Eukaryotic transcription initiation (Homo sapiens)

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TFIIDPrimary RNA transcriptTFIIARNA polymerase IRNA pol II5TFIIH33TFIIETFIID5cell growthTFIIB3TATA5dsDNATFIIF5Steps 5) RNA elongation with CDT phosphorylationTFIIFTFIIB(recognize surface DNA geometry)3TATASteps 2) Association of TIFs and RNA polymeraseTATA55Transcription Initiation Factors (TIFs)Steps 1) TBP binds TATA boxRNA polymerase II5TFIIATATA Box bindingproteinSteps 4) Transcription elongation by NTPs5Gene Regulatory ProteinsTFIIFRNA polymerase III(small stable RNAs)33TFIIH(mRNA, snRNPs)3(large ribosomal RNAs)53TFIIESteps 3) DNA melting by association with TFIIH35TAF5POLR2CPOLR2GTBPERCC3POLR3KGTF2A2POLR2JGTF2H2POLR3BCCNHMNAT1GTF2E2POLR1BPOLR2BPOLR2KPOLR3HILKPOLR3EPOLR3DGTF2H4GTF2BGTF2H3POLR2ITAF6ERCC2TAF9TAF13GTF2F2TAF7POLR2EPOLR2FCDK7Polr1ePOLR2APOLR1DPOLR1ATAF12GTF2E1GTF2H1POLR2H


Description

No description

Comments

GenMAPP notes 
Reference: http://www.web-books.com/MoBio/Free/Ch4E.htm
GenMAPP remarks 
right click for notes & references

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Quality Tags

Ontology Terms

 

Bibliography

  1. Lemon B, Tjian R; ''Orchestrated response: a symphony of transcription factors for gene control.''; Genes Dev, 2000 PubMed Europe PMC Scholia
  2. Lee TI, Young RA; ''Regulation of gene expression by TBP-associated proteins.''; Genes Dev, 1998 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
126311view17:30, 20 April 2023EgonwLicense is CCZero
118377view13:51, 27 May 2021EweitzOntology Term : 'PW:0000100' removed !
118376view13:51, 27 May 2021EweitzOntology Term : 'RNA polymerase II transcription initiation pathway' added !
118373view13:50, 27 May 2021EweitzOntology Term : 'RNA polymerase I transcription initiation pathway' added !
118372view13:50, 27 May 2021EweitzOntology Term : 'RNA polymerase III transcription initiation pathway' added !
117728view12:35, 22 May 2021EweitzOntology Term : 'transcription pathway' added !
117718view12:33, 22 May 2021EweitzModified title
94824view03:02, 6 October 2017KhanspersModified description
94823view03:02, 6 October 2017KhanspersModified description
94822view03:02, 6 October 2017Khanspersremoved GenMAPP notes
94821view03:01, 6 October 2017Khanspersconnected lines
88988view11:31, 18 August 2016MirellaKalafatiOntology Term : 'PW:0000004' removed !
88903view08:30, 17 August 2016MirellaKalafatiOntology Term : 'regulatory pathway' added !
73594view19:47, 3 February 2014MaintBotSpecify description
73593view19:46, 3 February 2014MaintBotRemoving extraneous group causing rendering issue
63187view20:46, 8 May 2013MaintBotUpdating gpml version
41116view23:36, 1 March 2011MaintBotRemoved redundant pathway information and comments
37350view18:09, 28 May 2010Khanspersconnectors
35509view13:47, 12 February 2010Thomasremoved genmapp remark
35508view13:46, 12 February 2010Thomasadded literature
35507view13:44, 12 February 2010ThomasModified description
34503view23:29, 16 December 2009KhanspersAdded connectors
34471view18:33, 10 December 2009MaintBotAutomatic update of empty xrefs
32424view17:10, 15 August 2009MaintBotFixed text labels
32083view13:40, 14 August 2009MaintBotFixed group labels
29565view08:45, 18 May 2009LauravanzonPeriodical save, work in progress
26587view18:26, 10 December 2008AlexanderPico
21534view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:RNA transcription Reactome]] moved to [[Pathway:WP405]]: Moved to stable identifier
14949view16:18, 24 May 2008MartijnVanIerselcreated groups
13006view11:05, 17 May 2008MaintBotSticky edges patch by Sjoerd
8366view13:46, 7 January 2008MaintBot[[Pathway:Human:RNA transcription Reactome]] moved to [[Pathway:Homo sapiens:RNA transcription Reactome]]: Renaming species
7801view16:18, 18 December 2007MaintBotfixed category names
7286view12:41, 4 November 2007MaintBotAdded categories to GPML
6365view22:18, 22 May 2007Nsalomonisgpml file for [[Human:RNA_transcription_Reactome]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CCNHGeneProduct902 (Entrez Gene)
CDK7GeneProduct1022 (Entrez Gene)
ERCC2GeneProduct2068 (Entrez Gene)
ERCC3GeneProduct2071 (Entrez Gene)
GTF2A2GeneProduct2958 (Entrez Gene)
GTF2BGeneProduct2959 (Entrez Gene)
GTF2E1GeneProduct2960 (Entrez Gene)
GTF2E2GeneProduct2961 (Entrez Gene)
GTF2F2GeneProduct2963 (Entrez Gene)
GTF2H1GeneProduct2965 (Entrez Gene)
GTF2H2GeneProduct2966 (Entrez Gene)
GTF2H3GeneProduct2967 (Entrez Gene)
GTF2H4GeneProduct2968 (Entrez Gene)
ILKGeneProduct3611 (Entrez Gene)
MNAT1GeneProduct4331 (Entrez Gene)
POLR1AGeneProduct25885 (Entrez Gene)
POLR1BGeneProduct84172 (Entrez Gene)
POLR1DGeneProduct51082 (Entrez Gene)
POLR2AGeneProduct5430 (Entrez Gene)
POLR2BGeneProduct5431 (Entrez Gene)
POLR2CGeneProduct5432 (Entrez Gene)
POLR2EGeneProduct5434 (Entrez Gene)
POLR2FGeneProduct5435 (Entrez Gene)
POLR2GGeneProduct5436 (Entrez Gene)
POLR2HGeneProduct5437 (Entrez Gene)
POLR2IGeneProduct5438 (Entrez Gene)
POLR2JGeneProduct5439 (Entrez Gene)
POLR2KGeneProduct5440 (Entrez Gene)
POLR3BGeneProduct55703 (Entrez Gene)
POLR3DGeneProduct661 (Entrez Gene)
POLR3EGeneProduct55718 (Entrez Gene)
POLR3HGeneProduct171568 (Entrez Gene)
POLR3KGeneProduct51728 (Entrez Gene)
Polr1eGeneProduct
TAF12GeneProduct6883 (Entrez Gene)
TAF13GeneProduct6884 (Entrez Gene)
TAF5GeneProduct6877 (Entrez Gene)
TAF6GeneProduct6878 (Entrez Gene)
TAF7GeneProduct6879 (Entrez Gene)
TAF9GeneProduct6880 (Entrez Gene)
TBPGeneProduct6908 (Entrez Gene)

Annotated Interactions

No annotated interactions
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