Prion disease pathway (Homo sapiens)
From WikiPathways
(Difference between revisions)
(Economize layout) |
Current revision (03:22, 24 April 2024) (view source) (Ontology Term : 'CL:0000540' removed !) |
||
Line 7: | Line 7: | ||
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3995 CPTAC Assay Portal]</Comment> | Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3995 CPTAC Assay Portal]</Comment> | ||
- | <Graphics BoardWidth="668.0" BoardHeight="636.0" /> | + | <Graphics BoardWidth="668.0" BoardHeight="636.0"/> |
<DataNode TextLabel="RFX5" GraphId="a13b8" Type="GeneProduct" GroupRef="ed0e2"> | <DataNode TextLabel="RFX5" GraphId="a13b8" Type="GeneProduct" GroupRef="ed0e2"> | ||
- | <Graphics CenterX="600.0" CenterY="86.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="600.0" CenterY="86.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/> |
- | <Xref Database="Ensembl" ID="ENSG00000143390" /> | + | <Xref Database="Ensembl" ID="ENSG00000143390"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="ELK1" GraphId="a1a32" Type="GeneProduct" GroupRef="d63a8"> | <DataNode TextLabel="ELK1" GraphId="a1a32" Type="GeneProduct" GroupRef="d63a8"> | ||
- | <Graphics CenterX="584.6666666666656" CenterY="463.0833333333312" Width="60.0" Height="23.499999999999524" ZOrder="32768" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="584.6666666666656" CenterY="463.0833333333312" Width="60.0" Height="23.499999999999524" ZOrder="32768" FontSize="12" Valign="Middle"/> |
- | <Xref Database="Ensembl" ID="ENSG00000126767" /> | + | <Xref Database="Ensembl" ID="ENSG00000126767"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="CREB1" GraphId="a4999" Type="Protein"> | <DataNode TextLabel="CREB1" GraphId="a4999" Type="Protein"> | ||
<Comment>https://classic.wikipathways.org/index.php/Pathway:WP1866</Comment> | <Comment>https://classic.wikipathways.org/index.php/Pathway:WP1866</Comment> | ||
- | <Graphics CenterX="500.66666666666674" CenterY="428.6666666666665" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="500.66666666666674" CenterY="428.6666666666665" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/> |
- | <Xref Database="Ensembl" ID="ENSG00000118260" /> | + | <Xref Database="Ensembl" ID="ENSG00000118260"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="FGFR1" GraphId="a5d1a" Type="GeneProduct"> | <DataNode TextLabel="FGFR1" GraphId="a5d1a" Type="GeneProduct"> | ||
<Comment>https://classic.wikipathways.org/index.php/Pathway:WP1866</Comment> | <Comment>https://classic.wikipathways.org/index.php/Pathway:WP1866</Comment> | ||
- | <Graphics CenterX="435.0000000000001" CenterY="392.0000000000001" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="435.0000000000001" CenterY="392.0000000000001" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/> |
- | <Xref Database="Ensembl" ID="ENSG00000077782" /> | + | <Xref Database="Ensembl" ID="ENSG00000077782"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="TBP" GraphId="a8c62" Type="GeneProduct" GroupRef="ed0e2"> | <DataNode TextLabel="TBP" GraphId="a8c62" Type="GeneProduct" GroupRef="ed0e2"> | ||
- | <Graphics CenterX="359.75" CenterY="111.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="359.75" CenterY="111.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/> |
- | <Xref Database="Ensembl" ID="ENSG00000112592" /> | + | <Xref Database="Ensembl" ID="ENSG00000112592"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="Z-DEVD-FMK" GraphId="a8ea8" Type="Metabolite"> | <DataNode TextLabel="Z-DEVD-FMK" GraphId="a8ea8" Type="Metabolite"> | ||
- | <Graphics CenterX="394.25" CenterY="539.0" Width="90.0" Height="20.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> | + | <Graphics CenterX="394.25" CenterY="539.0" Width="90.0" Height="20.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff"/> |
- | <Xref Database="ChEBI" ID="CHEBI:138013" /> | + | <Xref Database="ChEBI" ID="CHEBI:138013"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="BCL11A" GraphId="ac15a" Type="GeneProduct" GroupRef="ed0e2"> | <DataNode TextLabel="BCL11A" GraphId="ac15a" Type="GeneProduct" GroupRef="ed0e2"> | ||
- | <Graphics CenterX="480.0" CenterY="111.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="480.0" CenterY="111.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/> |
- | <Xref Database="Ensembl" ID="ENSG00000119866" /> | + | <Xref Database="Ensembl" ID="ENSG00000119866"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="STAT3" GraphId="ac17d" Type="GeneProduct" GroupRef="ed0e2"> | <DataNode TextLabel="STAT3" GraphId="ac17d" Type="GeneProduct" GroupRef="ed0e2"> | ||
- | <Graphics CenterX="540.0" CenterY="86.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="540.0" CenterY="86.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/> |
- | <Xref Database="Ensembl" ID="ENSG00000168610" /> | + | <Xref Database="Ensembl" ID="ENSG00000168610"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="CASP12" GraphId="ac228" Type="GeneProduct"> | <DataNode TextLabel="CASP12" GraphId="ac228" Type="GeneProduct"> | ||
<BiopaxRef>e7a</BiopaxRef> | <BiopaxRef>e7a</BiopaxRef> | ||
- | <Graphics CenterX="289.5" CenterY="483.5" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="289.5" CenterY="483.5" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/> |
- | <Xref Database="Ensembl" ID="ENSG00000204403" /> | + | <Xref Database="Ensembl" ID="ENSG00000204403"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="MAPK3" GraphId="ad1fd" Type="GeneProduct" GroupRef="d63a8"> | <DataNode TextLabel="MAPK3" GraphId="ad1fd" Type="GeneProduct" GroupRef="d63a8"> | ||
- | <Graphics CenterX="584.6666666666656" CenterY="439.4166666666657" Width="60.0" Height="25.833333333331517" ZOrder="32768" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="584.6666666666656" CenterY="439.4166666666657" Width="60.0" Height="25.833333333331517" ZOrder="32768" FontSize="12" Valign="Middle"/> |
