Phosphodiesterases in neuronal function (Homo sapiens)

From WikiPathways

Revision as of 15:00, 28 February 2018 by Fehrhart (Talk | contribs)
Jump to: navigation, search
1243neuron frontal cortexnucleussynaptic gapLegendrelease of neurotransmitters into synaptic gapbindingstimulationinhibitionNAc/CPUCaMKCilostazolGRIN2DGRIN2CCaffeinePDE?DARPP-32PDE3AGRIN2BL-GlutamateGMPPDE10ARolipramPDE5APDEGCAMPPDE4DDRD1PDE1BADORA2ACREBGRIN2APDE3BAMPAAC PKGCalciumDopamineSildenafilPKACyclic GMPCyclic AMPGRIN1D2L-GlutamateL-GlutamateCyclic AMPDopamineneuron neuron DopaminePDE10APDE4DPDE1BPDE4DL-GlutamateDopaminePKAD2GRIN1GRIN2DGRIN2CGRIN2AGRIN2BAMPA


Phosphodiesterases are enzymes which break phosphodiester bonds and play an importan role in signaling pathways, especially in second messenger pathways which involve cyclic AMP or GMP.

Try the New WikiPathways

View approved pathways at the new

Quality Tags

Ontology Terms



View all...
  1. Loughney K, Hill TR, Florio VA, Uher L, Rosman GJ, Wolda SL, Jones BA, Howard ML, McAllister-Lucas LM, Sonnenburg WK, Francis SH, Corbin JD, Beavo JA, Ferguson K; ''Isolation and characterization of cDNAs encoding PDE5A, a human cGMP-binding, cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase.''; Gene, 1998 PubMed Europe PMC Scholia
  2. Minami N, Suzuki Y, Yamamoto M, Kihira H, Imai E, Wada H, Kimura Y, Ikeda Y, Shiku H, Nishikawa M.; ''Inhibition of shear stress-induced platelet aggregation by cilostazol, a specific inhibitor of cGMP-inhibited phosphodiesterase, in vitro and ex vivo.''; Life Sci. , 1997 PubMed Europe PMC Scholia
  3. Kern A, Mavrikaki M, Ullrich C, Albarran-Zeckler R, Brantley AF, Smith RG; ''Hippocampal Dopamine/DRD1 Signaling Dependent on the Ghrelin Receptor.''; Cell, 2015 PubMed Europe PMC Scholia
  4. Heckman PR, van Duinen MA, Bollen EP, Nishi A, Wennogle LP, Blokland A, Prickaerts J; ''''; , PubMed Europe PMC Scholia
  5. Khairallah M, Khairallah RJ, Young ME, Allen BG, Gillis MA, Danialou G, Deschepper CF, Petrof BJ, Des Rosiers C.; ''Sildenafil and cardiomyocyte-specific cGMP signaling prevent cardiomyopathic changes associated with dystrophin deficiency.''; Proc Natl Acad Sci U S A., 2008 PubMed Europe PMC Scholia
  6. Kitabchi AE, Wilson DB, Sharma RK.; ''Steroidogenesis in isolated adrenal cells of rat. II. Effect of caffeine on ACTH and cyclic nucleotide-induced steroidogenesis and its relation to cyclic nucleotide phosphodiesterase (PDE).''; vBiochem Biophys Res Commun. , 1971 PubMed Europe PMC Scholia


View all...
132625view17:31, 7 June 2024Khanspersupdated incorrect mim-modification to mim-binding
124530view14:17, 5 November 2022EgonwMade a pathway clickable
124484view13:48, 31 October 2022Cenna Doornbos
124483view13:46, 31 October 2022Cenna DoornbosUppdated non-annotated nodes
124482view13:06, 31 October 2022Cenna DoornbosUpdated sildenafil pathway and protein names.
107160view14:24, 17 September 2019MaintBotChEBI identifier normalization
106137view12:03, 16 August 2019MaintBotHMDB identifier normalization
105135view12:00, 10 July 2019EgonwFixed the identifier for L-glutamate (a more accurate record)
96808view11:35, 9 April 2018Fehrhartfixed data node annotation
96231view13:22, 1 March 2018FehrhartOntology Term : 'attention deficit hyperactivity disorder' added !
96230view13:22, 1 March 2018FehrhartOntology Term : 'obsessive-compulsive disorder' added !
96229view13:22, 1 March 2018FehrhartOntology Term : 'Gilles de la Tourette syndrome' added !
96228view13:22, 1 March 2018FehrhartOntology Term : 'Huntington's disease' added !
96227view13:21, 1 March 2018FehrhartOntology Term : 'Parkinson's disease' added !
96226view13:21, 1 March 2018FehrhartOntology Term : 'schizophrenia' added !
96225view13:20, 1 March 2018FehrhartOntology Term : 'Alzheimer's disease' added !
96224view13:19, 1 March 2018FehrhartOntology Term : 'glutamate signaling pathway' added !
96223view13:19, 1 March 2018FehrhartOntology Term : 'dopamine signaling pathway' added !
96222view13:18, 1 March 2018FehrhartOntology Term : 'neuron-to-neuron signaling pathways' added !
96221view13:18, 1 March 2018FehrhartOntology Term : 'neuron' added !
96220view13:17, 1 March 2018Fehrhartwork in progress
96219view11:02, 1 March 2018Fehrhartwork in progress
96218view10:15, 1 March 2018FehrhartModified title
96216view15:31, 28 February 2018Fehrhartwork in progress
96215view15:00, 28 February 2018Fehrhartwork in progress
96214view14:21, 28 February 2018FehrhartNew pathway

External references


View all...
NameTypeDatabase referenceComment
AC GeneProduct
AMPMetaboliteHMDB03540 (HMDB)
CaMK GeneProduct
CaffeineMetaboliteHMDB01847 (HMDB)
CalciumMetaboliteHMDB00464 (HMDB)
CilostazolMetaboliteHMDB15297 (HMDB)
Cyclic AMPMetaboliteHMDB00058 (HMDB)
Cyclic GMPMetaboliteHMDB01314 (HMDB)
DopamineMetaboliteHMDB00073 (HMDB)
GMPMetaboliteHMDB0001397 (HMDB)
L-GlutamateMetaboliteHMDB60475 (HMDB)
PDE3AGeneProductENSG00000172572 (Ensembl)
PDE3BGeneProductENSG00000152270 (Ensembl)
PDE5AGeneProductENSG00000138735 (Ensembl)
RolipramMetabolite104872 (ChEBI)
SildenafilMetaboliteHMDB05039 (HMDB)

Annotated Interactions

No annotated interactions

Personal tools