Liver steatosis adverse outcome pathway (Homo sapiens)

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KE10110: Fatty liver cellsKE115: Increase, FA InfluxAMP-activated Protein Kinase (AMPK) SignalingKE860: Decreased, Mitochondrial Fatty Acid Beta OxidationKE66: Activation, ChREBPKE471: Inhibition, FoxA2KE10201: Endoplasmic reticulum stressPPAR Alpha PathwayConstitutive Androstane Receptor PathwaySterol Regulatory Element-Binding Proteins (SREBP) signallingFatty Acid BiosynthesisKE89: Synthesis, De Novo FAKE18: Activation, AhRMitochondrial LC-Fatty Acid Beta-OxidationBranched-chain amino acid catabolismKE291: Accumulation, TriglycerideKE245: Activation, PXR/SXRAngiopoietin Like Protein 8 Regulatory PathwayKE10101: PPARδKE228: PPARγMetabolic pathway of LDLKE264: Activation, SREBP-1cKE1214: Altered gene expression specific to CAR activation, HepatocytesKE116: Activation, FASKE474: Down Regulation, HMGCS2KE472: Down Regulation, CPT1AKE466: Up Regulation, LDLR (low density lipoprotein receptor)KE10106: Fatty Acid LysisKE10201: Nucleus distrortionPregnane X Receptor pathwayLiver X Receptor PathwayKE345: Liver steatosisKE258: Activation, SCD-1KE167: Activation, LXRLipid Metabolism PathwayCholesterol metabolismKE140: Decreased, HSD17B10 expressionKE54 Up Regulation, CD36KE10201: Mitochondrial disruptionKE10201: Cytoplasm displacementKE227: Activation, PPARαAryl Hydrocarbon Receptor NetpathAMP-activated Protein Kinase (AMPK) SignalingFatty Acid BiosynthesisFatty Acid BiosynthesisAngiopoietin Like Protein 8 Regulatory PathwayPPAR signaling PathwayPPAR signaling PathwayPPAR signaling Pathway


