Prion disease pathway (Homo sapiens)

From WikiPathways

(Difference between revisions)
Jump to: navigation, search
(Economize layout)
Current revision (03:22, 24 April 2024) (view source)
(Ontology Term : 'CL:0000540' removed !)
 
Line 7: Line 7:
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3995 CPTAC Assay Portal]</Comment>
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3995 CPTAC Assay Portal]</Comment>
-
   <Graphics BoardWidth="668.0" BoardHeight="636.0" />
+
   <Graphics BoardWidth="668.0" BoardHeight="636.0"/>
   <DataNode TextLabel="RFX5" GraphId="a13b8" Type="GeneProduct" GroupRef="ed0e2">
   <DataNode TextLabel="RFX5" GraphId="a13b8" Type="GeneProduct" GroupRef="ed0e2">
-
     <Graphics CenterX="600.0" CenterY="86.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="600.0" CenterY="86.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000143390" />
+
     <Xref Database="Ensembl" ID="ENSG00000143390"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ELK1" GraphId="a1a32" Type="GeneProduct" GroupRef="d63a8">
   <DataNode TextLabel="ELK1" GraphId="a1a32" Type="GeneProduct" GroupRef="d63a8">
-
     <Graphics CenterX="584.6666666666656" CenterY="463.0833333333312" Width="60.0" Height="23.499999999999524" ZOrder="32768" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="584.6666666666656" CenterY="463.0833333333312" Width="60.0" Height="23.499999999999524" ZOrder="32768" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000126767" />
+
     <Xref Database="Ensembl" ID="ENSG00000126767"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="CREB1" GraphId="a4999" Type="Protein">
   <DataNode TextLabel="CREB1" GraphId="a4999" Type="Protein">
     <Comment>https://classic.wikipathways.org/index.php/Pathway:WP1866</Comment>
     <Comment>https://classic.wikipathways.org/index.php/Pathway:WP1866</Comment>
-
     <Graphics CenterX="500.66666666666674" CenterY="428.6666666666665" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="500.66666666666674" CenterY="428.6666666666665" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000118260" />
+
     <Xref Database="Ensembl" ID="ENSG00000118260"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="FGFR1" GraphId="a5d1a" Type="GeneProduct">
   <DataNode TextLabel="FGFR1" GraphId="a5d1a" Type="GeneProduct">
     <Comment>https://classic.wikipathways.org/index.php/Pathway:WP1866</Comment>
     <Comment>https://classic.wikipathways.org/index.php/Pathway:WP1866</Comment>
-
     <Graphics CenterX="435.0000000000001" CenterY="392.0000000000001" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="435.0000000000001" CenterY="392.0000000000001" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000077782" />
+
     <Xref Database="Ensembl" ID="ENSG00000077782"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="TBP" GraphId="a8c62" Type="GeneProduct" GroupRef="ed0e2">
   <DataNode TextLabel="TBP" GraphId="a8c62" Type="GeneProduct" GroupRef="ed0e2">
-
     <Graphics CenterX="359.75" CenterY="111.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="359.75" CenterY="111.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000112592" />
+
     <Xref Database="Ensembl" ID="ENSG00000112592"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Z-DEVD-FMK" GraphId="a8ea8" Type="Metabolite">
   <DataNode TextLabel="Z-DEVD-FMK" GraphId="a8ea8" Type="Metabolite">
-
     <Graphics CenterX="394.25" CenterY="539.0" Width="90.0" Height="20.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" />
+
     <Graphics CenterX="394.25" CenterY="539.0" Width="90.0" Height="20.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff"/>
-
     <Xref Database="ChEBI" ID="CHEBI:138013" />
+
     <Xref Database="ChEBI" ID="CHEBI:138013"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="BCL11A" GraphId="ac15a" Type="GeneProduct" GroupRef="ed0e2">
   <DataNode TextLabel="BCL11A" GraphId="ac15a" Type="GeneProduct" GroupRef="ed0e2">
-
     <Graphics CenterX="480.0" CenterY="111.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="480.0" CenterY="111.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000119866" />
+
     <Xref Database="Ensembl" ID="ENSG00000119866"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="STAT3" GraphId="ac17d" Type="GeneProduct" GroupRef="ed0e2">
   <DataNode TextLabel="STAT3" GraphId="ac17d" Type="GeneProduct" GroupRef="ed0e2">
-
     <Graphics CenterX="540.0" CenterY="86.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="540.0" CenterY="86.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000168610" />
+
     <Xref Database="Ensembl" ID="ENSG00000168610"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="CASP12" GraphId="ac228" Type="GeneProduct">
   <DataNode TextLabel="CASP12" GraphId="ac228" Type="GeneProduct">
     <BiopaxRef>e7a</BiopaxRef>
     <BiopaxRef>e7a</BiopaxRef>
-
     <Graphics CenterX="289.5" CenterY="483.5" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="289.5" CenterY="483.5" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000204403" />
+
     <Xref Database="Ensembl" ID="ENSG00000204403"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="MAPK3" GraphId="ad1fd" Type="GeneProduct" GroupRef="d63a8">
   <DataNode TextLabel="MAPK3" GraphId="ad1fd" Type="GeneProduct" GroupRef="d63a8">
-
     <Graphics CenterX="584.6666666666656" CenterY="439.4166666666657" Width="60.0" Height="25.833333333331517" ZOrder="32768" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="584.6666666666656" CenterY="439.4166666666657" Width="60.0" Height="25.833333333331517" ZOrder="32768" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000102882" />
+
     <Xref Database="Ensembl" ID="ENSG00000102882"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HSP90B1" GraphId="af847" Type="GeneProduct">
   <DataNode TextLabel="HSP90B1" GraphId="af847" Type="GeneProduct">
-
     <Graphics CenterX="89.25" CenterY="448.25" Width="58.5" Height="25.0" ZOrder="32768" FillColor="ff6666" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="89.25" CenterY="448.25" Width="58.5" Height="25.0" ZOrder="32768" FillColor="ff6666" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000166598" />
+
