view13:03, 23 November 2014EgonwReplaced label Entrez Genes identifiers by their numeric IDs.
74009view15:25, 19 March 2014Joppe014connected lines
70016view01:50, 12 July 2013AlexanderPicoModified title
69985view21:32, 11 July 2013MaintBotupdated to 2013 schema
67378view10:44, 26 June 2013Christine ChichesterOntology Term : 'interleukin-4 signaling pathway' added !
63211view20:58, 8 May 2013MaintBotUpdating gpml version
48437view14:33, 24 May 2012NetPathModified description
45367view20:59, 7 October 2011AlexanderPicoOntology Term : 'DOID:8406' removed !
45131view00:50, 7 October 2011AlexanderPicofixed db refs
44846view09:47, 6 October 2011MartijnVanIerselOntology Term : 'Interleukin mediated signaling pathway' added !
44625view18:04, 22 September 2011Khanspersadded description
44624view18:03, 22 September 2011KhanspersUpdating content to NetSlim
44108view20:32, 24 August 2011KhanspersReverted to version '23:21, 1 March 2011' by Khanspers
44024view22:52, 22 August 2011KhanspersAdded category
44023view22:51, 22 August 2011KhanspersModified description
44022view22:49, 22 August 2011KhanspersUpdating pathway from NetSlim
41099view23:21, 1 March 2011MaintBotRemoved redundant pathway information and comments
35643view21:32, 12 February 2010KhanspersModified description
28126view19:19, 27 January 2009KhanspersCapitalized Pathway in name
21514view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:IL-4 NetPath 16]] moved to [[Pathway:WP395]]: Moved to stable identifier
8176view13:46, 7 January 2008MaintBot[[Pathway:Human:IL-4 NetPath 16]] moved to [[Pathway:Homo sapiens:IL-4 NetPath 16]]: Renaming species
7708view16:11, 18 December 2007MaintBotfixed category names
7247view12:41, 4 November 2007MaintBotAdded categories to GPML
6337view22:18, 22 May 2007A.Pandeygpml file for [[Human:IL-4_NetPath_16]]

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1GeneProduct207 (Entrez Gene)
ATF2GeneProduct1386 (Entrez Gene)
BADGeneProduct572 (Entrez Gene)
BIRC5 Rna332 (Entrez Gene)
CBLGeneProduct867
CEBPA GeneProduct1050 (Entrez Gene)
CEBPB GeneProduct1051 (Entrez Gene)
CHUKGeneProduct1147 (Entrez Gene)
DOK2GeneProduct9046 (Entrez Gene)
ELK1GeneProduct2002 (Entrez Gene)
EP300GeneProduct2033 (Entrez Gene)
FES GeneProduct2242 (Entrez Gene)
FOS Rna2353 (Entrez Gene)
GAB2 GeneProduct9846
GATA3 Rna2625 (Entrez Gene)
GRB2GeneProduct2885 (Entrez Gene)
HRH1 Rna3269 (Entrez Gene)
IKBKBGeneProduct3551 (Entrez Gene)
IL2RGGeneProduct3561 (Entrez Gene) IL-4 induces the formation of a complex consisting of IL-4 receptor alpha and common gamma chain.
IL4GeneProduct3565
IL4RGeneProduct3566 (Entrez Gene)
INPP5DGeneProduct3635 (Entrez Gene)
IRS1GeneProduct3667 (Entrez Gene)
IRS2GeneProduct8660 (Entrez Gene)
JAK1GeneProduct3716 (Entrez Gene)
JAK2GeneProduct3717
JAK3GeneProduct3718 (Entrez Gene)
LigandGeneProduct7040 (Entrez Gene)
MAPK11 GeneProduct5600 (Entrez Gene)
MAPK14 GeneProduct1432
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
NCOA3GeneProduct8262 (Entrez Gene)
NFIL3Rna4783 (Entrez Gene)
NFKB1GeneProduct4790 (Entrez Gene)
NFKBIAGeneProduct4792 (Entrez Gene)
PIK3CAGeneProduct5290 (Entrez Gene)
PIK3CDGeneProduct5293 (Entrez Gene) IL-4 induces the interaction of PIK3CD,PIK3CA with PIK3R1,PIK3R2 in human neutrophils.
PIK3R1GeneProduct5295 (Entrez Gene)
PIK3R2GeneProduct5296 (Entrez Gene)
PRKCZGeneProduct3716 (Entrez Gene)
PTPN11GeneProduct5781 (Entrez Gene)
PTPN6GeneProduct5777 (Entrez Gene)
ProteinProtein5894 (Entrez Gene)
ProteinProtein
RASA1GeneProduct9046 (Entrez Gene) IL-4 stimulation leads to tyrosine phosphorylation of DOK2 and subsequent interaction of DOK2 with N-terminal SH2 domain of RASA1 in 32D cells.
RELA GeneProduct5970 (Entrez Gene)
RELAGeneProduct2353 (Entrez Gene)
RPS6KB1 GeneProduct
ReceptorGeneProduct7040 (Entrez Gene)
SHC1 GeneProduct6464 (Entrez Gene)
SOCS1GeneProduct8651 (Entrez Gene)
SOCS3GeneProduct9021 (Entrez Gene)
SOCS5GeneProduct9655
SOS1GeneProduct6654 (Entrez Gene)
STAT1 GeneProduct6772 (Entrez Gene)
STAT3GeneProduct6774 (Entrez Gene)
STAT5AGeneProductSTAT5A (Entrez Gene)
STAT5BGeneProductSTAT5B (Entrez Gene)
STAT6GeneProduct6778
STAT6GeneProduct6778 (Entrez Gene)
STAT6GeneProduct6778 (Entrez Gene)
TYK2GeneProduct7297 (Entrez Gene)
mRNAProtein

Annotated Interactions

No annotated interactions

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