- | <Xref Database="Ensembl" ID="ENSG00000102882" /> | + | <Xref Database="Ensembl" ID="ENSG00000102882"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="HSP90B1" GraphId="af847" Type="GeneProduct"> | <DataNode TextLabel="HSP90B1" GraphId="af847" Type="GeneProduct"> | ||
- | <Graphics CenterX="89.25" CenterY="448.25" Width="58.5" Height="25.0" ZOrder="32768" FillColor="ff6666" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="89.25" CenterY="448.25" Width="58.5" Height="25.0" ZOrder="32768" FillColor="ff6666" FontSize="12" Valign="Middle"/> |
- | <Xref Database="Ensembl" ID="ENSG00000166598" /> | + | <Xref Database="Ensembl" ID="ENSG00000166598"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="RAD21" GraphId="b4927" Type="GeneProduct" GroupRef="ed0e2"> | <DataNode TextLabel="RAD21" GraphId="b4927" Type="GeneProduct" GroupRef="ed0e2"> | ||
- | <Graphics CenterX="480.0" CenterY="61.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="480.0" CenterY="61.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/> |
- | <Xref Database="Ensembl" ID="ENSG00000164754" /> | + | <Xref Database="Ensembl" ID="ENSG00000164754"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="NCAM1" GraphId="b6ad1" Type="GeneProduct"> | <DataNode TextLabel="NCAM1" GraphId="b6ad1" Type="GeneProduct"> | ||
- | <Graphics CenterX="479.3333333333326" CenterY="324.33333333333337" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="479.3333333333326" CenterY="324.33333333333337" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/> |
- | <Xref Database="Ensembl" ID="ENSG00000149294" /> | + | <Xref Database="Ensembl" ID="ENSG00000149294"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="PDIA3" GraphId="b7a96" Type="GeneProduct"> | <DataNode TextLabel="PDIA3" GraphId="b7a96" Type="GeneProduct"> | ||
- | <Graphics CenterX="89.25" CenterY="376.25" Width="58.5" Height="25.0" ZOrder="32768" FillColor="ff6666" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="89.25" CenterY="376.25" Width="58.5" Height="25.0" ZOrder="32768" FillColor="ff6666" FontSize="12" Valign="Middle"/> |
- | <Xref Database="Ensembl" ID="ENSG00000167004" /> | + | <Xref Database="Ensembl" ID="ENSG00000167004"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="PrP receptor ?" GraphId="b9897" Type="Protein"> | <DataNode TextLabel="PrP receptor ?" GraphId="b9897" Type="Protein"> | ||
<BiopaxRef>e7a</BiopaxRef> | <BiopaxRef>e7a</BiopaxRef> | ||
- | <Graphics CenterX="219.5" CenterY="269.25" Width="89.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="219.5" CenterY="269.25" Width="89.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/> |
- | <Xref Database="" ID="" /> | + | <Xref Database="" ID=""/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="CTCF" GraphId="bb022" Type="GeneProduct" GroupRef="ed0e2"> | <DataNode TextLabel="CTCF" GraphId="bb022" Type="GeneProduct" GroupRef="ed0e2"> | ||
- | <Graphics CenterX="540.0" CenterY="61.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="540.0" CenterY="61.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/> |
- | <Xref Database="Ensembl" ID="ENSG00000102974" /> | + | <Xref Database="Ensembl" ID="ENSG00000102974"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="PAX5" GraphId="bb35c" Type="GeneProduct" GroupRef="ed0e2"> | <DataNode TextLabel="PAX5" GraphId="bb35c" Type="GeneProduct" GroupRef="ed0e2"> | ||
- | <Graphics CenterX="359.75" CenterY="36.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="359.75" CenterY="36.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/> |
- | <Xref Database="Ensembl" ID="ENSG00000196092" /> | + | <Xref Database="Ensembl" ID="ENSG00000196092"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="FYN" GraphId="bbbf2" Type="GeneProduct" GroupRef="cdb0d"> | <DataNode TextLabel="FYN" GraphId="bbbf2" Type="GeneProduct" GroupRef="cdb0d"> | ||
- | <Graphics CenterX="364.6666666666672" CenterY="337.6666666666666" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="364.6666666666672" CenterY="337.6666666666666" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/> |
- | <Xref Database="Ensembl" ID="ENSG00000010810" /> | + | <Xref Database="Ensembl" ID="ENSG00000010810"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="PRNP" GraphId="bcc1f" Type="GeneProduct"> | <DataNode TextLabel="PRNP" GraphId="bcc1f" Type="GeneProduct"> | ||
<Comment>https://classic.wikipathways.org/index.php/Pathway:WP1866</Comment> | <Comment>https://classic.wikipathways.org/index.php/Pathway:WP1866</Comment> | ||
- | <Graphics CenterX="480.0" CenterY="181.91666666666666" Width="60.0" Height="31.5" ZOrder="32768" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="480.0" CenterY="181.91666666666666" Width="60.0" Height="31.5" ZOrder="32768" FontSize="12" Valign="Middle"/> |
- | <Xref Database="Ensembl" ID="ENSG00000171867" /> | + | <Xref Database="Ensembl" ID="ENSG00000171867"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="PRNP (+ mutations)" GraphId="c8929" Type="GeneProduct"> | <DataNode TextLabel="PRNP (+ mutations)" GraphId="c8929" Type="GeneProduct"> | ||
- | <Graphics CenterX="112.91666666666669" CenterY="151.24999999999994" Width="119.66666666666592" Height="25.0" ZOrder="32768" FillColor="99ffff" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="112.91666666666669" CenterY="151.24999999999994" Width="119.66666666666592" Height="25.0" ZOrder="32768" FillColor="99ffff" FontSize="12" Valign="Middle"/> |
- | <Xref Database="Ensembl" ID="ENSG00000171867" /> | + | <Xref Database="Ensembl" ID="ENSG00000171867"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="PRNP" GraphId="d27ea" Type="Protein"> | <DataNode TextLabel="PRNP" GraphId="d27ea" Type="Protein"> | ||
<BiopaxRef>e7a</BiopaxRef> | <BiopaxRef>e7a</BiopaxRef> | ||
- | <Graphics CenterX="220.0" CenterY="110.25" Width="60.0" Height="37.0" ZOrder="32768" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="220.0" CenterY="110.25" Width="60.0" Height="37.0" ZOrder="32768" FontSize="12" Valign="Middle"/> |