     <Xref Database="Ensembl" ID="ENSG00000166598"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="RAD21" GraphId="b4927" Type="GeneProduct" GroupRef="ed0e2">
   <DataNode TextLabel="RAD21" GraphId="b4927" Type="GeneProduct" GroupRef="ed0e2">
-
     <Graphics CenterX="480.0" CenterY="61.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="480.0" CenterY="61.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000164754" />
+
     <Xref Database="Ensembl" ID="ENSG00000164754"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NCAM1" GraphId="b6ad1" Type="GeneProduct">
   <DataNode TextLabel="NCAM1" GraphId="b6ad1" Type="GeneProduct">
-
     <Graphics CenterX="479.3333333333326" CenterY="324.33333333333337" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="479.3333333333326" CenterY="324.33333333333337" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000149294" />
+
     <Xref Database="Ensembl" ID="ENSG00000149294"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PDIA3" GraphId="b7a96" Type="GeneProduct">
   <DataNode TextLabel="PDIA3" GraphId="b7a96" Type="GeneProduct">
-
     <Graphics CenterX="89.25" CenterY="376.25" Width="58.5" Height="25.0" ZOrder="32768" FillColor="ff6666" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="89.25" CenterY="376.25" Width="58.5" Height="25.0" ZOrder="32768" FillColor="ff6666" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000167004" />
+
     <Xref Database="Ensembl" ID="ENSG00000167004"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PrP receptor ?" GraphId="b9897" Type="Protein">
   <DataNode TextLabel="PrP receptor ?" GraphId="b9897" Type="Protein">
     <BiopaxRef>e7a</BiopaxRef>
     <BiopaxRef>e7a</BiopaxRef>
-
     <Graphics CenterX="219.5" CenterY="269.25" Width="89.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="219.5" CenterY="269.25" Width="89.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="CTCF" GraphId="bb022" Type="GeneProduct" GroupRef="ed0e2">
   <DataNode TextLabel="CTCF" GraphId="bb022" Type="GeneProduct" GroupRef="ed0e2">
-
     <Graphics CenterX="540.0" CenterY="61.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="540.0" CenterY="61.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000102974" />
+
     <Xref Database="Ensembl" ID="ENSG00000102974"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PAX5" GraphId="bb35c" Type="GeneProduct" GroupRef="ed0e2">
   <DataNode TextLabel="PAX5" GraphId="bb35c" Type="GeneProduct" GroupRef="ed0e2">
-
     <Graphics CenterX="359.75" CenterY="36.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="359.75" CenterY="36.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000196092" />
+
     <Xref Database="Ensembl" ID="ENSG00000196092"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="FYN" GraphId="bbbf2" Type="GeneProduct" GroupRef="cdb0d">
   <DataNode TextLabel="FYN" GraphId="bbbf2" Type="GeneProduct" GroupRef="cdb0d">
-
     <Graphics CenterX="364.6666666666672" CenterY="337.6666666666666" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="364.6666666666672" CenterY="337.6666666666666" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000010810" />
+
     <Xref Database="Ensembl" ID="ENSG00000010810"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PRNP" GraphId="bcc1f" Type="GeneProduct">
   <DataNode TextLabel="PRNP" GraphId="bcc1f" Type="GeneProduct">
     <Comment>https://classic.wikipathways.org/index.php/Pathway:WP1866</Comment>
     <Comment>https://classic.wikipathways.org/index.php/Pathway:WP1866</Comment>
-
     <Graphics CenterX="480.0" CenterY="181.91666666666666" Width="60.0" Height="31.5" ZOrder="32768" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="480.0" CenterY="181.91666666666666" Width="60.0" Height="31.5" ZOrder="32768" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000171867" />
+
     <Xref Database="Ensembl" ID="ENSG00000171867"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PRNP (+ mutations)" GraphId="c8929" Type="GeneProduct">
   <DataNode TextLabel="PRNP (+ mutations)" GraphId="c8929" Type="GeneProduct">
-
     <Graphics CenterX="112.91666666666669" CenterY="151.24999999999994" Width="119.66666666666592" Height="25.0" ZOrder="32768" FillColor="99ffff" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="112.91666666666669" CenterY="151.24999999999994" Width="119.66666666666592" Height="25.0" ZOrder="32768" FillColor="99ffff" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000171867" />
+
     <Xref Database="Ensembl" ID="ENSG00000171867"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PRNP" GraphId="d27ea" Type="Protein">
   <DataNode TextLabel="PRNP" GraphId="d27ea" Type="Protein">
     <BiopaxRef>e7a</BiopaxRef>
     <BiopaxRef>e7a</BiopaxRef>
-
     <Graphics CenterX="220.0" CenterY="110.25" Width="60.0" Height="37.0" ZOrder="32768" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="220.0" CenterY="110.25" Width="60.0" Height="37.0" ZOrder="32768" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000171867" />
+
     <Xref Database="Ensembl" ID="ENSG00000171867"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="POU2F2" GraphId="d2b38" Type="GeneProduct" GroupRef="ed0e2">
   <DataNode TextLabel="POU2F2" GraphId="d2b38" Type="GeneProduct" GroupRef="ed0e2">
-
     <Graphics CenterX="420.0" CenterY="36.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="420.0" CenterY="36.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000028277" />
+
     <Xref Database="Ensembl" ID="ENSG00000028277"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="MEF2C" GraphId="d46a0" Type="GeneProduct" GroupRef="ed0e2">
   <DataNode TextLabel="MEF2C" GraphId="d46a0" Type="GeneProduct" GroupRef="ed0e2">
-
     <Graphics CenterX="359.75" CenterY="86.25" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="359.75" CenterY="86.25" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000081189" />
+
     <Xref Database="Ensembl" ID="ENSG00000081189"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NFKB1" GraphId="d7cd4" Type="GeneProduct" GroupRef="ed0e2">
   <DataNode TextLabel="NFKB1" GraphId="d7cd4" Type="GeneProduct" GroupRef="ed0e2">
-
     <Graphics CenterX="480.0" CenterY="36.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="480.0" CenterY="36.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000109320" />