Description

Liver steatosis AOP

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Maglich JM, Parks DJ, Moore LB, Collins JL, Goodwin B, Billin AN, Stoltz CA, Kliewer SA, Lambert MH, Willson TM, Moore JT; ''Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  2. Echchgadda I, Song CS, Oh T, Ahmed M, De La Cruz IJ, Chatterjee B; ''The xenobiotic-sensing nuclear receptors pregnane X receptor, constitutive androstane receptor, and orphan nuclear receptor hepatocyte nuclear factor 4alpha in the regulation of human steroid-/bile acid-sulfotransferase.''; Mol Endocrinol, 2007 PubMed Europe PMC Scholia
  3. Maglich JM, Watson J, McMillen PJ, Goodwin B, Willson TM, Moore JT; ''The nuclear receptor CAR is a regulator of thyroid hormone metabolism during caloric restriction.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  4. Dentin R, Benhamed F, Hainault I, Fauveau V, Foufelle F, Dyck JR, Girard J, Postic C; ''Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice.''; Diabetes, 2006 PubMed Europe PMC Scholia
  5. Hashimoto K, Mori M; ''Crosstalk of thyroid hormone receptor and liver X receptor in lipid metabolism and beyond [Review].''; Endocr J, 2011 PubMed Europe PMC Scholia
  6. Brigitte Landesmann, Marina Goumenou, Sharon Munn, Maurice Whelan; ''Description of Prototype Modes-of-Action Related to Repeated Dose Toxicity ''; http://publications.jrc.ec.europa.eu/repository/bitstream/JRC75689/lb-na-25631-en-n.pdf, 2012
  7. Sugatani J, Kojima H, Ueda A, Kakizaki S, Yoshinari K, Gong QH, Owens IS, Negishi M, Sueyoshi T; ''The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR.''; Hepatology, 2001 PubMed Europe PMC Scholia
  8. Hariparsad N, Chu X, Yabut J, Labhart P, Hartley DP, Dai X, Evers R; ''Identification of pregnane-X receptor target genes and coactivator and corepressor binding to promoter elements in human hepatocytes.''; Nucleic Acids Res, 2009 PubMed Europe PMC Scholia
  9. Kodama S; ''Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes''; Mol Cell Biol, 2004 PubMed Europe PMC Scholia
  10. Kolluri SK, Weiss C, Koff A, Göttlicher M; ''p27(Kip1) induction and inhibition of proliferation by the intracellular Ah receptor in developing thymus and hepatoma cells.''; Genes Dev, 1999 PubMed Europe PMC Scholia
  11. Mellor CL, Steinmetz FP, Cronin MT; ''The identification of nuclear receptors associated with hepatic steatosis to develop and extend adverse outcome pathways.''; Crit Rev Toxicol, 2016 PubMed Europe PMC Scholia
  12. Pavek P, Dvorak Z; ''Xenobiotic-induced transcriptional regulation of xenobiotic metabolizing enzymes of the cytochrome P450 superfamily in human extrahepatic tissues.''; Curr Drug Metab, 2008 PubMed Europe PMC Scholia
  13. Handschin C, Meyer UA; ''Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR.''; Arch Biochem Biophys, 2005 PubMed Europe PMC Scholia
  14. Nebert DW, Petersen DD, Puga A; ''Human AH locus polymorphism and cancer: inducibility of CYP1A1 and other genes by combustion products and dioxin.''; Pharmacogenetics, 1991 PubMed Europe PMC Scholia
  15. Handschin C, Meyer UA; ''Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR.''; Arch Biochem Biophys, 2005 PubMed Europe PMC Scholia
  16. Tang YM, Wo YY, Stewart J, Hawkins AL, Griffin CA, Sutter TR, Greenlee WF; ''Isolation and characterization of the human cytochrome P450 CYP1B1 gene.''; J Biol Chem, 1996 PubMed Europe PMC Scholia
  17. Bock KW; ''From differential induction of UDP-glucuronosyltransferases in rat liver to characterization of responsible ligand-activated transcription factors, and their multilevel crosstalk in humans.''; Biochem Pharmacol, 2011 PubMed Europe PMC Scholia
  18. Shimada T, Oda Y, Gillam EM, Guengerich FP, Inoue K; ''Metabolic activation of polycyclic aromatic hydrocarbons and other procarcinogens by cytochromes P450 1A1 and P450 1B1 allelic variants and other human cytochromes P450 in Salmonella typhimurium NM2009.''; Drug Metab Dispos, 2001 PubMed Europe PMC Scholia
  19. Quattrochi LC, Vu T, Tukey RH; ''The human CYP1A2 gene and induction by 3-methylcholanthrene. A region of DNA that supports AH-receptor binding and promoter-specific induction.''; J Biol Chem, 1994 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129354view09:32, 27 March 2024MkutmonOntology Term : 'disease pathway' added !
128765view13:41, 21 February 2024Marvin M2Reverted to version '11:25, 23 June 2021' by Marvin M2
128764view13:41, 21 February 2024MysticArchers
128763view13:39, 21 February 2024Marvin M2Reverted to version '11:25, 23 June 2021' by Marvin M2
128762view13:38, 21 February 2024Marvin M2
119296view11:25, 23 June 2021FinterlyAdded ISBN for book citation
118491view08:46, 28 May 2021FinterlyReplace DataNode Type "Key Event" with "Event"
116509view10:44, 7 May 2021EweitzModified title
115813view20:37, 14 March 2021ChesdeWindtFixed incorrect reference on KE 860
115727view08:51, 9 March 2021Marvin M2Updated PPARa and b/d KE pathways, and cleaned the AOP
115692view17:12, 4 March 2021Jkearns445Fixed interactions
115688view10:40, 4 March 2021ChesdeWindtModified description
115648view14:35, 3 March 2021Jkearns445
115644view14:28, 3 March 2021Jkearns445
115643view14:27, 3 March 2021Jkearns445
115642view14:10, 3 March 2021Jkearns445
115627view18:32, 2 March 2021ChesdeWindt
115626view17:12, 2 March 2021ChesdeWindtAdded KE479 to KE227
115578view22:58, 27 February 2021ChesdeWindtModified description
115545view15:10, 26 February 2021Jkearns445
115544view15:08, 26 February 2021Jkearns445
115543view15:06, 26 February 2021Jkearns445Cleaned up the patway, added a new pathway
115542view14:59, 26 February 2021Jkearns445
115540view14:19, 26 February 2021Jkearns445
115539view14:14, 26 February 2021Jkearns445
115526view13:24, 25 February 2021Jkearns445
115525view13:13, 25 February 2021Jkearns445
115524view12:54, 25 February 2021Marvin M2Ontology Term : 'hepatocyte' added !
115523view12:52, 25 February 2021Marvin M2Ontology Term : 'fatty liver disease' added !
115522view22:17, 24 February 2021ChesdeWindtModified description
115495view07:22, 24 February 2021Jkearns445
115494view07:20, 24 February 2021Jkearns445
115346view09:56, 15 February 2021Jkearns445
115332view18:56, 13 February 2021Jkearns445
115331view18:54, 13 February 2021Jkearns445
115330view18:53, 13 February 2021Jkearns445
115327view11:17, 13 February 2021Jkearns445
115326view11:03, 13 February 2021Jkearns445Cleaned up the pathway and added pathways to KE nodes
115314view07:28, 12 February 2021Jkearns445
115313view07:18, 12 February 2021Jkearns445
115310view17:13, 11 February 2021Marvin M2updated KE title of KE66
115309view17:11, 11 February 2021Marvin M2Added Key Event type to KE66
115304view13:11, 11 February 2021Jkearns445
115303view12:43, 11 February 2021Jkearns445Added database IDs for more Key Events
115302view12:24, 11 February 2021Jkearns445Added database IDs for Key Events and changed the shape of the pathway nodes
115301view10:49, 11 February 2021Marvin M2
115300view10:48, 11 February 2021Marvin M2
95148view03:34, 17 November 2017AlexanderPicofixed interactions
93179view11:11, 2 August 2017JJvdHeijdenMaking the AOP network (biological) more compact
93178view11:10, 2 August 2017JJvdHeijdenDeleted a error

