Proteoglycan biosynthesis (Homo sapiens)

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45, 9-11, 13...158, 122, 73, 153, 1511563, 153, 155, 9-11, 13...615PG Core ProteinGlcUA-Gal-Gal-Xyl-proteinExtracellular spaceSulfation ofproteoglycanSulfur-containing amino acid metabolismNewly synthesizedproteoglycannGolgi apparatusChondroitin sulfateCytoplasmGlycosylated proteoglycanProteoglycan core synthesized inRough Endoplasmic Reticulum14CSGALNACT1CHST14PAPSS2XYLT1SLC35B2XYLT2EXTL3B3GALT6EXT1Phosphoadenosine phosphatePO4(.2-)SLC35B3Sulfate ion (SO42-)B3GAT3Udp xyloseB4GALT7Udp galactosePAPSSLC26A2EXT2CHST3ADENOSINE MONOPHOSPHATEIMPAD1XyloseUMPCANT1D-glucuronic acidgalactoseUDPuridine diphosphateglucuronic acidN-AcetylgalactosaminechlorideCHSY1Sulfate ion (SO42-)chloridePAPSgalactoseUdp galactoseGlcUA-Gal-Gal-Xyl-proteinN-AcetylgalactosamineGlcUA-Gal-Gal-Xyl-proteinN-acetylglucosaminesD-glucuronic acidD-glucuronic acidL-Iduronic acidN-AcetylgalactosamineN-AcetylgalactosamineN-acetylglucosaminesNewly synthesizedproteoglycanDermatan sulfateHeparan sulfatennOMIM:600972Achondrogenesis, Type IBOMIM:256050Atelosteogenesis, Type IIOMIM:615777Desbuquois Dysplasia 2OMIM:605822Spondyloocular SyndromeOMIM:612847Brachyolmia Type 4 With Mild Epiphyseal And Metaphyseal ChangesOMIM:150230Trichorhinophalangeal Syndrome, Type IIOMIM:614078Chondrodysplasia With Joint Dislocations, gPAPP TypeOMIM:222600Diastrophic DysplasiaOMIM:143095Spondyloepiphyseal Dysplasia With Congenital Joint DislocationsOMIM:130070Ehlers-Danlos Syndrome, Spondylodysplastic Type, 1OMIM:605282Temtamy Preaxial Brachydactyly SyndromeOMIM:616615CSGALNACT1 deficiency (joint dislocations and mild skeletal dysplasia)OMIM:226900Epiphyseal Dysplasia, Multiple, 4OMIM:133700Exostoses, Multiple, Type IOMIM:617719Epiphyseal Dysplasia, Multiple, 7OMIM:271640Spondyloepimetaphyseal Dysplasia With Joint Laxity, Type 1, With Or Without FracturesOMIM:251450Desbuquois Dysplasia 1OMIM:245600Multiple Joint Dislocations, Short Stature, And Craniofacial Dysmorphism With Or Without Congenital Heart DefectsOMIM:601776Ehlers-Danlos Syndrome, Musculocontractural Type, 1OMIM:617425Immunoskeletal Dysplasia With Neurodevelopmental Abnormalities