+
     <Xref Database="Ensembl" ID="ENSG00000109320"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="CASP3" GraphId="d9137" Type="GeneProduct">
   <DataNode TextLabel="CASP3" GraphId="d9137" Type="GeneProduct">
     <BiopaxRef>e7a</BiopaxRef>
     <BiopaxRef>e7a</BiopaxRef>
-
     <Graphics CenterX="394.25" CenterY="483.5" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="394.25" CenterY="483.5" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000164305" />
+
     <Xref Database="Ensembl" ID="ENSG00000164305"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="BATF" GraphId="da7af" Type="GeneProduct" GroupRef="ed0e2">
   <DataNode TextLabel="BATF" GraphId="da7af" Type="GeneProduct" GroupRef="ed0e2">
-
     <Graphics CenterX="420.0" CenterY="86.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="420.0" CenterY="86.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000156127" />
+
     <Xref Database="Ensembl" ID="ENSG00000156127"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SPI1" GraphId="db498" Type="GeneProduct" GroupRef="ed0e2">
   <DataNode TextLabel="SPI1" GraphId="db498" Type="GeneProduct" GroupRef="ed0e2">
-
     <Graphics CenterX="600.0" CenterY="61.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="600.0" CenterY="61.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000066336" />
+
     <Xref Database="Ensembl" ID="ENSG00000066336"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="EP300" GraphId="dc211" Type="GeneProduct" GroupRef="ed0e2">
   <DataNode TextLabel="EP300" GraphId="dc211" Type="GeneProduct" GroupRef="ed0e2">
-
     <Graphics CenterX="359.75" CenterY="61.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="359.75" CenterY="61.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000100393" />
+
     <Xref Database="Ensembl" ID="ENSG00000100393"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PRNP" GraphId="ddeeb" Type="Protein">
   <DataNode TextLabel="PRNP" GraphId="ddeeb" Type="Protein">
     <BiopaxRef>e7a</BiopaxRef>
     <BiopaxRef>e7a</BiopaxRef>
-
     <Graphics CenterX="220.0" CenterY="191.75" Width="60.0" Height="37.0" ZOrder="32768" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="220.0" CenterY="191.75" Width="60.0" Height="37.0" ZOrder="32768" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000171867" />
+
     <Xref Database="Ensembl" ID="ENSG00000171867"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="EBF1" GraphId="e0647" Type="GeneProduct" GroupRef="ed0e2">
   <DataNode TextLabel="EBF1" GraphId="e0647" Type="GeneProduct" GroupRef="ed0e2">
-
     <Graphics CenterX="540.0" CenterY="111.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="540.0" CenterY="111.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000164330" />
+
     <Xref Database="Ensembl" ID="ENSG00000164330"/>
   </DataNode>
   </DataNode>
-
   <DataNode TextLabel="BCL2&#xA;Anti-apoptotic" GraphId="e09da" Type="GeneProduct">
+
   <DataNode TextLabel="BCL2&#10;Anti-apoptotic" GraphId="e09da" Type="GeneProduct">
     <BiopaxRef>e7a</BiopaxRef>
     <BiopaxRef>e7a</BiopaxRef>
-
     <Graphics CenterX="193.75" CenterY="513.25" Width="80.5" Height="43.5" ZOrder="32768" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="193.75" CenterY="513.25" Width="80.5" Height="43.5" ZOrder="32768" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000171791" />
+
     <Xref Database="Ensembl" ID="ENSG00000171791"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="IRF4" GraphId="e2222" Type="GeneProduct" GroupRef="ed0e2">
   <DataNode TextLabel="IRF4" GraphId="e2222" Type="GeneProduct" GroupRef="ed0e2">
-
     <Graphics CenterX="600.0" CenterY="111.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="600.0" CenterY="111.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000137265" />
+
     <Xref Database="Ensembl" ID="ENSG00000137265"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SMC3" GraphId="e55a9" Type="GeneProduct" GroupRef="ed0e2">
   <DataNode TextLabel="SMC3" GraphId="e55a9" Type="GeneProduct" GroupRef="ed0e2">
-
     <Graphics CenterX="479.75" CenterY="85.875" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="479.75" CenterY="85.875" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000108055" />
+
     <Xref Database="Ensembl" ID="ENSG00000108055"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="RXRA" GraphId="e869b" Type="GeneProduct" GroupRef="ed0e2">
   <DataNode TextLabel="RXRA" GraphId="e869b" Type="GeneProduct" GroupRef="ed0e2">
-
     <Graphics CenterX="420.0" CenterY="111.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="420.0" CenterY="111.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000186350" />
+
     <Xref Database="Ensembl" ID="ENSG00000186350"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Ca2+" GraphId="eaec8" Type="Metabolite">
   <DataNode TextLabel="Ca2+" GraphId="eaec8" Type="Metabolite">
     <BiopaxRef>e7a</BiopaxRef>
     <BiopaxRef>e7a</BiopaxRef>
-
     <Graphics CenterX="217.0" CenterY="379.0" Width="40.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" />
+
     <Graphics CenterX="217.0" CenterY="379.0" Width="40.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff"/>
-
     <Xref Database="ChEBI" ID="CHEBI:29108" />
+
     <Xref Database="ChEBI" ID="CHEBI:29108"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Apoptosis" GraphId="ec843" Type="Pathway">
   <DataNode TextLabel="Apoptosis" GraphId="ec843" Type="Pathway">
-
     <Graphics CenterX="501.0" CenterY="484.5" Width="70.0" Height="25.0" ZOrder="32768" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="14961e" />
+
     <Graphics CenterX="501.0" CenterY="484.5" Width="70.0" Height="25.0" ZOrder="32768" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="14961e"/>
-
     <Xref Database="WikiPathways" ID="WP254" />
+
     <Xref Database="WikiPathways" ID="WP254"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="MAPK1" GraphId="ecc1f" Type="GeneProduct" GroupRef="d63a8">
   <DataNode TextLabel="MAPK1" GraphId="ecc1f" Type="GeneProduct" GroupRef="d63a8">
-