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AMP-activated Protein Kinase (AMPK) SignalingPathwayWP1403 (WikiPathways)
Angiopoietin Like Protein 8 Regulatory PathwayPathwayWP3915 (WikiPathways)
Aryl Hydrocarbon Receptor NetpathPathwayWP2586 (WikiPathways)
Branched-chain amino acid catabolismPathwayWP3556 (WikiPathways)
Cholesterol metabolismPathwayWP4718 (WikiPathways)
Constitutive Androstane Receptor PathwayPathwayWP2875 (WikiPathways)
Fatty Acid BiosynthesisPathwayWP357 (WikiPathways)
KE10101: PPARδKey Event10101 (AOP-Wiki KE)
KE10106: Fatty Acid LysisKey Event10106 (AOP-Wiki KE)
KE10110: Fatty liver cellsKey Event10110 (AOP-Wiki KE)
KE10201: Cytoplasm displacementKey Event10201 (AOP-Wiki KE)
KE10201: Endoplasmic reticulum stressKey Event10201 (AOP-Wiki KE)
KE10201: Mitochondrial disruptionKey Event10201 (AOP-Wiki KE)
KE10201: Nucleus distrortionKey Event10201 (AOP-Wiki KE)
KE115: Increase, FA InfluxKey Event115 (AOP-Wiki KE)
KE116: Activation, FASKey Event116 (AOP-Wiki KE)
KE1214: Altered gene expression specific to CAR activation, HepatocytesKey Event1214 (AOP-Wiki KE)
KE140: Decreased, HSD17B10 expressionKey Event140 (AOP-Wiki KE)
KE167: Activation, LXRKey Event167 (AOP-Wiki KE)
KE18: Activation, AhRKey Event18 (AOP-Wiki KE)
KE227: Activation, PPARαKey Event227 (AOP-Wiki KE)
KE228: PPARγKey Event228 (AOP-Wiki KE)
KE245: Activation, PXR/SXRKey Event245 (AOP-Wiki KE)
KE258: Activation, SCD-1Key Event258 (AOP-Wiki KE)
KE264: Activation, SREBP-1cKey Event264 (AOP-Wiki KE)
KE291: Accumulation, TriglycerideKey Event291 (AOP-Wiki KE)
KE345: Liver steatosisKey Event345 (AOP-Wiki KE)
KE466: Up Regulation, LDLR (low density lipoprotein receptor)Key Event466 (AOP-Wiki KE)
KE471: Inhibition, FoxA2Key Event471 (AOP-Wiki KE)
KE472: Down Regulation, CPT1AKey Event472 (AOP-Wiki KE)
KE474: Down Regulation, HMGCS2Key Event474 (AOP-Wiki KE)
KE54 Up Regulation, CD36Key Event54 (AOP-Wiki KE)
KE66: Activation, ChREBPKey Event66 (AOP-Wiki KE)
KE860: Decreased, Mitochondrial Fatty Acid Beta OxidationKey Event860 (AOP-Wiki KE)
KE89: Synthesis, De Novo FAKey Event89 (AOP-Wiki KE)
Lipid Metabolism PathwayPathwayWP3965 (WikiPathways)
Liver X Receptor PathwayPathwayWP2874 (WikiPathways)
Metabolic pathway of LDLPathwayWP4522 (WikiPathways)
Mitochondrial LC-Fatty Acid Beta-OxidationPathwayWP357 (WikiPathways)
PPAR Alpha PathwayPathwayWP2878 (WikiPathways)
PPAR signaling PathwayPathwayWP3942 (WikiPathways)
Pregnane X Receptor pathwayPathwayWP2876 (WikiPathways)
Sterol Regulatory Element-Binding Proteins (SREBP) signallingPathwayWP1982 (WikiPathways)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP4010"
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