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Bibliography

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  1. Kamiyama S, Sasaki N, Goda E, Ui-Tei K, Saigo K, Narimatsu H, Jigami Y, Kannagi R, Irimura T, Nishihara S; ''Molecular cloning and characterization of a novel 3'-phosphoadenosine 5'-phosphosulfate transporter, PAPST2.''; J Biol Chem, 2006 PubMed Europe PMC Scholia
  2. Kitagawa H, Izumikawa T, Uyama T, Sugahara K; ''Molecular cloning of a chondroitin polymerizing factor that cooperates with chondroitin synthase for chondroitin polymerization.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  3. Paganini C, Costantini R, Superti-Furga A, Rossi A; ''Bone and connective tissue disorders caused by defects in glycosaminoglycan biosynthesis: a panoramic view.''; FEBS J, 2019 PubMed Europe PMC Scholia
  4. Hästbacka J, Kaitila I, Sistonen P, de la Chapelle A; ''Diastrophic dysplasia gene maps to the distal long arm of chromosome 5.''; Proc Natl Acad Sci U S A, 1990 PubMed Europe PMC Scholia
  5. Vynios DH; ''Metabolism of cartilage proteoglycans inhealth and disease.''; Biomed Res Int, 2014 PubMed Europe PMC Scholia
  6. Sato T, Gotoh M, Kiyohara K, Akashima T, Iwasaki H, Kameyama A, Mochizuki H, Yada T, Inaba N, Togayachi A, Kudo T, Asada M, Watanabe H, Imamura T, Kimata K, Narimatsu H; ''Differential roles of two N-acetylgalactosaminyltransferases, CSGalNAcT-1, and a novel enzyme, CSGalNAcT-2. Initiation and elongation in synthesis of chondroitin sulfate.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  7. Kamiyama S, Suda T, Ueda R, Suzuki M, Okubo R, Kikuchi N, Chiba Y, Goto S, Toyoda H, Saigo K, Watanabe M, Narimatsu H, Jigami Y, Nishihara S; ''Molecular cloning and identification of 3'-phosphoadenosine 5'-phosphosulfate transporter.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  8. Prydz K; ''Determinants of Glycosaminoglycan (GAG)Structure.''; Biomolecules, 2015 PubMed Europe PMC Scholia
  9. Izumikawa T, Uyama T, Okuura Y, Sugahara K, Kitagawa H; ''Involvement of chondroitin sulfate synthase-3 (chondroitin synthase-2) in chondroitin polymerization through its interaction with chondroitin synthase-1 or chondroitin-polymerizing factor.''; Biochem J, 2007 PubMed Europe PMC Scholia
  10. Mihov D, Spiess M; ''Glycosaminoglycans: Sorting determinants in intracellular protein traffic.''; Int J Biochem Cell Biol, 2015 PubMed Europe PMC Scholia
  11. Mizumoto S, Yamada S, Sugahara K; ''Mutations in Biosynthetic Enzymes for the Protein Linker Region of Chondroitin/Dermatan/Heparan Sulfate Cause Skeletal and Skin Dysplasias.''; Biomed Res Int, 2015 PubMed Europe PMC Scholia
  12. Mizumoto S, Yamada S, Sugahara K; ''Human genetic disorders and knockout mice deficient in glycosaminoglycan.''; Biomed Res Int, 2014 PubMed Europe PMC Scholia
  13. Kitagawa H, Uyama T, Sugahara K; ''Molecular cloning and expression of a human chondroitin synthase.''; J Biol Chem, 2001 PubMed Europe PMC Scholia
  14. Uyama T, Kitagawa H, Tamura Ji J, Sugahara K; ''Molecular cloning and expression of human chondroitin N-acetylgalactosaminyltransferase: the key enzyme for chain initiation and elongation of chondroitin/dermatan sulfate on the protein linkage region tetrasaccharide shared by heparin/heparan sulfate.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  15. Frederick JP, Tafari AT, Wu SM, Megosh LC, Chiou ST, Irving RP, York JD; ''A role for a lithium-inhibited Golgi nucleotidase in skeletal development and sulfation.''; Proc Natl Acad Sci U S A, 2008 PubMed Europe PMC Scholia