     <Graphics CenterX="584.6666666666656" CenterY="413.99999999999994" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="584.6666666666656" CenterY="413.99999999999994" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000100030" />
+
     <Xref Database="Ensembl" ID="ENSG00000100030"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PTK2" GraphId="f0245" Type="GeneProduct" GroupRef="cdb0d">
   <DataNode TextLabel="PTK2" GraphId="f0245" Type="GeneProduct" GroupRef="cdb0d">
-
     <Graphics CenterX="364.66666666666674" CenterY="312.33333333333366" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="364.66666666666674" CenterY="312.33333333333366" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000169398" />
+
     <Xref Database="Ensembl" ID="ENSG00000169398"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PRO CASP12" GraphId="f0fc1" Type="GeneProduct">
   <DataNode TextLabel="PRO CASP12" GraphId="f0fc1" Type="GeneProduct">
     <BiopaxRef>e7a</BiopaxRef>
     <BiopaxRef>e7a</BiopaxRef>
-
     <Graphics CenterX="217.25" CenterY="447.75" Width="93.5" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="217.25" CenterY="447.75" Width="93.5" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000204403" />
+
     <Xref Database="Ensembl" ID="ENSG00000204403"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="CHD2" GraphId="f14dd" Type="GeneProduct" GroupRef="ed0e2">
   <DataNode TextLabel="CHD2" GraphId="f14dd" Type="GeneProduct" GroupRef="ed0e2">
-
     <Graphics CenterX="420.0" CenterY="61.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="420.0" CenterY="61.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000173575" />
+
     <Xref Database="Ensembl" ID="ENSG00000173575"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PRNP (+ mutations)" GraphId="f301f" Type="GeneProduct">
   <DataNode TextLabel="PRNP (+ mutations)" GraphId="f301f" Type="GeneProduct">
-
     <Graphics CenterX="380.16666666666686" CenterY="235.9999999999999" Width="126.33333333333297" Height="25.0" ZOrder="32768" FillColor="99ffff" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="380.16666666666686" CenterY="235.9999999999999" Width="126.33333333333297" Height="25.0" ZOrder="32768" FillColor="99ffff" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000171867" />
+
     <Xref Database="Ensembl" ID="ENSG00000171867"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HSPA5" GraphId="f8335" Type="GeneProduct">
   <DataNode TextLabel="HSPA5" GraphId="f8335" Type="GeneProduct">
-
     <Graphics CenterX="89.25" CenterY="411.75" Width="58.5" Height="25.0" ZOrder="32768" FillColor="ff6666" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="89.25" CenterY="411.75" Width="58.5" Height="25.0" ZOrder="32768" FillColor="ff6666" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000044574" />
+
     <Xref Database="Ensembl" ID="ENSG00000044574"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NFKB1" GraphId="fae8f" Type="GeneProduct" GroupRef="d63a8">
   <DataNode TextLabel="NFKB1" GraphId="fae8f" Type="GeneProduct" GroupRef="d63a8">
-
     <Graphics CenterX="584.6666666666656" CenterY="487.333333333331" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="584.6666666666656" CenterY="487.333333333331" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000109320" />
+
     <Xref Database="Ensembl" ID="ENSG00000109320"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="FYN" GraphId="ac9c1" Type="GeneProduct" GroupRef="afe36">
   <DataNode TextLabel="FYN" GraphId="ac9c1" Type="GeneProduct" GroupRef="afe36">
-
     <Graphics CenterX="584.6666666666656" CenterY="311.9999999999999" Width="60.0" Height="25.0" ZOrder="32770" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="584.6666666666656" CenterY="311.9999999999999" Width="60.0" Height="25.0" ZOrder="32770" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000010810" />
+
     <Xref Database="Ensembl" ID="ENSG00000010810"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PTK2" GraphId="a47f2" Type="GeneProduct" GroupRef="afe36">
   <DataNode TextLabel="PTK2" GraphId="a47f2" Type="GeneProduct" GroupRef="afe36">
-
     <Graphics CenterX="584.6666666666656" CenterY="336.0000000000004" Width="60.0" Height="25.0" ZOrder="32771" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="584.6666666666656" CenterY="336.0000000000004" Width="60.0" Height="25.0" ZOrder="32771" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000169398" />
+
     <Xref Database="Ensembl" ID="ENSG00000169398"/>
   </DataNode>
   </DataNode>
   <State GraphRef="d27ea" TextLabel="" GraphId="a10d0">
   <State GraphRef="d27ea" TextLabel="" GraphId="a10d0">
     <Comment>Cellular</Comment>
     <Comment>Cellular</Comment>
-
     <Graphics RelX="0.981042654028436" RelY="0.8235294117647058" Width="27.5" Height="25.5" ShapeType="Oval" />
+
     <Graphics RelX="0.981042654028436" RelY="0.8235294117647058" Width="27.5" Height="25.5" ShapeType="Oval"/>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </State>
   </State>
   <State GraphRef="ddeeb" TextLabel="" GraphId="c717e">
   <State GraphRef="ddeeb" TextLabel="" GraphId="c717e">
-
     <Graphics RelX="1.0" RelY="1.0" Width="26.5" Height="24.5" ShapeType="Oval" />
+
     <Graphics RelX="1.0" RelY="1.0" Width="26.5" Height="24.5" ShapeType="Oval"/>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </State>
   </State>
   <State GraphRef="ac9c1" TextLabel="" GraphId="dc85b">
   <State GraphRef="ac9c1" TextLabel="" GraphId="dc85b">
-
     <Graphics RelX="1.0" RelY="-1.0" Width="15.0" Height="15.0" ShapeType="Oval" />
+
     <Graphics RelX="1.0" RelY="-1.0" Width="15.0" Height="15.0" ShapeType="Oval"/>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </State>
   </State>
   <State GraphRef="a47f2" TextLabel="" GraphId="faff9">
   <State GraphRef="a47f2" TextLabel="" GraphId="faff9">
-
     <Graphics RelX="1.0" RelY="1.0" Width="15.0" Height="15.0" ShapeType="Oval" />
+
     <Graphics RelX="1.0" RelY="1.0" Width="15.0" Height="15.0" ShapeType="Oval"/>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </State>
   </State>
   <Interaction GraphId="id1349402c">
   <Interaction GraphId="id1349402c">
     <Graphics ZOrder="12288" LineThickness="1.0">
     <Graphics ZOrder="12288" LineThickness="1.0">
-
       <Point X="394.25" Y="529.0" GraphRef="a8ea8" RelX="0.0" RelY="-1.0" />