- | <Xref Database="Ensembl" ID="ENSG00000171867" /> | + | <Xref Database="Ensembl" ID="ENSG00000171867"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="POU2F2" GraphId="d2b38" Type="GeneProduct" GroupRef="ed0e2"> | <DataNode TextLabel="POU2F2" GraphId="d2b38" Type="GeneProduct" GroupRef="ed0e2"> | ||
- | <Graphics CenterX="420.0" CenterY="36.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="420.0" CenterY="36.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/> |
- | <Xref Database="Ensembl" ID="ENSG00000028277" /> | + | <Xref Database="Ensembl" ID="ENSG00000028277"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="MEF2C" GraphId="d46a0" Type="GeneProduct" GroupRef="ed0e2"> | <DataNode TextLabel="MEF2C" GraphId="d46a0" Type="GeneProduct" GroupRef="ed0e2"> | ||
- | <Graphics CenterX="359.75" CenterY="86.25" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="359.75" CenterY="86.25" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/> |
- | <Xref Database="Ensembl" ID="ENSG00000081189" /> | + | <Xref Database="Ensembl" ID="ENSG00000081189"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="NFKB1" GraphId="d7cd4" Type="GeneProduct" GroupRef="ed0e2"> | <DataNode TextLabel="NFKB1" GraphId="d7cd4" Type="GeneProduct" GroupRef="ed0e2"> | ||
- | <Graphics CenterX="480.0" CenterY="36.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="480.0" CenterY="36.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/> |
- | <Xref Database="Ensembl" ID="ENSG00000109320" /> | + | <Xref Database="Ensembl" ID="ENSG00000109320"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="CASP3" GraphId="d9137" Type="GeneProduct"> | <DataNode TextLabel="CASP3" GraphId="d9137" Type="GeneProduct"> | ||
<BiopaxRef>e7a</BiopaxRef> | <BiopaxRef>e7a</BiopaxRef> | ||
- | <Graphics CenterX="394.25" CenterY="483.5" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="394.25" CenterY="483.5" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/> |
- | <Xref Database="Ensembl" ID="ENSG00000164305" /> | + | <Xref Database="Ensembl" ID="ENSG00000164305"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="BATF" GraphId="da7af" Type="GeneProduct" GroupRef="ed0e2"> | <DataNode TextLabel="BATF" GraphId="da7af" Type="GeneProduct" GroupRef="ed0e2"> | ||
- | <Graphics CenterX="420.0" CenterY="86.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="420.0" CenterY="86.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/> |
- | <Xref Database="Ensembl" ID="ENSG00000156127" /> | + | <Xref Database="Ensembl" ID="ENSG00000156127"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="SPI1" GraphId="db498" Type="GeneProduct" GroupRef="ed0e2"> | <DataNode TextLabel="SPI1" GraphId="db498" Type="GeneProduct" GroupRef="ed0e2"> | ||
- | <Graphics CenterX="600.0" CenterY="61.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="600.0" CenterY="61.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/> |
- | <Xref Database="Ensembl" ID="ENSG00000066336" /> | + | <Xref Database="Ensembl" ID="ENSG00000066336"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="EP300" GraphId="dc211" Type="GeneProduct" GroupRef="ed0e2"> | <DataNode TextLabel="EP300" GraphId="dc211" Type="GeneProduct" GroupRef="ed0e2"> | ||
- | <Graphics CenterX="359.75" CenterY="61.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="359.75" CenterY="61.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/> |
- | <Xref Database="Ensembl" ID="ENSG00000100393" /> | + | <Xref Database="Ensembl" ID="ENSG00000100393"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="PRNP" GraphId="ddeeb" Type="Protein"> | <DataNode TextLabel="PRNP" GraphId="ddeeb" Type="Protein"> | ||
<BiopaxRef>e7a</BiopaxRef> | <BiopaxRef>e7a</BiopaxRef> | ||
- | <Graphics CenterX="220.0" CenterY="191.75" Width="60.0" Height="37.0" ZOrder="32768" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="220.0" CenterY="191.75" Width="60.0" Height="37.0" ZOrder="32768" FontSize="12" Valign="Middle"/> |
- | <Xref Database="Ensembl" ID="ENSG00000171867" /> | + | <Xref Database="Ensembl" ID="ENSG00000171867"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="EBF1" GraphId="e0647" Type="GeneProduct" GroupRef="ed0e2"> | <DataNode TextLabel="EBF1" GraphId="e0647" Type="GeneProduct" GroupRef="ed0e2"> | ||
- | <Graphics CenterX="540.0" CenterY="111.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="540.0" CenterY="111.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/> |
- | <Xref Database="Ensembl" ID="ENSG00000164330" /> | + | <Xref Database="Ensembl" ID="ENSG00000164330"/> |
</DataNode> | </DataNode> | ||
- | <DataNode TextLabel="BCL2&# | + | <DataNode TextLabel="BCL2 Anti-apoptotic" GraphId="e09da" Type="GeneProduct"> |
<BiopaxRef>e7a</BiopaxRef> | <BiopaxRef>e7a</BiopaxRef> | ||
- | <Graphics CenterX="193.75" CenterY="513.25" Width="80.5" Height="43.5" ZOrder="32768" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="193.75" CenterY="513.25" Width="80.5" Height="43.5" ZOrder="32768" FontSize="12" Valign="Middle"/> |
- | <Xref Database="Ensembl" ID="ENSG00000171791" /> | + | <Xref Database="Ensembl" ID="ENSG00000171791"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="IRF4" GraphId="e2222" Type="GeneProduct" GroupRef="ed0e2"> | <DataNode TextLabel="IRF4" GraphId="e2222" Type="GeneProduct" GroupRef="ed0e2"> | ||
- | <Graphics CenterX="600.0" CenterY="111.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="600.0" CenterY="111.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/> |
- | <Xref Database="Ensembl" ID="ENSG00000137265" /> | + | <Xref Database="Ensembl" ID="ENSG00000137265"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="SMC3" GraphId="e55a9" Type="GeneProduct" GroupRef="ed0e2"> | <DataNode TextLabel="SMC3" GraphId="e55a9" Type="GeneProduct" GroupRef="ed0e2"> | ||
