Insulin signaling (Rattus norvegicus)

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1p90 Rsk Kinasesp70 S6 KinasesPI 3-KinaseRas-MAPK SignalingMetabolic RegulationTranscriptional Regulators & Immediate Early GenesPDK/Akt SignalingInsulin Receptor SubstratesVesicular TraffickingMEK/MAP KinasesModulators of Insulin ActionTor SignalingTranslation RegulationGlucose TransportGyg1SrfPik3c3PtprfPrkaa1Irs1MAP3K5LOC303823PrkchPIK3CAPtpn11MtorEif4ebp1LipeRps6ka6Gsk3bGys2MAP4K4Sgk1Map2k7CrkInsrRps6ka5Map3k4Rps6kb1Igf1rMapk8Snap25CblcHrasSlc2a4CblbFlot1Mapk4FosIkbkbRhojKif5bInpp4aMapk10Mapk14Map3k1Pik3r4Map3k8Rps6ka1Pik3r2CblMap3k14LOC303259Foxo3Rac1Grb10Rac2Pik3cbAkt2Ehd1SGKLXbp1Stxbp1Flot2Map2k1Map4k1Raf1Akt1Stx4Tsc2Map2k2Stxbp3Mapk1Stxbp2Sos1Gys1RAPGEF1PrkciShc3Mapk8Kif3aPrkcaEnpp1Map4k2RradMapk13Mapk12Mapk6Slc2a1Gstt2Map3k11Pik3cdSocs3Cap1Egr1Map3k12Rps6ka3PfklMap2k5Map2k3JunSgk2RHEBStxbp4Snap23Pdpk1PrkcqRps6ka2Tsc1Grb14Eif4ePik3c2aElk1Map2k6Arf6Map3k9Map3k3Ehd2RPS6KB2Map3k2Pik3cgMapk9Mapk11Grb2RPS6KA4Irs2Map3k7PfkmGsk3aMap2k4Shc1PrkczSNX26TBC1D4Arf1Shc2Sorbs1Pik3c2gFoxo1Trib3Socs1Pik3r3Gab1Map4k5Inppl1PtenMap3k6PrkcbMap3k10Cyth3SOS2Rab4aMAPK7Ptpn1Mapk3PrkcdSh2b2RhoqVamp2IRS4Myo1cMap4k3Prkaa2Ppp1r3aPik3r1


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP481(r28132) with a 91% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Bevan P; ''Insulin signalling.''; J Cell Sci, 2001 PubMed Europe PMC Scholia
  2. Saltiel AR, Kahn CR; ''Insulin signalling and the regulation of glucose and lipid metabolism.''; Nature, 2001 PubMed Europe PMC Scholia
  3. Quon MJ, Campfield LA; ''A mathematical model and computer simulation study of insulin sensitive glucose transporter regulation.''; J Theor Biol, 1991 PubMed Europe PMC Scholia
  4. Saxton RA, Sabatini DM; ''mTOR Signaling in Growth, Metabolism, and Disease.''; Cell, 2017 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116789view09:59, 14 May 2021EweitzModified title
96431view13:59, 14 March 2018Tristanvanderlindenadded a literature reference
96430view13:56, 14 March 2018TristanvanderlindenRaptor was added to the mTORC1
95774view14:28, 19 January 2018MkutmonHomology conversion update
69418view19:02, 8 July 2013MaintBotUpdated to 2013 gpml schema
67394view10:47, 26 June 2013Christine ChichesterOntology Term : 'insulin signaling pathway' added !