+
       <Point X="394.25" Y="529.0" GraphRef="a8ea8" RelX="0.0" RelY="-1.0"/>
-
       <Point X="394.25" Y="496.0" GraphRef="d9137" RelX="0.0" RelY="1.0" ArrowHead="mim-inhibition" />
+
       <Point X="394.25" Y="496.0" GraphRef="d9137" RelX="0.0" RelY="1.0" ArrowHead="mim-inhibition"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction GraphId="id1461a80d">
   <Interaction GraphId="id1461a80d">
     <Graphics ZOrder="12288" LineThickness="1.0">
     <Graphics ZOrder="12288" LineThickness="1.0">
-
       <Point X="480.375" Y="131.5" GraphRef="c0ce5" RelX="0.0" RelY="1.0" />
+
       <Point X="480.375" Y="131.5" GraphRef="c0ce5" RelX="0.0" RelY="1.0"/>
-
       <Point X="480.0" Y="166.16666666666666" GraphRef="bcc1f" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
+
       <Point X="480.0" Y="166.16666666666666" GraphRef="bcc1f" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction GraphId="id1ee6ed76">
   <Interaction GraphId="id1ee6ed76">
     <Graphics ZOrder="12288" LineThickness="1.0">
     <Graphics ZOrder="12288" LineThickness="1.0">
-
       <Point X="584.6666666666656" Y="356.50000000000034" GraphRef="c6f8f" RelX="0.0" RelY="1.0" />
+
       <Point X="584.6666666666656" Y="356.50000000000034" GraphRef="c6f8f" RelX="0.0" RelY="1.0"/>
-
       <Point X="584.6666666666656" Y="393.5" GraphRef="c39fb" RelX="0.0" RelY="-1.0" ArrowHead="mim-stimulation" />
+
       <Point X="584.6666666666656" Y="393.5" GraphRef="c39fb" RelX="0.0" RelY="-1.0" ArrowHead="mim-stimulation"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction GraphId="id2178c482">
   <Interaction GraphId="id2178c482">
     <Graphics ZOrder="12288" LineThickness="1.0">
     <Graphics ZOrder="12288" LineThickness="1.0">
-
       <Point X="220.0" Y="128.75" GraphRef="d27ea" RelX="0.0" RelY="1.0" />
+
       <Point X="220.0" Y="128.75" GraphRef="d27ea" RelX="0.0" RelY="1.0"/>
-
       <Point X="220.0" Y="173.25" GraphRef="ddeeb" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" />
+
       <Point X="220.0" Y="173.25" GraphRef="ddeeb" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion"/>
-
       <Anchor Position="0.5217391304347826" Shape="None" GraphId="a3914" />
+
       <Anchor Position="0.5217391304347826" Shape="None" GraphId="a3914"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction GraphId="id2e087c1c">
   <Interaction GraphId="id2e087c1c">
     <Graphics ZOrder="12288" LineThickness="1.0">
     <Graphics ZOrder="12288" LineThickness="1.0">
-
       <Point X="500.66666666666674" Y="441.1666666666665" GraphRef="a4999" RelX="0.0" RelY="1.0" />
+
       <Point X="500.66666666666674" Y="441.1666666666665" GraphRef="a4999" RelX="0.0" RelY="1.0"/>
-
       <Point X="501.0" Y="472.0" GraphRef="ec843" RelX="0.0" RelY="-1.0" ArrowHead="mim-inhibition" />
+
       <Point X="501.0" Y="472.0" GraphRef="ec843" RelX="0.0" RelY="-1.0" ArrowHead="mim-inhibition"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction GraphId="id2e93f68">
   <Interaction GraphId="id2e93f68">
     <Graphics ZOrder="12288" LineThickness="1.0">
     <Graphics ZOrder="12288" LineThickness="1.0">
-
       <Point X="217.25" Y="460.25" GraphRef="f0fc1" RelX="0.0" RelY="1.0" />
+
       <Point X="217.25" Y="460.25" GraphRef="f0fc1" RelX="0.0" RelY="1.0"/>
-
       <Point X="259.5" Y="483.5" GraphRef="ac228" RelX="-1.0" RelY="0.0" ArrowHead="mim-conversion" />
+
       <Point X="259.5" Y="483.5" GraphRef="ac228" RelX="-1.0" RelY="0.0" ArrowHead="mim-conversion"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction GraphId="id45687820">
   <Interaction GraphId="id45687820">
     <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0">
     <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0">
-
       <Point X="443.33333333333337" Y="235.9999999999999" GraphRef="f301f" RelX="1.0" RelY="0.0" />
+
       <Point X="443.33333333333337" Y="235.9999999999999" GraphRef="f301f" RelX="1.0" RelY="0.0"/>
-
       <Point X="479.5170842190423" Y="280.365994155578" GraphRef="c8d75" RelX="0.0" RelY="0.0" ArrowHead="mim-inhibition" />
+
       <Point X="479.5170842190423" Y="280.365994155578" GraphRef="c8d75" RelX="0.0" RelY="0.0" ArrowHead="mim-inhibition"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction GraphId="id48beda23">
   <Interaction GraphId="id48beda23">
     <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0">
     <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0">
-
       <Point X="479.3333333333326" Y="336.83333333333337" GraphRef="b6ad1" RelX="0.0" RelY="1.0" />
+
       <Point X="479.3333333333326" Y="336.83333333333337" GraphRef="b6ad1" RelX="0.0" RelY="1.0"/>
-
       <Point X="435.0000000000001" Y="379.5000000000001" GraphRef="a5d1a" RelX="0.0" RelY="-1.0" ArrowHead="mim-stimulation" />
+
       <Point X="435.0000000000001" Y="379.5000000000001" GraphRef="a5d1a" RelX="0.0" RelY="-1.0" ArrowHead="mim-stimulation"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction GraphId="id57252e4c">
   <Interaction GraphId="id57252e4c">
     <Graphics ZOrder="12288" LineThickness="1.0">
     <Graphics ZOrder="12288" LineThickness="1.0">
-
       <Point X="220.0" Y="210.25" GraphRef="ddeeb" RelX="0.0" RelY="1.0" />
+
       <Point X="220.0" Y="210.25" GraphRef="ddeeb" RelX="0.0" RelY="1.0"/>
-
       <Point X="219.5" Y="256.75" GraphRef="b9897" RelX="0.0" RelY="-1.0" ArrowHead="mim-binding" />
+
       <Point X="219.5" Y="256.75" GraphRef="b9897" RelX="0.0" RelY="-1.0" ArrowHead="mim-binding"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction GraphId="id5cc64764">
   <Interaction GraphId="id5cc64764">
     <Graphics ZOrder="12288" LineThickness="1.0">
     <Graphics ZOrder="12288" LineThickness="1.0">
-
       <Point X="172.74999999999966" Y="151.24999999999994" GraphRef="c8929" RelX="1.0" RelY="0.0" />
+
       <Point X="172.74999999999966" Y="151.24999999999994" GraphRef="c8929" RelX="1.0" RelY="0.0"/>
-
       <Point X="220.0" Y="151.9673913043478" GraphRef="a3914" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
+
       <Point X="220.0" Y="151.9673913043478" GraphRef="a3914" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction GraphId="id6292d207">
   <Interaction GraphId="id6292d207">