- | <Graphics CenterX="479.75" CenterY="85.875" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="479.75" CenterY="85.875" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/> |
- | <Xref Database="Ensembl" ID="ENSG00000108055" /> | + | <Xref Database="Ensembl" ID="ENSG00000108055"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="RXRA" GraphId="e869b" Type="GeneProduct" GroupRef="ed0e2"> | <DataNode TextLabel="RXRA" GraphId="e869b" Type="GeneProduct" GroupRef="ed0e2"> | ||
- | <Graphics CenterX="420.0" CenterY="111.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="420.0" CenterY="111.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/> |
- | <Xref Database="Ensembl" ID="ENSG00000186350" /> | + | <Xref Database="Ensembl" ID="ENSG00000186350"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="Ca2+" GraphId="eaec8" Type="Metabolite"> | <DataNode TextLabel="Ca2+" GraphId="eaec8" Type="Metabolite"> | ||
<BiopaxRef>e7a</BiopaxRef> | <BiopaxRef>e7a</BiopaxRef> | ||
- | <Graphics CenterX="217.0" CenterY="379.0" Width="40.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" /> | + | <Graphics CenterX="217.0" CenterY="379.0" Width="40.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff"/> |
- | <Xref Database="ChEBI" ID="CHEBI:29108" /> | + | <Xref Database="ChEBI" ID="CHEBI:29108"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="Apoptosis" GraphId="ec843" Type="Pathway"> | <DataNode TextLabel="Apoptosis" GraphId="ec843" Type="Pathway"> | ||
- | <Graphics CenterX="501.0" CenterY="484.5" Width="70.0" Height="25.0" ZOrder="32768" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="14961e" /> | + | <Graphics CenterX="501.0" CenterY="484.5" Width="70.0" Height="25.0" ZOrder="32768" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="14961e"/> |
- | <Xref Database="WikiPathways" ID="WP254" /> | + | <Xref Database="WikiPathways" ID="WP254"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="MAPK1" GraphId="ecc1f" Type="GeneProduct" GroupRef="d63a8"> | <DataNode TextLabel="MAPK1" GraphId="ecc1f" Type="GeneProduct" GroupRef="d63a8"> | ||
- | <Graphics CenterX="584.6666666666656" CenterY="413.99999999999994" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="584.6666666666656" CenterY="413.99999999999994" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/> |
- | <Xref Database="Ensembl" ID="ENSG00000100030" /> | + | <Xref Database="Ensembl" ID="ENSG00000100030"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="PTK2" GraphId="f0245" Type="GeneProduct" GroupRef="cdb0d"> | <DataNode TextLabel="PTK2" GraphId="f0245" Type="GeneProduct" GroupRef="cdb0d"> | ||
- | <Graphics CenterX="364.66666666666674" CenterY="312.33333333333366" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="364.66666666666674" CenterY="312.33333333333366" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/> |
- | <Xref Database="Ensembl" ID="ENSG00000169398" /> | + | <Xref Database="Ensembl" ID="ENSG00000169398"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="PRO CASP12" GraphId="f0fc1" Type="GeneProduct"> | <DataNode TextLabel="PRO CASP12" GraphId="f0fc1" Type="GeneProduct"> | ||
<BiopaxRef>e7a</BiopaxRef> | <BiopaxRef>e7a</BiopaxRef> | ||
- | <Graphics CenterX="217.25" CenterY="447.75" Width="93.5" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="217.25" CenterY="447.75" Width="93.5" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/> |
- | <Xref Database="Ensembl" ID="ENSG00000204403" /> | + | <Xref Database="Ensembl" ID="ENSG00000204403"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="CHD2" GraphId="f14dd" Type="GeneProduct" GroupRef="ed0e2"> | <DataNode TextLabel="CHD2" GraphId="f14dd" Type="GeneProduct" GroupRef="ed0e2"> | ||
- | <Graphics CenterX="420.0" CenterY="61.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="420.0" CenterY="61.0" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/> |
- | <Xref Database="Ensembl" ID="ENSG00000173575" /> | + | <Xref Database="Ensembl" ID="ENSG00000173575"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="PRNP (+ mutations)" GraphId="f301f" Type="GeneProduct"> | <DataNode TextLabel="PRNP (+ mutations)" GraphId="f301f" Type="GeneProduct"> | ||
- | <Graphics CenterX="380.16666666666686" CenterY="235.9999999999999" Width="126.33333333333297" Height="25.0" ZOrder="32768" FillColor="99ffff" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="380.16666666666686" CenterY="235.9999999999999" Width="126.33333333333297" Height="25.0" ZOrder="32768" FillColor="99ffff" FontSize="12" Valign="Middle"/> |
- | <Xref Database="Ensembl" ID="ENSG00000171867" /> | + | <Xref Database="Ensembl" ID="ENSG00000171867"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="HSPA5" GraphId="f8335" Type="GeneProduct"> | <DataNode TextLabel="HSPA5" GraphId="f8335" Type="GeneProduct"> | ||
- | <Graphics CenterX="89.25" CenterY="411.75" Width="58.5" Height="25.0" ZOrder="32768" FillColor="ff6666" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="89.25" CenterY="411.75" Width="58.5" Height="25.0" ZOrder="32768" FillColor="ff6666" FontSize="12" Valign="Middle"/> |
- | <Xref Database="Ensembl" ID="ENSG00000044574" /> | + | <Xref Database="Ensembl" ID="ENSG00000044574"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="NFKB1" GraphId="fae8f" Type="GeneProduct" GroupRef="d63a8"> | <DataNode TextLabel="NFKB1" GraphId="fae8f" Type="GeneProduct" GroupRef="d63a8"> | ||
- | <Graphics CenterX="584.6666666666656" CenterY="487.333333333331" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="584.6666666666656" CenterY="487.333333333331" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/> |
- | <Xref Database="Ensembl" ID="ENSG00000109320" /> | + | <Xref Database="Ensembl" ID="ENSG00000109320"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="FYN" GraphId="ac9c1" Type="GeneProduct" GroupRef="afe36"> | <DataNode TextLabel="FYN" GraphId="ac9c1" Type="GeneProduct" GroupRef="afe36"> | ||