  16. Izumikawa T, Koike T, Shiozawa S, Sugahara K, Tamura J, Kitagawa H; ''Identification of chondroitin sulfate glucuronyltransferase as chondroitin synthase-3 involved in chondroitin polymerization: chondroitin polymerization is achieved by multiple enzyme complexes consisting of chondroitin synthase family members.''; J Biol Chem, 2008 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
128877view00:01, 24 February 2024EweitzStandardize case
128876view23:55, 23 February 2024EweitzSoften disease color
128875view23:46, 23 February 2024EweitzOntology Term : 'trichorhinophalangeal syndrome type I' added !
128874view23:44, 23 February 2024EweitzOntology Term : 'hereditary multiple exostoses' added !
128873view23:43, 23 February 2024EweitzOntology Term : 'brachyolmia' added !
128872view23:42, 23 February 2024EweitzOntology Term : 'diastrophic dysplasia' added !
128871view23:41, 23 February 2024EweitzOntology Term : 'multiple epiphyseal dysplasia 4' added !
128870view23:40, 23 February 2024EweitzOntology Term : 'atelosteogenesis' added !
128869view23:40, 23 February 2024EweitzOntology Term : 'achondrogenesis type IB' added !
128868view23:39, 23 February 2024EweitzOntology Term : 'multiple epiphyseal dysplasia 7' added !
128867view23:39, 23 February 2024EweitzOntology Term : 'Desbuquois dysplasia' added !
128866view22:49, 23 February 2024EweitzModified description
111633view02:45, 1 September 2020AzanklModified description
110986view14:55, 25 June 2020EgonwConverted three mim-conversions to Arrow (they're translocations)
110015view18:37, 12 April 2020EgonwReplaced secondary ChEBI identifiers with a primary identifiers.
109334view23:36, 13 March 2020KhanspersOntology Term : 'classic metabolic pathway' added !
108790view01:08, 30 January 2020RleeModified description
108789view01:06, 30 January 2020RleeNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADENOSINE MONOPHOSPHATEMetaboliteCHEBI:16027 (ChEBI)
B3GALT6GeneProductENSG00000176022 (Ensembl)
B3GAT3GeneProductENSG00000149541 (Ensembl)
B4GALT7GeneProductENSG00000027847 (Ensembl)
CANT1GeneProductENSG00000171302 (Ensembl)
CHST14GeneProductENSG00000169105 (Ensembl)
CHST3GeneProductENSG00000122863 (Ensembl)
CHSY1GeneProductENSG00000131873 (Ensembl)
CSGALNACT1GeneProductENSG00000147408 (Ensembl)
D-glucuronic acidMetaboliteCHEBI:4178 (ChEBI)
EXT1GeneProductENSG00000182197 (Ensembl)
EXT2GeneProductENSG00000151348 (Ensembl)
EXTL3GeneProductENSG00000012232 (Ensembl)
IMPAD1GeneProductENSG00000104331 (Ensembl)
L-Iduronic acidMetaboliteCHEBI:24769 (ChEBI)
N-AcetylgalactosamineMetaboliteCHEBI:7201 (ChEBI)
N-acetylglucosaminesMetaboliteCHEBI:59640 (ChEBI)
PAPSMetaboliteCHEBI:1353 (ChEBI)
PAPSS2GeneProductENSG00000198682 (Ensembl)
PO4(.2-)MetaboliteCHEBI:29932 (ChEBI)
Phosphoadenosine phosphateMetaboliteCHEBI:2475 (ChEBI)
SLC26A2GeneProductENSG00000155850 (Ensembl)
SLC35B2GeneProductENSG00000157593 (Ensembl)
SLC35B3GeneProductENSG00000124786 (Ensembl)
Sulfate ion (SO42-)MetaboliteCHEBI:16189 (ChEBI)
UDPMetaboliteCHEBI:9802 (ChEBI)
UMPMetaboliteCHEBI:9849 (ChEBI)
Udp galactoseMetaboliteCHEBI:18307 (ChEBI)
Udp xyloseMetaboliteCHEBI:16082 (ChEBI)
XYLT1GeneProductENSG00000103489 (Ensembl)
XYLT2GeneProductENSG00000015532 (Ensembl)
XyloseMetaboliteCHEBI:10085 (ChEBI)
chlorideMetaboliteCHEBI:13970 (ChEBI)
galactoseMetaboliteCHEBI:28260 (ChEBI)
uridine diphosphate glucuronic acidMetaboliteCHEBI:17200 (ChEBI)

Annotated Interactions

No annotated interactions

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