     <Graphics ZOrder="12288" LineThickness="1.0">
     <Graphics ZOrder="12288" LineThickness="1.0">
-
       <Point X="424.25" Y="483.5" GraphRef="d9137" RelX="1.0" RelY="0.0" />
+
       <Point X="424.25" Y="483.5" GraphRef="d9137" RelX="1.0" RelY="0.0"/>
-
       <Point X="466.0" Y="484.5" GraphRef="ec843" RelX="-1.0" RelY="0.0" ArrowHead="mim-stimulation" />
+
       <Point X="466.0" Y="484.5" GraphRef="ec843" RelX="-1.0" RelY="0.0" ArrowHead="mim-stimulation"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction GraphId="id70dad0b8">
   <Interaction GraphId="id70dad0b8">
     <Graphics ZOrder="12288" LineThickness="1.0">
     <Graphics ZOrder="12288" LineThickness="1.0">
-
       <Point X="193.75" Y="491.5" GraphRef="e09da" RelX="0.0" RelY="-1.0" />
+
       <Point X="193.75" Y="491.5" GraphRef="e09da" RelX="0.0" RelY="-1.0"/>
-
       <Point X="193.875" Y="460.25" GraphRef="f0fc1" RelX="-0.5" RelY="1.0" ArrowHead="mim-inhibition" />
+
       <Point X="193.875" Y="460.25" GraphRef="f0fc1" RelX="-0.5" RelY="1.0" ArrowHead="mim-inhibition"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction GraphId="id7ece7bf7">
   <Interaction GraphId="id7ece7bf7">
     <Graphics ZOrder="12288" LineThickness="1.0">
     <Graphics ZOrder="12288" LineThickness="1.0">
-
       <Point X="480.0" Y="197.66666666666666" GraphRef="bcc1f" RelX="0.0" RelY="1.0" />
+
       <Point X="480.0" Y="197.66666666666666" GraphRef="bcc1f" RelX="0.0" RelY="1.0"/>
-
       <Point X="479.3333333333326" Y="311.83333333333337" GraphRef="b6ad1" RelX="0.0" RelY="-1.0" ArrowHead="mim-binding" />
+
       <Point X="479.3333333333326" Y="311.83333333333337" GraphRef="b6ad1" RelX="0.0" RelY="-1.0" ArrowHead="mim-binding"/>
-
       <Anchor Position="0.7243736714357194" Shape="None" GraphId="c8d75" />
+
       <Anchor Position="0.7243736714357194" Shape="None" GraphId="c8d75"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction GraphId="id8922ec03">
   <Interaction GraphId="id8922ec03">
     <Graphics ZOrder="12288" LineThickness="1.0">
     <Graphics ZOrder="12288" LineThickness="1.0">
-
       <Point X="219.5" Y="281.75" GraphRef="b9897" RelX="0.0" RelY="1.0" />
+
       <Point X="219.5" Y="281.75" GraphRef="b9897" RelX="0.0" RelY="1.0"/>
-
       <Point X="217.0" Y="366.5" GraphRef="eaec8" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
+
       <Point X="217.0" Y="366.5" GraphRef="eaec8" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction GraphId="idbf404bc2">
   <Interaction GraphId="idbf404bc2">
     <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0">
     <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0">
-
       <Point X="569.6666666666656" Y="348.5000000000004" GraphRef="a47f2" RelX="-0.5" RelY="1.0" />
+
       <Point X="569.6666666666656" Y="348.5000000000004" GraphRef="a47f2" RelX="-0.5" RelY="1.0"/>
-
       <Point X="500.66666666666674" Y="416.1666666666665" GraphRef="a4999" RelX="0.0" RelY="-1.0" ArrowHead="mim-stimulation" />
+
       <Point X="500.66666666666674" Y="416.1666666666665" GraphRef="a4999" RelX="0.0" RelY="-1.0" ArrowHead="mim-stimulation"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction GraphId="idc3c11ab4">
   <Interaction GraphId="idc3c11ab4">
     <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0">
     <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0">
-
       <Point X="217.0" Y="391.5" GraphRef="eaec8" RelX="0.0" RelY="1.0" />
+
       <Point X="217.0" Y="391.5" GraphRef="eaec8" RelX="0.0" RelY="1.0"/>
-
       <Point X="217.25" Y="435.25" GraphRef="f0fc1" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
+
       <Point X="217.25" Y="435.25" GraphRef="f0fc1" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction GraphId="idc6b66933">
   <Interaction GraphId="idc6b66933">
     <Graphics ZOrder="12288" LineThickness="1.0">
     <Graphics ZOrder="12288" LineThickness="1.0">
-
       <Point X="509.3333333333326" Y="324.33333333333337" GraphRef="b6ad1" RelX="1.0" RelY="0.0" />
+
       <Point X="509.3333333333326" Y="324.33333333333337" GraphRef="b6ad1" RelX="1.0" RelY="0.0"/>
-
       <Point X="546.6666666666656" Y="324.5" ArrowHead="mim-conversion" />
+
       <Point X="546.6666666666656" Y="324.5" ArrowHead="mim-conversion"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction GraphId="idc96a7001">
   <Interaction GraphId="idc96a7001">
     <Graphics ZOrder="12288" LineThickness="1.0">
     <Graphics ZOrder="12288" LineThickness="1.0">
-
       <Point X="402.6666666666672" Y="325.0000000000001" GraphRef="d48db" RelX="1.0" RelY="0.0" />
+
       <Point X="402.6666666666672" Y="325.0000000000001" GraphRef="d48db" RelX="1.0" RelY="0.0"/>
-
       <Point X="449.3333333333326" Y="324.33333333333337" GraphRef="b6ad1" RelX="-1.0" RelY="0.0" ArrowHead="mim-binding" />
+
       <Point X="449.3333333333326" Y="324.33333333333337" GraphRef="b6ad1" RelX="-1.0" RelY="0.0" ArrowHead="mim-binding"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction GraphId="ide7295d3e">
   <Interaction GraphId="ide7295d3e">
     <Graphics ZOrder="12288" LineThickness="1.0">
     <Graphics ZOrder="12288" LineThickness="1.0">
-
       <Point X="319.5" Y="483.5" GraphRef="ac228" RelX="1.0" RelY="0.0" />
+
       <Point X="319.5" Y="483.5" GraphRef="ac228" RelX="1.0" RelY="0.0"/>
-
       <Point X="364.25" Y="483.5" GraphRef="d9137" RelX="-1.0" RelY="0.0" ArrowHead="mim-stimulation" />
+
       <Point X="364.25" Y="483.5" GraphRef="d9137" RelX="-1.0" RelY="0.0" ArrowHead="mim-stimulation"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Label TextLabel="Regulators of PRNP" GraphId="a62ab" GroupRef="ed0e2">
   <Label TextLabel="Regulators of PRNP" GraphId="a62ab" GroupRef="ed0e2">
-
     <Graphics CenterX="572.5" CenterY="35.25" Width="117.0" Height="25.0" ZOrder="28672" FillColor="ffffff" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="572.5" CenterY="35.25" Width="117.0" Height="25.0" ZOrder="28672" FillColor="ffffff" FontSize="12" Valign="Middle"/>
   </Label>
   </Label>
   <Label TextLabel="?" GraphId="a6b6b">
   <Label TextLabel="?" GraphId="a6b6b">
-