- | <Graphics CenterX="584.6666666666656" CenterY="311.9999999999999" Width="60.0" Height="25.0" ZOrder="32770" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="584.6666666666656" CenterY="311.9999999999999" Width="60.0" Height="25.0" ZOrder="32770" FontSize="12" Valign="Middle"/> |
- | <Xref Database="Ensembl" ID="ENSG00000010810" /> | + | <Xref Database="Ensembl" ID="ENSG00000010810"/> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="PTK2" GraphId="a47f2" Type="GeneProduct" GroupRef="afe36"> | <DataNode TextLabel="PTK2" GraphId="a47f2" Type="GeneProduct" GroupRef="afe36"> | ||
- | <Graphics CenterX="584.6666666666656" CenterY="336.0000000000004" Width="60.0" Height="25.0" ZOrder="32771" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="584.6666666666656" CenterY="336.0000000000004" Width="60.0" Height="25.0" ZOrder="32771" FontSize="12" Valign="Middle"/> |
- | <Xref Database="Ensembl" ID="ENSG00000169398" /> | + | <Xref Database="Ensembl" ID="ENSG00000169398"/> |
</DataNode> | </DataNode> | ||
<State GraphRef="d27ea" TextLabel="" GraphId="a10d0"> | <State GraphRef="d27ea" TextLabel="" GraphId="a10d0"> | ||
<Comment>Cellular</Comment> | <Comment>Cellular</Comment> | ||
- | <Graphics RelX="0.981042654028436" RelY="0.8235294117647058" Width="27.5" Height="25.5" ShapeType="Oval" /> | + | <Graphics RelX="0.981042654028436" RelY="0.8235294117647058" Width="27.5" Height="25.5" ShapeType="Oval"/> |
- | <Xref Database="" ID="" /> | + | <Xref Database="" ID=""/> |
</State> | </State> | ||
<State GraphRef="ddeeb" TextLabel="" GraphId="c717e"> | <State GraphRef="ddeeb" TextLabel="" GraphId="c717e"> | ||
- | <Graphics RelX="1.0" RelY="1.0" Width="26.5" Height="24.5" ShapeType="Oval" /> | + | <Graphics RelX="1.0" RelY="1.0" Width="26.5" Height="24.5" ShapeType="Oval"/> |
- | <Xref Database="" ID="" /> | + | <Xref Database="" ID=""/> |
</State> | </State> | ||
<State GraphRef="ac9c1" TextLabel="" GraphId="dc85b"> | <State GraphRef="ac9c1" TextLabel="" GraphId="dc85b"> | ||
- | <Graphics RelX="1.0" RelY="-1.0" Width="15.0" Height="15.0" ShapeType="Oval" /> | + | <Graphics RelX="1.0" RelY="-1.0" Width="15.0" Height="15.0" ShapeType="Oval"/> |
- | <Xref Database="" ID="" /> | + | <Xref Database="" ID=""/> |
</State> | </State> | ||
<State GraphRef="a47f2" TextLabel="" GraphId="faff9"> | <State GraphRef="a47f2" TextLabel="" GraphId="faff9"> | ||
- | <Graphics RelX="1.0" RelY="1.0" Width="15.0" Height="15.0" ShapeType="Oval" /> | + | <Graphics RelX="1.0" RelY="1.0" Width="15.0" Height="15.0" ShapeType="Oval"/> |
- | <Xref Database="" ID="" /> | + | <Xref Database="" ID=""/> |
</State> | </State> | ||
<Interaction GraphId="id1349402c"> | <Interaction GraphId="id1349402c"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="394.25" Y="529.0" GraphRef="a8ea8" RelX="0.0" RelY="-1.0" /> | + | <Point X="394.25" Y="529.0" GraphRef="a8ea8" RelX="0.0" RelY="-1.0"/> |
- | <Point X="394.25" Y="496.0" GraphRef="d9137" RelX="0.0" RelY="1.0" ArrowHead="mim-inhibition" /> | + | <Point X="394.25" Y="496.0" GraphRef="d9137" RelX="0.0" RelY="1.0" ArrowHead="mim-inhibition"/> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID="" /> | + | <Xref Database="" ID=""/> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="id1461a80d"> | <Interaction GraphId="id1461a80d"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="480.375" Y="131.5" GraphRef="c0ce5" RelX="0.0" RelY="1.0" /> | + | <Point X="480.375" Y="131.5" GraphRef="c0ce5" RelX="0.0" RelY="1.0"/> |
- | <Point X="480.0" Y="166.16666666666666" GraphRef="bcc1f" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> | + | <Point X="480.0" Y="166.16666666666666" GraphRef="bcc1f" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID="" /> | + | <Xref Database="" ID=""/> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="id1ee6ed76"> | <Interaction GraphId="id1ee6ed76"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="584.6666666666656" Y="356.50000000000034" GraphRef="c6f8f" RelX="0.0" RelY="1.0" /> | + | <Point X="584.6666666666656" Y="356.50000000000034" GraphRef="c6f8f" RelX="0.0" RelY="1.0"/> |
- | <Point X="584.6666666666656" Y="393.5" GraphRef="c39fb" RelX="0.0" RelY="-1.0" ArrowHead="mim-stimulation" /> | + | <Point X="584.6666666666656" Y="393.5" GraphRef="c39fb" RelX="0.0" RelY="-1.0" ArrowHead="mim-stimulation"/> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID="" /> | + | <Xref Database="" ID=""/> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="id2178c482"> | <Interaction GraphId="id2178c482"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="220.0" Y="128.75" GraphRef="d27ea" RelX="0.0" RelY="1.0" /> | + | <Point X="220.0" Y="128.75" GraphRef="d27ea" RelX="0.0" RelY="1.0"/> |
- | <Point X="220.0" Y="173.25" GraphRef="ddeeb" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" /> | + | <Point X="220.0" Y="173.25" GraphRef="ddeeb" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion"/> |
- | <Anchor Position="0.5217391304347826" Shape="None" GraphId="a3914" /> | + | <Anchor Position="0.5217391304347826" Shape="None" GraphId="a3914"/> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID="" /> | + | <Xref Database="" ID=""/> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="id2e087c1c"> | <Interaction GraphId="id2e087c1c"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="500.66666666666674" Y="441.1666666666665" GraphRef="a4999" RelX="0.0" RelY="1.0" /> | + | <Point X="500.66666666666674" Y="441.1666666666665" GraphRef="a4999" RelX="0.0" RelY="1.0"/> |
- | <Point X="501.0" Y="472.0" GraphRef="ec843" RelX="0.0" RelY="-1.0" ArrowHead="mim-inhibition" /> | + | <Point X="501.0" Y="472.0" GraphRef="ec843" RelX="0.0" RelY="-1.0" ArrowHead="mim-inhibition"/> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID="" /> | + | <Xref Database="" ID=""/> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="id2e93f68"> | <Interaction GraphId="id2e93f68"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="217.25" Y="460.25" GraphRef="f0fc1" RelX="0.0" RelY="1.0" /> | + | <Point X="217.25" Y="460.25" GraphRef="f0fc1" RelX="0.0" RelY="1.0"/> |