47777view05:44, 6 April 2012Khanspersupdated xref
41741view02:40, 2 March 2011MaintBotRemoved redundant pathway information and comments
34114view19:24, 9 December 2009MaintBotAutomatic update of empty xrefs
32431view17:13, 15 August 2009MaintBotFixed text labels
32099view13:44, 14 August 2009MaintBotFixed group labels
31451view21:11, 13 August 2009MaintBotFixed text labels
30915view00:32, 30 July 2009MaintBotConverted from Homo sapiens
21604view11:32, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:Insulin Signaling]] moved to [[Pathway:WP439]]: Moved to stable identifier
8216view13:46, 7 January 2008MaintBot[[Pathway:Rat:Insulin Signaling]] moved to [[Pathway:Rattus norvegicus:Insulin Signaling]]: Renaming species
7728view16:13, 18 December 2007MaintBotfixed category names
7267view12:41, 4 November 2007MaintBotAdded categories to GPML
19497view22:20, 22 May 2007BruceConklingpml file for [[Rat:Insulin_Signaling]]
6568view22:20, 22 May 2007Nsalomonisgpml file for [[Rat:Insulin_Signaling]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Akt1GeneProduct24185 (Entrez Gene)
Akt2GeneProduct25233 (Entrez Gene)
Arf1GeneProduct64310 (Entrez Gene)
Arf6GeneProduct79121 (Entrez Gene)
Cap1GeneProduct64185 (Entrez Gene)
CblGeneProduct500985 (Entrez Gene)
CblbGeneProduct171136 (Entrez Gene)
CblcGeneProduct292699 (Entrez Gene)
CrkGeneProduct54245 (Entrez Gene)
Cyth3GeneProduct116693 (Entrez Gene)
Egr1GeneProduct24330 (Entrez Gene)
Ehd1GeneProduct293692 (Entrez Gene)
Ehd2GeneProduct361512 (Entrez Gene)
Eif4eGeneProduct117045 (Entrez Gene)
Eif4ebp1GeneProduct116636 (Entrez Gene)
Elk1GeneProduct314436 (Entrez Gene)
Enpp1GeneProduct85496 (Entrez Gene)
Flot1GeneProduct64665 (Entrez Gene)
Flot2GeneProduct83764 (Entrez Gene)
FosGeneProduct314322 (Entrez Gene)
Foxo1GeneProduct84482 (Entrez Gene)
Foxo3GeneProduct294515 (Entrez Gene)
Gab1GeneProduct361388 (Entrez Gene)
Grb10GeneProduct498416 (Entrez Gene)
Grb14GeneProduct58844 (Entrez Gene)
Grb2GeneProduct81504 (Entrez Gene)
Gsk3aGeneProduct50686 (Entrez Gene)
Gsk3bGeneProduct84027 (Entrez Gene)
Gstt2GeneProduct29487 (Entrez Gene)
Gyg1GeneProduct81675 (Entrez Gene)
Gys1GeneProduct690987 (Entrez Gene)
Gys2GeneProduct25623 (Entrez Gene)
HrasGeneProduct293621 (Entrez Gene)
IRS4GeneProduct315350 (Entrez Gene)
Igf1rGeneProduct25718 (Entrez Gene)
IkbkbGeneProduct84351 (Entrez Gene)
Inpp4aGeneProduct80849 (Entrez Gene)
Inppl1GeneProduct65038 (Entrez Gene)
InsrGeneProduct24954 (Entrez Gene)
Irs1GeneProduct25467 (Entrez Gene)
Irs2GeneProduct29376 (Entrez Gene)
JunGeneProduct24516 (Entrez Gene)
Kif3aGeneProduct84392 (Entrez Gene)
Kif5bGeneProduct117550 (Entrez Gene)
LOC303259GeneProduct303259 (Entrez Gene)
LOC303823GeneProduct303823 (Entrez Gene)
LipeGeneProduct25330 (Entrez Gene)
MAP3K5GeneProduct293015 (Entrez Gene)
MAP4K4GeneProduct301363 (Entrez Gene)
MAPK7GeneProduct114509 (Entrez Gene)
Map2k1GeneProduct170851 (Entrez Gene)
Map2k2GeneProduct58960 (Entrez Gene)
Map2k3GeneProduct303200 (Entrez Gene)
Map2k4GeneProduct287398 (Entrez Gene)
Map2k5GeneProduct29568 (Entrez Gene)
Map2k6GeneProduct114495 (Entrez Gene)
Map2k7GeneProduct363855 (Entrez Gene)
Map3k10GeneProduct308463 (Entrez Gene)
Map3k1GeneProduct116667 (Entrez Gene)
Map3k11GeneProduct309168 (Entrez Gene)
Map3k12GeneProduct25579 (Entrez Gene)
Map3k14GeneProduct360640 (Entrez Gene)
Map3k2GeneProduct171492 (Entrez Gene)
Map3k3GeneProduct303604 (Entrez Gene)
Map3k4GeneProduct308106 (Entrez Gene)
Map3k6GeneProduct313022 (Entrez Gene)