     <Graphics CenterX="235.41666666666595" CenterY="151.25" Width="90.0" Height="25.0" ZOrder="28672" FillColor="ffffff" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="235.41666666666595" CenterY="151.25" Width="90.0" Height="25.0" ZOrder="28672" FillColor="ffffff" FontSize="12" Valign="Middle"/>
   </Label>
   </Label>
   <Label TextLabel="Neuron" GraphId="c75da">
   <Label TextLabel="Neuron" GraphId="c75da">
-
     <Graphics CenterX="584.5" CenterY="538.0" Width="70.0" Height="25.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="584.5" CenterY="538.0" Width="70.0" Height="25.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle"/>
   </Label>
   </Label>
   <Label TextLabel="P" GraphId="dc871">
   <Label TextLabel="P" GraphId="dc871">
-
     <Graphics CenterX="615.0" CenterY="300.0" Width="25.0" Height="25.0" ZOrder="32773" FillColor="ffffff" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="615.0" CenterY="300.0" Width="25.0" Height="25.0" ZOrder="32773" FillColor="ffffff" FontSize="12" Valign="Middle"/>
   </Label>
   </Label>
   <Label TextLabel="P" GraphId="b1946">
   <Label TextLabel="P" GraphId="b1946">
-
     <Graphics CenterX="615.0" CenterY="349.0" Width="25.0" Height="25.0" ZOrder="32774" FillColor="ffffff" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="615.0" CenterY="349.0" Width="25.0" Height="25.0" ZOrder="32774" FillColor="ffffff" FontSize="12" Valign="Middle"/>
   </Label>
   </Label>
   <Label TextLabel="C" GraphId="e532e">
   <Label TextLabel="C" GraphId="e532e">
-
     <Graphics CenterX="248.0" CenterY="125.75" Width="25.0" Height="25.0" ZOrder="32775" FillColor="ffffff" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="248.0" CenterY="125.75" Width="25.0" Height="25.0" ZOrder="32775" FillColor="ffffff" FontSize="12" Valign="Middle"/>
   </Label>
   </Label>
   <Label TextLabel="Sc" GraphId="d3518">
   <Label TextLabel="Sc" GraphId="d3518">
-
     <Graphics CenterX="249.0" CenterY="211.0" Width="94.0" Height="30.5" ZOrder="32776" FillColor="ffffff" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="249.0" CenterY="211.0" Width="94.0" Height="30.5" ZOrder="32776" FillColor="ffffff" FontSize="12" Valign="Middle"/>
   </Label>
   </Label>
   <Shape GraphId="ac3e8">
   <Shape GraphId="ac3e8">
-
     <Attribute Key="org.pathvisio.CellularComponentProperty" Value="Cell" />
+
     <Attribute Key="org.pathvisio.CellularComponentProperty" Value="Cell"/>
-
     <Attribute Key="org.pathvisio.DoubleLineProperty" Value="Double" />
+
     <Attribute Key="org.pathvisio.DoubleLineProperty" Value="Double"/>
-
     <Graphics CenterX="338.91666666666663" CenterY="412.8333333333336" Width="598.1666666666667" Height="286.3333333333328" ZOrder="-4" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" LineThickness="3.0" Color="c0c0c0" Rotation="0.0" />
+
     <Graphics CenterX="338.91666666666663" CenterY="412.8333333333336" Width="598.1666666666667" Height="286.3333333333328" ZOrder="-4" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" LineThickness="3.0" Color="c0c0c0" Rotation="0.0"/>
   </Shape>
   </Shape>
   <Shape GraphId="ff20a">
   <Shape GraphId="ff20a">
-
     <Attribute Key="org.pathvisio.CellularComponentProperty" Value="Endoplasmic Reticulum" />
+
     <Attribute Key="org.pathvisio.CellularComponentProperty" Value="Endoplasmic Reticulum"/>
-
     <Graphics CenterX="195.0" CenterY="395.0" Width="150.0" Height="148.0" ZOrder="-2" FontSize="12" Valign="Middle" ShapeType="Endoplasmic Reticulum" LineThickness="3.0" Color="c0c0c0" Rotation="0.0" />
+
     <Graphics CenterX="195.0" CenterY="395.0" Width="150.0" Height="148.0" ZOrder="-2" FontSize="12" Valign="Middle" ShapeType="Endoplasmic Reticulum" LineThickness="3.0" Color="c0c0c0" Rotation="0.0"/>
   </Shape>
   </Shape>
-
   <Group GroupId="ed0e2" GraphId="c0ce5" Style="Group" />
+
   <Group GroupId="ed0e2" GraphId="c0ce5" Style="Group"/>
-
   <Group GroupId="d63a8" GraphId="c39fb" Style="Group" />
+
   <Group GroupId="d63a8" GraphId="c39fb" Style="Group"/>
-
   <Group GroupId="afe36" GraphId="c6f8f" Style="Group" />
+
   <Group GroupId="afe36" GraphId="c6f8f" Style="Group"/>
-
   <Group GroupId="cdb0d" GraphId="d48db" Style="Group" />
+
   <Group GroupId="cdb0d" GraphId="d48db" Style="Group"/>
-
   <Group GroupId="edf91" GraphId="db5ff" Style="Complex" />
+
   <Group GroupId="edf91" GraphId="db5ff" Style="Complex"/>
-
   <InfoBox CenterX="0.0" CenterY="0.0" />
+
   <InfoBox CenterX="0.0" CenterY="0.0"/>
   <Biopax>
   <Biopax>
-
     <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
+
      
-
      <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">neuron</bp:TERM>
+
-
      <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CL:0000540</bp:ID>
+
-
      <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cell Type</bp:Ontology>
+
-
    </bp:openControlledVocabulary>
+
     <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
     <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
       <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">prion disease</bp:TERM>
       <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">prion disease</bp:TERM>
Line 415: Line 411:
       <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
       <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
     </bp:openControlledVocabulary>
     </bp:openControlledVocabulary>
-
     <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
+
      
-
      <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">neuron</bp:TERM>
+
-
      <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CL:0000540</bp:ID>
+
-
      <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cell Type</bp:Ontology>
+
-
    </bp:openControlledVocabulary>
+
     <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
     <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
       <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">disease pathway</bp:TERM>
       <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">disease pathway</bp:TERM>

Current revision

Error rendering pathway page

This revision of the pathway probably contains invalid GPML code. If this happens to the most recent revision, try reverting the pathway using the pathway history displayed below or contact the site administrators (see WikiPathways:About) to resolve this problem.