- | <Point X="259.5" Y="483.5" GraphRef="ac228" RelX="-1.0" RelY="0.0" ArrowHead="mim-conversion" /> | + | <Point X="259.5" Y="483.5" GraphRef="ac228" RelX="-1.0" RelY="0.0" ArrowHead="mim-conversion"/> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID="" /> | + | <Xref Database="" ID=""/> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="id45687820"> | <Interaction GraphId="id45687820"> | ||
<Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> | <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="443.33333333333337" Y="235.9999999999999" GraphRef="f301f" RelX="1.0" RelY="0.0" /> | + | <Point X="443.33333333333337" Y="235.9999999999999" GraphRef="f301f" RelX="1.0" RelY="0.0"/> |
- | <Point X="479.5170842190423" Y="280.365994155578" GraphRef="c8d75" RelX="0.0" RelY="0.0" ArrowHead="mim-inhibition" /> | + | <Point X="479.5170842190423" Y="280.365994155578" GraphRef="c8d75" RelX="0.0" RelY="0.0" ArrowHead="mim-inhibition"/> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID="" /> | + | <Xref Database="" ID=""/> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="id48beda23"> | <Interaction GraphId="id48beda23"> | ||
<Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> | <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="479.3333333333326" Y="336.83333333333337" GraphRef="b6ad1" RelX="0.0" RelY="1.0" /> | + | <Point X="479.3333333333326" Y="336.83333333333337" GraphRef="b6ad1" RelX="0.0" RelY="1.0"/> |
- | <Point X="435.0000000000001" Y="379.5000000000001" GraphRef="a5d1a" RelX="0.0" RelY="-1.0" ArrowHead="mim-stimulation" /> | + | <Point X="435.0000000000001" Y="379.5000000000001" GraphRef="a5d1a" RelX="0.0" RelY="-1.0" ArrowHead="mim-stimulation"/> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID="" /> | + | <Xref Database="" ID=""/> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="id57252e4c"> | <Interaction GraphId="id57252e4c"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="220.0" Y="210.25" GraphRef="ddeeb" RelX="0.0" RelY="1.0" /> | + | <Point X="220.0" Y="210.25" GraphRef="ddeeb" RelX="0.0" RelY="1.0"/> |
- | <Point X="219.5" Y="256.75" GraphRef="b9897" RelX="0.0" RelY="-1.0" ArrowHead="mim-binding" /> | + | <Point X="219.5" Y="256.75" GraphRef="b9897" RelX="0.0" RelY="-1.0" ArrowHead="mim-binding"/> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID="" /> | + | <Xref Database="" ID=""/> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="id5cc64764"> | <Interaction GraphId="id5cc64764"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="172.74999999999966" Y="151.24999999999994" GraphRef="c8929" RelX="1.0" RelY="0.0" /> | + | <Point X="172.74999999999966" Y="151.24999999999994" GraphRef="c8929" RelX="1.0" RelY="0.0"/> |
- | <Point X="220.0" Y="151.9673913043478" GraphRef="a3914" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> | + | <Point X="220.0" Y="151.9673913043478" GraphRef="a3914" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis"/> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID="" /> | + | <Xref Database="" ID=""/> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="id6292d207"> | <Interaction GraphId="id6292d207"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="424.25" Y="483.5" GraphRef="d9137" RelX="1.0" RelY="0.0" /> | + | <Point X="424.25" Y="483.5" GraphRef="d9137" RelX="1.0" RelY="0.0"/> |
- | <Point X="466.0" Y="484.5" GraphRef="ec843" RelX="-1.0" RelY="0.0" ArrowHead="mim-stimulation" /> | + | <Point X="466.0" Y="484.5" GraphRef="ec843" RelX="-1.0" RelY="0.0" ArrowHead="mim-stimulation"/> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID="" /> | + | <Xref Database="" ID=""/> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="id70dad0b8"> | <Interaction GraphId="id70dad0b8"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="193.75" Y="491.5" GraphRef="e09da" RelX="0.0" RelY="-1.0" /> | + | <Point X="193.75" Y="491.5" GraphRef="e09da" RelX="0.0" RelY="-1.0"/> |
- | <Point X="193.875" Y="460.25" GraphRef="f0fc1" RelX="-0.5" RelY="1.0" ArrowHead="mim-inhibition" /> | + | <Point X="193.875" Y="460.25" GraphRef="f0fc1" RelX="-0.5" RelY="1.0" ArrowHead="mim-inhibition"/> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID="" /> | + | <Xref Database="" ID=""/> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="id7ece7bf7"> | <Interaction GraphId="id7ece7bf7"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="480.0" Y="197.66666666666666" GraphRef="bcc1f" RelX="0.0" RelY="1.0" /> | + | <Point X="480.0" Y="197.66666666666666" GraphRef="bcc1f" RelX="0.0" RelY="1.0"/> |
- | <Point X="479.3333333333326" Y="311.83333333333337" GraphRef="b6ad1" RelX="0.0" RelY="-1.0" ArrowHead="mim-binding" /> | + | <Point X="479.3333333333326" Y="311.83333333333337" GraphRef="b6ad1" RelX="0.0" RelY="-1.0" ArrowHead="mim-binding"/> |
- | <Anchor Position="0.7243736714357194" Shape="None" GraphId="c8d75" /> | + | <Anchor Position="0.7243736714357194" Shape="None" GraphId="c8d75"/> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID="" /> | + | <Xref Database="" ID=""/> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="id8922ec03"> | <Interaction GraphId="id8922ec03"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="219.5" Y="281.75" GraphRef="b9897" RelX="0.0" RelY="1.0" /> | + | <Point X="219.5" Y="281.75" GraphRef="b9897" RelX="0.0" RelY="1.0"/> |
- | <Point X="217.0" Y="366.5" GraphRef="eaec8" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> | + | <Point X="217.0" Y="366.5" GraphRef="eaec8" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID="" /> | + | <Xref Database="" ID=""/> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="idbf404bc2"> | <Interaction GraphId="idbf404bc2"> | ||
<Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> | <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="569.6666666666656" Y="348.5000000000004" GraphRef="a47f2" RelX="-0.5" RelY="1.0" /> | + | <Point X="569.6666666666656" Y="348.5000000000004" GraphRef="a47f2" RelX="-0.5" RelY="1.0"/> |
- | <Point X="500.66666666666674" Y="416.1666666666665" GraphRef="a4999" RelX="0.0" RelY="-1.0" ArrowHead="mim-stimulation" /> | + | <Point X="500.66666666666674" Y="416.1666666666665" GraphRef="a4999" RelX="0.0" RelY="-1.0" ArrowHead="mim-stimulation"/> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID="" /> | + | <Xref Database="" ID=""/> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="idc3c11ab4"> | <Interaction GraphId="idc3c11ab4"> | ||
<Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> | <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="217.0" Y="391.5" GraphRef="eaec8" RelX="0.0" RelY="1.0" /> | + | <Point X="217.0" Y="391.5" GraphRef="eaec8" RelX="0.0" RelY="1.0"/> |
- | <Point X="217.25" Y="435.25" GraphRef="f0fc1" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> | + | <Point X="217.25" Y="435.25" GraphRef="f0fc1" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID="" /> | + | <Xref Database="" ID=""/> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="idc6b66933"> | <Interaction GraphId="idc6b66933"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="509.3333333333326" Y="324.33333333333337" GraphRef="b6ad1" RelX="1.0" RelY="0.0" /> | + | <Point X="509.3333333333326" Y="324.33333333333337" GraphRef="b6ad1" RelX="1.0" RelY="0.0"/> |
- | <Point X="546.6666666666656" Y="324.5" ArrowHead="mim-conversion" /> | + | <Point X="546.6666666666656" Y="324.5" ArrowHead="mim-conversion"/> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID="" /> | + | <Xref Database="" ID=""/> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="idc96a7001"> | <Interaction GraphId="idc96a7001"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="402.6666666666672" Y="325.0000000000001" GraphRef="d48db" RelX="1.0" RelY="0.0" /> | + | <Point X="402.6666666666672" Y="325.0000000000001" GraphRef="d48db" RelX="1.0" RelY="0.0"/> |
- | <Point X="449.3333333333326" Y="324.33333333333337" GraphRef="b6ad1" RelX="-1.0" RelY="0.0" ArrowHead="mim-binding" /> | + | <Point X="449.3333333333326" Y="324.33333333333337" GraphRef="b6ad1" RelX="-1.0" RelY="0.0" ArrowHead="mim-binding"/> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID="" /> | + | <Xref Database="" ID=""/> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="ide7295d3e"> | <Interaction GraphId="ide7295d3e"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="319.5" Y="483.5" GraphRef="ac228" RelX="1.0" RelY="0.0" /> | + | <Point X="319.5" Y="483.5" GraphRef="ac228" RelX="1.0" RelY="0.0"/> |
- | <Point X="364.25" Y="483.5" GraphRef="d9137" RelX="-1.0" RelY="0.0" ArrowHead="mim-stimulation" /> | + | <Point X="364.25" Y="483.5" GraphRef="d9137" RelX="-1.0" RelY="0.0" ArrowHead="mim-stimulation"/> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID="" /> | + | <Xref Database="" ID=""/> |
</Interaction> | </Interaction> | ||
<Label TextLabel="Regulators of PRNP" GraphId="a62ab" GroupRef="ed0e2"> | <Label TextLabel="Regulators of PRNP" GraphId="a62ab" GroupRef="ed0e2"> | ||
- | <Graphics CenterX="572.5" CenterY="35.25" Width="117.0" Height="25.0" ZOrder="28672" FillColor="ffffff" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="572.5" CenterY="35.25" Width="117.0" Height="25.0" ZOrder="28672" FillColor="ffffff" FontSize="12" Valign="Middle"/> |
</Label> | </Label> | ||
<Label TextLabel="?" GraphId="a6b6b"> | <Label TextLabel="?" GraphId="a6b6b"> | ||
- | <Graphics CenterX="235.41666666666595" CenterY="151.25" Width="90.0" Height="25.0" ZOrder="28672" FillColor="ffffff" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="235.41666666666595" CenterY="151.25" Width="90.0" Height="25.0" ZOrder="28672" FillColor="ffffff" FontSize="12" Valign="Middle"/> |
</Label> | </Label> | ||
<Label TextLabel="Neuron" GraphId="c75da"> | <Label TextLabel="Neuron" GraphId="c75da"> | ||
- | <Graphics CenterX="584.5" CenterY="538.0" Width="70.0" Height="25.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="584.5" CenterY="538.0" Width="70.0" Height="25.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle"/> |
</Label> | </Label> | ||
<Label TextLabel="P" GraphId="dc871"> | <Label TextLabel="P" GraphId="dc871"> | ||
- | <Graphics CenterX="615.0" CenterY="300.0" Width="25.0" Height="25.0" ZOrder="32773" FillColor="ffffff" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="615.0" CenterY="300.0" Width="25.0" Height="25.0" ZOrder="32773" FillColor="ffffff" FontSize="12" Valign="Middle"/> |
</Label> | </Label> | ||
<Label TextLabel="P" GraphId="b1946"> | <Label TextLabel="P" GraphId="b1946"> | ||
- | <Graphics CenterX="615.0" CenterY="349.0" Width="25.0" Height="25.0" ZOrder="32774" FillColor="ffffff" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="615.0" CenterY="349.0" Width="25.0" Height="25.0" ZOrder="32774" FillColor="ffffff" FontSize="12" Valign="Middle"/> |
</Label> | </Label> | ||
<Label TextLabel="C" GraphId="e532e"> | <Label TextLabel="C" GraphId="e532e"> | ||
- | <Graphics CenterX="248.0" CenterY="125.75" Width="25.0" Height="25.0" ZOrder="32775" FillColor="ffffff" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="248.0" CenterY="125.75" Width="25.0" Height="25.0" ZOrder="32775" FillColor="ffffff" FontSize="12" Valign="Middle"/> |
</Label> | </Label> | ||
<Label TextLabel="Sc" GraphId="d3518"> | <Label TextLabel="Sc" GraphId="d3518"> | ||
- | <Graphics CenterX="249.0" CenterY="211.0" Width="94.0" Height="30.5" ZOrder="32776" FillColor="ffffff" FontSize="12" Valign="Middle" /> | + | <Graphics CenterX="249.0" CenterY="211.0" Width="94.0" Height="30.5" ZOrder="32776" FillColor="ffffff" FontSize="12" Valign="Middle"/> |
</Label> | </Label> | ||