Map3k7GeneProduct313121 (Entrez Gene)
Map3k8GeneProduct116596 (Entrez Gene)
Map3k9GeneProduct500690 (Entrez Gene)
Map4k1GeneProduct292763 (Entrez Gene)
Map4k2GeneProduct293694 (Entrez Gene)
Map4k3GeneProduct170920 (Entrez Gene)
Map4k5GeneProduct503027 (Entrez Gene)
Mapk10GeneProduct25272 (Entrez Gene)
Mapk1GeneProduct116590 (Entrez Gene)
Mapk11GeneProduct689314 (Entrez Gene)
Mapk12GeneProduct60352 (Entrez Gene)
Mapk13GeneProduct29513 (Entrez Gene)
Mapk14GeneProduct81649 (Entrez Gene)
Mapk3GeneProduct50689 (Entrez Gene)
Mapk4GeneProduct54268 (Entrez Gene)
Mapk6GeneProduct58840 (Entrez Gene)
Mapk8GeneProduct116554 (Entrez Gene)
Mapk9GeneProduct50658 (Entrez Gene)
MtorGeneProduct56718 (Entrez Gene)
Myo1cGeneProduct65261 (Entrez Gene)
PIK3CAGeneProduct170911 (Entrez Gene)
Pdpk1GeneProduct81745 (Entrez Gene)
PfklGeneProduct25741 (Entrez Gene)
PfkmGeneProduct65152 (Entrez Gene)
Pik3c2aGeneProduct361632 (Entrez Gene)
Pik3c2gGeneProduct116720 (Entrez Gene)
Pik3c3GeneProduct65052 (Entrez Gene)
Pik3cbGeneProduct85243 (Entrez Gene)
Pik3cdGeneProduct366508 (Entrez Gene)
Pik3cgGeneProduct298947 (Entrez Gene)
Pik3r1GeneProduct25513 (Entrez Gene)
Pik3r2GeneProduct29741 (Entrez Gene)
Pik3r3GeneProduct60664 (Entrez Gene)
Pik3r4GeneProduct363131 (Entrez Gene)
Ppp1r3aGeneProduct500036 (Entrez Gene)
Prkaa1GeneProduct65248 (Entrez Gene)
Prkaa2GeneProduct78975 (Entrez Gene)
PrkcaGeneProduct24680 (Entrez Gene)
PrkcbGeneProduct25023 (Entrez Gene)
PrkcdGeneProduct170538 (Entrez Gene)
PrkchGeneProduct81749 (Entrez Gene)
PrkciGeneProduct84006 (Entrez Gene)
PrkcqGeneProduct85420 (Entrez Gene)
PrkczGeneProduct25522 (Entrez Gene)
PtenGeneProduct50557 (Entrez Gene)
Ptpn11GeneProduct25622 (Entrez Gene)
Ptpn1GeneProduct24697 (Entrez Gene)
PtprfGeneProduct360406 (Entrez Gene)
RAPGEF1GeneProduct63881 (Entrez Gene)
RHEBGeneProduct26954 (Entrez Gene)
RPS6KA4GeneProduct
RPS6KB2GeneProduct361696 (Entrez Gene)
Rab4aGeneProduct25532 (Entrez Gene)
Rac1GeneProduct363875 (Entrez Gene)
Rac2GeneProduct366957 (Entrez Gene)
Raf1GeneProduct24703 (Entrez Gene)
RhojGeneProduct299145 (Entrez Gene)
RhoqGeneProduct85428 (Entrez Gene)
Rps6ka1GeneProduct81771 (Entrez Gene)
Rps6ka2GeneProduct117269 (Entrez Gene)
Rps6ka3GeneProduct501560 (Entrez Gene)
Rps6ka5GeneProduct314384 (Entrez Gene)
Rps6ka6GeneProduct317203 (Entrez Gene)
Rps6kb1GeneProduct83840 (Entrez Gene)
RradGeneProduct83521 (Entrez Gene)
SGKLGeneProduct
SNX26GeneProduct361540 (Entrez Gene)
SOS2GeneProduct85384 (Entrez Gene)
Sgk1GeneProduct29517 (Entrez Gene)
Sgk2GeneProduct171497 (Entrez Gene)
Sh2b2GeneProduct114203 (Entrez Gene)
Shc1GeneProduct85385 (Entrez Gene)
Shc2GeneProduct314612 (Entrez Gene)
Shc3GeneProduct114858 (Entrez Gene)
Slc2a1GeneProduct24778 (Entrez Gene)
Slc2a4GeneProduct25139 (Entrez Gene)
Snap23GeneProduct64630 (Entrez Gene)
Snap25GeneProduct25012 (Entrez Gene)
Socs1GeneProduct252971 (Entrez Gene)
Socs3GeneProduct89829 (Entrez Gene)
Sorbs1GeneProduct686098 (Entrez Gene)
Sos1GeneProduct313845 (Entrez Gene)
SrfGeneProduct501099 (Entrez Gene)
Stx4GeneProduct81803 (Entrez Gene)
Stxbp1GeneProduct25558 (Entrez Gene)
Stxbp2GeneProduct81804 (Entrez Gene)
Stxbp3GeneProduct114095 (Entrez Gene)
Stxbp4GeneProduct303443 (Entrez Gene)
TBC1D4GeneProduct
Trib3GeneProduct246273 (Entrez Gene)
Tsc1GeneProduct60445 (Entrez Gene)
Tsc2GeneProduct24855 (Entrez Gene)
Vamp2GeneProduct24803 (Entrez Gene)
Xbp1GeneProduct289754 (Entrez Gene)

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP439"