Pathway history

View all...
CompareRevisionActionTimeUserComment
129475view03:22, 24 April 2024EweitzOntology Term : 'CL:0000540' removed !
128423view17:46, 4 February 2024EweitzEconomize layout
128402view04:16, 4 February 2024EweitzUse same height for altered-state PRNP nodes
128401view04:15, 4 February 2024EweitzUse same height for single-line nodes
128395view03:24, 4 February 2024EweitzOntology Term : 'CL:0000540' removed !
128394view03:23, 4 February 2024EweitzUpgrade pathway node, note cell type
128393view03:19, 4 February 2024EweitzRefine z-index, positions
128392view03:14, 4 February 2024EweitzEconomize layout, standardize case
127628view21:53, 9 November 2023Khanspersmoved link to WP1866 from literature reference to node comment
119304view13:06, 23 June 2021Finterlyadded WPID to PublicationXref
108089view11:55, 28 November 2019FehrhartOntology Term : 'disease pathway' added !
106531view23:51, 5 September 2019KhanspersModified description
105792view19:49, 15 August 2019KhanspersModified description
104288view12:48, 15 May 2019FehrhartOntology Term : 'CL:0000540' removed !
96400view10:15, 12 March 2018EgonwReplaced a secondary ChEBI identifier with a primary identifier.
94740view15:08, 5 October 2017Mkutmonfix unconnected line
93157view14:41, 1 August 2017FehrhartRe-added Z-DEVD-FMK after being added to ChEBI
93045view09:03, 27 July 2017FehrhartConnected interactions
92788view12:26, 6 July 2017LvdWouwModified description
92787view12:09, 6 July 2017LvdWouw
92775view08:31, 4 July 2017LvdWouw
92774view08:03, 4 July 2017LvdWouw
92752view12:01, 3 July 2017LvdWouwAdded PRNP regulators from ENCODE
92750view06:14, 3 July 2017FehrhartOntology Term : 'neuron' added !
92749view06:12, 3 July 2017FehrhartOntology Term : 'prion disease' added !
92720view08:15, 30 June 2017LvdWouw
92718view07:06, 30 June 2017LvdWouw
92705view09:03, 29 June 2017LvdWouw
92683view17:41, 28 June 2017MaintBotfixed unconnected
92664view16:21, 27 June 2017LvdWouwOntology Term : 'prion diseases pathway' added !
92663view16:21, 27 June 2017LvdWouwOntology Term : 'PW:0000267' removed !
92662view16:20, 27 June 2017LvdWouwOntology Term : 'neuron' added !
92661view16:19, 27 June 2017LvdWouwModified title
92660view16:19, 27 June 2017LvdWouwModified title
92659view16:17, 27 June 2017LvdWouw
92658view16:08, 27 June 2017LvdWouwModified description
92657view16:07, 27 June 2017LvdWouwModified description
92522view10:56, 13 June 2017FehrhartOntology Term : 'fatal familial insomnia pathway' added !
92519view08:12, 13 June 2017LvdWouw
92518view07:52, 13 June 2017LvdWouwAdded state (phosphorylation)
92514view07:56, 12 June 2017LvdWouw
92513view07:56, 12 June 2017LvdWouw
92512view07:47, 12 June 2017LvdWouwModified title
92511view07:47, 12 June 2017LvdWouwModified title
92510view07:47, 12 June 2017LvdWouwNew pathway

Error details

exception 'Exception' with message 'Unable to convert to /var/www/wikipathways/images/4/40/WP3995_prev.svg:
<BR>Status:1
<BR>Message:Exception in thread "main" java.lang.NullPointerException
	at org.pathvisio.core.Engine.getPathwayImporters(Unknown Source)
	at org.pathvisio.core.Engine.importPathway(Unknown Source)
	at org.pathvisio.core.util.Converter.main(Unknown Source)

<BR>Command:java -Xmx1024M -jar /var/www/wikipathways/wpi/bin/pathvisio_core.jar "/var/www/wikipathways" "/var/www/wikipathways/images/4/40/WP3995_prev.svg" 2>&1<BR>' in /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php:1255
Stack trace:
#0 /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php(1227): Pathway::convertWithPathVisio(false, '/var/www/wikipa...')
#1 /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php(1137): Pathway->saveConvertedByPathVisioCache('svg')
#2 /var/www/wikipathways/wpi/extensions/Pathways/PathwayPage.php(21): Pathway->updateCache('svg')
#3 [internal function]: renderPathwayPage(Object(Parser), '<?xml version="...', Object(StripState))
#4 /var/www/wikipathways/includes/Hooks.php(125): call_user_func_array('renderPathwayPa...', Array)
#5 /var/www/wikipathways/includes/parser/Parser.php(318): wfRunHooks('ParserBeforeStr...', Array)
#6 /var/www/wikipathways/includes/OutputPage.php(405): Parser->parse('<?xml version="...', Object(Title), Object(ParserOptions), true, true, 129475)
#7 /var/www/wikipathways/includes/OutputPage.php(391): OutputPage->addWikiTextTitle('<?xml version="...', Object(Title), true, true)
#8 /var/www/wikipathways/includes/OutputPage.php(500): OutputPage->addWikiTextTitleTidy('<?xml version="...', Object(Title), true)
#9 /var/www/wikipathways/includes/DifferenceEngine.php(313): OutputPage->addWikiTextTidy('<?xml version="...')
#10 /var/www/wikipathways/includes/DifferenceEngine.php(271): DifferenceEngine->renderNewRevision()
#11 /var/www/wikipathways/includes/Article.php(729): DifferenceEngine->showDiffPage(false)
#12 /var/www/wikipathways/includes/Wiki.php(437): Article->view()
#13 /var/www/wikipathways/includes/Wiki.php(59): MediaWiki->performAction(Object(OutputPage), Object(Article), Object(Title), Object(User), Object(WebRequest))
#14 /var/www/wikipathways/index.php(93): MediaWiki->initialize(Object(Title), Object(Article), Object(OutputPage), Object(User), Object(WebRequest))
#15 {main}
Personal tools