<Shape GraphId="ac3e8"> | <Shape GraphId="ac3e8"> | ||
- | <Attribute Key="org.pathvisio.CellularComponentProperty" Value="Cell" /> | + | <Attribute Key="org.pathvisio.CellularComponentProperty" Value="Cell"/> |
- | <Attribute Key="org.pathvisio.DoubleLineProperty" Value="Double" /> | + | <Attribute Key="org.pathvisio.DoubleLineProperty" Value="Double"/> |
- | <Graphics CenterX="338.91666666666663" CenterY="412.8333333333336" Width="598.1666666666667" Height="286.3333333333328" ZOrder="-4" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" LineThickness="3.0" Color="c0c0c0" Rotation="0.0" /> | + | <Graphics CenterX="338.91666666666663" CenterY="412.8333333333336" Width="598.1666666666667" Height="286.3333333333328" ZOrder="-4" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" LineThickness="3.0" Color="c0c0c0" Rotation="0.0"/> |
</Shape> | </Shape> | ||
<Shape GraphId="ff20a"> | <Shape GraphId="ff20a"> | ||
- | <Attribute Key="org.pathvisio.CellularComponentProperty" Value="Endoplasmic Reticulum" /> | + | <Attribute Key="org.pathvisio.CellularComponentProperty" Value="Endoplasmic Reticulum"/> |
- | <Graphics CenterX="195.0" CenterY="395.0" Width="150.0" Height="148.0" ZOrder="-2" FontSize="12" Valign="Middle" ShapeType="Endoplasmic Reticulum" LineThickness="3.0" Color="c0c0c0" Rotation="0.0" /> | + | <Graphics CenterX="195.0" CenterY="395.0" Width="150.0" Height="148.0" ZOrder="-2" FontSize="12" Valign="Middle" ShapeType="Endoplasmic Reticulum" LineThickness="3.0" Color="c0c0c0" Rotation="0.0"/> |
</Shape> | </Shape> | ||
- | <Group GroupId="ed0e2" GraphId="c0ce5" Style="Group" /> | + | <Group GroupId="ed0e2" GraphId="c0ce5" Style="Group"/> |
- | <Group GroupId="d63a8" GraphId="c39fb" Style="Group" /> | + | <Group GroupId="d63a8" GraphId="c39fb" Style="Group"/> |
- | <Group GroupId="afe36" GraphId="c6f8f" Style="Group" /> | + | <Group GroupId="afe36" GraphId="c6f8f" Style="Group"/> |
- | <Group GroupId="cdb0d" GraphId="d48db" Style="Group" /> | + | <Group GroupId="cdb0d" GraphId="d48db" Style="Group"/> |
- | <Group GroupId="edf91" GraphId="db5ff" Style="Complex" /> | + | <Group GroupId="edf91" GraphId="db5ff" Style="Complex"/> |
- | <InfoBox CenterX="0.0" CenterY="0.0" /> | + | <InfoBox CenterX="0.0" CenterY="0.0"/> |
<Biopax> | <Biopax> | ||
- | + | ||
- | + | ||
- | + | ||
- | + | ||
- | + | ||
<bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> | <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> | ||
<bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">prion disease</bp:TERM> | <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">prion disease</bp:TERM> | ||
Line 415: | Line 411: | ||
<bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology> | <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology> | ||
</bp:openControlledVocabulary> | </bp:openControlledVocabulary> | ||
- | + | ||
- | + | ||
- | + | ||
- | + | ||
- | + | ||
<bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> | <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> | ||
<bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">disease pathway</bp:TERM> | <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">disease pathway</bp:TERM> |
Current revision
Error rendering pathway page
This revision of the pathway probably contains invalid GPML code. If this happens to the most recent revision, try reverting the pathway using the pathway history displayed below or contact the site administrators (see WikiPathways:About) to resolve this problem.
Pathway history
View all... |
Error details
exception 'Exception' with message 'Unable to convert to /var/www/wikipathways/images/4/40/WP3995_prev.svg: <BR>Status:1 <BR>Message:Exception in thread "main" java.lang.NullPointerException at org.pathvisio.core.Engine.getPathwayImporters(Unknown Source) at org.pathvisio.core.Engine.importPathway(Unknown Source) at org.pathvisio.core.util.Converter.main(Unknown Source) <BR>Command:java -Xmx1024M -jar /var/www/wikipathways/wpi/bin/pathvisio_core.jar "/var/www/wikipathways" "/var/www/wikipathways/images/4/40/WP3995_prev.svg" 2>&1<BR>' in /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php:1255 Stack trace: #0 /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php(1227): Pathway::convertWithPathVisio(false, '/var/www/wikipa...') #1 /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php(1137): Pathway->saveConvertedByPathVisioCache('svg') #2 /var/www/wikipathways/wpi/extensions/Pathways/PathwayPage.php(21): Pathway->updateCache('svg') #3 [internal function]: renderPathwayPage(Object(Parser), '<?xml version="...', Object(StripState)) #4 /var/www/wikipathways/includes/Hooks.php(125): call_user_func_array('renderPathwayPa...', Array) #5 /var/www/wikipathways/includes/parser/Parser.php(318): wfRunHooks('ParserBeforeStr...', Array) #6 /var/www/wikipathways/includes/OutputPage.php(405): Parser->parse('<?xml version="...', Object(Title), Object(ParserOptions), true, true, 129475) #7 /var/www/wikipathways/includes/OutputPage.php(391): OutputPage->addWikiTextTitle('<?xml version="...', Object(Title), true, true) #8 /var/www/wikipathways/includes/OutputPage.php(500): OutputPage->addWikiTextTitleTidy('<?xml version="...', Object(Title), true) #9 /var/www/wikipathways/includes/DifferenceEngine.php(313): OutputPage->addWikiTextTidy('<?xml version="...') #10 /var/www/wikipathways/includes/DifferenceEngine.php(271): DifferenceEngine->renderNewRevision() #11 /var/www/wikipathways/includes/Article.php(729): DifferenceEngine->showDiffPage(false) #12 /var/www/wikipathways/includes/Wiki.php(437): Article->view() #13 /var/www/wikipathways/includes/Wiki.php(59): MediaWiki->performAction(Object(OutputPage), Object(Article), Object(Title), Object(User), Object(WebRequest)) #14 /var/www/wikipathways/index.php(93): MediaWiki->initialize(Object(Title), Object(Article), Object(OutputPage), Object(User), Object(WebRequest)) #15 {main}